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    Chemistry

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    Also known as: 3505-38-2, Carbinoxamine maleate salt, Lergefin, Clistin, Ciberon, Cliston
    Molecular Formula
    C20H23ClN2O5
    Molecular Weight
    406.9  g/mol
    InChI Key
    GVNWHCVWDRNXAZ-BTJKTKAUSA-N
    FDA UNII
    02O55696WH
    Carbinoxamine
    Carbinoxamine Maleate is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties. Carbinoxamine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries, and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscle. Carbinoxamine maleate is used to provide symptomatic relieve of allergic symptoms.
    1 2D Structure

    Carbinoxamine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine
    2.1.2 InChI
    InChI=1S/C16H19ClN2O.C4H4O4/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-10,16H,11-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    GVNWHCVWDRNXAZ-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    02O55696WH
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Carbinoxamine

    2. Histex Ct

    3. Histex I-e

    4. Histex Pd

    2.3.2 Depositor-Supplied Synonyms

    1. 3505-38-2

    2. Carbinoxamine Maleate Salt

    3. Lergefin

    4. Clistin

    5. Ciberon

    6. Cliston

    7. P-carbinoxamine Maleate

    8. Allergefon Maleate

    9. Paracarbinoxamine Maleate

    10. Nsc-62362

    11. Chebi:31353

    12. 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Maleate

    13. Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-n,n-dimethyl-, (z)-2-butenedioate (1:1)

    14. 02o55696wh

    15. 3505-38-2 (carbinoxamine Maleate)

    16. Hislosine

    17. Ziriton

    18. Histine Sirup

    19. Polistin T-caps

    20. 2-((4-chlorophenyl)(pyridin-2-yl)methoxy)-n,n-dimethylethan-1-amine Maleate

    21. Polistine T-caps

    22. Dsstox_cid_27805

    23. Dsstox_rid_82573

    24. Dsstox_gsid_47828

    25. Carbinoxamine Hydrogen Maleate

    26. Arbinoxa

    27. {2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine Maleate

    28. Clistine Maleate

    29. Clistin-d

    30. Karbinal Er

    31. (z)-but-2-enedioic Acid;2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-n,n-dimethylethanamine

    32. Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-n,n-dimethyl-, (2z)-2-butenedioate (1:1)

    33. Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-n,n-dimethyl-, (2z)-2-butenedioate (1:1)

    34. Component Of Clistin-d

    35. Sr-01000736676

    36. Ncgc00166141-01

    37. Einecs 222-498-0

    38. Nsc 62362

    39. Clistin Maleate

    40. Unii-02o55696wh

    41. Carbinoxamine Maleate [usp:jan]

    42. Prestwick_238

    43. Arbinoxamine Maleate

    44. Clistin (tn)

    45. Karbinal Er (tn)

    46. 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-n,n-dimethylethanamine Maleate

    47. Carbinoxamine (maleate)

    48. Carbinoxaminemaleate

    49. 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Bimaleate

    50. 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Maleate (1:1)

    51. Cas-3505-38-2

    52. Schembl97703

    53. Spectrum1500161

    54. Chembl1200974

    55. Dtxsid0047828

    56. Hms502i21

    57. Hy-b1589a

    58. Carbinoxamine Maleate (jan/usp)

    59. Carbinoxamine Maleate [mi]

    60. Hms1570b03

    61. Hms1920i21

    62. Hms2091a04

    63. Hms2097b03

    64. Hms3259g22

    65. Hms3714b03

    66. Hms3885f18

    67. Pharmakon1600-01500161

    68. Carbinoxamine Maleate [jan]

    69. Bcp28449

    70. Nsc62362

    71. Tox21_112336

    72. Carbinoxamine Maleate [vandf]

    73. Ccg-40113

    74. Mfcd00050923

    75. Nsc756670

    76. S4696

    77. Carbinoxamine Maleate [mart.]

    78. Wln: Qv1u1vq -c &621

    79. Akos015962162

    80. Carbinoxamine Maleate [usp-rs]

    81. Carbinoxamine Maleate [who-dd]

    82. Tox21_112336_1

    83. Ac-5508

    84. Cs-8018

    85. Nc00602

    86. Nsc-756670

    87. Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-n,n-dimethyl-,(2z)-2-butenedioate (1:1)

    88. Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)-, Maleate (1:1)

    89. Ncgc00095302-01

    90. Ncgc00166141-06

    91. Bs-43784

    92. Carbinoxamine Maleate [orange Book]

    93. Carbinoxamine Maleate [usp Monograph]

    94. Carbinoxamine Maleate Salt, Analytical Standard

    95. D01336

    96. Ethanamine,n-dimethyl-, (z)-2-butenedioate (1:1)

    97. Sr-01000736676-2

    98. Sr-01000736676-3

    99. Q27114280

    100. 2-[p-chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]pyridine Bimaleate

    101. 2-[p-chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]pyridine Maleate

    102. Carbinoxamine Maleate, United States Pharmacopeia (usp) Reference Standard

    103. 2-(p-chloro-.alpha.-(2-(dimethylamino)ethoxy)benzyl)pyridine Maleate (1:1)

    104. 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-n,n-dimethylethanamine (2z)-but-2-enedioate

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 406.9 g/mol
    Molecular Formula C20H23ClN2O5
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count8
    Exact Mass406.1295495 g/mol
    Monoisotopic Mass406.1295495 g/mol
    Topological Polar Surface Area100 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity386
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameCarbinoxamine maleate
    Drug LabelCarbinoxamine maleate is a histamine-H1 receptor blocking agent.Each 5 mL (teaspoonful) of oral solution contains 4 mg carbinoxamine maleate and the following inactive ingredients: artificial bubble gum flavor, citric acid (anhydrous), glycerin, meth...
    Active IngredientCarbinoxamine maleate
    Dosage FormTablet; Solution
    Routeoral; Oral
    Strength4mg; 4mg/5ml
    Market StatusPrescription
    CompanyVintage Pharms; Cypress Pharm; Lynrose Labs; Mikart; Invagen Pharms

    2 of 4  
    Drug NameKarbinal er
    PubMed HealthCarbinoxamine (By mouth)
    Drug ClassesCold/Cough Agent, Respiratory Agent
    Drug LabelEach 5 mL of Karbinal ER Extended-release Oral Suspension contains carbinoxamine complexed with polistirex equivalent to 4 mg carbinoxamine maleate and the following inactive ingredients: citric acid anhydrous, strawberry-banana flavor, glycerin, hig...
    Active IngredientCarbinoxamine maleate
    Dosage FormSuspension, extended release
    RouteOral
    Strength4mg/5ml
    Market StatusPrescription
    CompanyTris Pharma

    3 of 4  
    Drug NameCarbinoxamine maleate
    Drug LabelCarbinoxamine maleate is a histamine-H1 receptor blocking agent.Each 5 mL (teaspoonful) of oral solution contains 4 mg carbinoxamine maleate and the following inactive ingredients: artificial bubble gum flavor, citric acid (anhydrous), glycerin, meth...
    Active IngredientCarbinoxamine maleate
    Dosage FormTablet; Solution
    Routeoral; Oral
    Strength4mg; 4mg/5ml
    Market StatusPrescription
    CompanyVintage Pharms; Cypress Pharm; Lynrose Labs; Mikart; Invagen Pharms

    4 of 4  
    Drug NameKarbinal er
    PubMed HealthCarbinoxamine (By mouth)
    Drug ClassesCold/Cough Agent, Respiratory Agent
    Drug LabelEach 5 mL of Karbinal ER Extended-release Oral Suspension contains carbinoxamine complexed with polistirex equivalent to 4 mg carbinoxamine maleate and the following inactive ingredients: citric acid anhydrous, strawberry-banana flavor, glycerin, hig...
    Active IngredientCarbinoxamine maleate
    Dosage FormSuspension, extended release
    RouteOral
    Strength4mg/5ml
    Market StatusPrescription
    CompanyTris Pharma

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]

    API Reference Price

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    01-Feb-2021
    31-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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