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Also known as: 814-80-2, Calcium dilactate, Calphosan, Hemicalcium l-lactate, Lactic acid, calcium salt (2:1), Calcium;2-hydroxypropanoate

Molecular Formula

C₆H₁₀CaO₆

Molecular Weight

218.22 g/mol

InChI Key

MKJXYGKVIBWPFZ-UHFFFAOYSA-L

FDA UNII

2URQ2N32W3

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener. Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.

1 2D Structure

Calcium Lactate API

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

calcium;2-hydroxypropanoate

2.1.2 InChI

InChI=1S/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2

2.1.3 InChI Key

MKJXYGKVIBWPFZ-UHFFFAOYSA-L

2.1.4 Canonical SMILES

CC(C(=O)[O-])O.CC(C(=O)[O-])O.[Ca+2]

2.2 Other Identifiers

2.2.1 UNII

2URQ2N32W3

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ca Lactate

2.3.2 Depositor-Supplied Synonyms

1. 814-80-2

2. Calcium Dilactate

3. Calphosan

4. Hemicalcium L-lactate

5. Lactic Acid, Calcium Salt (2:1)

6. Calcium;2-hydroxypropanoate

7. Calcium 2-hydroxypropanoate

8. Propanoic Acid, 2-hydroxy-, Calcium Salt (2:1)

9. 2-hydroxypropanoic Acid Calcium Salt

10. 5743-48-6

11. Calcium Lactate Anhydrous

12. Calcium 2-hydroxypropanoate (1:2)

13. 63690-56-2

14. Calcium (as Lactate)

15. Calcium Bis(2-hydroxypropanoate)

16. Calcium Lactate, Anhydrous

17. Ins No.327

18. 28305-25-1

19. 2urq2n32w3

20. Ins-327

21. Ins-327-

22. Dsstox_cid_236

23. Conclyte Calcium

24. E-327

25. Dsstox_rid_75451

26. Dsstox_gsid_20236

27. Ca Lactate

28. Cas-814-80-2

29. Calcium Lactate [usan:jan]

30. Ccris 3669

31. Hsdb 976

32. Einecs 212-406-7

33. Unii-2urq2n32w3

34. Ai3-04468

35. Calcium Dl-lactate

36. Einecs 227-266-2

37. Calcium Lactate [ii]

38. Calcium Lactate [mi]

39. Calcium Lactate [fcc]

40. Calcium Lactate [hsdb]

41. Calcium Lactate [inci]

42. Calcium Lactate (1:2)

43. Calcium Lactate [vandf]

44. Ec 212-406-7

45. Calcium Lactate [who-dd]

46. Schembl4319

47. Calcium (as Lactate) [vandf]

48. Chembl2106111

49. Dtxsid0020236

50. Hy-b2227a

51. Calcium Lactate [usp-rs]

52. Lactic Acid Calcium Salt (2:1)

53. Amy37027

54. Tox21_201378

55. Tox21_302896

56. Bis(2-hydroxypropanoic Acid) Calcium

57. Mfcd00035548

58. Akos015837558

59. Calcium Lactate [ep Monograph]

60. Db13231

61. Ncgc00256365-01

62. Ncgc00258929-01

63. (+/-)-lactic Acid, Calcium Salt (2:1)

64. Db-023012

65. Cs-0021602

66. Ft-0623403

67. Ft-0652809

68. F16480

69. Calcium Lactate Anhydrous [usp Monograph]

70. Calcium Lactate, Anhydrous [ep Impurity]

71. A840142

72. Q419693

73. L(+) Lactic Acid Calcium Salt Pentahydr. 98%, Fcc

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₆H₁₀CaO₆
Molecular Weight	218.22 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	0
Exact Mass	218.0103289 g/mol
Monoisotopic Mass	218.0103289 g/mol
Topological Polar Surface Area	121 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	53.5
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Therapeutic Uses

EXPTL USE: ORAL ADMIN OF CALCIUM LACTATE (7.7 G) LOWERED PLASMA PARATHYROID HORMONE BY 40-43% & DECR URINARY EXCRETION OF CYCLIC ADENOSINE MONOPHOSPHATE BY 30-54% IN SKELETAL-TYPE HYPERPARATHYROIDISM BUT NOT IN OTHER TYPES OR IN CONTROLS.

SOHN HE ET AL; NIPPON NAIBUMPI GAKKAI ZASSHI 58(2) 110 (1982)

EXPTL USE: HIGH DOSES OF ORAL CALCIUM LACTATE DECR URINARY CYCLIC ADENOSINE MONOPHOSPHATE EXCRETION IN BORDERLINE CASES OF UROLITHIC AND CHEM HYPERPARATHYROIDISM.

SOHN HE ET AL; NIPPON NAIBUMPI GAKKAI ZASSHI 58(2) 110 (1982)

May be used to treat mild hypocalcemia and for maintenance therapy. /From table/

American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994., p. 2246

MEDICATION (VET): IN CALCIUM THERAPY

SRI

4.2 Drug Warning

CALCIUM GLUCONATE & BOROGLUCONATE ARE CONSIDERED TO BE SIGNIFICANTLY LESS TOXIC THAN THE LACTATE OR THE CHLORIDE.

Humphreys, D.J. Veterinary Toxicology. 3rd ed. London, England: Bailliere Tindell, 1988., p. 28

4.3 Drug Indication

Indicated for use as the nutritional supplement.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively.

5.2 ATC Code

A - Alimentary tract and metabolism

A12 - Mineral supplements

A12A - Calcium

A12AA - Calcium

A12AA05 - Calcium lactate

5.3 Absorption, Distribution and Excretion

Absorption

In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins. The mean calcium absorption is about 25% of calcium intake (range is 10 40%) in the small intestine, and is mediated by both passive diffusion and active transport.

Route of Elimination

Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours.

Volume of Distribution

The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity.

Clearance

No pharmacokinetic data available.

5.4 Metabolism/Metabolites

In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle.

RUMINAL INGESTA FROM COWS FED 2.5 L GRAIN-ALFALFA HAY MIXT PROVIDING 545 G OF SODIUM LACTATE & CALCIUM LACTATE DAILY INCUBATED WITH SODIUM LACTATE OR 17 POLY LACTIC ACID. ACETATE WAS PRIMARY END PRODUCT BUT OXIDN OF LACTATE CAUSED SYNTH OF BUTYRATE FROM ACETATE.

SATTER LD, ESDALE WJ; APPL MICROBIOL 16(5) 680 (1968)

5.5 Biological Half-Life

No pharmacokinetic data available.

5.6 Mechanism of Action

In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis.

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