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    Calcium Acid Phosphate

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: 7757-93-9, Calcium phosphate dibasic, Dicalcium phosphate, Calcium phosphate, dibasic, Dibasic calcium phosphate, Phosphoric acid, calcium salt (1:1)
    Molecular Formula
    CaHO4P
    Molecular Weight
    136.06  g/mol
    InChI Key
    FUFJGUQYACFECW-UHFFFAOYSA-L
    FDA UNII
    L11K75P92J
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium;hydrogen phosphate
    2.1.2 InChI
    InChI=1S/Ca.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2
    2.1.3 InChI Key
    FUFJGUQYACFECW-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    OP(=O)([O-])[O-].[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    L11K75P92J
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Anhydrous Dibasic Calcium Phosphate

    2. Calcium Phosphate (cahpo4)

    3. Calcium Phosphate, Dibasic, Anhydrous

    4. Dibasic Calcium Phosphate, Anhydrous

    5. Monetite

    2.3.2 Depositor-Supplied Synonyms

    1. 7757-93-9

    2. Calcium Phosphate Dibasic

    3. Dicalcium Phosphate

    4. Calcium Phosphate, Dibasic

    5. Dibasic Calcium Phosphate

    6. Phosphoric Acid, Calcium Salt (1:1)

    7. Secondary Calcium Phosphate

    8. Calcium Phosphate (1:1)

    9. Dicalcium Orthophosphate

    10. Calcium Hydrogen Orthophosphate

    11. Monocalcium Acid Phosphate

    12. Dicalcium Phosphate Anhydrous

    13. Calcium Monohydrogen Phosphate

    14. Calciumphosphate,dibasic

    15. Calcium Phosphate Dibasic Anhydrous

    16. Anhydrous Dibasic Calcium Phosphate

    17. Calcium Phosphate,dibasic

    18. Mfcd00010909

    19. Calcium Phosphate (dibasic)

    20. Chebi:32596

    21. Ins-341(ii)

    22. L11k75p92j

    23. Calcium Phosphate, Dibasic, Anhydrous

    24. E-341(ii)

    25. Biofos

    26. Fujicalin S

    27. Dicafos An

    28. 7557-93-9

    29. Anhydrous Emcompress

    30. Ipifosc 20

    31. A-tab

    32. D-glucopyranosiduronicacid, 1-(2,4-dichlorophenyl)ethyl

    33. Calcium Acid Phosphate

    34. Calcium Dibasic Phosphate

    35. Calcium Secondary Phosphate

    36. Calcium Phosphate (cahpo4)

    37. Monohydrogen Calcium Phosphate

    38. Ccris 1337

    39. Hsdb 992

    40. Cahpo4

    41. Calcium Phosphate, Dibasic [jan]

    42. Einecs 231-826-1

    43. Calcium Hydrogenorthophosphate

    44. Calcium Phosphate, Dibasic, Dental Grade

    45. Unii-l11k75p92j

    46. Calstar (tn)

    47. Calcium Monohydrogen Phosphate Anhydrous

    48. Calcii Hydrogenophosphas

    49. Calcium;hydrogen Phosphate

    50. Ec 231-826-1

    51. Calcium Monohydrogenphosphate

    52. Dicalcium Phosphate, Anhydrous

    53. Calcium (as Phosphate,dibasic)

    54. Ins No.341(ii)

    55. Chembl2107567

    56. Dtxsid20872529

    57. Dicalcium Phosphate [inci]

    58. Phosphoric Acid Calcium Salt

    59. Calcium Hydrogen Monophosphate

    60. Calcium Hydrogen Phosphate, Anhydrous

    61. Akos015965054

    62. Calcium Hydrogenorthophosphate Anhydrous

    63. Calcium Phosphate, Dibasic [mi]

    64. Calcium Phosphate,dibasic [vandf]

    65. Calcium Hydrogenorthophosphate, With A Fluorine Content Of Less Than 0,005 Per Cent By Weight On The Dry Anhydrous Product

    66. Calcium Phosphate, Dibasic [hsdb]

    67. Dibasic Calcium Phosphate Anhydrous

    68. Calcium Hydrogen Phosphate Anhydrous

    69. Calcium Phosphate Dibasic [who-dd]

    70. Calcium Phosphate, Dibasic (99.95%-ca)

    71. Phosphorus (as Dicalcium Phosphate)

    72. Calcium Phosphate (1:1) [who-ip]

    73. Calcium Phosphate Dibasic, 98.0-105.0%

    74. Calcium Phosphate, Dibasic Anhydrous

    75. Dibasic Calcium Phosphate, Anhydrous (jan)

    76. Calcium Phosphate Dibasic, Puriss., 98.0%

    77. Ft-0623397

    78. Calcium (calcium Phosphate (dibasic))

    79. Calcium Hydrogen Phosphate (anhydrous)

    80. Calcii Hydrogenophosphas [who-ip Latin]

    81. Calcium (as Phosphate,dibasic) [vandf]

    82. D03302

    83. Anhydrous Dibasic Calcium Phosphate [jan]

    84. Calcium Hydrogen Phosphate [ep Monograph]

    85. Calcium Phosphate Dibasic Anhydrous, Usp Fcc Pe

    86. Calcium Phosphate Dibasic, Usp, 98.0-103.0%

    87. Calcium Phosphate, Dibasic, Anhydrous [ii]

    88. Q414619

    89. Phosphorus (as Dicalcium Phosphate) [vandf]

    90. Calcium Hydrogen Phosphate, Anhydrous [who-ip]

    91. Anhydrous Dibasic Calcium Phosphate [usp Monograph]

    92. Dibasic Calcium Phosphate, Meets Usp Testing Specifications

    93. Phosphorus (as Calcium Phosphate,dibasic) [vandf]

    94. Calcium Phosphate Dibasic, Puriss. P.a., Anhydrous, >98.5% (kt)

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 136.06 g/mol
    Molecular Formula CaHO4P
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass135.9238364 g/mol
    Monoisotopic Mass135.9238364 g/mol
    Topological Polar Surface Area83.4 Ų
    Heavy Atom Count6
    Formal Charge0
    Complexity46.5
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    USES--EXCELLENT SOURCE OF CALCIUM & PHOSPHORUS DURING PREGNANCY, LACTATION, OR MILD TO MODERATE HYPOCALCEMIA CHARACTERIZED BY LOW DEGREE OF TETANY. ... IF TETANY IS SEVERE, IV CALCIUM MEDICATION IS ADMIN. ... DOSE--1 TO 5 G/DAY IN 2 OR MORE DIVIDED DOSES.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 770

    IT IS NOT MARKETED IN SINGLE ENTITY FORM, SO THAT DOSE OF OTHER INGREDIENTS MAY HAVE TO BE CONSIDERED IN ARRIVING @ SUITABLE SCHEDULE. CALCIUM IS BETTER ABSORBED IF TAKEN IN SMALL DOSES @ FREQUENT INTERVALS.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 770

    MEDICATION (VET): FOR PREVENTION & TREATMENT OF RICKETS ALONG WITH VITAMIN D THERAPY, & AS NUTRIENT SOURCE OF CALCIUM & PHOSPHORUS IN FEEDSTUFFS. ... OPTIMUM CALCIUM:PHOSPHORUS RATIO IN DIET MUST ALSO BE MAINTAINED.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 71

    DIBASIC CALCIUM PHOSPHATE, NATIONAL FORMULARY ... /IS AMONG CMPD/ CLASSIFIED AS NONSYSTEMIC GASTRIC ANTACIDS, BUT THEIR EFFICACY IS LOW & THEY ARE SELDOM EMPLOYED.

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 967

    Medication (VET): Has been used as a dietary supplement, and as an antacid.

    Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 256

    4.2 Drug Warning

    BECAUSE OF PHOSPHATE CONTENT, IT IS CONTRAINDICATED IN /PERSONS WITH/ HYPOPARATHYROIDISM.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 770

    5 Pharmacology and Biochemistry
    5.1 Absorption, Distribution and Excretion

    ... ITS ELEMENTS ARE SLOWLY ABSORBED FROM SMALL INTESTINE.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 71