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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 4 USDMF, 1 CEP/COS

4 API Suppliers
4 USDMF
1 CEP/COS

FINISHED DOSAGE FORMULATIONS

19 FDF Dossiers, 3 FDA Orange Book, 3 Canada, 5 Australia, 6 South Africa, 2 Listed Dossiers

19 FDF Dossiers
3 FDA Orange Book
3 Canada
5 Australia
6 South Africa
2 Listed Dossiers

DIGITAL CONTENT

2 NEWS #PharmaBuzz

media
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions

globalSalesInformation
2 US Medicaid Prescriptions

MARKET PLACE

1 FDF Dossiers

marketPlace
1 FDF Dossiers

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

163,676,673

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 8049-62-5, Insulin zinc suspension, Caninsulin, Monotard, Insulin lente, Lente insulin

Molecular Formula

C₂₅₇H₃₈₃N₆₅O₇₇S₆Zn

Molecular Weight

5873 g/mol

InChI Key

LEMUFSYUPGXXCM-JNEQYSBXSA-N

An insulin, zinc chloride preparation in the form of a suspension of crystals and amorphous material in a ratio of approximately 7:3. Typically, lente insulin has a duration of activity that lasts between 13-20 hours after dosage.

1 2D Structure

Caninsulin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4S)-4-[[2-[[(1R,6R,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,50S,53S,56S,59S,62S,65S,68S,71S,74R,77S,80S,83S,88R)-88-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]-6-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoyl]amino]-3-(4H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-47-[[(1S)-3-amino-1-carboxy-3-oxopropyl]carbamoyl]-53-(2-amino-2-oxoethyl)-62-(3-amino-3-oxopropyl)-77-[(2S)-butan-2-yl]-24,56-bis(2-carboxyethyl)-83-[(1R)-1-hydroxyethyl]-12,71,80-tris(hydroxymethyl)-33,50,65-tris[(4-hydroxyphenyl)methyl]-15-(4H-imidazol-4-ylmethyl)-27-methyl-18,30,36,59,68-pentakis(2-methylpropyl)-7,10,13,16,19,22,25,28,31,34,37,40,49,52,55,58,61,64,67,70,73,76,79,82,85,87-hexacosaoxo-21,39-di(propan-2-yl)-3,4,44,45,90,91-hexathia-8,11,14,17,20,23,26,29,32,35,38,41,48,51,54,57,60,63,66,69,72,75,78,81,84,86-hexacosazabicyclo[72.11.7]dononacontane-42-carbonyl]amino]acetyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[(2S)-2-[[(2S)-6-amino-1-[[(1S)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-oxopentanoic acid;zinc

2.1.2 InChI

InChI=1S/C257H383N65O77S6.Zn/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137;/h31-39,44-49,53-68,105-106,119-136,144-145,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271);/t131-,132-,133-,134+,135+,136?,144?,145?,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-;/m0./s1

2.1.3 InChI Key

LEMUFSYUPGXXCM-JNEQYSBXSA-N

2.1.4 Canonical SMILES

CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(CSSCC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)CC(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)NC(CC(=O)N)C(=O)O)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC5=CC=CC=C5)C(=O)NC(CC6=CC=CC=C6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(C(C)O)C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)O)C(C)C)CC(C)C)CC9=CC=C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2C=NC=N2)CO)NC(=O)C(CC(C)C)NC(=O)C(CC2C=NC=N2)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC2=CC=CC=C2)N)C(=O)NC(C(=O)NC(C(=O)N1)CO)C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(C(C)CC)NC(=O)CN.[Zn]

2.1.5 Isomeric SMILES

CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CC(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N8CCC[C@H]8C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)O)C(=O)O)C(C)C)CC(C)C)CC9=CC=C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2C=NC=N2)CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2C=NC=N2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=CC=C2)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CO)[C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CN.[Zn]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Insulin Novo Monotard

2. Insulin, Lente

3. Insulin, Lente, Monocomponent

4. Insulin, Monotard

5. Lente Insulin

6. Monotard Insulin

7. Monotard, Insulin Novo

8. Novo Monotard, Insulin

2.2.2 Depositor-Supplied Synonyms

1. 8049-62-5

2. Insulin Zinc Suspension

3. Caninsulin

4. Monotard

5. Insulin Lente

6. Lente Insulin

7. Zinc-insulinum

8. Insulin Zinc

9. Insulin, Lente

10. Insulin Semilente

11. Novolin U

12. Nph Insulin

13. Semilente Insulin

14. Insulin Nph

15. Insulin Lente Mc

16. Ultralente Insulin

17. Nph Iletin

18. Insulin Novo Lente

19. Insulin, Ultralente

20. Ultra Lente Iszilin

21. Insulin Zinc Complex

22. Insulin, Crystalline

23. Insulin, Semi-lente

24. Izsab

25. Iletin U 40

26. Zinc Insulin

27. Suspensio Zinc-insulini

28. Ultralenta Zinc Insulin

29. Insulin, Crystalline Zinc

30. Insulini Zinci Suspensio Mixta

31. Prompt Insulin Zinc Suspension

32. Lente Iletin

33. Insulin Isophane

34. Extended Zinc Insulin Suspension

35. Insulini Zinci Amorphi Suspensio

36. Iniectabile Insulini Zinci Amorphi

37. Insulin Human Zinc

38. Insulini Zinco Amorphi Aquosuspensa

39. Einecs 232-469-4

40. Iniectabile Insulini Zinci Compositum

41. Injectio Insulini Cum Zinco Neutralis

42. Insulini Zinci Cristallisati Suspensio

43. Iniectabile Insulini Zinci Cristallisati

44. Insulini Zinco Cristallisati Aquosuspensa

45. Insulin, Isophane

46. Insulina-zinco Sospensione Composta [dcit]

47. Suspension Injectable D'insuline Zinc Mixte

48. Insulina-zinco Sospensione (amorfa) [dcit]

49. Suspension Injectable D'insuline Zinc Amorphe

50. Insulin Zinc [usp:ban]

51. Insulin Human Zinc [usp]

52. Insulini Cum Zinco (crystallisati) [inn-latin]

53. Insulina-zinco Sospensione (crisstallina) [dcit]

54. Suspension Injectable D'insuline Zinc Cristallisee

55. Suspension D'insuline Zinc (amorphe) [inn-french]

56. Insulini Cum Zinco (amorphi) Suspensio [inn-latin]

57. Suspension D'insuline Zinc (composee) [inn-french]

58. Suspension De Insulina Cinc (amorfa) [inn-spanish]

59. Suspension De Insulina Cinc (compuesta) [inn-spanish]

60. Suspension De Insulina Cinc (cristal.) [inn-spanish]

61. Suspension D'insuline Zinc (cristallisee) [inn-french]

62. Insulini Cum Zinco Suspensio Compositacompound [inn-latin]

63. Insulina-zinco Sospensione Composta

64. Insulini Cum Zinco (crystallisati)

65. Insulina-zinco Sospensione (amorfa)

66. Suspension D'insuline Zinc (amorphe)

67. Suspension De Insulina Cinc (amorfa)

68. Suspension D'insuline Zinc (composee)

69. Insulini Cum Zinco (amorphi) Suspensio

70. Suspension De Insulina Cinc (cristal.)

71. Suspension De Insulina Cinc (compuesta)

72. Insulin Zinc Suspension, Compound

73. Insulin Zinc Suspension, Compound [inn]

74. Insulina-zinco Sospensione (crisstallina)

75. Nph

76. Suspension D'insuline Zinc (cristallisee)

77. Insulini Cum Zinco Suspensio Compositacompound

78. Insulin Zinc Injection (aqueous Suspension)

79. Insulin Zinc Injection (aqueous Suspension) [jan]

80. Insulin Zinc Purified Porcine (suspension)

81. Insulin Zinc Purified Porcine (suspension) [jan]

2.3 Create Date

2008-07-11

3 Chemical and Physical Properties

Molecular Formula	C₂₅₇H₃₈₃N₆₅O₇₇S₆Zn
Molecular Weight	5873 g/mol
Hydrogen Bond Donor Count	76
Hydrogen Bond Acceptor Count	89
Rotatable Bond Count	179
Exact Mass	5869.573502 g/mol
Monoisotopic Mass	5867.566792 g/mol
Topological Polar Surface Area	2440 Å²
Heavy Atom Count	406
Formal Charge	0
Complexity	14800
Isotope Atom Count	0
Defined Atom Stereocenter Count	51
Undefined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2