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    Finished Dosage Form (FDF) export of Calcium Citrate obtained from Indian Custom Trade Statistics

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    Chemistry

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    Also known as: 813-94-5, Tricalcium dicitrate, Tricalcium citrate, Acicontral, Calcitrate, Calcium citrate, tribasic
    Molecular Formula
    C12H10Ca3O14
    Molecular Weight
    498.4  g/mol
    InChI Key
    FNAQSUUGMSOBHW-UHFFFAOYSA-H
    FDA UNII
    86117BWO7P
    Calcium Citrate
    A colorless crystalline or white powdery organic, tricarboxylic acid occurring in plants, especially citrus fruits, and used as a flavoring agent, as an antioxidant in foods, and as a sequestrating agent. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
    1 2D Structure

    Calcium Citrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    tricalcium;2-hydroxypropane-1,2,3-tricarboxylate
    2.1.2 InChI
    InChI=1S/2C6H8O7.3Ca/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6
    2.1.3 InChI Key
    FNAQSUUGMSOBHW-UHFFFAOYSA-H
    2.1.4 Canonical SMILES
    C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Ca+2].[Ca+2].[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    86117BWO7P
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Calcium Citrates

    2. Citrate, Calcium

    3. Citrates, Calcium

    2.3.2 Depositor-Supplied Synonyms

    1. 813-94-5

    2. Tricalcium Dicitrate

    3. Tricalcium Citrate

    4. Acicontral

    5. Calcitrate

    6. Calcium Citrate, Tribasic

    7. Calcium Citrate Anhydrous

    8. Calcium 2-hydroxy-1,2,3-propanetricarboxylate (3:2)

    9. Tricalcium Citrate Tetrahydrate

    10. Ins No.333(iii)

    11. Ins-333(iii)

    12. 2-hydroxy-1,2,3-propanetricarboxylic Acid Calcium Salt (2:3)

    13. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Calcium Salt (2:3)

    14. 86117bwo7p

    15. E-333(iii)

    16. Tricalcium;2-hydroxypropane-1,2,3-tricarboxylate

    17. Calcimax

    18. Citrical

    19. Calcium (as Citrate)

    20. Calcium 2-hydroxypropane-1,2,3-tricarboxylate (3:2)

    21. Tribasic Calcium Citrate

    22. Calcium Citrate [usan]

    23. 7693-13-2

    24. Hsdb 5756

    25. Citric Acid, Calcium Salt (2:3)

    26. Einecs 212-391-7

    27. Calciumcitrate

    28. Unii-86117bwo7p

    29. Lime Citrate

    30. Calcium Citrate Powder

    31. Calcium Citrate Tribasic

    32. Calcium Citrate, Anhydrous

    33. Ec 212-391-7

    34. Calcium Citrate Usp, Fcc

    35. Tricalcium Bis(citric Acid)

    36. Calcium Citrate [mi]

    37. Calcium Citrate [hsdb]

    38. Chembl2106123

    39. Dtxsid7061148

    40. Calcium Citrate [who-dd]

    41. Citric Acid Calcium Salt (2:3)

    42. Chebi:190513

    43. Mfcd00078618

    44. Akos015839590

    45. Db11093

    46. Calcium Citrate Malate Glycinate 21% 40m

    47. Q420280

    48. Calcium Citrate Malate Carbonate 23%, Coarse Granu

    49. J-509604

    50. Calcium 2-hydroxypropane-1,2,3-tricarboxylate (3/2)

    51. Tricalcium Bis(2-hydroxypropane-1,2,3-tricarboxylic Acid)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 498.4 g/mol
    Molecular Formula C12H10Ca3O14
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count4
    Exact Mass497.8948275 g/mol
    Monoisotopic Mass497.8948275 g/mol
    Topological Polar Surface Area281 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity211
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count5
    4 Drug and Medication Information
    4.1 Drug Indication

    For use as an over the counter calcium supplement.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Increases plasma calcium levels leading to a decrease in calcium flux and increase in calcium deposition into bone

    5.2 MeSH Pharmacological Classification

    Food Additives

    Substances used in the processing or storage of foods or animal feed including ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS; EXCIPIENTS and other similarly used substances. Many of the same substances are used as PHARMACEUTIC AIDS. (See all compounds classified as Food Additives.)

    5.3 ATC Code

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12A - Calcium

    A12AA - Calcium

    A12AA13 - Calcium citrate

    5.4 Absorption, Distribution and Excretion

    Absorption

    The percentage of calcium absorbed varies inversely with intake. Tmax of about 3.5-5h varying with formulation.

    Route of Elimination

    Cleared via the kidneys but largely reabsorbed (98-99%) under normal conditions.

    5.5 Mechanism of Action

    Calcium citrate increases plasma calcium levels. This reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.

    API Reference Price

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","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"NESTLE INDIA LIMITED","customerCountry":"INDIA","quantity":"16000.00","actualQuantity":"16000","unit":"KGS","unitRateFc":"4.5","totalValueFC":"77842.7","currency":"USD","unitRateINR":"406.3","date":"22-Apr-2024","totalValueINR":"6500436.16","totalValueInUsd":"77842.7","indian_port":"JNPT","hs_no":"29181590","bill_no":"3145735","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"Add: NO. 209, LAIY ANG ROAD ,JUXIAN ECONOMIC DEVELOPMENT ZONE,RIZHAO CITY, SHANDONG PROVINCE CHINA","customerAddress":"M-5A CONNUGHT CIRCUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714761000,"product":"TRICALCIUM CITRATE M1098 (NON MEDICINAL USE, RAW MATERIAL)","address":"M-5A CONNUGHT CIRCUS","city":"NEW DELHI","supplier":"JUNGBUNZLAUER INTERNATIONAL AG","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"NESTLE INDIA LIMITED","customerCountry":"INDIA","quantity":"16640.00","actualQuantity":"16640","unit":"KGS","unitRateFc":"6.5","totalValueFC":"108856.6","currency":"USD","unitRateINR":"545.3","date":"04-May-2024","totalValueINR":"9073648.58","totalValueInUsd":"108856.6","indian_port":"JNPT","hs_no":"29181590","bill_no":"3329832","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"AM HAFEN 18DE-68526LADENBURG GERMANY","customerAddress":"M-5A CONNUGHT CIRCUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715884200,"product":"TRICALCIUM CITRATE M1098 (NON MEDICINAL USE, RAW MATERIAL)","address":"M-5A CONNUGHT CIRCUS","city":"NEW DELHI","supplier":"JUNGBUNZLAUER INTERNATIONAL AG","supplierCountry":"GERMANY","foreign_port":"BREMERHAVEN","customer":"NESTLE INDIA LIMITED","customerCountry":"INDIA","quantity":"16710.00","actualQuantity":"16710","unit":"KGS","unitRateFc":"6.5","totalValueFC":"109314.5","currency":"USD","unitRateINR":"545.3","date":"17-May-2024","totalValueINR":"9111818.99","totalValueInUsd":"109314.5","indian_port":"JNPT","hs_no":"29181590","bill_no":"3524107","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"BREMERHAVEN","supplierAddress":"AM HAFEN 18DE-68526LADENBURG GERMANY","customerAddress":"M-5A CONNUGHT CIRCUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720722600,"product":"TRICALCIUM CITRATE M1098 (NON MEDICINAL USE, RAW MATERIAL)","address":"M-5A CONNUGHT CIRCUS","city":"NEW DELHI","supplier":"JUNGBUNZLAUER INTERNATIONAL AG","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"NESTLE INDIA LIMITED","customerCountry":"INDIA","quantity":"16760.00","actualQuantity":"16760","unit":"KGS","unitRateFc":"4.8","totalValueFC":"81413.6","currency":"USD","unitRateINR":"406.1","date":"12-Jul-2024","totalValueINR":"6805453.18","totalValueInUsd":"81413.6","indian_port":"JNPT","hs_no":"29181590","bill_no":"4463876","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"AM HAFEN 18DE-68526LADENBURG GERMANY","customerAddress":"M-5A CONNUGHT CIRCUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723660200,"product":"TRICALCIUM CITRATE M1098 (NON MEDICINAL USE, RAW MATERIAL)","address":"M-5A CONNUGHT CIRCUS","city":"NEW DELHI","supplier":"JUNGBUNZLAUER INTERNATIONAL AG","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"NESTLE INDIA LIMITED","customerCountry":"INDIA","quantity":"16760.00","actualQuantity":"16760","unit":"KGS","unitRateFc":"4.8","totalValueFC":"81518.8","currency":"USD","unitRateINR":"408","date":"15-Aug-2024","totalValueINR":"6837679.31","totalValueInUsd":"81518.8","indian_port":"JNPT","hs_no":"29181590","bill_no":"5069965","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"AM HAFEN 18DE-68526LADENBURG GERMANY","customerAddress":"M-5A CONNUGHT CIRCUS"}]
    06-Jan-2021
    31-Aug-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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