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Chemistry

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Also known as: 3505-38-2, Carbinoxamine maleate salt, Lergefin, Clistin, Ciberon, Cliston
Molecular Formula
C20H23ClN2O5
Molecular Weight
406.9  g/mol
InChI Key
GVNWHCVWDRNXAZ-BTJKTKAUSA-N
FDA UNII
02O55696WH

Carbinoxamine
Carbinoxamine Maleate is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties. Carbinoxamine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries, and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscle. Carbinoxamine maleate is used to provide symptomatic relieve of allergic symptoms.
1 2D Structure

Carbinoxamine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(Z)-but-2-enedioic acid;2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine
2.1.2 InChI
InChI=1S/C16H19ClN2O.C4H4O4/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-10,16H,11-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
2.1.3 InChI Key
GVNWHCVWDRNXAZ-BTJKTKAUSA-N
2.1.4 Canonical SMILES
CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
02O55696WH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Carbinoxamine

2. Histex Ct

3. Histex I-e

4. Histex Pd

2.3.2 Depositor-Supplied Synonyms

1. 3505-38-2

2. Carbinoxamine Maleate Salt

3. Lergefin

4. Clistin

5. Ciberon

6. Cliston

7. P-carbinoxamine Maleate

8. Allergefon Maleate

9. Paracarbinoxamine Maleate

10. Nsc-62362

11. Chebi:31353

12. 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Maleate

13. Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-n,n-dimethyl-, (z)-2-butenedioate (1:1)

14. 02o55696wh

15. 3505-38-2 (carbinoxamine Maleate)

16. Hislosine

17. Ziriton

18. Histine Sirup

19. Polistin T-caps

20. 2-((4-chlorophenyl)(pyridin-2-yl)methoxy)-n,n-dimethylethan-1-amine Maleate

21. Polistine T-caps

22. Dsstox_cid_27805

23. Dsstox_rid_82573

24. Dsstox_gsid_47828

25. Carbinoxamine Hydrogen Maleate

26. Arbinoxa

27. {2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine Maleate

28. Clistine Maleate

29. Clistin-d

30. Karbinal Er

31. (z)-but-2-enedioic Acid;2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-n,n-dimethylethanamine

32. Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-n,n-dimethyl-, (2z)-2-butenedioate (1:1)

33. Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-n,n-dimethyl-, (2z)-2-butenedioate (1:1)

34. Component Of Clistin-d

35. Sr-01000736676

36. Ncgc00166141-01

37. Einecs 222-498-0

38. Nsc 62362

39. Clistin Maleate

40. Unii-02o55696wh

41. Carbinoxamine Maleate [usp:jan]

42. Prestwick_238

43. Arbinoxamine Maleate

44. Clistin (tn)

45. Karbinal Er (tn)

46. 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-n,n-dimethylethanamine Maleate

47. Carbinoxamine (maleate)

48. Carbinoxaminemaleate

49. 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Bimaleate

50. 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Maleate (1:1)

51. Cas-3505-38-2

52. Schembl97703

53. Spectrum1500161

54. Chembl1200974

55. Dtxsid0047828

56. Hms502i21

57. Hy-b1589a

58. Carbinoxamine Maleate (jan/usp)

59. Carbinoxamine Maleate [mi]

60. Hms1570b03

61. Hms1920i21

62. Hms2091a04

63. Hms2097b03

64. Hms3259g22

65. Hms3714b03

66. Hms3885f18

67. Pharmakon1600-01500161

68. Carbinoxamine Maleate [jan]

69. Bcp28449

70. Nsc62362

71. Tox21_112336

72. Carbinoxamine Maleate [vandf]

73. Ccg-40113

74. Mfcd00050923

75. Nsc756670

76. S4696

77. Carbinoxamine Maleate [mart.]

78. Wln: Qv1u1vq -c &621

79. Akos015962162

80. Carbinoxamine Maleate [usp-rs]

81. Carbinoxamine Maleate [who-dd]

82. Tox21_112336_1

83. Ac-5508

84. Cs-8018

85. Nc00602

86. Nsc-756670

87. Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-n,n-dimethyl-,(2z)-2-butenedioate (1:1)

88. Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)-, Maleate (1:1)

89. Ncgc00095302-01

90. Ncgc00166141-06

91. Bs-43784

92. Carbinoxamine Maleate [orange Book]

93. Carbinoxamine Maleate [usp Monograph]

94. Carbinoxamine Maleate Salt, Analytical Standard

95. D01336

96. Ethanamine,n-dimethyl-, (z)-2-butenedioate (1:1)

97. Sr-01000736676-2

98. Sr-01000736676-3

99. Q27114280

100. 2-[p-chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]pyridine Bimaleate

101. 2-[p-chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]pyridine Maleate

102. Carbinoxamine Maleate, United States Pharmacopeia (usp) Reference Standard

103. 2-(p-chloro-.alpha.-(2-(dimethylamino)ethoxy)benzyl)pyridine Maleate (1:1)

104. 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-n,n-dimethylethanamine (2z)-but-2-enedioate

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 406.9 g/mol
Molecular Formula C20H23ClN2O5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass406.1295495 g/mol
Monoisotopic Mass406.1295495 g/mol
Topological Polar Surface Area100 Ų
Heavy Atom Count28
Formal Charge0
Complexity386
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameCarbinoxamine maleate
Drug LabelCarbinoxamine maleate is a histamine-H1 receptor blocking agent.Each 5 mL (teaspoonful) of oral solution contains 4 mg carbinoxamine maleate and the following inactive ingredients: artificial bubble gum flavor, citric acid (anhydrous), glycerin, meth...
Active IngredientCarbinoxamine maleate
Dosage FormTablet; Solution
Routeoral; Oral
Strength4mg; 4mg/5ml
Market StatusPrescription
CompanyVintage Pharms; Cypress Pharm; Lynrose Labs; Mikart; Invagen Pharms

2 of 4  
Drug NameKarbinal er
PubMed HealthCarbinoxamine (By mouth)
Drug ClassesCold/Cough Agent, Respiratory Agent
Drug LabelEach 5 mL of Karbinal ER Extended-release Oral Suspension contains carbinoxamine complexed with polistirex equivalent to 4 mg carbinoxamine maleate and the following inactive ingredients: citric acid anhydrous, strawberry-banana flavor, glycerin, hig...
Active IngredientCarbinoxamine maleate
Dosage FormSuspension, extended release
RouteOral
Strength4mg/5ml
Market StatusPrescription
CompanyTris Pharma

3 of 4  
Drug NameCarbinoxamine maleate
Drug LabelCarbinoxamine maleate is a histamine-H1 receptor blocking agent.Each 5 mL (teaspoonful) of oral solution contains 4 mg carbinoxamine maleate and the following inactive ingredients: artificial bubble gum flavor, citric acid (anhydrous), glycerin, meth...
Active IngredientCarbinoxamine maleate
Dosage FormTablet; Solution
Routeoral; Oral
Strength4mg; 4mg/5ml
Market StatusPrescription
CompanyVintage Pharms; Cypress Pharm; Lynrose Labs; Mikart; Invagen Pharms

4 of 4  
Drug NameKarbinal er
PubMed HealthCarbinoxamine (By mouth)
Drug ClassesCold/Cough Agent, Respiratory Agent
Drug LabelEach 5 mL of Karbinal ER Extended-release Oral Suspension contains carbinoxamine complexed with polistirex equivalent to 4 mg carbinoxamine maleate and the following inactive ingredients: citric acid anhydrous, strawberry-banana flavor, glycerin, hig...
Active IngredientCarbinoxamine maleate
Dosage FormSuspension, extended release
RouteOral
Strength4mg/5ml
Market StatusPrescription
CompanyTris Pharma

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]

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26-Apr-2021
14-Nov-2024
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ABOUT THIS PAGE

Carbinoxamine Manufacturers

A Carbinoxamine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Carbinoxamine, including repackagers and relabelers. The FDA regulates Carbinoxamine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Carbinoxamine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Carbinoxamine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Carbinoxamine Suppliers

A Carbinoxamine supplier is an individual or a company that provides Carbinoxamine active pharmaceutical ingredient (API) or Carbinoxamine finished formulations upon request. The Carbinoxamine suppliers may include Carbinoxamine API manufacturers, exporters, distributors and traders.

click here to find a list of Carbinoxamine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Carbinoxamine USDMF

A Carbinoxamine DMF (Drug Master File) is a document detailing the whole manufacturing process of Carbinoxamine active pharmaceutical ingredient (API) in detail. Different forms of Carbinoxamine DMFs exist exist since differing nations have different regulations, such as Carbinoxamine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Carbinoxamine DMF submitted to regulatory agencies in the US is known as a USDMF. Carbinoxamine USDMF includes data on Carbinoxamine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Carbinoxamine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Carbinoxamine suppliers with USDMF on PharmaCompass.

Carbinoxamine WC

A Carbinoxamine written confirmation (Carbinoxamine WC) is an official document issued by a regulatory agency to a Carbinoxamine manufacturer, verifying that the manufacturing facility of a Carbinoxamine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Carbinoxamine APIs or Carbinoxamine finished pharmaceutical products to another nation, regulatory agencies frequently require a Carbinoxamine WC (written confirmation) as part of the regulatory process.

click here to find a list of Carbinoxamine suppliers with Written Confirmation (WC) on PharmaCompass.

Carbinoxamine NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Carbinoxamine as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Carbinoxamine API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Carbinoxamine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Carbinoxamine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Carbinoxamine NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Carbinoxamine suppliers with NDC on PharmaCompass.

Carbinoxamine GMP

Carbinoxamine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Carbinoxamine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Carbinoxamine GMP manufacturer or Carbinoxamine GMP API supplier for your needs.

Carbinoxamine CoA

A Carbinoxamine CoA (Certificate of Analysis) is a formal document that attests to Carbinoxamine's compliance with Carbinoxamine specifications and serves as a tool for batch-level quality control.

Carbinoxamine CoA mostly includes findings from lab analyses of a specific batch. For each Carbinoxamine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Carbinoxamine may be tested according to a variety of international standards, such as European Pharmacopoeia (Carbinoxamine EP), Carbinoxamine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Carbinoxamine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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