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Canertinib

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INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

Synopsis

ACTIVE PHARMA INGREDIENTS

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JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

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1INTERMEDIATES

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Canada

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Chemistry

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Also known as: 267243-28-7, Ci-1033, Pd-183805, Canertinib (ci-1033), Canertinib free base, N-(4-(3-chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide

Molecular Formula

C₂₄H₂₅ClFN₅O₃

Molecular Weight

485.9 g/mol

InChI Key

OMZCMEYTWSXEPZ-UHFFFAOYSA-N

FDA UNII

C78W1K5ASF

Canertinib is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hypoxia as determined by PET.

1 2D Structure

Canertinib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide

2.1.2 InChI

InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)

2.1.3 InChI Key

OMZCMEYTWSXEPZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

2.2 Other Identifiers

2.2.1 UNII

C78W1K5ASF

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ci 1033

2. Ci-1033

3. Ci1033

2.3.2 Depositor-Supplied Synonyms

1. 267243-28-7

2. Ci-1033

3. Pd-183805

4. Canertinib (ci-1033)

5. Canertinib Free Base

6. N-(4-(3-chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide

7. N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide

8. C78w1k5asf

9. Chembl31965

10. N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide

11. Chebi:61399

12. 267243-28-7 (free Base)

13. N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide

14. Ncgc00182713-01

15. Pd183805

16. Canertinib [inn]

17. Canertinib [inn:ban]

18. Sn-26606

19. Ci-1033(canertinib)

20. Ci1033

21. Unii-c78w1k5asf

22. Canetinib

23. Canertinib [mi]

24. Caneritinib; Ci-1033

25. Canertinib - Ci-1033

26. Ci-1033 (canertinib)

27. Canertinib [who-dd]

28. Dsstox_cid_28869

29. Dsstox_rid_83138

30. Dsstox_gsid_48943

31. Schembl54837

32. Mls004774146

33. Pd 183805 Dihydrochloride

34. Bdbm4779

35. Cid_156414

36. Gtpl5675

37. Dtxsid8048943

38. Ex-a078

39. Bcpp000301

40. Hms3244m17

41. Hms3244m18

42. Hms3244n17

43. Bcp01790

44. Tox21_113361

45. Nsc780019

46. Nsc801011

47. S1019

48. Zinc27439698

49. Akos005145818

50. Bcp9000481

51. Bcp9000482

52. Bcp9000525

53. Ccg-269588

54. Cs-0121

55. Db05424

56. Nsc-780019

57. Nsc-801011

58. Sb16594

59. N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide

60. N-[4-(3-chloro-4-fluoro-anilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]prop-2-enamide

61. Ncgc00182713-02

62. Ncgc00182713-18

63. As-56189

64. Hy-10367

65. Smr003500789

66. Pd0183805

67. Cas-267243-28-7

68. Ft-0654215

69. Ec-000.2258

70. A25038

71. 499c452

72. Q5032274

73. 2-propenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-morpholinyl)propoxy)-6-quinazolinyl)-

74. N-(4-(3-chloro-4-fluorophenyl)amino)-7-(3-morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide

75. N-[4-(3-chloro-4-fluoro-phenyl-amino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₅ClFN₅O₃
Molecular Weight	485.9 g/mol
XLogP3	3.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	485.1629955 g/mol
Monoisotopic Mass	485.1629955 g/mol
Topological Polar Surface Area	88.6 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	671
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Investigated for use/treatment in breast cancer and lung cancer.

5 Pharmacology and Biochemistry

5.1 Mechanism of Action

CI-1033 effectively inhibits the growth of esophageal squamous cell carcinoma which co-expresses both EGFR and HER2 with the inhibition of phosphorylation of both MAPK and AKT. Some studies suggest that CI-1033 holds significant clinical potential in esophageal cancer.

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ABOUT THIS PAGE

Canertinib Manufacturers

A Canertinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Canertinib, including repackagers and relabelers. The FDA regulates Canertinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Canertinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Canertinib Suppliers

A Canertinib supplier is an individual or a company that provides Canertinib active pharmaceutical ingredient (API) or Canertinib finished formulations upon request. The Canertinib suppliers may include Canertinib API manufacturers, exporters, distributors and traders.

Canertinib GMP

Canertinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Canertinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Canertinib GMP manufacturer or Canertinib GMP API supplier for your needs.

Canertinib CoA

A Canertinib CoA (Certificate of Analysis) is a formal document that attests to Canertinib's compliance with Canertinib specifications and serves as a tool for batch-level quality control.

Canertinib CoA mostly includes findings from lab analyses of a specific batch. For each Canertinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Canertinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Canertinib EP), Canertinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Canertinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.