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Calcium Phosphate Dibasic Anhydrous

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ACTIVE PHARMA INGREDIENTS

12 API Suppliers, 5 USDMF, 1 NDC API, 7 Listed Suppliers

12 API Suppliers
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1 NDC API
7 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 Europe

1 FDF Dossiers
1 Europe

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Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

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FDF

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FDF Dossiers

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Chemistry

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Also known as: 7757-93-9, Calcium phosphate dibasic, Dicalcium phosphate, Calcium phosphate, dibasic, Dibasic calcium phosphate, Phosphoric acid, calcium salt (1:1)

Molecular Formula

CaHO₄P

Molecular Weight

136.06 g/mol

InChI Key

FUFJGUQYACFECW-UHFFFAOYSA-L

FDA UNII

L11K75P92J

1 2D Structure

Calcium Acid Phosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

calcium;hydrogen phosphate

2.1.2 InChI

InChI=1S/Ca.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2

2.1.3 InChI Key

FUFJGUQYACFECW-UHFFFAOYSA-L

2.1.4 Canonical SMILES

OP(=O)([O-])[O-].[Ca+2]

2.2 Other Identifiers

2.2.1 UNII

L11K75P92J

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Anhydrous Dibasic Calcium Phosphate

2. Calcium Phosphate (cahpo4)

3. Calcium Phosphate, Dibasic, Anhydrous

4. Dibasic Calcium Phosphate, Anhydrous

5. Monetite

2.3.2 Depositor-Supplied Synonyms

1. 7757-93-9

2. Calcium Phosphate Dibasic

3. Dicalcium Phosphate

4. Calcium Phosphate, Dibasic

5. Dibasic Calcium Phosphate

6. Phosphoric Acid, Calcium Salt (1:1)

7. Secondary Calcium Phosphate

8. Calcium Phosphate (1:1)

9. Dicalcium Orthophosphate

10. Calcium Hydrogen Orthophosphate

11. Monocalcium Acid Phosphate

12. Dicalcium Phosphate Anhydrous

13. Calcium Monohydrogen Phosphate

14. Calciumphosphate,dibasic

15. Calcium Phosphate Dibasic Anhydrous

16. Anhydrous Dibasic Calcium Phosphate

17. Calcium Phosphate,dibasic

18. Mfcd00010909

19. Calcium Phosphate (dibasic)

20. Chebi:32596

21. Ins-341(ii)

22. L11k75p92j

23. Calcium Phosphate, Dibasic, Anhydrous

24. E-341(ii)

25. Biofos

26. Fujicalin S

27. Dicafos An

28. 7557-93-9

29. Anhydrous Emcompress

30. Ipifosc 20

31. A-tab

32. D-glucopyranosiduronicacid, 1-(2,4-dichlorophenyl)ethyl

33. Calcium Acid Phosphate

34. Calcium Dibasic Phosphate

35. Calcium Secondary Phosphate

36. Calcium Phosphate (cahpo4)

37. Monohydrogen Calcium Phosphate

38. Ccris 1337

39. Hsdb 992

40. Cahpo4

41. Calcium Phosphate, Dibasic [jan]

42. Einecs 231-826-1

43. Calcium Hydrogenorthophosphate

44. Calcium Phosphate, Dibasic, Dental Grade

45. Unii-l11k75p92j

46. Calstar (tn)

47. Calcium Monohydrogen Phosphate Anhydrous

48. Calcii Hydrogenophosphas

49. Calcium;hydrogen Phosphate

50. Ec 231-826-1

51. Calcium Monohydrogenphosphate

52. Dicalcium Phosphate, Anhydrous

53. Calcium (as Phosphate,dibasic)

54. Ins No.341(ii)

55. Chembl2107567

56. Dtxsid20872529

57. Dicalcium Phosphate [inci]

58. Phosphoric Acid Calcium Salt

59. Calcium Hydrogen Monophosphate

60. Calcium Hydrogen Phosphate, Anhydrous

61. Akos015965054

62. Calcium Hydrogenorthophosphate Anhydrous

63. Calcium Phosphate, Dibasic [mi]

64. Calcium Phosphate,dibasic [vandf]

65. Calcium Hydrogenorthophosphate, With A Fluorine Content Of Less Than 0,005 Per Cent By Weight On The Dry Anhydrous Product

66. Calcium Phosphate, Dibasic [hsdb]

67. Dibasic Calcium Phosphate Anhydrous

68. Calcium Hydrogen Phosphate Anhydrous

69. Calcium Phosphate Dibasic [who-dd]

70. Calcium Phosphate, Dibasic (99.95%-ca)

71. Phosphorus (as Dicalcium Phosphate)

72. Calcium Phosphate (1:1) [who-ip]

73. Calcium Phosphate Dibasic, 98.0-105.0%

74. Calcium Phosphate, Dibasic Anhydrous

75. Dibasic Calcium Phosphate, Anhydrous (jan)

76. Calcium Phosphate Dibasic, Puriss., 98.0%

77. Ft-0623397

78. Calcium (calcium Phosphate (dibasic))

79. Calcium Hydrogen Phosphate (anhydrous)

80. Calcii Hydrogenophosphas [who-ip Latin]

81. Calcium (as Phosphate,dibasic) [vandf]

82. D03302

83. Anhydrous Dibasic Calcium Phosphate [jan]

84. Calcium Hydrogen Phosphate [ep Monograph]

85. Calcium Phosphate Dibasic Anhydrous, Usp Fcc Pe

86. Calcium Phosphate Dibasic, Usp, 98.0-103.0%

87. Calcium Phosphate, Dibasic, Anhydrous [ii]

88. Q414619

89. Phosphorus (as Dicalcium Phosphate) [vandf]

90. Calcium Hydrogen Phosphate, Anhydrous [who-ip]

91. Anhydrous Dibasic Calcium Phosphate [usp Monograph]

92. Dibasic Calcium Phosphate, Meets Usp Testing Specifications

93. Phosphorus (as Calcium Phosphate,dibasic) [vandf]

94. Calcium Phosphate Dibasic, Puriss. P.a., Anhydrous, >98.5% (kt)

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	CaHO₄P
Molecular Weight	136.06 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	135.9238364 g/mol
Monoisotopic Mass	135.9238364 g/mol
Topological Polar Surface Area	83.4 Å²
Heavy Atom Count	6
Formal Charge	0
Complexity	46.5
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Therapeutic Uses

USES--EXCELLENT SOURCE OF CALCIUM & PHOSPHORUS DURING PREGNANCY, LACTATION, OR MILD TO MODERATE HYPOCALCEMIA CHARACTERIZED BY LOW DEGREE OF TETANY. ... IF TETANY IS SEVERE, IV CALCIUM MEDICATION IS ADMIN. ... DOSE--1 TO 5 G/DAY IN 2 OR MORE DIVIDED DOSES.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 770

IT IS NOT MARKETED IN SINGLE ENTITY FORM, SO THAT DOSE OF OTHER INGREDIENTS MAY HAVE TO BE CONSIDERED IN ARRIVING @ SUITABLE SCHEDULE. CALCIUM IS BETTER ABSORBED IF TAKEN IN SMALL DOSES @ FREQUENT INTERVALS.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 770

MEDICATION (VET): FOR PREVENTION & TREATMENT OF RICKETS ALONG WITH VITAMIN D THERAPY, & AS NUTRIENT SOURCE OF CALCIUM & PHOSPHORUS IN FEEDSTUFFS. ... OPTIMUM CALCIUM:PHOSPHORUS RATIO IN DIET MUST ALSO BE MAINTAINED.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 71

DIBASIC CALCIUM PHOSPHATE, NATIONAL FORMULARY ... /IS AMONG CMPD/ CLASSIFIED AS NONSYSTEMIC GASTRIC ANTACIDS, BUT THEIR EFFICACY IS LOW & THEY ARE SELDOM EMPLOYED.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 967

Medication (VET): Has been used as a dietary supplement, and as an antacid.

Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 256

4.2 Drug Warning

BECAUSE OF PHOSPHATE CONTENT, IT IS CONTRAINDICATED IN /PERSONS WITH/ HYPOPARATHYROIDISM.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 770

5 Pharmacology and Biochemistry

5.1 Absorption, Distribution and Excretion

... ITS ELEMENTS ARE SLOWLY ABSORBED FROM SMALL INTESTINE.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 71

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