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    Also known as: 813-94-5, Tricalcium dicitrate, Tricalcium citrate, Acicontral, Calcitrate, Calcium citrate, tribasic
    Molecular Formula
    C12H10Ca3O14
    Molecular Weight
    498.4  g/mol
    InChI Key
    FNAQSUUGMSOBHW-UHFFFAOYSA-H
    FDA UNII
    86117BWO7P
    Calcium Citrate
    A colorless crystalline or white powdery organic, tricarboxylic acid occurring in plants, especially citrus fruits, and used as a flavoring agent, as an antioxidant in foods, and as a sequestrating agent. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
    1 2D Structure

    Calcium Citrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    tricalcium;2-hydroxypropane-1,2,3-tricarboxylate
    2.1.2 InChI
    InChI=1S/2C6H8O7.3Ca/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6
    2.1.3 InChI Key
    FNAQSUUGMSOBHW-UHFFFAOYSA-H
    2.1.4 Canonical SMILES
    C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Ca+2].[Ca+2].[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    86117BWO7P
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Calcium Citrates

    2. Citrate, Calcium

    3. Citrates, Calcium

    2.3.2 Depositor-Supplied Synonyms

    1. 813-94-5

    2. Tricalcium Dicitrate

    3. Tricalcium Citrate

    4. Acicontral

    5. Calcitrate

    6. Calcium Citrate, Tribasic

    7. Calcium Citrate Anhydrous

    8. Calcium 2-hydroxy-1,2,3-propanetricarboxylate (3:2)

    9. Tricalcium Citrate Tetrahydrate

    10. Ins No.333(iii)

    11. Ins-333(iii)

    12. 2-hydroxy-1,2,3-propanetricarboxylic Acid Calcium Salt (2:3)

    13. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Calcium Salt (2:3)

    14. 86117bwo7p

    15. E-333(iii)

    16. Tricalcium;2-hydroxypropane-1,2,3-tricarboxylate

    17. Calcimax

    18. Citrical

    19. Calcium (as Citrate)

    20. Calcium 2-hydroxypropane-1,2,3-tricarboxylate (3:2)

    21. Tribasic Calcium Citrate

    22. Calcium Citrate [usan]

    23. 7693-13-2

    24. Hsdb 5756

    25. Citric Acid, Calcium Salt (2:3)

    26. Einecs 212-391-7

    27. Calciumcitrate

    28. Unii-86117bwo7p

    29. Lime Citrate

    30. Calcium Citrate Powder

    31. Calcium Citrate Tribasic

    32. Calcium Citrate, Anhydrous

    33. Ec 212-391-7

    34. Calcium Citrate Usp, Fcc

    35. Tricalcium Bis(citric Acid)

    36. Calcium Citrate [mi]

    37. Calcium Citrate [hsdb]

    38. Chembl2106123

    39. Dtxsid7061148

    40. Calcium Citrate [who-dd]

    41. Citric Acid Calcium Salt (2:3)

    42. Chebi:190513

    43. Mfcd00078618

    44. Akos015839590

    45. Db11093

    46. Calcium Citrate Malate Glycinate 21% 40m

    47. Q420280

    48. Calcium Citrate Malate Carbonate 23%, Coarse Granu

    49. J-509604

    50. Calcium 2-hydroxypropane-1,2,3-tricarboxylate (3/2)

    51. Tricalcium Bis(2-hydroxypropane-1,2,3-tricarboxylic Acid)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 498.4 g/mol
    Molecular Formula C12H10Ca3O14
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count4
    Exact Mass497.8948275 g/mol
    Monoisotopic Mass497.8948275 g/mol
    Topological Polar Surface Area281 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity211
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count5
    4 Drug and Medication Information
    4.1 Drug Indication

    For use as an over the counter calcium supplement.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Increases plasma calcium levels leading to a decrease in calcium flux and increase in calcium deposition into bone

    5.2 MeSH Pharmacological Classification

    Food Additives

    Substances used in the processing or storage of foods or animal feed including ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS; EXCIPIENTS and other similarly used substances. Many of the same substances are used as PHARMACEUTIC AIDS. (See all compounds classified as Food Additives.)

    5.3 ATC Code

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12A - Calcium

    A12AA - Calcium

    A12AA13 - Calcium citrate

    5.4 Absorption, Distribution and Excretion

    Absorption

    The percentage of calcium absorbed varies inversely with intake. Tmax of about 3.5-5h varying with formulation.

    Route of Elimination

    Cleared via the kidneys but largely reabsorbed (98-99%) under normal conditions.

    5.5 Mechanism of Action

    Calcium citrate increases plasma calcium levels. This reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.

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","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"NESTLE INDIA LIMITED","customerCountry":"INDIA","quantity":"16000.00","actualQuantity":"16000","unit":"KGS","unitRateFc":"4.5","totalValueFC":"77842.7","currency":"USD","unitRateINR":"406.3","date":"22-Apr-2024","totalValueINR":"6500436.16","totalValueInUsd":"77842.7","indian_port":"JNPT","hs_no":"29181590","bill_no":"3145735","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"Add: NO. 209, LAIY ANG ROAD ,JUXIAN ECONOMIC DEVELOPMENT ZONE,RIZHAO CITY, SHANDONG PROVINCE CHINA","customerAddress":"M-5A CONNUGHT CIRCUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719513000,"product":"TRICALCIUM CITRATE TETRAHYDRATE USP\/JSFA\/FCC\/E333 BELOW 10UMMESH (NON MEDICINAL USE, RAW MATERIAL)","address":"M-5A CONNUGHT CIRCUS","city":"NEW DELHI","supplier":"RZBC JUXIAN CO. ","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"NESTLE INDIA LIMITED","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"4.5","totalValueFC":"41160.9","currency":"USD","unitRateINR":"429.5","date":"28-Jun-2024","totalValueINR":"3436090.89","totalValueInUsd":"41160.9","indian_port":"JNPT","hs_no":"29181590","bill_no":"4223614","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"Add: NO. 209, LAIY ANG ROAD ,JUXIAN ECONOMIC DEVELOPMENT ZONE,RIZHAO CITY, SHANDONG PROVINCE CHINA","customerAddress":"M-5A CONNUGHT CIRCUS"}]
    05-Feb-2021
    20-Dec-2024
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    ABOUT THIS PAGE

    Calcium Citrate Manufacturers

    A Calcium Citrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Calcium Citrate, including repackagers and relabelers. The FDA regulates Calcium Citrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Calcium Citrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Calcium Citrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Calcium Citrate Suppliers

    A Calcium Citrate supplier is an individual or a company that provides Calcium Citrate active pharmaceutical ingredient (API) or Calcium Citrate finished formulations upon request. The Calcium Citrate suppliers may include Calcium Citrate API manufacturers, exporters, distributors and traders.

    click here to find a list of Calcium Citrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Calcium Citrate USDMF

    A Calcium Citrate DMF (Drug Master File) is a document detailing the whole manufacturing process of Calcium Citrate active pharmaceutical ingredient (API) in detail. Different forms of Calcium Citrate DMFs exist exist since differing nations have different regulations, such as Calcium Citrate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Calcium Citrate DMF submitted to regulatory agencies in the US is known as a USDMF. Calcium Citrate USDMF includes data on Calcium Citrate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Calcium Citrate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Calcium Citrate suppliers with USDMF on PharmaCompass.

    Calcium Citrate WC

    A Calcium Citrate written confirmation (Calcium Citrate WC) is an official document issued by a regulatory agency to a Calcium Citrate manufacturer, verifying that the manufacturing facility of a Calcium Citrate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Calcium Citrate APIs or Calcium Citrate finished pharmaceutical products to another nation, regulatory agencies frequently require a Calcium Citrate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Calcium Citrate suppliers with Written Confirmation (WC) on PharmaCompass.

    Calcium Citrate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Calcium Citrate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Calcium Citrate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Calcium Citrate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Calcium Citrate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Calcium Citrate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Calcium Citrate suppliers with NDC on PharmaCompass.

    Calcium Citrate GMP

    Calcium Citrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Calcium Citrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Calcium Citrate GMP manufacturer or Calcium Citrate GMP API supplier for your needs.

    Calcium Citrate CoA

    A Calcium Citrate CoA (Certificate of Analysis) is a formal document that attests to Calcium Citrate's compliance with Calcium Citrate specifications and serves as a tool for batch-level quality control.

    Calcium Citrate CoA mostly includes findings from lab analyses of a specific batch. For each Calcium Citrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Calcium Citrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Calcium Citrate EP), Calcium Citrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Calcium Citrate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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