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    Chemistry

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    Also known as: 76-22-2, 2-camphanone, Dl-camphor, (+/-)-camphor, 2-bornanone, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
    Molecular Formula
    C10H16O
    Molecular Weight
    152.23  g/mol
    InChI Key
    DSSYKIVIOFKYAU-UHFFFAOYSA-N
    Camphor
    A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.
    1 2D Structure

    Camphor

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
    2.1.2 InChI
    InChI=1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3
    2.1.3 InChI Key
    DSSYKIVIOFKYAU-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1(C2CCC1(C(=O)C2)C)C
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Camphor, (+-)-isomer

    2. Camphor, (1r)-isomer

    3. Camphor, (1s)-isomer

    2.2.2 Depositor-Supplied Synonyms

    1. 76-22-2

    2. 2-camphanone

    3. Dl-camphor

    4. (+/-)-camphor

    5. 2-bornanone

    6. 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

    7. (+)-camphor

    8. Bornan-2-one

    9. Root Bark Oil

    10. Kampfer

    11. 21368-68-3

    12. Spirit Of Camphor

    13. 2-camphonone

    14. Gum Camphor

    15. 464-48-2

    16. L-(-)-camphor

    17. 1,7,7-trimethylnorcamphor

    18. Alphanon

    19. 1,7,7-trimethylbicyclo[2.2.1]-2-heptanone

    20. D-(+)-camphor

    21. 2-keto-1,7,7-trimethylnorcamphane

    22. Formosa Camphor

    23. Laurel Camphor

    24. Matricaria Camphor

    25. Camphor, Synthetic

    26. 4,7,7-trimethylbicyclo[2.2.1]heptan-3-one

    27. Bornane, 2-oxo-

    28. Camphor (synthetic)

    29. Huile De Camphre

    30. Chebi:36773

    31. 2-kamfanon

    32. Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-

    33. Dl-bornan-2-one

    34. (-)-alcanfor

    35. Norcamphor, 1,7,7-trimethyl-

    36. Camphor, (1r,4r)-(+)-

    37. Synthetic Camphor

    38. 1,7,7-trimethylbicyclo(2.2.1)heptan-2-one

    39. Camphor Oil

    40. Camphor Powder

    41. Formosa

    42. Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (.+/-.)-

    43. Japan Camphor

    44. Camphor (usp)

    45. Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1r)-

    46. Racemic Camphor

    47. Disperseyellow3

    48. Dl-2-bornanone

    49. Heet (salt/mix)

    50. Dextro,laevo-camphor

    51. Sarna (salt/mix)

    52. (?)-camphor

    53. Dl-camphor (jp17)

    54. (.+/-.)-camphor

    55. Camphor Powder - Synthetic

    56. (1rs,4rs)-1,7,7-trimethylbicyclo(2.2.1)heptan-2-one

    57. Dsstox_cid_10955

    58. Dsstox_rid_78860

    59. Dsstox_gsid_30955

    60. Schembl16068

    61. Camphor, (.+/-.)-

    62. Mls001055495

    63. Chembl15768

    64. Divk1c_000724

    65. Gtpl2422

    66. Dtxsid5030955

    67. Hms502e06

    68. Kbio1_000724

    69. Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1s)-

    70. Ninds_000724

    71. Hms2268a06

    72. Hms3885j06

    73. Hy-n0808

    74. Tox21_200237

    75. Bbl012963

    76. Mfcd00074738

    77. S3851

    78. S4516

    79. Stk803534

    80. ( Inverted Exclamation Marka)-camphor

    81. Akos000118728

    82. Akos022060577

    83. Ac-5284

    84. Ccg-266237

    85. Ccg-266238

    86. Db14156

    87. Lmpr0102120001

    88. Un 2717

    89. Cas-76-22-2

    90. Idi1_000724

    91. Ncgc00090681-05

    92. Ncgc00090730-01

    93. Ncgc00090730-02

    94. Ncgc00090730-05

    95. Ncgc00257791-01

    96. Ac-15523

    97. Smr000386909

    98. Vs-03622

    99. (1r,4r)-1,7,7-trimethylnorbornan-2-one

    100. Db-051377

    101. Db-056037

    102. Db-070734

    103. C1251

    104. Cs-0009813

    105. Ft-0607017

    106. Ft-0607018

    107. Ft-0608303

    108. 4,7,7-trimethyl-3-bicyclo[2.2.1]heptanone

    109. 1,7,7-trimethyl-bicyclo[2.2.1]heptan-6-one

    110. C00809

    111. C18369

    112. D00098

    113. E75814

    114. 1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one

    115. A838646

    116. Q181559

    117. Q-200784

    118. W-109539

    119. W-110530

    120. (+/-)-1,7,7-trimethyl-bicyclo[2,2,1]heptane-2-one

    121. F0001-0763

    122. Z940713494

    2.3 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 152.23 g/mol
    Molecular Formula C10H16O
    XLogP32.2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count0
    Exact Mass152.120115130 g/mol
    Monoisotopic Mass152.120115130 g/mol
    Topological Polar Surface Area17.1 Ų
    Heavy Atom Count11
    Formal Charge0
    Complexity217
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Anti-Infective Agents, Local

    National Library of Medicine's Medical Subject Headings online file (MeSH, 2014); Available from, as of July 31, 2014: https://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?term=Camphor

    It /SRP: was formerly/ used ... In humans for inflamed joints, sprains, and rheumatic and other inflammatory conditions such as colds in throat and chest. ... patient may feel improved /however/ inflammation is not affected.

    Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 724

    MEDICATION (VET): Locally, camphor is weakly antiseptic and has a rubefacient action when applied to skin. It is a common ingredient of many liniments.

    Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 414

    MEDICATION (VET): /Camphor/ ... As a steam inhalant has been popular in respiratory diseases of horses and poultry. Orally, it has been popular in antiferment and carminative mixtures for calf scours, and in expectorant mixtures.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 74

    For more Therapeutic Uses (Complete) data for CAMPHOR (10 total), please visit the HSDB record page.

    4.2 Drug Warning

    Keep pharmaceutical preparations and moth-repellents out of the reach of children and irresponsible people. Label camphorated oil appropriately to avoid mistaking it for castor oil and cough syrups. Do not place camphor ointments into infants' nostrils. Do not use the rubefacient on abraded skin.

    IPCS; Poisons Information Monograph 095: Camphor. (Date of last update: May 1989). Available from, as of June 30, 2014: https://www.inchem.org/documents/pims/pharm/camphor.htm#SectionTitle:1.5%20Brand%20names,%20Trade%20na

    Camphor and camphor containing products should be avoided in children who have a history of febrile convulsions or other predisposing factors for convulsions.

    National Poisons Information Service Center, United Kingdom; Poisons Information Monograph: Camphor. (March 1996). Available from, as of June 30, 2014: https://www.inchem.org/documents/ukpids/ukpids/ukpid19.htm

    Camphor should not be applied to the nostrils of infants even in small quantities, as this may cause immediate collapse.

    SWEETMAN, S.C. (ed.) Martindale-The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press, 2009., p. 2273

    The UK Committee on the Review of Medicines recommended that camphor should not be included in products intended for the treatment of hepatic and biliary disorders, gallstones, colic, renal disorders, urinary tract infections, or ureteral stones. The use of camphor parenterally or as irrigants was considered undesirable due to the associated safety hazard.

    SWEETMAN, S.C. (ed.) Martindale-The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press, 2009., p. 2273

    For more Drug Warnings (Complete) data for CAMPHOR (11 total), please visit the HSDB record page.

    4.3 Minimum/Potential Fatal Human Dose

    ...fatalities in children have been recorded from 1g.

    SWEETMAN, S.C. (ed.) Martindale-The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press, 2009., p. 2273

    ...The literature from 1964-1983 /was reviewed/, and... the mean dose ingested by patients with major symptoms /was/ 124 mg/kg, with the mean dose in fatal cases being 199 mg/kg. /It was/... suggested, based on /the/ analysis of these figures, that patients ingesting <10 mg/kg of camphor and displaying no symptoms required no treatment. Adults have survived ingestions of up to 42 g, but usually doses in excess of 2 g produce dangerous effects. Fatal doses in children have ranged from 0.7-1.0 g.

    National Poisons Information Service Center, United Kingdom; Poisons Information Monograph: Camphor. (March 1996). Available from, as of June 30, 2014: https://www.inchem.org/documents/ukpids/ukpids/ukpid19.htm

    Dosages exceeding 2.0 grams have been reported to be /CNS depressant/ and may cause convulsions, delirium, hallucinations, and death.

    McGuffin M, Hobbs C et al., eds; American Herbal Products Association's Botanical Safety Handbook. p. 31 (1997)

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Infective Agents, Local

    Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

    5.2 Absorption, Distribution and Excretion

    Camphor is rapidly absorbed from the mucous membranes and the gastrointestinal tract. ... It is also absorbed through inhalation, through dermal application, and by nasal instillation.

    Ford MD, Delaney KA, Ling LJ, Erickson T; Clinical Toxicology. W.B. Saunders Company., Philadelphia, PA. 2001, p. 339

    ... after camphor ingestion by mothers ... camphor was detectable in maternal blood 15 min after ingestion, but not after 8 hr. At delivery 36 hr later ... it was present in amnionic fluid, cord and fetal blood and fetal brain, liver and kidneys.

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-85

    Alimentary absorption of pure camphor, or of alcohol solution ... is quite rapid, but from the oil preparation absorption is constant. Camphor is ... slowly absorbed from sc or im depots.

    Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger, 1972., p. 16

    Absorbed camphor is mainly eliminated as the oxidized camphorol in the urine, although some appears in the breath, sweat, and feces.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 74

    For more Absorption, Distribution and Excretion (Complete) data for CAMPHOR (7 total), please visit the HSDB record page.

    5.3 Metabolism/Metabolites

    In the liver microsomes of female mice, two induction phases during inhalation of DL-camphor were found. During the first 24 hr the apparent molar activity of the ethylumbelliferone dealkylase decreased. In the second phase, the molar ethylumbelliferone dealkylase activity was constant.

    Mohn G; Different phases of hydroxylase induction in liver microsomes of female mice during inhalation of cyclohexane and D,L-camphor; Microsomes Drug Oxid, Proc Int Symp, 3rd: 59-66 (1977)

    The metabolism of (+)-camphor and (-)-camphor was investigated in rabbits after administration /through/ stomach tube; metabolites of (+)-camphor were (+)-borneol, (+)-5-endo-hydroxycamphor, and (+)-3-endohydroxycamphor.

    ROBERTSON JS, HUSSAIN M; METABOLISM OF CAMPHORS AND RELATED COMPOUNDS; BIOCHEM J 113 (1): 57-65 (1969)

    Camphor is rapidly oxidized to campherols (2-hydroxycamphor and 3-hydroxycamphor), and then conjugated in the liver to the glucuronide form. Camphor-related metabolites are relatively fat-soluble and may accumulate in fatty tissue.

    IPCS; Poisons Information Monograph 095: Camphor. (Date of last update:May 1989). Available from, as of June 30, 2014: https://www.inchem.org/documents/pims/pharm/camphor.htm#SectionTitle:1.5%20Brand%20names,%20Trade%20na

    5.4 Biological Half-Life

    167 minutes (200 mg camphor ingested alone); 93 minutes (200 mg camphor ingested with a solvent - Tween 80).

    National Poisons Information Service Center, United Kingdom; Poisons Information Monograph: Camphor. (March 1996). Available from, as of June 30, 2014: https://www.inchem.org/documents/ukpids/ukpids/ukpid19.htm

    5.5 Mechanism of Action

    Camphor is a naturally occurring compound that is used as a major active ingredient of balms and liniments supplied as topical analgesics. ... Capsaicin and menthol, two other topically applied agents widely used for similar purposes, are known to excite and desensitize sensory nerves by acting on two members of transient receptor potential (TRP) channel superfamily: heat-sensitive TRP vanilloid subtype 1 (TRPV1) and cold-sensitive TRP channel M8, respectively. Camphor has recently been shown to activate TRPV3, and here /investigators/ show that camphor also activates heterologously expressed TRPV1, requiring higher concentrations than capsaicin. Activation was enhanced by phospholipase C-coupled receptor stimulation mimicking inflamed conditions. Similar camphor-activated TRPV1-like currents were observed in isolated rat DRG neurons and were strongly potentiated after activation of protein kinase C with phorbol-12-myristate-13-acetate. Camphor activation of rat TRPV1 was mediated by distinct channel regions from capsaicin, as indicated by camphor activation in the presence of the competitive inhibitor capsazepine and in a capsaicin-insensitive point mutant. Camphor did not activate the capsaicin-insensitive chicken TRPV1. TRPV1 desensitization is believed to contribute to the analgesic actions of capsaicin. /The authors/ found that, although camphor activates TRPV1 less effectively, camphor application desensitized TRPV1 more rapidly and completely than capsaicin. Conversely, TRPV3 current sensitized after repeated camphor applications, which is inconsistent with the analgesic role of camphor. /Investigators/ also found that camphor inhibited several other related TRP channels, including ankyrin-repeat TRP 1 (TRPA1). The camphor-induced desensitization of TRPV1 and block of TRPA1 may underlie the analgesic effects of camphor.

    PMID:16192383 Xu H et al; J Neurosci. 25(39):8924-37 (2005).

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K","supplierAddress":"700 BLAIR ROAD, CARTERET, NJ 07008 SDNF SDNF US","customerAddress":"1-5 SEVEN WELLS STREET"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728239400,"product":"L-CAMPHOR SULFONIC ACID","address":"PLOT NO.12\/A, IDA, PHASE-III,","city":"","supplier":"ZHEJIANG UEASY BUSINESS SERVICE CO,LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SMILAX LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"16.9","totalValueFC":"33869.8","currency":"USD","unitRateINR":"1423","date":"07-Oct-2024","totalValueINR":"2845960","totalValueInUsd":"33869.8","indian_port":"Vizag Sea","hs_no":"29142990","bill_no":"5989435","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM.302 NO.22 CHANGCHENG STREET GONGSHU DISTRICT HANGZHOU CN","customerAddress":"PLOT NO.12\/A, IDA, PHASE-III,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728585000,"product":"CAMPHOR DAB 6","address":"908, TULSIANI CHAMBERS,","city":"MUMBAI","supplier":"WUHAN CHANGHEYING IMP & EXP CO.,LTD","supplierCountry":"CHINA","foreign_port":"NANSHA","customer":"INFINITY ENTERPRISE","customerCountry":"INDIA","quantity":"15000.00","actualQuantity":"15000","unit":"KGS","unitRateFc":"4.2","totalValueFC":"63920.3","currency":"USD","unitRateINR":"358.1","date":"11-Oct-2024","totalValueINR":"5371005","totalValueInUsd":"63920.3","indian_port":"JNPT","hs_no":"29142922","bill_no":"6068787","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NANSHA","supplierAddress":"NO.8 JIANGHAN NORTH ROAD,JINMAO BUI LDING ANNEX 4WUHAN SDNF CHINA","customerAddress":"908, TULSIANI CHAMBERS,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728757800,"product":"CAMPHOR POWDER NATURAL","address":"22\/23, CHAMPAKLAL INDL. ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"JIAXING BARTON CHEMICALS ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"ASHAPURA AROMAS","customerCountry":"INDIA","quantity":"12000.00","actualQuantity":"12000","unit":"KGS","unitRateFc":"4","totalValueFC":"47873","currency":"USD","unitRateINR":"335.2","date":"13-Oct-2024","totalValueINR":"4022602","totalValueInUsd":"47873","indian_port":"JNPT","hs_no":"29142921","bill_no":"6091295","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO 162, FU MING RD. HONG HE TOWN, J IAXING , ZHEJIANG CHINA - 314023 SDNF CHINA","customerAddress":"22\/23, CHAMPAKLAL INDL. ESTATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729017000,"product":"(1R)-(-)-10-CAMPHORSULFONIC ACID","address":"PLOT NO. 193, HOUSE NO. 5-35\/50,","city":"HYDERABAD, AP","supplier":"MILVERPHARMA PVT LTD","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"INDIA","quantity":"150.00","actualQuantity":"150","unit":"KGS","unitRateFc":"35","totalValueFC":"5301.4","currency":"USD","unitRateINR":"2969.8","date":"16-Oct-2024","totalValueINR":"445462.5","totalValueInUsd":"5301.4","indian_port":"Hyderabad Air","hs_no":"29147990","bill_no":"6153114","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"9TH FLOOR,1#,NO.98 CHUANGYUAN RD, SMART PARK, HI-TECH ZONE NINGBO CHINA CN","customerAddress":"PLOT NO. 193, HOUSE NO. 5-35\/50,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730140200,"product":"L-CAMPHOR SULFONIC ACID","address":"PLOT NO.12\/A, IDA, PHASE-III,","city":"","supplier":"ZHEJIANG UEASY BUSINESS SERVICE CO,LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SMILAX LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"4000.00","actualQuantity":"4000","unit":"KGS","unitRateFc":"16.9","totalValueFC":"67739.5","currency":"USD","unitRateINR":"1423","date":"29-Oct-2024","totalValueINR":"5691920","totalValueInUsd":"67739.5","indian_port":"Vizag Sea","hs_no":"29142990","bill_no":"6392658","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM.302 NO.22 CHANGCHENG STREET GONGSHU DISTRICT HANGZHOU CN","customerAddress":"PLOT NO.12\/A, IDA, PHASE-III,"}]
    01-Jan-2021
    30-Oct-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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