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Also known as: Calcium folinate, Calcium citrovorum factor, Folinic acid calcium salt, Folinic acid-sf, calcium salt, (+)-l-folinic acid, calcium salt, 1492-18-8
Molecular Formula
C20H23CaN7O7+2
Molecular Weight
513.5  g/mol
InChI Key
KVUAALJSMIVURS-ZEDZUCNESA-N

Calcium Folinate
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
1 2D Structure

Calcium Folinate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
2.1.2 InChI
InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/t12?,13-;/m0./s1
2.1.3 InChI Key
KVUAALJSMIVURS-ZEDZUCNESA-N
2.1.4 Canonical SMILES
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O.[Ca+2]
2.1.5 Isomeric SMILES
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.[Ca+2]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 5 Formyltetrahydrofolate

2. 5 Formyltetrahydropteroylglutamate

3. 5-formyltetrahydrofolate

4. 5-formyltetrahydropteroylglutamate

5. Acid, Folinic

6. Calcium Folinate

7. Citrovorum Factor

8. Factor, Citrovorum

9. Folinate, Calcium

10. Folinic Acid

11. Folinic Acid Sf

12. Folinic Acid-sf

13. Leucovorin

14. Leucovorin, (d)-isomer

15. Leucovorin, (dl)-isomer

16. Leucovorin, (r)-isomer

17. Leucovorin, Calcium

18. Leucovorin, Calcium (1:1) Salt

19. Leucovorin, Calcium (1:1) Salt, (dl)-isomer

20. Leucovorin, Calcium (1:1) Salt, Pentahydrate

21. Leucovorin, Monosodium Salt

22. Leukovorin

23. Leukovorum

24. Monosodium Salt Leucovorin

25. N(5)-formyltetrahydrofolate

26. Wellcovorin

2.2.2 Depositor-Supplied Synonyms

1. Calcium Folinate

2. Calcium Citrovorum Factor

3. Folinic Acid Calcium Salt

4. Folinic Acid-sf, Calcium Salt

5. (+)-l-folinic Acid, Calcium Salt

6. 1492-18-8

7. Nsc3590

8. Sr-05000001662

9. Pharmakon1600-01500364

10. Nsc757083

11. Nsc-757083

12. Sr-05000001662-1

13. Sr-05000001662-2

14. Glutamic Acid,6,7,8-tetrahydro-4-hydroxy-6- Pteridinyl)methyl]amino]benzoyl]-, Calcium Salt (1:1), L-

15. L-glutamic Acid,4,5,6,7,8-hexahydro-4-oxo-6- Pteridinyl)methyl]amino]benzoyl]-, Calcium Salt (1:1), (s)-

2.3 Create Date
2019-01-15
3 Chemical and Physical Properties
Molecular Weight 513.5 g/mol
Molecular Formula C20H23CaN7O7+2
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass513.1284869 g/mol
Monoisotopic Mass513.1284869 g/mol
Topological Polar Surface Area216 Ų
Heavy Atom Count35
Formal Charge2
Complexity911
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antidotes

Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)


Vitamin B Complex

A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)


4.2 ATC Code

V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AF - Detoxifying agents for antineoplastic treatment

V03AF03 - Calcium folinate


API SUPPLIERS

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Rochem International Inc

U.S.A

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Sichuan Huiyu Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024
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Sichuan Huiyu Pharmaceutical

China

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Huzhou Zhanwang Pharmaceutical Co....

China

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Huzhou Zhanwang Pharmaceutical Co....

China

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MERCK & CIE

Switzerland

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MERCK & CIE

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GMT Fine Chemicals SA

Switzerland

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GMT Fine Chemicals SA

Switzerland

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Cerbios-Pharma SA

Switzerland

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Cerbios-Pharma SA

Switzerland

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ALP Pharm

China

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ALP Pharm

China

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GMT Fine Chemicals SA

Switzerland

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GMT Fine Chemicals SA

Switzerland

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USDMF

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Medlab Asia & Asia Health
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Cerbios Pharma Sa

Switzerland

USDMF

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02

Cerbios Pharma Sa

Switzerland
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GDUFA

DMF Review : Complete

Rev. Date : 2013-10-04

Pay. Date : 2013-09-25

DMF Number : 5046

Submission : 1983-06-30

Status : Active

Type : II

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Gmt Fine Chemcals Sa

Switzerland

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03

Gmt Fine Chemcals Sa

Switzerland
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 16718

Submission : 2003-07-18

Status : Inactive

Type : II

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Gmt Fine Chemicals Sa

Switzerland

USDMF

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Gmt Fine Chemicals Sa

Switzerland
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GDUFA

DMF Review : Complete

Rev. Date : 2019-08-16

Pay. Date : 2019-06-24

DMF Number : 33740

Submission : 2019-05-18

Status : Active

Type : II

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Medlab Asia & Asia Health
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Medlab Asia & Asia Health
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GDUFA

DMF Review : Complete

Rev. Date : 2024-07-26

Pay. Date : 2024-06-10

DMF Number : 38878

Submission : 2023-09-27

Status : Active

Type : II

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Merck And Cie Kmg

Switzerland

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Merck And Cie Kmg

Switzerland
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GDUFA

DMF Review : Complete

Rev. Date : 2018-03-02

Pay. Date : 2018-02-20

DMF Number : 5261

Submission : 1984-01-23

Status : Active

Type : II

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Medlab Asia & Asia Health
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Medlab Asia & Asia Health
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GDUFA

DMF Review : Complete

Rev. Date : 2024-10-18

Pay. Date : 2024-09-19

DMF Number : 40427

Submission : 2024-09-04

Status : Active

Type : II

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Labochim Spa

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Labochim Spa

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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 10232

Submission : 1993-03-06

Status : Inactive

Type : II

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Monsanto Co

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Monsanto Co

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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 5429

Submission : 1984-07-09

Status : Inactive

Type : II

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Cyanamid Gmbh

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Cyanamid Gmbh

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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 3715

Submission : 1980-02-11

Status : Inactive

Type : II

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EU WC

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Calcium Folinate IP/EP/USP

Date of Issue : 2022-06-17

Valid Till : 2025-07-07

Written Confirmation Number : WC-0104

Address of the Firm : #125 & 126, Sipcot Industrial Complex, Hosur-635 126, Tamilnadu

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Listed Suppliers

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Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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Calcium Folinate

About the Company : Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quali...

Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quality ingredients manufactured in China. Headquartered in the Hauppauge, New York, Rochem has 16 offices spread across the globe to cater to the needs of its customers. Rochem’s operations are fully cGMP compliant and has been audited by the USFDA as well as several multinational organizations. It also trains and audits its partners to ensure all of their technologies and systems are FDA-compliant.
Rochem

02

Allastir

India
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Allastir

India
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Leucovorin Calcium

About the Company : Allastir instituted the services in 2010 with a motive to cater the pharmaceutical industry with niche API's. In Allastir we strongly believe in team work and customer satisfaction...

Allastir instituted the services in 2010 with a motive to cater the pharmaceutical industry with niche API's. In Allastir we strongly believe in team work and customer satisfaction. Allastir is backed by the strong R&D team who are passionate about what they do. We manufacture niche API's with high quality which are suitable for formulations like tablets, capsules, soft gelatins and oral liquids.To be the larder to develop innovative niche molecule to the health care industry for the betterment of human life.Our Vision is to be the Number ONE company in Health care Industry in the World.
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Calcium Folinate

About the Company : Anthem Biosciences is a leading contract research and innovation service provider (CRISP) in Bengaluru, India, which manufactures novel drug actives. Established in 2007, it specia...

Anthem Biosciences is a leading contract research and innovation service provider (CRISP) in Bengaluru, India, which manufactures novel drug actives. Established in 2007, it specializes in both biological and chemistry-based products and services. It has a strong track record in drug and product development, and supports development, optimization and testing of various compounds including proteins, monoclonal antibodies, peptides, large & small molecules and toxins. Inspected by USFDA, Japan’s PMDA, EU QPs, it develops nutritional products using organic synthesis and offers quality control and regulatory compliance assistance to clients.
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Cerbios-Pharma SA

Switzerland
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Cerbios-Pharma SA

Switzerland
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Calcium Folinate

About the Company : Cerbios is a privately held company located in Lugano, Switzerland. Cerbios is the ideal CDMO partner from clinical to commercial supply of ADCs, HPAPIs, Proteins and Antibodies. ...

Cerbios is a privately held company located in Lugano, Switzerland. Cerbios is the ideal CDMO partner from clinical to commercial supply of ADCs, HPAPIs, Proteins and Antibodies. Services offered include Process & Analytical Development, Scale-up and Clinical Supply, Industrial Validation, Commercial Supply and Full CMC Regulatory Support. Cerbios supplies also generic APIs primarily used in Oncology, Respiratory and Dermatology. Cerbios has additionally a 40 years’ experience in the probiotics field: the portfolio includes a FDF based on proprietary strain SF68® for treatment of diarrhea & dysbiosis, ACNE & Seborrheic dermatitis.
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DEAFARMA

Italy
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DEAFARMA

Italy
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Calcium Folinate

About the Company : In the dinamic pharmaceutical field, DEAFARMA is the reference point for primaries Pharmaceutical Laboratories for over twenty years, even in the national and international territo...

In the dinamic pharmaceutical field, DEAFARMA is the reference point for primaries Pharmaceutical Laboratories for over twenty years, even in the national and international territory. DEAFARMA works with success in the pharmaceutical raw materials field through Agencies and professional relations with the most important European and Asiatic factories. Our partners are well known, reliable producers and all of them are operating in accordance with the latest GMP Rules. The APIs mentioned in the DEAFARMA catalogue are always supported by DMF and/or CEP.
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Leucovorin Calcium

About the Company : As an EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979 as Calcium Ind...

As an EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979 as Calcium India. Today, Global Calcium represents the true hallmark of quality when it comes to pharmaceutical products. Global Calcium is backed by an excellent management team comprising of industry specialists, technocrats, entrepreneurs and business specialists bringing in strong domain expertise in fields such as investment banking, to consulting to behind the scenes pure sciences.
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Medlab Asia & Asia Health
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Calcium Folinate

About the Company : HENGDIAN GROUP was established in 1975, till now it has become a transnational,conglomerate group and been one of the largest private-owned enterprises in China. The Pharmaceutical...

HENGDIAN GROUP was established in 1975, till now it has become a transnational,conglomerate group and been one of the largest private-owned enterprises in China. The Pharmaceutical & Chemical division has 3 sub-companies with over 3,000 employees of which over 30% are technicians; This division is mainly producing APIs, Agrochemical and Dyestuffs with related intermediates as well as other special chemicals. The group also focuses on CONTRACT MANUFACTURE service under GMP and confidential agreement with our clients.
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Leucovorin

About the Company : Established in the year 2004, Sakar is engaged in manufacturing of Pharmaceutical products providing Liquid Orals, Cephalosporin Tablet, Capsule, Dry Powder Syrup, Dry Powder Injec...

Established in the year 2004, Sakar is engaged in manufacturing of Pharmaceutical products providing Liquid Orals, Cephalosporin Tablet, Capsule, Dry Powder Syrup, Dry Powder Injections, Liquid Injectables (SVP) in Ampoules and Vials & Lyophilized Injections. Sakar is managed by a team of professionals with an endeavour to offer Quality Pharmaceutical & Health Care Products in various countries. The company operates as contract development and manufacturing organisation (CDMO), being the EU GMP approved CMO for leading multinational pharmaceutical companies.
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LEUCOVORIN CALCIUM

About the Company : Shouyuan chemical (one of the leading chemicals supplier in China) specializes in manufacturing, supplying, and custom synsthesis latest chemicals. Our products cover all kinds of ...

Shouyuan chemical (one of the leading chemicals supplier in China) specializes in manufacturing, supplying, and custom synsthesis latest chemicals. Our products cover all kinds of range like pharmaceuticals, agrochemicals, electronic chemicals, surfactants and other specialty chemicals.
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Calcium Folinate

About the Company : Huiyu Pharma, established in Oct. 2010, is a specialized pharmaceutical company focusing on developing and manufacturing high-quality oncology products. At present, products in our...

Huiyu Pharma, established in Oct. 2010, is a specialized pharmaceutical company focusing on developing and manufacturing high-quality oncology products. At present, products in our list include the following:Azacitidine, Bendamustine HCl, Bortezomib, Camptothecin, Carboplatin, Decitabine, Docetaxel, Doxorubicin HCl, Epirubicin HCl, Gemcitabine Hydrochloride, Irinotecan Hydrochloride, Methotrexate, Oxaliplatin, Paclitaxel, Pemetrexed disodium...We welcome those traders, distributors, and wholesalers who are interested in our products.
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API Reference Price

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DIST, HYDERABAD","supplier":"GMT FINE CHEMICALS SA","supplierCountry":"SWITZERLAND","foreign_port":"ZURICH","customer":"ZENARA PHARMA","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"4600","totalValueFC":"18585.7","currency":"USD","unitRateINR":"388010","date":"08-Apr-2024","totalValueINR":"1552040","totalValueInUsd":"18585.7","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"2926955","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"ZURICH","supplierAddress":"RUE DES LLES 62108 COUVETSDNF CH","customerAddress":"PLOT NO. 87-96, SY.NO. 174 (P),"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714329000,"product":"LEUCOVORIN CALCIUM CRYSTALLINE (USP),CALCIUM FOLINATE HYDRATE CRYSTALLINE(PH.EUR.)BATCH#FKG117401","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"MERCK GROUP","supplierCountry":"SWITZERLAND","foreign_port":"ZURICH","customer":"VIATRIS","customerCountry":"INDIA","quantity":"26.22","actualQuantity":"26.22","unit":"KGS","unitRateFc":"3808","totalValueFC":"100913.1","currency":"USD","unitRateINR":"321395.2","date":"29-Apr-2024","totalValueINR":"8426982.14","totalValueInUsd":"100913.1","indian_port":"Bangalore Air","hs_no":"29362990","bill_no":"3259681","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Crystalline","supplierPort":"ZURICH","supplierAddress":"Im Laternenacker 5, 8200 Schaffhausen,SDNF Switzerland","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714329000,"product":"LEUCOVORIN CALCIUM CRYSTALLINE (USP),CALCIUM FOLINATE HYDRATE CRYSTALLINE(PH.EUR.)BATCH#FKG117601","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"MERCK GROUP","supplierCountry":"SWITZERLAND","foreign_port":"ZURICH","customer":"VIATRIS","customerCountry":"INDIA","quantity":"28.46","actualQuantity":"28.46","unit":"KGS","unitRateFc":"3808","totalValueFC":"109534.2","currency":"USD","unitRateINR":"321395.2","date":"29-Apr-2024","totalValueINR":"9146907.39","totalValueInUsd":"109534.2","indian_port":"Bangalore Air","hs_no":"29362990","bill_no":"3259681","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Crystalline","supplierPort":"ZURICH","supplierAddress":"Im Laternenacker 5, 8200 Schaffhausen,SDNF Switzerland","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714329000,"product":"LEUCOVORIN CALCIUM CRYSTALLINE (USP),CALCIUM FOLINATE HYDRATE CRYSTALLINE(PH.EUR.)BATCH#FKG117801","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"MERCK GROUP","supplierCountry":"SWITZERLAND","foreign_port":"ZURICH","customer":"VIATRIS","customerCountry":"INDIA","quantity":"29.23","actualQuantity":"29.23","unit":"KGS","unitRateFc":"3808","totalValueFC":"112497.7","currency":"USD","unitRateINR":"321395.2","date":"29-Apr-2024","totalValueINR":"9394381.7","totalValueInUsd":"112497.7","indian_port":"Bangalore Air","hs_no":"29362990","bill_no":"3259681","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Crystalline","supplierPort":"ZURICH","supplierAddress":"Im Laternenacker 5, 8200 Schaffhausen,SDNF Switzerland","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721413800,"product":"CALCIUM FOLINATE HYDRATE EP\/LEUCOVORIN CALCIUM USP","address":"PLOT NO. 87-96, SY.NO. 174 (P),","city":"R.R. DIST, HYDERABAD","supplier":"GMT FINE CHEMICALS SA","supplierCountry":"SWITZERLAND","foreign_port":"ZURICH","customer":"ZENARA PHARMA","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"4600","totalValueFC":"13958.3","currency":"USD","unitRateINR":"388930","date":"20-Jul-2024","totalValueINR":"1166790","totalValueInUsd":"13958.3","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"4608561","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"ZURICH","supplierAddress":"RUE DES LLES 62108 COUVETSDNF CH","customerAddress":"PLOT NO. 87-96, SY.NO. 174 (P),"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724956200,"product":"CALCIUM FOLINATE\/LEUCOVORIN CALCIUM IP ( LIST 04 SR NO. 21 )","address":"304,TOWN CENTRE,","city":"MUMBAI \/ MAHARASHTRA","supplier":"CERBIOS-PHARMA SA","supplierCountry":"SWITZERLAND","foreign_port":"ZURICH","customer":"NAPROD LIFE SCIENCES","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"3000","totalValueFC":"91042.4","currency":"USD","unitRateINR":"254550","date":"30-Aug-2024","totalValueINR":"7636500","totalValueInUsd":"91042.4","indian_port":"Bombay Air","hs_no":"29362990","bill_no":"5329140","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"ZURICH","supplierAddress":"VIA FIGINO 6, 6917 BARBENGO \/LUGANOSWITZERLAND SWITZERLAND","customerAddress":"304,TOWN CENTRE,"}]
22-Feb-2021
30-Oct-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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Drugs in Development

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Details:

ST316 is a first-in-class peptide antagonist of the interaction between β-catenin and its co-activator, BCL9. It is being evaluated for the treatment of colorectal cancer.


Lead Product(s): ST316,Irinotecan Hydrochloride,Calcium Folinate

Therapeutic Area: Oncology Brand Name: ST316

Study Phase: Phase I/ Phase IIProduct Type: Peptide

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 01, 2024

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01

AES 2024
Not Confirmed
AES 2024
Not Confirmed

Details : ST316 is a first-in-class peptide antagonist of the interaction between β-catenin and its co-activator, BCL9. It is being evaluated for the treatment of colorectal cancer.

Brand Name : ST316

Molecule Type : Peptide

Upfront Cash : Not Applicable

October 01, 2024

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Details:

Through the collaboration, Lisata will utilize MRD technology to detect ctDNA in a clinical trial evaluating CEND-1 (certepetide) combined with chemotherapy for the treatment of pancreatic cancer.


Lead Product(s): Certepetide,Panitumumab,Calcium Folinate

Therapeutic Area: Oncology Brand Name: CEND-1

Study Phase: Phase I/ Phase IIProduct Type: Peptide

Sponsor: Lisata Therapeutics

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration July 18, 2024

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02

AES 2024
Not Confirmed
AES 2024
Not Confirmed

Details : Through the collaboration, Lisata will utilize MRD technology to detect ctDNA in a clinical trial evaluating CEND-1 (certepetide) combined with chemotherapy for the treatment of pancreatic cancer.

Brand Name : CEND-1

Molecule Type : Peptide

Upfront Cash : Undisclosed

July 18, 2024

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Details:

Enlituo (cetuximab beta) is a EGFR inhibitor indicated in combination with the FOLFIRI regimen as a first-line treatment for RAS/BRAF wild-type metastatic colorectal cancer (mCRC).


Lead Product(s): Cetuximab,Irinotecan Hydrochloride,Calcium Folinate

Therapeutic Area: Oncology Brand Name: Enlituo

Study Phase: ApprovedProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 26, 2024

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03

AES 2024
Not Confirmed
AES 2024
Not Confirmed

Details : Enlituo (cetuximab beta) is a EGFR inhibitor indicated in combination with the FOLFIRI regimen as a first-line treatment for RAS/BRAF wild-type metastatic colorectal cancer (mCRC).

Brand Name : Enlituo

Molecule Type : Large molecule

Upfront Cash : Not Applicable

June 26, 2024

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Details:

Natrunix is an immunoglobulin cloned from healthy human donor which blocks IL-1α it is being investigated in combination with chemotherapy regimen for pancreatic cancer.


Lead Product(s): Vilamakitug,Irinotecan Hydrochloride,Calcium Folinate

Therapeutic Area: Oncology Brand Name: Natrunix

Study Phase: Phase I/ Phase IIProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 18, 2024

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XBiotech

U.S.A
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AES 2024
Not Confirmed

XBiotech

U.S.A
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AES 2024
Not Confirmed

Details : Natrunix is an immunoglobulin cloned from healthy human donor which blocks IL-1α it is being investigated in combination with chemotherapy regimen for pancreatic cancer.

Brand Name : Natrunix

Molecule Type : Large molecule

Upfront Cash : Not Applicable

June 18, 2024

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Details:

Ipsen acquired exclusive commercialization rights for Onivyde, an encapsulated formulation of irinotecan as a first-line treatment for metastatic adenocarcinoma of the pancreas in the US.


Lead Product(s): Irinotecan Hydrochloride,Fluorouracil,Calcium Folinate

Therapeutic Area: Oncology Brand Name: Onivyde

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Ipsen

Deal Size: $1,025.0 million Upfront Cash: $575.0 million

Deal Type: Acquisition March 27, 2024

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AES 2024
Not Confirmed
AES 2024
Not Confirmed

Details : Ipsen acquired exclusive commercialization rights for Onivyde, an encapsulated formulation of irinotecan as a first-line treatment for metastatic adenocarcinoma of the pancreas in the US.

Brand Name : Onivyde

Molecule Type : Small molecule

Upfront Cash : $575.0 million

March 27, 2024

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Details:

Astellas' Vyloy (zolbetuximab), a CLDN 18.2 inhibitor has been approved in combination with chemotherapy for HER2-negative, CLDN18.2 positive, unresectable, advanced or recurrent gastric cancer.


Lead Product(s): Zolbetuximab,Oxaliplatin,Calcium Folinate

Therapeutic Area: Oncology Brand Name: VYLOY

Study Phase: ApprovedProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 26, 2024

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AES 2024
Not Confirmed
AES 2024
Not Confirmed

Details : Astellas' Vyloy (zolbetuximab), a CLDN 18.2 inhibitor has been approved in combination with chemotherapy for HER2-negative, CLDN18.2 positive, unresectable, advanced or recurrent gastric cancer.

Brand Name : VYLOY

Molecule Type : Large molecule

Upfront Cash : Not Applicable

March 26, 2024

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Details:

AbilityPharma to obtain financing for the clinical development of ABTL0812 in combination with folfirinox. It is being evaluated in Phase I/II clinical trial studies for Metastatic Pancreatic Cancer.


Lead Product(s): ABTL0812,Calcium Folinate,Fluorouracil

Therapeutic Area: Oncology Brand Name: ABTL0812

Study Phase: Phase I/ Phase IIProduct Type: Small molecule

Sponsor: CTI Life Sciences

Deal Size: $7.6 million Upfront Cash: Undisclosed

Deal Type: Financing March 11, 2024

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AES 2024
Not Confirmed
AES 2024
Not Confirmed

Details : AbilityPharma to obtain financing for the clinical development of ABTL0812 in combination with folfirinox. It is being evaluated in Phase I/II clinical trial studies for Metastatic Pancreatic Cancer.

Brand Name : ABTL0812

Molecule Type : Small molecule

Upfront Cash : Undisclosed

March 11, 2024

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Details:

Oncotelic's lead product candidate, OT-101, is a TGF beta-2 inhibitor combined with folfirinox. It is currently under evaluation in Phase 2/3 trials for treating pancreatic ductal adenocarcinoma.


Lead Product(s): OT-101,Calcium Folinate,Fluorouracil

Therapeutic Area: Oncology Brand Name: OT-101

Study Phase: Phase II/ Phase IIIProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 04, 2024

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AES 2024
Not Confirmed
AES 2024
Not Confirmed

Details : Oncotelic's lead product candidate, OT-101, is a TGF beta-2 inhibitor combined with folfirinox. It is currently under evaluation in Phase 2/3 trials for treating pancreatic ductal adenocarcinoma.

Brand Name : OT-101

Molecule Type : Large molecule

Upfront Cash : Not Applicable

March 04, 2024

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Details:

Onivyde (irinotecan), liposomal injection is a small molecule drug that blocks an enzyme called topoisomerase I. It is being developed for the treatment of metastatic pancreatic adenocarcinoma.


Lead Product(s): Irinotecan Hydrochloride,Fluorouracil,Calcium Folinate

Therapeutic Area: Oncology Brand Name: Onivyde

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 13, 2024

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Ipsen

France
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AES 2024
Not Confirmed

Ipsen

France
arrow
AES 2024
Not Confirmed

Details : Onivyde (irinotecan), liposomal injection is a small molecule drug that blocks an enzyme called topoisomerase I. It is being developed for the treatment of metastatic pancreatic adenocarcinoma.

Brand Name : Onivyde

Molecule Type : Small molecule

Upfront Cash : Not Applicable

February 13, 2024

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Details:

AMP945 (narmafotinib) is a novel focal adhesion kinase (FAK) inhibitor. It is being evaluated in precliical studies for the treatment of patients with pancreatic cancer.


Lead Product(s): AMP945,Calcium Folinate,Fluorouracil

Therapeutic Area: Oncology Brand Name: AMP945

Study Phase: IND EnablingProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 17, 2024

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10

AES 2024
Not Confirmed
AES 2024
Not Confirmed

Details : AMP945 (narmafotinib) is a novel focal adhesion kinase (FAK) inhibitor. It is being evaluated in precliical studies for the treatment of patients with pancreatic cancer.

Brand Name : AMP945

Molecule Type : Small molecule

Upfront Cash : Not Applicable

January 17, 2024

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FDF Dossiers

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothBiophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

Flag India
Digital Content Digital Content

Regulatory Info :

Registration Country : India

LEUCOVORIN CALCIUM

Brand Name :

Dosage Form : Tablet

Dosage Strength : 5MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

Biophore

02

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Antibody Engineering
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAthena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

Flag France
Digital Content Digital Content

Regulatory Info :

Registration Country : France

Leucovorin

Brand Name :

Dosage Form : Tablet

Dosage Strength : 5MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : France

Athena Company Banner

03

Ethypharm

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothEthypharm is an international Pharma company with European roots manufacturing and commercializing essential drugs all over the world.

Flag France
Digital Content Digital Content

Regulatory Info :

Registration Country : France

Calcium Folinate

Brand Name :

Dosage Form : Vial

Dosage Strength : 50MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : France

Ethypharm

04

Ethypharm

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothEthypharm is an international Pharma company with European roots manufacturing and commercializing essential drugs all over the world.

Flag France
Digital Content Digital Content

Regulatory Info :

Registration Country : France

Calcium Folinate

Brand Name :

Dosage Form : Vial

Dosage Strength : 350MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : France

Ethypharm

05

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Antibody Engineering
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

Flag India
Digital Content Digital Content

Regulatory Info :

Registration Country : India

Calcium Folinate

Brand Name :

Dosage Form : Injection

Dosage Strength : 50MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

Supriya

06

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Antibody Engineering
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

Flag India
Digital Content Digital Content

Regulatory Info :

Registration Country : India

Calcium Folinate

Brand Name :

Dosage Form : Injection

Dosage Strength : 100MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

Supriya

07

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Antibody Engineering
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

Flag India
Digital Content Digital Content

Regulatory Info :

Registration Country : India

Calcium Folinate

Brand Name :

Dosage Form : Injection

Dosage Strength : 200MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

Supriya

08

arrow
Antibody Engineering
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

Flag India
Digital Content Digital Content

Regulatory Info :

Registration Country : India

Calcium Folinate

Brand Name :

Dosage Form : Injection

Dosage Strength : 350MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

Supriya

09

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Antibody Engineering
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

Flag India
Digital Content Digital Content

Regulatory Info :

Registration Country : India

Calcium Leucovorin

Brand Name :

Dosage Form : Injection

Dosage Strength : 100MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

Supriya

10

arrow
Antibody Engineering
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

Flag India
Digital Content Digital Content

Regulatory Info :

Registration Country : India

Calcium Leucovorin

Brand Name :

Dosage Form : Injection

Dosage Strength : 200MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

Supriya
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FDA Orange Book

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01

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : LEUCOVORIN CALCIUM

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 15MG BASE

Approval Date : 2021-05-19

Application Number : 74544

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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02

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : LEUCOVORIN CALCIUM PRESERVATIVE FREE

Dosage Form : INJECTABLE;INJECTION

Dosage Strength : EQ 200MG BASE/VIAL

Approval Date : 1999-02-26

Application Number : 40258

RX/OTC/DISCN : RX

RLD : No

TE Code : AP

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03

GLAXOSMITHKLINE

United Kingdom
Antibody Engineering
Not Confirmed
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GLAXOSMITHKLINE

United Kingdom
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Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : WELLCOVORIN

Dosage Form : INJECTABLE;INJECTION

Dosage Strength : EQ 50MG BASE/VIAL

Approval Date : 1989-01-23

Application Number : 89465

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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04

HAINAN POLY

China
Antibody Engineering
Not Confirmed
arrow

HAINAN POLY

China
arrow
Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : LEUCOVORIN CALCIUM

Dosage Form : INJECTABLE;INJECTION

Dosage Strength : EQ 50MG BASE/VIAL

Approval Date : 2023-07-10

Application Number : 217021

RX/OTC/DISCN : RX

RLD : No

TE Code : AP

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05

HOSPIRA

U.S.A
Antibody Engineering
Not Confirmed
arrow

HOSPIRA

U.S.A
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Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : LEUCOVORIN CALCIUM

Dosage Form : FOR SOLUTION;ORAL

Dosage Strength : EQ 60MG BASE/VIAL

Approval Date : 1987-01-30

Application Number : 8107

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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06

NOVAST LABS

China
Antibody Engineering
Not Confirmed
arrow

NOVAST LABS

China
arrow
Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : LEUCOVORIN CALCIUM

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 15MG BASE

Approval Date : 2020-07-30

Application Number : 211132

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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07

PAR PHARM

U.S.A
Antibody Engineering
Not Confirmed
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PAR PHARM

U.S.A
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Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : LEUCOVORIN CALCIUM

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 5MG BASE

Approval Date : 1987-10-14

Application Number : 71600

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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08

PHARMACHEMIE

Netherlands
Antibody Engineering
Not Confirmed
arrow

PHARMACHEMIE

Netherlands
arrow
Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : LEUCOVORIN CALCIUM

Dosage Form : INJECTABLE;INJECTION

Dosage Strength : EQ 350MG BASE/VIAL

Approval Date : 1999-12-15

Application Number : 40262

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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09

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : LEUCOVORIN CALCIUM PRESERVATIVE FREE

Dosage Form : INJECTABLE;INJECTION

Dosage Strength : EQ 50MG BASE/VIAL

Approval Date : 2012-09-06

Application Number : 200753

RX/OTC/DISCN : RX

RLD : No

TE Code : AP

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10

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

LEUCOVORIN CALCIUM

Brand Name : LEUCOVORIN CALCIUM PRESERVATIVE FREE

Dosage Form : INJECTABLE;INJECTION

Dosage Strength : EQ 100MG BASE/VIAL

Approval Date : 2012-09-06

Application Number : 200753

RX/OTC/DISCN : RX

RLD : No

TE Code : AP

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Europe

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01

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

Calcium Folinate

Brand Name : ANTREX

Dosage Form : Tablet

Dosage Strength : 15MG

Packaging : 100 Tablet Plastic Bottle

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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02

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

Calcium Folinate

Brand Name : Citofolin

Dosage Form :

Dosage Strength : Os Soluz 10 Vials 15 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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03

Antibody Engineering
Not Confirmed
arrow
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Antibody Engineering
Not Confirmed

Calcium Folinate

Brand Name : Citofolin

Dosage Form :

Dosage Strength : 6 Ampoules Im Ev 3 Mg + 6 Vials Solv 1 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

blank

04

Antibody Engineering
Not Confirmed
arrow
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Antibody Engineering
Not Confirmed

Calcium Folinate

Brand Name : Citofolin

Dosage Form :

Dosage Strength : 6 Ampoules Im Ev 15 Mg + 6 Vials Solv 1 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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05

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

calcium folinate (anhydrous)

Brand Name : Calciumfolinat Hospira

Dosage Form : SOLUTION FOR INJECTION

Dosage Strength : 10 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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06

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

Calcium Folinate

Brand Name : Folidar

Dosage Form :

Dosage Strength : 30 Cpr 15 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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07

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

Acidum folinicum

Brand Name : Calcium folinate Sandoz eco

Dosage Form : Inj Solution

Dosage Strength : 500mg/50ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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08

Antibody Engineering
Not Confirmed
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Antibody Engineering
Not Confirmed

Calcium Folinate

Brand Name : Calciumfolinate Teva

Dosage Form : Injection fluid, resolution

Dosage Strength : 10 mg/ml

Packaging : Hood glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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09

IST.CHIM.INTERNAZ. RENDE Srl

Country
Antibody Engineering
Not Confirmed
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IST.CHIM.INTERNAZ. RENDE Srl

Country
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Antibody Engineering
Not Confirmed

Calcium Folinate

Brand Name : Folaren

Dosage Form :

Dosage Strength : 10 Cpr 15 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

blank

10

EBEWE Pharma Ges.m.b.H Nfg. KG

Country
Antibody Engineering
Not Confirmed
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EBEWE Pharma Ges.m.b.H Nfg. KG

Country
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Antibody Engineering
Not Confirmed

Calcium Folinate

Brand Name : Calciumfolinat Ebewe

Dosage Form : Injection fluid, resolution

Dosage Strength : 10 mg/ml

Packaging : Hood glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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01

Brand Name : Ferritin Complex

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Brand Name : Ferritin Complex

Italy
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Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate

Dosage Form :

Dosage Strength : Os Soluz 10 Vials Of 8 Ml  

Price Per Pack (Euro) : 11.06

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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02

Brand Name : Ferrofolin

Germany
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Medlab Asia & Asia Health
Not Confirmed

Brand Name : Ferrofolin

Germany
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Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate

Dosage Form :

Dosage Strength : Os Soluz 10 Vials 15 Ml  

Price Per Pack (Euro) : 13.87

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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03

Brand Name : Citofolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Brand Name : Citofolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate

Dosage Form :

Dosage Strength : 10 Cpr 15 Mg  

Price Per Pack (Euro) : 8

Published in :

Country : Italy

RX/OTC/DISCN : Class C

blank

04

Brand Name : Citofolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Brand Name : Citofolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate

Dosage Form :

Dosage Strength : Os Soluz 10 Vials 15 Mg  

Price Per Pack (Euro) : 8.2

Published in :

Country : Italy

RX/OTC/DISCN : Class C

blank

05

Brand Name : Citofolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Brand Name : Citofolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate

Dosage Form :

Dosage Strength : 6 Ampoules Im Ev 3 Mg + 6 Vials Solv 1 Ml ...

Price Per Pack (Euro) : 4.13

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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06

Brand Name : Citofolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Brand Name : Citofolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate

Dosage Form :

Dosage Strength : 6 Ampoules Im Ev 15 Mg + 6 Vials Solv 1 Ml...

Price Per Pack (Euro) : 7.9

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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07

Brand Name : Eparmefolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Brand Name : Eparmefolin

Italy
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Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate; Vitamin B12

Dosage Form :

Dosage Strength : 30 Cpr Riv 0.1 Mg + 0.5 Mg  

Price Per Pack (Euro) : 4.79

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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08

Brand Name : Eparmefolin

Italy
arrow
Medlab Asia & Asia Health
Not Confirmed

Brand Name : Eparmefolin

Italy
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Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate; Vitamin B12

Dosage Form :

Dosage Strength : To 6 Vials Im Ev + 6 Vials Solv 1.5 Ml  

Price Per Pack (Euro) : 8.15

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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09

Brand Name : Calcium Folinate

Country
arrow
Medlab Asia & Asia Health
Not Confirmed

Brand Name : Calcium Folinate

Country
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Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate

Dosage Form :

Dosage Strength : 10 Cpr 15 Mg  

Price Per Pack (Euro) : 6.3

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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10

Brand Name : Calcium Folinate

Country
arrow
Medlab Asia & Asia Health
Not Confirmed

Brand Name : Calcium Folinate

Country
arrow
Medlab Asia & Asia Health
Not Confirmed

Calcium Folinate

Dosage Form :

Dosage Strength : Os Soluz 10 Vials 15 Mg  

Price Per Pack (Euro) : 8.25

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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