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    Chemistry

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    Also known as: Aragonite, 471-34-1, Limestone, Calcite, Chalk, Carbonic acid calcium salt (1:1)
    Molecular Formula
    CCaO3
    Molecular Weight
    100.09  g/mol
    InChI Key
    VTYYLEPIZMXCLO-UHFFFAOYSA-L
    FDA UNII
    H0G9379FGK
    Calcium Carbonate
    Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
    1 2D Structure

    Calcium Carbonate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium;carbonate
    2.1.2 InChI
    InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
    2.1.3 InChI Key
    VTYYLEPIZMXCLO-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    C(=O)([O-])[O-].[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    H0G9379FGK
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aragonite

    2. Calcite

    3. Calcium Milk

    4. Carbonate, Calcium

    5. Chalk

    6. Limestone

    7. Marble

    8. Milk Of Calcium

    9. Vaterite

    2.3.2 Depositor-Supplied Synonyms

    1. Aragonite

    2. 471-34-1

    3. Limestone

    4. Calcite

    5. Chalk

    6. Carbonic Acid Calcium Salt (1:1)

    7. Aeromatt

    8. Calciumcarbonate

    9. Calcium Carbonate (1:1)

    10. Calofort U

    11. Calcite (ca(co3))

    12. Precipitated Calcium Carbonate

    13. 1317-65-3

    14. Marble Dust

    15. Caco3

    16. Calciumcarbonat

    17. Glauberitum

    18. Kalziumkarbonat

    19. Calcitum

    20. Calcium Carbonate Slurry

    21. Hydrolyzed Pearl

    22. Calcium Carbonate, Powder

    23. Ci 77220

    24. Han Shui Shi

    25. Kohlensaurer Kalk

    26. Limestone, Ground

    27. Carbonato De Calcio

    28. Chalk, Precipitated

    29. Carbonate De Calcium

    30. Phx Cal-carb Buffer

    31. Calcium (as Carbonate)

    32. Calcium Trioxidocarbonate

    33. Calcium Carbonate [usp]

    34. Carbonate (calcium)

    35. Marble

    36. Precpitated Calcium Carbonate

    37. Kalkspar

    38. Calcium (as Calcium Carbonate)

    39. Chebi:3311

    40. H0g9379fgk

    41. Ins No.170(i)

    42. Ins-170(i)

    43. Mfcd00010906

    44. Akadama

    45. Albacar

    46. Albafil

    47. Albaglos

    48. Atomite

    49. Calcicoll

    50. Calibrite

    51. Calmote

    52. Calseeds

    53. Calwhite

    54. Carbium

    55. Chemcarb

    56. Clefnon

    57. Duramite

    58. E-170(i)

    59. Hydrocarb

    60. Kotamite

    61. Microcarb

    62. Micromya

    63. Neoanticid

    64. Atomit

    65. Calmos

    66. Caltec

    67. Dacote

    68. Marfil

    69. Levigated Chalk

    70. Allied Whiting

    71. Tums

    72. Marble White

    73. Calcium Carbonate (usp)

    74. Camel-carb

    75. Camel-wite

    76. Camel-tex

    77. Britomya M

    78. Britomya S

    79. Calofort S

    80. Calofort T

    81. Calopake F

    82. Calopake H

    83. Hakuenka O

    84. Multiflex Mm

    85. Multiflex Sc

    86. Albaglos Sf

    87. Calopake Fs

    88. Calopake Pc

    89. Carusis P

    90. Garolite Sa

    91. Gilder's Whiting

    92. Hakuenka Cc

    93. Hakuenka Dd

    94. Hakuenka Px

    95. Hakuenka Pz

    96. Homocal D

    97. Multifex Mm

    98. Neolite F

    99. Calcene Co

    100. Calcene Nc

    101. Calcene Tm

    102. Carbium Mm

    103. Hakuenka Ccr

    104. Neolite Sp

    105. Crystic Prefil S

    106. Neolite Tps

    107. Calcilit 8

    108. Carborex 2

    109. Cal-sup

    110. Microwhite 25

    111. R Jutan

    112. Calcium Carbonate Nanopowder

    113. Hakuenka T-dd

    114. Brilliant 15

    115. Filtex White Base

    116. Hydrocarb 60

    117. Hydrocarb 65

    118. Marblewhite 325

    119. Cal-light Sa

    120. Calcidar 40

    121. Carbital 90

    122. Durcal 2nh

    123. Non-fer-al

    124. Ccc G-white

    125. Kredafil Rm 5

    126. Brilliant Br 15

    127. Calofil A 4

    128. Calofil B 1

    129. Calofil E 2

    130. C.i. Pigment White 18

    131. Calcilit 100

    132. Hakuenka R 06

    133. Micromic Cr 16

    134. Calcium Monocarbonate

    135. Durcal 10

    136. Durcal 40

    137. Monocalcium Carbonate

    138. Brilliant 1500

    139. Calofor U 50

    140. Calopake High Opacity

    141. Ccc No.aa Oolitic

    142. Eskalon 100

    143. Eskalon 200

    144. Eskalon 400

    145. Eskalon 800

    146. Finncarb 6002

    147. C 50 (carbonate)

    148. Kredafil 150 Extra

    149. Albacar 5970

    150. Caswell No. 139

    151. Eskalon 1500

    152. Msk-po

    153. Msk-c

    154. Msk-g

    155. Msk-k

    156. Msk-p

    157. Msk-v

    158. Ncc-p

    159. Slaker Rejects

    160. Mylanta Soothing Lozenges

    161. Natural Calcium Carbonate

    162. Oyster Shell

    163. Ground Limestone

    164. Mc-t

    165. Calcium, Reference Standard Solution

    166. Durcal C 640305

    167. P-lite 500

    168. P-lite 700

    169. Di-gel Tablets

    170. Carbonic Acid Calcium Salt

    171. Precipitated Chalk

    172. Egri M 5

    173. Pigment White 18

    174. Kulu 40

    175. Calcium Carbonate, Precipitated

    176. Brt 30

    177. Ccris 1333

    178. Hsdb 927

    179. Ncc 45

    180. Tylenol Headache Plus

    181. Bs 32

    182. Vaterite (ca(co3))

    183. Brt 1500

    184. Carbonic Acid, Calcium Salt (1:1)

    185. Einecs 207-439-9

    186. Ax 363

    187. Bf 200

    188. Ks 500

    189. Ns 100

    190. Ns 200

    191. Ns 400

    192. Epa Pesticide Chemical Code 073502

    193. Ks 1300

    194. Ks 1500

    195. Ks 1800

    196. Ks 2100

    197. Ns 2500

    198. Unii-h0g9379fgk

    199. N 34

    200. N 43

    201. Caltan

    202. Calcii Carbonas

    203. Kalk

    204. Chalk Powder

    205. Coral Calcium

    206. Marble Chips

    207. Carbonate Calcium

    208. C.i. 77220

    209. K 250

    210. Calcium Carb Onate

    211. Copper Nickel Foil

    212. Marble, Cp

    213. T 130-2500

    214. Cal-sup (tn)

    215. Calcium(ii) Carbonate

    216. Calcium Carbonate, Cp

    217. Calcium Carbonate,(s)

    218. Acid Controller Complete

    219. Calcite [inci]

    220. Calcium Carbonate (as)

    221. Chalk [inci]

    222. Chalk [who-dd]

    223. Ec 207-439-9

    224. Schembl3261

    225. Calcium Carbonate Dispersion

    226. Calcium Carbonate Granular Dc

    227. Calcium Carbonate Precipitated

    228. Ca (c O3)

    229. Calcium Carbonate [ii]

    230. Calcium Carbonate [mi]

    231. Calcium Carbonate Nanoparticles

    232. Ndi 443 [fdms]

    233. Calcium Carbonate [fcc]

    234. Calcium Carbonate Microparticles

    235. Hydrolyzed Pearl [inci]

    236. Calcium Carbonate [hsdb]

    237. Calcium Carbonate [inci]

    238. Chembl1200539

    239. Dtxsid3036238

    240. Limestone, Ground [fcc]

    241. Calcium Carbonate [vandf]

    242. Ndi 443

    243. Calcium Carbonate [mart.]

    244. Calcium Carbonate, Reagentplus(r)

    245. Calcium Carbonate,puratronic Powder

    246. Ci 77220 [inci]

    247. Calcium Carbonate [usp-rs]

    248. Calcium Carbonate [who-dd]

    249. Calcium Carbonate [who-ip]

    250. Calcium Carbonate, Ar, >=98.5%

    251. Calcium Carbonate, Lr, >=98.5%

    252. Akos015903256

    253. Calcium Carbonate, Precipitated (jan)

    254. Calcii Carbonas [who-ip Latin]

    255. Calcium Carbonate [orange Book]

    256. Calcium Carbonate, Chelometric Standard

    257. Children's Mylanta Upset Stomach Relief

    258. Db06724

    259. Precipitated Calcium Carbonate (jp17)

    260. Calcium (as Carbonate) [vandf]

    261. Calcium Carbonate [ep Monograph]

    262. Calcium Carbonate, Bioxtra, >=99.0%

    263. Calcium Carbonate, Monocalcium Carbonate

    264. Calcium Carbonate [usp Monograph]

    265. 13701-58-1

    266. Calcium Carbonate, Powder A.c.s. Reagent

    267. E170

    268. Precpitated Calcium Carbonate [jan]

    269. Calcium Carbonate, Puriss. P.a., >=99%

    270. Calcium Carbonate, Usp, 98.0-100.5%

    271. Calcium Carbonate, Nist(r) Srm(r) 915b

    272. E 170

    273. Ft-0623383

    274. Calcium Carbonate (99.999%-ca) Puratrem

    275. C08129

    276. Calcium (as Calcium Carbonate) [vandf]

    277. Calcium Carbonate, Saj First Grade, >=98.0%

    278. Calcium Carbonate, Tested According To Ph.eur.

    279. D00932

    280. Q23767

    281. Calcium Carbonate, 99.999% Trace Metals Basis

    282. Calcium Carbonate, Jis Special Grade, >=99.5%

    283. Calcium Carbonate, P.a., 99.0%, Acs Reagent

    284. Calcium Carbonate Dc (spray Dried) [ndi]

    285. Calcium Carbonate, >=99.995% Trace Metals Basis

    286. Calcium Carbonate, Vetec(tm) Reagent Grade, 99%

    287. Pepcid Complete Component Calcium Carbonate

    288. Calcium Carbonate, Acs Reagent, >=99.0%, Powder

    289. Calcium Carbonate Component Of Pepcid Complete

    290. Calcium Carbonate, Bioultra, Precipitated, >=99.0% (kt)

    291. Calcium Carbonate, Powder, <=30 Mum Particle Size, 98%

    292. Calcium Carbonate, Primary Reference Standard, 99.95-100.05%

    293. Nbs 18 (carbon Isotopes In Carbonatite), Nist(r) Rm 8543

    294. Calcium Carbonate, Trace Metals Grade 99.99% Trace Metals Basis

    295. Calcium Carbonate (as), United States Pharmacopeia (usp) Reference Standard

    296. Calcium Carbonate, Bioreagent, Suitable For Insect Cell Culture, >=99.0%

    297. Calcium, Ion Chromatography Standard Solution, Specpure?, Ca2+ 1000?g/ml

    298. Calcium Carbonate, Acs Reagent, Chelometric Standard, 99.95-100.05% Dry Basis

    299. Calcium Carbonate, Anhydrous, Free-flowing, Redi-dri(tm), Acs Reagent, >=99%

    300. Calcium Carbonate, Anhydrous, Free-flowing, Redi-dri(tm), Reagentplus(r), >=99%

    301. Calcium Carbonate, Pharmaceutical Secondary Standard; Certified Reference Material

    302. Calcium Carbonate, Certified Reference Material For Titrimetry, Certified By Bam, According To Iso 17025, >=99.5%

    303. Calcium Carbonate, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, Fcc, E170, Precipitated, 98.5-100.5% (based On Anhydrous Substance)

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 100.09 g/mol
    Molecular Formula CCaO3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count0
    Exact Mass99.9473347 g/mol
    Monoisotopic Mass99.9473347 g/mol
    Topological Polar Surface Area63.2 Ų
    Heavy Atom Count5
    Formal Charge0
    Complexity18.8
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Mesh Heading: Antacids

    National Library of Medicine, SIS; ChemIDplus Record for Calcium Carbonate (471-34-1).>> Available from, as of April 17, 2006: https://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

    /EXPL THER/ The aim of the present study was to test the hypothesis that a fibrin matrix enhances the osteogenic differentiation and expression of vascular endothelial growth factor (VEGF) by human bone marrow stromal cells (hBMSCs) seeded into mineralised scaffolds. Porous calcium carbonate scaffolds were droplet seeded with hBMSCs using a matrix containing 3 % fibrinogen and cultured for 3 weeks. Seeded scaffolds without the fibrin matrix served as controls. The scaffolds were evaluated, using undecalcified thick sections, for fluorescence staining for nuclei, osteocalcin (OC) and VEGF. The sections were systematically scanned using optical sectioning and three dimensional distributions of cells and positive staining indicating expression of OC and VEGF were reconstructed from the z-stacks. The fibrin matrix maintained a significantly higher level of cell numbers after 2 d and 1 week and delayed the onset of osteogenic differentiation while sustaining a significantly higher level of OC and VEGF expression after 2 and 3 weeks, starting from the periphery of the scaffolds. There was a decrease in cell density from the periphery to the centre of the scaffolds in both groups. The percentage of cells expressing OC and VEGF was significantly different between the centre and the periphery of the scaffolds in the fibrin(+) group but not in the controls. It is concluded that the fibrin matrix used appears to be a useful adjunct for supporting and sustaining osteogenic and angiogenic activity of hBMSCs in tissue engineered constructs. This could help to improve their performance in a clinical setting.

    PMID:22665163 Lohse N et al; Eur Cell Mater. 23: 413-23 (2012)

    /EXPL THER/ Thirty coral-derived calcium carbonate-based macroporous constructs with limited hydrothermal conversion to hydroxyapatite (7% HA/CC) were implanted in the rectus abdominis of three adult non-human primate Papio ursinus to investigate the intrinsic induction of bone formation. Macroporous constructs with 125 ug human recombinant osteogenic protein-1 (hOP-1) or 125 ug human recombinant transforming growth factor-beta(3) (hTGF-beta(3)) were also implanted. The potential synergistic interaction between morphogens was tested by implanting binary applications of hOP-1 and hTGF-beta(3) 5:1 by weight, respectively. To evaluate the role of osteoclastic activity on the implanted macroporous surfaces, coral-derived constructs were pre-loaded with 0.24 mg of bisphosphonate zoledronate (Zometa). To correlate the morphology of tissue induction with osteogenic gene expression and activation, harvested specimens on day 90 were analyzed for changes in OP-1 and TGF-beta(3) mRNA synthesis by quantitative real-time polymerase chain reaction (qRT-PCR). The induction of bone formation in 7% HA/CC solo correlated with OP-1 expression. Massive bone induction formed by binary applications of the recombinant morphogens. Single applications of hOP-1 and hTGF-beta(3) also resulted in substantial bone formation, not comparable however to synergistic binary applications. Zoledronate-treated macroporous constructs showed limited bone formation and in two specimens bone formation was altogether absent; qRT-PCR showed a prominent reduction of OP-1 gene expression whilst TGF-beta(3) expression was far greater than OP-1. The lack of bone formation by zoledronate-treated specimens indicates that osteoclastic activity on the implanted coral-derived constructs is critical for the spontaneous induction of bone formation. Indirectly, zoledronate-treated samples showing lack of OP-1 gene expression and absent or very limited bone formation by induction confirm that the spontaneous induction of bone formation by coral-derived macroporous constructs is initiated by secreted BMPs/OPs, in context the OP-1 isoform.

    PMID:20493522 Ripamonti U et al; Biomaterials. 31 (25): 6400-10 (2010)

    /EXPL THER/ Calcium is an essential cotherapy in osteoporosis treatment. The relative effectiveness of various calcium salts for this purpose is uncertain. Many older women with osteoporosis have phosphorus intakes of <70% of the Recommended Dietary Allowance. /The study's/ objective was to test the hypothesis that calcium phosphate would better support anabolic bone building than would calcium carbonate. This study was a 12-mo, randomized, positive-comparator, 2-arm, single-blind clinical trial in 211 patients treated with teriparatide who consumed <1000 mg phosphorus/d. Participants were randomly assigned to receive, in addition to teriparatide and 1000 IU cholecalciferol, 1800 mg calcium/d as either tricalcium phosphate or calcium carbonate. The primary endpoints were changes in lumbar spine and total hip bone mineral densities (BMDs); secondary endpoints were changes in bone resorption biomarkers and serum and urine calcium and phosphorus concentrations. In the combined group, the lumbar spine BMD increased by 7.2%, and total hip BMD increased by 2.1% (P < 0.01 for both). However, there was no significant difference between calcium-treatment groups, and there were no significant between-group differences in serum calcium and phosphorus concentrations or in urine calcium concentrations. Bone resorption biomarkers increased in both groups, as expected with teriparatide, but the increases in the 2 calcium groups did not differ significantly.Tricalcium phosphate and calcium carbonate appear to be approximately equally effective in supporting bone building with a potent anabolic agent; phosphate salt may be preferable in patients with restricted phosphorus intakes.

    PMID:20484446 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884321 Heaney RP et al; Am J Clin Nutr. 92 (1): 101-5 (2010)

    For more Therapeutic Uses (Complete) data for CALCIUM CARBONATE (20 total), please visit the HSDB record page.

    4.2 Drug Warning

    Large doses of calcium carbonate (above 2 g) increase gastric secretion for a period of time that considerably outlasts elevation of pH. ... With single doses below 2 g, this effect is negligible.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 733

    After ingestion /of CaCO3 tablets/, it is converted to sol calcium salts in bowel, and calcium is thereby made available for absorption. Patients with achlorhydria may not solubilize calcium from ... preparation.

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1528

    Gastric hypersecretory action is counter productive and may possibly account for various reports that calcium carbonate is less efficacious than other antacids. Calcium carbonate has been known to cause fecal concretions.

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 993

    Constipating effects and chalky taste of calcium carbonate are clinically disadvantageous.

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 993

    For more Drug Warnings (Complete) data for CALCIUM CARBONATE (23 total), please visit the HSDB record page.

    4.3 Drug Indication

    For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.

    5.2 MeSH Pharmacological Classification

    Antacids

    Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT. (See all compounds classified as Antacids.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Calcium [CS]; Cations, Divalent [CS]; Increased Coagulation Factor Activity [PE]; Blood Coagulation Factor [EPC]
    5.4 ATC Code

    A - Alimentary tract and metabolism

    A02 - Drugs for acid related disorders

    A02A - Antacids

    A02AC - Calcium compounds

    A02AC01 - Calcium carbonate

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12A - Calcium

    A12AA - Calcium

    A12AA04 - Calcium carbonate

    5.5 Absorption, Distribution and Excretion

    Absorption

    Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.

    Route of Elimination

    Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.

    Volume of Distribution

    Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.

    Calcium absorption is best when a person consumes no more than 500 mg at one time. So a person who takes 1,000 mg/day of calcium from supplements, for example, should split the dose rather than take it all at once.

    NIH Office of Dietary Supplements. Dietary Supplement Fact Sheet for Calcium. Available from, as of August 26, 2013: https://ods.od.nih.gov/factsheets/Calcium-QuickFacts/

    Amount of calcium absorbed from calcium carbonate is usually stated to be 10%, but ... depends upon amount of gastric acid; in 1 study, 0-2% of single 2 g dose was ... absorbed in achlorhydric persons, 9-16% in normal subjects, and 11-37% in patients with peptic ulcer ...

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 992

    Fraction absorbed seems to be nearly the same when CaCO3 is given chronically in daily doses of 20 g /as when it is given in single 2 g dose/. ... Amount absorbed probably reaches a plateau at a dose of about 20 g.

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 992

    ... Increased calcium excretion almost always follows admin of antacid doses of calcium carbonate ...

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 992

    For more Absorption, Distribution and Excretion (Complete) data for CALCIUM CARBONATE (15 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    None.

    After ingestion /of CaCO3 tablets/, it is converted to sol calcium salts in stomach, and calcium is thereby made available for absorption.

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1528

    5.7 Mechanism of Action

    Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).

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CHEMICALS ","supplierCountry":"GERMANY","foreign_port":"NA","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"549.6","totalValueFC":"55866.3","currency":"INR","unitRateINR":"573.9","date":"21-Jun-2023","totalValueINR":"4591999.965","totalValueInUsd":"55866.3","indian_port":"JNPT","hs_no":"29096000","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"2106 \/ 5 BRIJWASI INDUSTRIAL ESTAT E,GROUND FLOOR I B PATEL ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1699900200,"product":"PERKADOX 14-40B-GR-S DI(TERT-BUTYLPEROXYISOPROPYL) BENZENEPOWDER 40% ON CALCIUM CARBONATE AND SILICA CARRIER","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON FUNCTIONAL CHEMICALS ","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"443","totalValueFC":"43856.9","currency":"INR","unitRateINR":"456.5","date":"14-Nov-2023","totalValueINR":"3652000","totalValueInUsd":"43856.9","indian_port":"JNPT","hs_no":"29096000","bill_no":"8762171","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"HAAKSBERGWEG 88 1101 BZAMSTERDAM POBOX 873621080 JJ AMSTERDAMSDNF NETHERLANDS","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709231400,"product":"PERKADOX BC-40BD-PD (DICUMYL PEROXIDE, POWDER 40% WITH CALCIUM CARBONATE AND SILICA)","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON CHEMICALS LLC","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"1.7","totalValueFC":"15193.4","currency":"USD","unitRateINR":"157.7","date":"01-Mar-2024","totalValueINR":"1261600","totalValueInUsd":"15193.4","indian_port":"JNPT","hs_no":"29096000","bill_no":"2380240","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.1801 MID-HAITIAN ROAD, XIEPUTOWN,ZHENHAI DISTRICT 315204,NINGBO CITY, CHINA CHINA","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709922600,"product":"PERKADOX 14-40B-GR-S DI(TERT-BUTYLPEROXYISOPROPYL) BENZENEPOWDER 40% ON CALCIUM CARBONATE AND SILICA CARRIER","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON FUNCTIONAL CHEMICALS ","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"443","totalValueFC":"43981","currency":"INR","unitRateINR":"456.5","date":"09-Mar-2024","totalValueINR":"3652000","totalValueInUsd":"43981","indian_port":"JNPT","hs_no":"29096000","bill_no":"2503926","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"HAAKSBERGWEG 88 1101 BZAMSTERDAM POBOX 873621080 JJ AMSTERDAMSDNF NETHERLANDS","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1712946600,"product":"PERKADOX BC-40BD-PD (DICUMYL PEROXIDE, POWDER 40% WITH CALCIUM CARBONATE AND SILICA)","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON CHEMICALS LLC","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"1.7","totalValueFC":"15107.7","currency":"USD","unitRateINR":"157.7","date":"13-Apr-2024","totalValueINR":"1261600","totalValueInUsd":"15107.7","indian_port":"JNPT","hs_no":"29096000","bill_no":"3003490","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.1801 MID-HAITIAN ROAD, XIEPUTOWN,ZHENHAI DISTRICT 315204,NINGBO CITY, CHINA CHINA","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713465000,"product":"COLINK DCP-40BPD (DICUMYL PEROXIDE 40% ON CALCIUM CARBONATE)","address":"3, VITHAL CHAMBERS, 1ST FLOOR,","city":"MUMBAI. MAHARASHTRA","supplier":"COSMOS CHEMICAL MATERIALS ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"B P CHEMICALS","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"2.6","totalValueFC":"2627.8","currency":"USD","unitRateINR":"219.4","date":"19-Apr-2024","totalValueINR":"219440","totalValueInUsd":"2627.8","indian_port":"JNPT","hs_no":"29096000","bill_no":"3095259","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"4F-2, NO 8 RUEIGUANG RD, TAIPEI114SDNFSDNF TAIWAN","customerAddress":"3, VITHAL CHAMBERS, 1ST FLOOR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714156200,"product":"PERKADOX BC-40BD-PD (DICUMYL PEROXIDE, POWDER 40% WITH CALCIUM CARBONATE AND SILICA)","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON CHEMICALS LLC","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"1.7","totalValueFC":"17493.1","currency":"USD","unitRateINR":"182.6","date":"27-Apr-2024","totalValueINR":"1460800","totalValueInUsd":"17493.1","indian_port":"JNPT","hs_no":"29096000","bill_no":"3224051","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.1801 MID-HAITIAN ROAD, XIEPUTOWN,ZHENHAI DISTRICT 315204,NINGBO CITY, CHINA CHINA","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720636200,"product":"PERKADOX BC-40BD-PD (DICUMYL PEROXIDE, POWDER 40% WITH CALCIUM CARBONATE AND SILICA)","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON CHEMICALS LLC","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"1.7","totalValueFC":"17475.6","currency":"USD","unitRateINR":"182.6","date":"11-Jul-2024","totalValueINR":"1460800","totalValueInUsd":"17475.6","indian_port":"JNPT","hs_no":"29096000","bill_no":"4439221","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.1801 MID-HAITIAN ROAD, XIEPUTOWN,ZHENHAI DISTRICT 315204,NINGBO CITY, CHINA CHINA","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721500200,"product":"COLINK DCP-40BPD (DICUMYL PEROXIDE 40% ON CALCIUM CARBONATE)","address":"3, VITHAL CHAMBERS, 1ST FLOOR,","city":"MUMBAI. MAHARASHTRA","supplier":"COSMOS CHEMICAL MATERIALS ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"B P CHEMICALS","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"2.7","totalValueFC":"2731","currency":"USD","unitRateINR":"228.3","date":"21-Jul-2024","totalValueINR":"228285","totalValueInUsd":"2731","indian_port":"JNPT","hs_no":"29096000","bill_no":"4627329","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"4F-2, NO 8 RUEIGUANG RD, TAIPEI114SDNFSDNF TAIWAN","customerAddress":"3, VITHAL CHAMBERS, 1ST FLOOR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722623400,"product":"PERKADOX 14-40BD-PD DI(TERT-BUTYLPEROXYISOPROPYL) BENZENE POWDER 40% ON CALCIUM CARBONATE AND SILICA CARRIER","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON CHEMICALS LLC","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"4.1","totalValueFC":"41164.3","currency":"USD","unitRateINR":"431.6","date":"03-Aug-2024","totalValueINR":"3452800","totalValueInUsd":"41164.3","indian_port":"JNPT","hs_no":"29096000","bill_no":"4866656","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.1801 MID-HAITIAN ROAD, XIEPUTOWN,ZHENHAI DISTRICT 315204,NINGBO CITY, CHINA CHINA","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723833000,"product":"PERKADOX 14-40B-GR-S DI(TERT-BUTYLPEROXYISOPROPYL) BENZENEPOWDER 40% ON CALCIUM CARBONATE AND SILICA CARRIER","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON FUNCTIONAL CHEMICALS ","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"4000.00","actualQuantity":"4000","unit":"KGS","unitRateFc":"4.1","totalValueFC":"20582.1","currency":"EUR","unitRateINR":"431.6","date":"17-Aug-2024","totalValueINR":"1726400","totalValueInUsd":"20582.1","indian_port":"JNPT","hs_no":"29096000","bill_no":"5099838","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"HAAKSBERGWEG 88 1101 BZAMSTERDAM POBOX 873621080 JJ AMSTERDAMSDNF NETHERLANDS","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724005800,"product":"FARIDA BIPB- 40A BIS[1-(TERT-BUTYLPEROXY)-1-METHYLETHYL]BENZENE 40% WITH CALCIUM CARBONATE AND SILICA","address":"3, VITHAL CHAMBERS, 1ST FLOOR,","city":"MUMBAI. MAHARASHTRA","supplier":"HUNAN FARIDA TECHNOLOGY CO LTD","supplierCountry":"CHINA","foreign_port":"SHEKOU","customer":"B P CHEMICALS","customerCountry":"INDIA","quantity":"4000.00","actualQuantity":"4000","unit":"KGS","unitRateFc":"6.6","totalValueFC":"26705.8","currency":"USD","unitRateINR":"560","date":"19-Aug-2024","totalValueINR":"2240040","totalValueInUsd":"26705.8","indian_port":"JNPT","hs_no":"29096000","bill_no":"5132658","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHEKOU","supplierAddress":"RM 401-1 NO 8 KEHUI 1STHUANGPU DISTRICTGUANGXHOUSDNF CHINA","customerAddress":"3, VITHAL CHAMBERS, 1ST FLOOR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726252200,"product":"PERKADOX 14-40B-GR-S DI(TERT-BUTYLPEROXYISOPROPYL) BENZENEPOWDER 40% ON CALCIUM CARBONATE AND SILICA CARRIER","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON FUNCTIONAL CHEMICALS ","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"4.1","totalValueFC":"43579.3","currency":"EUR","unitRateINR":"456.5","date":"14-Sep-2024","totalValueINR":"3652000","totalValueInUsd":"43579.3","indian_port":"JNPT","hs_no":"29096000","bill_no":"5607599","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"HAAKSBERGWEG 88 1101 BZAMSTERDAM PO BOX 873621080 JJ AMSTERDAM SDNF NETHERLANDS","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727461800,"product":"PERKADOX BC-40BD-PD (DICUMYL PEROXIDE, POWDER 40% WITH CALCIUM CARBONATE AND SILICA)","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON CHEMICALS LLC","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"1.7","totalValueFC":"18233.6","currency":"USD","unitRateINR":"191","date":"28-Sep-2024","totalValueINR":"1528000","totalValueInUsd":"18233.6","indian_port":"JNPT","hs_no":"29096000","bill_no":"5862018","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.1801 MID-HAITIAN ROAD, XIEPUTOWN ,ZHENHAI DISTRICT 315204,NINGBO CIT Y, CHINA CHINA","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729535400,"product":"CALCIUM CARBONATE HEAVY 10165","address":"ADCOCK INGRAM PHARMA PRIVATE LIMITED","city":"BANGALORE","supplier":"ADCOCK INGRAM","supplierCountry":"SOUTH AFRICA","foreign_port":"DURBAN","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"65.5","totalValueFC":"95.5","currency":"ZAR","unitRateINR":"321","date":"22-Oct-2024","totalValueINR":"8023.75","totalValueInUsd":"95.5","indian_port":"Bangalore Air","hs_no":"29339990","bill_no":"6256628","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"DURBAN","supplierAddress":"1 NEW ROAD MIDRAND, 1685 SDNF SOUTH AFRICA","customerAddress":"ADCOCK INGRAM PHARMA PRIVATE LIMITED"}]
    16-Feb-2021
    22-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    Fillers, Diluents & Binders

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    01

    Rochem International Inc

    U.S.A
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    Suppliers Night Expo
    Attending
    • fda
    • EDQM
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    Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

    Brand Name : Xylitol

    Application : Chewable & Orodispersible Aids, Coating Systems & Additives, Fillers, Diluents & Binders

    Excipient Details : Xylitol is used as filler, binder & a coating agent in various oral dosage forms in both pharmaceutical and nutraceutical applications.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Xylitol Excipient

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    Xylitol

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    02

    Rochem International Inc

    U.S.A
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    Suppliers Night Expo
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

    Brand Name : Gum Arabic

    Application : API Stability Enhancers, Emulsifying Agents, Fillers, Diluents & Binders

    Excipient Details : Acacia, also known as gum arabic, is used in the pharmaceutical industry as an emulsifier, stabilizing agent, & tablet binder in various formulations.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Gum Arabic

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    Gum Arabic

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    03

    Rochem International Inc

    U.S.A
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    Suppliers Night Expo
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

    Dosage Form : Tablet

    Grade : Oral

    Category : Fillers, Diluents & Binders, Taste Masking

    Brand Name : Mannitol

    Application : Fillers, Diluents & Binders, Taste Masking

    Excipient Details : Mannitol is used as a filler, bulking agent and taste masking agent in ODT formulations such as tablets.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Mannitol

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    Mannitol

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    04

    SPI Pharma

    U.S.A
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    AES 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothSPI Pharma has been solving formulation challenges using superior functional materials.

    Brand Name : Pharmaburst 500

    Application : Chewable & Orodispersible Aids, Direct Compression, Fillers, Diluents & Binders, Taste Masking

    Excipient Details : Pharmaburst® 500 is a directly compressible pharmaceutical excipient used to create orally disintegrating tablets quickly and easily.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Mannitol

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    Pharmaburst 500

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    05

    SPI Pharma

    U.S.A
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    AES 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothSPI Pharma has been solving formulation challenges using superior functional materials.

    Dosage Form : Tablet

    Grade : Oral

    Category : Direct Compression, Fillers, Diluents & Binders, Taste Masking

    Brand Name : Mannogem® XL Opal

    Application : Direct Compression, Fillers, Diluents & Binders, Taste Masking

    Excipient Details : Mannogem® XL Opal, directly compressible 160 µm spray-dried mannitol provides superior binding properties and tabletability.

    Pharmacopoeia Ref : NA

    Technical Specs : 160 µm Powder Mannitol

    Ingredient(s) : Mannitol

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    SPI Pharma Mannogem® XL Opal

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    06

    DKSH

    Switzerland
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    AES 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothDKSH is your trusted partner for companies looking to grow their business in Asia & beyond.

    Dosage Form : Capsule, Granule / Pellet, Tablet

    Grade : Oral

    Category : Fillers, Diluents & Binders

    Brand Name : CALCITEC PURO PH V/40S HT

    Application : Fillers, Diluents & Binders

    Excipient Details : Calcitec Puro PHV/40S HT is used as filler and binder in oral solid dosage forms including tablets, capsules, granules, and pellets.

    Pharmacopoeia Ref : N/A

    Technical Specs : N/A

    Ingredient(s) : Calcium Carbonate Excipient

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    CALCITEC PURO PH V/40S HT

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    07

    Faran Shimi Pharmaceutical

    Iran
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    AES 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothFaran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

    Dosage Form : Tablet

    Grade : Oral

    Category : Fillers, Diluents & Binders

    Brand Name : Lactose Monohydrate

    Application : Fillers, Diluents & Binders

    Excipient Details : Lactose monohydrate is widely used as a filler and diluent in solid dosage forms such as tablets.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Lactose Monohydrate

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    Lactose Monohydrate

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    08

    Faran Shimi Pharmaceutical

    Iran
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    AES 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothFaran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

    Dosage Form : Tablet

    Grade : Oral

    Category : Co-Processed Excipients

    Brand Name : Mannitol

    Application : Co-Processed Excipients

    Excipient Details : Mannitol is a co-processed excipient with superior compactibility, lower disintegration time, and hygroscopicity.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Mannitol

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    Mannitol

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    09

    Faran Shimi Pharmaceutical

    Iran
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    AES 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothFaran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

    Dosage Form : Tablet

    Grade : Oral

    Category : Fillers, Diluents & Binders

    Brand Name : Pregelatinized Corn Starch

    Application : Fillers, Diluents & Binders

    Excipient Details : Corn starch is used as a filler and binder in pharmaceutical oral solid dosage forms, including tablets.

    Pharmacopoeia Ref : BP/USP

    Technical Specs : NA

    Ingredient(s) : Corn Starch, Pregelatinized

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    Pregelatinized Corn Starch

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    10

    Faran Shimi Pharmaceutical

    Iran
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    AES 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothFaran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

    Dosage Form : Tablet

    Grade : Oral

    Category : Fillers, Diluents & Binders

    Brand Name : Polyvinylpyrrolidone

    Application : Fillers, Diluents & Binders

    Excipient Details : Polyvinylpyrrolidone is used as a low viscosity wet binder in solid dosage forms such as tablets.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Polyvinylpyrrolidone

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    Polyvinylpyrrolidone

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