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1. Camptothecine
1. Camptothecine
2. 7689-03-4
3. (s)-(+)-camptothecin
4. Campathecin
5. (+)-camptothecine
6. D-camptothecin
7. (+)-camptothecin
8. 20(s)-camptothecine
9. 21,22-secocamptothecin-21-oic Acid Lactone
10. Nsc94600
11. Camptothecine (s,+)
12. Chembl65
13. (4s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
14. Nsc-94600
15. Topotecan Related Compound C
16. (s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
17. Mls000766223
18. Xt3z54z28a
19. Chebi:27656
20. Mfcd00081076
21. (19s)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
22. Nsc 100880
23. 251316-95-7
24. (s)-camptothecin
25. (19s)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
26. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-, (4s)-
27. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-, (s)-
28. 1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-, (4s)-
29. 20(s)-camptothecin
30. 4-ethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
31. Sr-01000075798
32. Sr-01000597379
33. D-camptothecine
34. (s)-camptothecine
35. Camptothecin,(s)
36. ( )-camptothecin
37. (4s)-4-ethyl-4-hydroxy-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione
38. (s)-4-ethyl-4-hydroxy-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione
39. (s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4h,12h)-dione
40. 1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-, (s)-
41. Prestwick_102
42. (+)-camptothecin;
43. Camptothecine (8ci)
44. Spectrum_000299
45. Tocris-1100
46. Specplus_000712
47. Prestwick0_000200
48. Prestwick1_000200
49. Prestwick2_000200
50. Prestwick3_000200
51. Spectrum2_000903
52. Spectrum3_001203
53. Spectrum4_000738
54. Spectrum5_001126
55. Camptothecin [mi]
56. Lopac-c-9911
57. Schembl6038
58. Unii-xt3z54z28a
59. Lopac0_000341
60. Bspbio_000159
61. Bspbio_002586
62. Kbiogr_001036
63. Kbioss_000779
64. Kbioss_002283
65. Cid_24360
66. Camptothecin [who-dd]
67. Divk1c_000826
68. Divk1c_006808
69. Spectrum1502232
70. Spbio_000746
71. Spbio_002080
72. Bpbio1_000175
73. Ccris 8162
74. Dtxsid0030956
75. Hms502j08
76. Kbio1_000826
77. Kbio1_001752
78. Kbio2_000779
79. Kbio2_003347
80. Kbio2_005915
81. Kbio3_002086
82. 4-ethyl-4-hydroxy-1h-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
83. Ninds_000826
84. Bio1_000400
85. Bio1_000889
86. Bio1_001378
87. Hms1568h21
88. Hms1921n08
89. Hms2089f08
90. Hms2095h21
91. Hms3261e03
92. Hms3414j17
93. Hms3654d13
94. Hms3678j15
95. Hms3712h21
96. Zinc105309
97. Act02668
98. Bcp02857
99. Tox21_500341
100. Ac-202
101. Bbl033963
102. Bdbm50008923
103. Ccg-40255
104. Gr-301
105. Nsc 94600
106. S1288
107. Stk801886
108. Akos004119861
109. Cs-1049
110. Db04690
111. Ks-5235
112. Lp00341
113. Sdccgmls-0066688.p001
114. Sdccgsbi-0050329.p003
115. Brn 0631069
116. Cas-2114454
117. Idi1_000826
118. Ncgc00015290-01
119. Ncgc00016994-01
120. Ncgc00016994-02
121. Ncgc00016994-03
122. Ncgc00016994-04
123. Ncgc00016994-05
124. Ncgc00016994-06
125. Ncgc00016994-07
126. Ncgc00016994-08
127. Ncgc00016994-09
128. Ncgc00016994-10
129. Ncgc00016994-11
130. Ncgc00016994-12
131. Ncgc00016994-16
132. Ncgc00016994-29
133. Ncgc00024997-01
134. Ncgc00024997-02
135. Ncgc00024997-03
136. Ncgc00024997-04
137. Ncgc00024997-05
138. Ncgc00024997-06
139. Ncgc00178592-01
140. Ncgc00178592-02
141. Ncgc00261026-01
142. Hy-16560
143. Nci60_042105
144. Smr000445686
145. Sy010324
146. Ai3-62475
147. Eu-0100341
148. N1868
149. Sw196414-3
150. Topotecan Related Compound C [usp-rs]
151. C 9911
152. C01897
153. M01564
154. Ab00052452-08
155. Ab00052452-09
156. Ab00052452_10
157. (s)-(+)-camptothecin, >=90% (hplc), Powder
158. 689c034
159. A838882
160. Q419964
161. Q-200785
162. Sr-01000075798-1
163. Sr-01000075798-4
164. Sr-01000597379-1
165. Sr-01000597379-3
166. Brd-k37890730-001-09-4
167. Brd-k37890730-001-10-2
168. (s)-4-ethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione
169. (s)-4-ethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
170. 4-ethyl-4-hydroxy-1h-pyrano-[3[,4[:6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
171. Topotecan Related Compound C, United States Pharmacopeia (usp) Reference Standard
172. (s)-4-ethyl-4-hydroxy-1h-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
173. (s)-4-ethyl-4-hydroxy-1h-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione;(s)-(+)-camptothecin
174. (s)-4-ethyl-4-hydroxy-1h-pyrano[3 Inverted Exclamation Mark ,4 Inverted Exclamation Mark :6,7]indolizino[1,2-b]quinoline-3,14-(4h,12h)-dione
175. 1h-pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-, (s)-
176. 4(s)-ethyl-4-hydroxy-1h-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14 (4h,12h)-dione
177. 4-ethyl-4-hydroxy-(4s)-3,4,12,14-tetrahydro-1h-pyrano[3'',4'':6,7]indolizino[1,2-b]quinoline-3,14-dione
178. 4-ethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin Or Cpt)
179. 4-ethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin)
180. 4-ethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (cpt, Camptothecin)
| Molecular Weight | 348.4 g/mol |
|---|---|
| Molecular Formula | C20H16N2O4 |
| XLogP3 | 1 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 1 |
| Exact Mass | 348.11100700 g/mol |
| Monoisotopic Mass | 348.11100700 g/mol |
| Topological Polar Surface Area | 79.7 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 742 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Investigated for the treatment of cancer.
Camptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. Camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication.
Topoisomerase I Inhibitors
Compounds that inhibit the activity of DNA TOPOISOMERASE I. (See all compounds classified as Topoisomerase I Inhibitors.)
Antineoplastic Agents, Phytogenic
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)
Camptothecin binds to the topoisomerase I and DNA complex resulting in a ternary complex, stabilizing it and preventing DNA re-ligation and therefore causes DNA damage which results in apoptosis.
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A Camptothecine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Camptothecine, including repackagers and relabelers. The FDA regulates Camptothecine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Camptothecine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Camptothecine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Camptothecine supplier is an individual or a company that provides Camptothecine active pharmaceutical ingredient (API) or Camptothecine finished formulations upon request. The Camptothecine suppliers may include Camptothecine API manufacturers, exporters, distributors and traders.
click here to find a list of Camptothecine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Camptothecine DMF (Drug Master File) is a document detailing the whole manufacturing process of Camptothecine active pharmaceutical ingredient (API) in detail. Different forms of Camptothecine DMFs exist exist since differing nations have different regulations, such as Camptothecine USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Camptothecine DMF submitted to regulatory agencies in the US is known as a USDMF. Camptothecine USDMF includes data on Camptothecine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Camptothecine USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Camptothecine suppliers with USDMF on PharmaCompass.
Camptothecine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Camptothecine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Camptothecine GMP manufacturer or Camptothecine GMP API supplier for your needs.
A Camptothecine CoA (Certificate of Analysis) is a formal document that attests to Camptothecine's compliance with Camptothecine specifications and serves as a tool for batch-level quality control.
Camptothecine CoA mostly includes findings from lab analyses of a specific batch. For each Camptothecine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Camptothecine may be tested according to a variety of international standards, such as European Pharmacopoeia (Camptothecine EP), Camptothecine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Camptothecine USP).
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