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Chemistry

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Also known as: 7758-87-4, Tricalcium phosphate, Synthos, Calcium phosphate tribasic, Calcium orthophosphate, Tricalcium diphosphate
Molecular Formula
Ca3O8P2
Molecular Weight
310.18  g/mol
InChI Key
QORWJWZARLRLPR-UHFFFAOYSA-H
FDA UNII
K4C08XP666

Calcium Phosphate
Calcium Phosphate is the calcium salt of phosphoric acid with widely used applications. This agent can be used as a countermeasure for exposure to strontium and radium radionuclides. Upon oral uptake, calcium phosphate competes for and blocks the absorption of radium (Ra-226) and strontium (Sr-90) in the gastrointestinal (GI) tract.
1 2D Structure

Calcium Phosphate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
tricalcium;diphosphate
2.1.2 InChI
InChI=1S/3Ca.2H3O4P/c;;;2*1-5(2,3)4/h;;;2*(H3,1,2,3,4)/q3*+2;;/p-6
2.1.3 InChI Key
QORWJWZARLRLPR-UHFFFAOYSA-H
2.1.4 Canonical SMILES
[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[Ca+2].[Ca+2].[Ca+2]
2.2 Other Identifiers
2.2.1 UNII
K4C08XP666
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 7758-87-4

2. Tricalcium Phosphate

3. Synthos

4. Calcium Phosphate Tribasic

5. Calcium Orthophosphate

6. Tricalcium Diphosphate

7. Calcigenol Simple

8. Beta-tcp

9. Tricalcium Orthophosphate

10. Beta-tricalcium Phosphate

11. Calcium Tertiary Phosphate

12. Tertiary Calcium Phosphate

13. Phosphoric Acid, Calcium Salt (2:3)

14. Fema No. 3081

15. Calcium Phosphate (3:2)

16. Tri-calcium Phosphate

17. Tricalcium;diphosphate

18. 10103-46-5

19. Calciresorb;tcp

20. Phosphoric Acid, Calcium Salt

21. Tricalcium Bis(phosphate)

22. Alpha-tricalcium Phosphate

23. Ins No.341(iii)

24. Chebi:9679

25. Ins-341(iii)

26. E-341(iii)

27. K4c08xp666

28. Synthograft

29. Bonarka

30. Cerasorb

31. Osferion

32. Natural Whitlockite

33. Caswell No. 148

34. Ceredex

35. Multifos

36. Ostram

37. Vitoss

38. Calciumphosphate

39. Tricos

40. Calipharm T

41. Tricafos P

42. 21063-37-6

43. Tricalcium Bis(orthophosphate)

44. Ccris 3668

45. Hsdb 879

46. Jax Tcp

47. Calcium Phosphate (ca3(po4)2)

48. Calcium Orthophosphate, Tri-(tert)

49. Tricalcium Phosphate (ca3(po4)2)

50. Einecs 231-840-8

51. Einecs 233-283-6

52. Unii-97z1wi3ndx

53. Epa Pesticide Chemical Code 076401

54. Posture (calcium Supplement)

55. Bone Phosphate

56. Phosphoric Acid Calcium(2+) Salt (2:3)

57. Unii-k4c08xp666

58. Ca3(po4)2

59. Calcium-phosphate

60. Alpha-tcp

61. Calcium Phosphates

62. Tricalciumphosphate

63. Posture (tn)

64. Hydroxyapatite Powder

65. Mfcd00015984

66. Calcigenol

67. Calcium Phosphate Basic

68. Beta Tricalcium Phosphate

69. Ai3-25607

70. Ec 231-840-8

71. 97z1wi3ndx

72. Chembl2106566

73. Dtxsid1049803

74. Calcium Phosphate [who-dd]

75. Tricalcium Phosphate [fhfi]

76. Tricalcium Phosphate [inci]

77. Precipitated Calcium Phosphate

78. Akos015833108

79. Phosphoric Acid, Calcium Salt (1:?)

80. Cx-0072

81. Db11348

82. Calcium Phosphate, Tribasic [mi]

83. Tricalcium Bis(orthophosphate), With A Fluorine Content Of Less Than 0,005 % By Weight On The Dry Anhydrous Product

84. Calcium Phosphate, Tribasic (ca.37% Ca)

85. Calcium Phosphate, Tribasic [hsdb]

86. Calcium Phosphate,anhydrous [vandf]

87. C3736

88. Cs-0013475

89. Ft-0645103

90. C08136

91. D00938

92. Q278387

93. Calcium Phosphate, Reagent For Transient & Stable Dna Transfections

94. Beta-tri-calcium Phosphate, >=95% Beta-phase Basis (unsintered Powder)

95. Calcium Phosphate, Purum P.a., >=96.0% (calc. As Ca3(po4)2, Kt)

96. Tricalcium Phosphate Hydrate, Nanopowder, <200 Nm Particle Size (bet)

97. Alpha-tri-calcium Phosphate, Puriss. P.a., >=75% Alpha-phase Basis (sinterted Powder)

98. Alpha-tri-calcium Phosphate, Reagent For Transient & Stable Dna Transfections

99. Beta-tri-calcium Phosphate, Puriss. P.a., >=95% Beta-phase Basis (sintered Powder)

100. Beta-tri-calcium Phosphate, Puriss. P.a., >=98% Beta-phase Basis (sintered Powder)

101. Beta-tri-calcium Phosphate, Puriss. P.a., >=98% Beta-phase Basis (unsintered Powder)

102. Calcium Phosphate (3:2) Mixture With Calcium Phosphate (1:1) [who-ip]

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 310.18 g/mol
Molecular Formula Ca3O8P2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count0
Exact Mass309.7946135 g/mol
Monoisotopic Mass309.7946135 g/mol
Topological Polar Surface Area173 Ų
Heavy Atom Count13
Formal Charge0
Complexity36.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count5
4 Drug and Medication Information
4.1 Therapeutic Uses

... CHIEFLY USED AS GASTRIC ANTACID ... VALUABLE SOURCE OF CALCIUM ION, ESPECIALLY WHEN IT IS DESIRED TO SUPPLY BOTH CALCIUM & PHOSPHORUS. /FORMER USE/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1528


... /THIS/ ORALLY ADMIN CALCIUM ... /SALT/ CAN BE USED IN TREATMENT OF MILD & LATENT HYPOCALCEMIC TETANY & FOR MAINTENANCE THERAPY ... .

American Medical Association, Council on Drugs. AMA Drug Evaluations. 2nd ed. Acton, Mass.: Publishing Sciences Group, Inc., 1973., p. 202


AN EXCELLENT SOURCE OF BOTH CALCIUM AND PHOSPHORUS USEFUL IN SUPPLEMENTING CALCIUM INTAKE, AS, FOR EXAMPLE, DURING PREGNANCY & LACTATION, OR AS SOURCE OF CALCIUM IN DISEASES OF CALCIUM DEFICIENCY.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 770


Calcium replenisher

Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 256


For more Therapeutic Uses (Complete) data for TRICALCIUM PHOSPHATE (6 total), please visit the HSDB record page.


4.2 Drug Warning

... CONTRAINDICATED IN TREATMENT OF HYPOCALCEMIA WITH HYPERPHOSPHATEMIA, WHICH MAY OCCUR IN HYPOPARATHYROIDISM AND RENAL FAILURE.

American Medical Association, Council on Drugs. AMA Drug Evaluations. 2nd ed. Acton, Mass.: Publishing Sciences Group, Inc., 1973., p. 201


Ceramic implant materials, including tricalcium phosphate, are biocompatible and are currently being used to restore alveolar bone loss resulting from periodontal disease, endodontic infections, and residual alveolar ridge resorption. However, use of such a material in this case led to persistent infection and additional bone destruction. Thus, the use of a ceramic implant material to accelerate periapical bone repair is not recommended in areas where a chronic bacterial infection is present.

PMID:3457349 Barkhordar RA, Meyer JR; Oral Surg Oral Med Oral Pathol 61 (2): 201-6 (1986)


4.3 Drug Indication

For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Calcium phosphate reacts with acid in the stomach to raise the pH. In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth. As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Calcium [CS]; Cations, Divalent [CS]; Increased Coagulation Factor Activity [PE]; Blood Coagulation Factor [EPC]
5.3 ATC Code

A - Alimentary tract and metabolism

A12 - Mineral supplements

A12A - Calcium

A12AA - Calcium

A12AA01 - Calcium phosphate


5.4 Absorption, Distribution and Excretion

/Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1524


5.5 Metabolism/Metabolites

A defect in phosphate metabolism occurs in a variety of diseases. ... Rickets ... Osteomalacia ... Primary or Secondary Hyperparathyroidism ... Chronic Renal Failure. /Phosphates/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1525


5.6 Mechanism of Action

The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.


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ABOUT THIS PAGE

Calcium Phosphate Manufacturers

A Calcium Phosphate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Calcium Phosphate, including repackagers and relabelers. The FDA regulates Calcium Phosphate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Calcium Phosphate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Calcium Phosphate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Calcium Phosphate Suppliers

A Calcium Phosphate supplier is an individual or a company that provides Calcium Phosphate active pharmaceutical ingredient (API) or Calcium Phosphate finished formulations upon request. The Calcium Phosphate suppliers may include Calcium Phosphate API manufacturers, exporters, distributors and traders.

click here to find a list of Calcium Phosphate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Calcium Phosphate USDMF

A Calcium Phosphate DMF (Drug Master File) is a document detailing the whole manufacturing process of Calcium Phosphate active pharmaceutical ingredient (API) in detail. Different forms of Calcium Phosphate DMFs exist exist since differing nations have different regulations, such as Calcium Phosphate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Calcium Phosphate DMF submitted to regulatory agencies in the US is known as a USDMF. Calcium Phosphate USDMF includes data on Calcium Phosphate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Calcium Phosphate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Calcium Phosphate suppliers with USDMF on PharmaCompass.

Calcium Phosphate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Calcium Phosphate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Calcium Phosphate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Calcium Phosphate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Calcium Phosphate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Calcium Phosphate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Calcium Phosphate suppliers with NDC on PharmaCompass.

Calcium Phosphate GMP

Calcium Phosphate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Calcium Phosphate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Calcium Phosphate GMP manufacturer or Calcium Phosphate GMP API supplier for your needs.

Calcium Phosphate CoA

A Calcium Phosphate CoA (Certificate of Analysis) is a formal document that attests to Calcium Phosphate's compliance with Calcium Phosphate specifications and serves as a tool for batch-level quality control.

Calcium Phosphate CoA mostly includes findings from lab analyses of a specific batch. For each Calcium Phosphate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Calcium Phosphate may be tested according to a variety of international standards, such as European Pharmacopoeia (Calcium Phosphate EP), Calcium Phosphate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Calcium Phosphate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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