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ACTIVE PHARMA INGREDIENTS

42 API Suppliers, 17 USDMF, 17 CEP/COS, 5 JDMF, 7 EU WC, 3 KDMF, 7 NDC API, 26 Listed Suppliers, $ API Reference Price

42 API Suppliers
17 USDMF
17 CEP/COS
5 JDMF
7 EU WC
3 KDMF
7 NDC API
26 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

222 Drugs in Development

222 Drugs in Development

INTERMEDIATES

6 Intermediates Suppliers

6 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

248 FDF Dossiers, 114 FDA Orange Book, 85 Europe, 3 Canada, 2 Australia, 16 South Africa, 28 Listed Dossiers

248 FDF Dossiers
114 FDA Orange Book
85 Europe
3 Canada
2 Australia
16 South Africa
28 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 12 SPI Pharma, 1 Pfanstiehl, 1 BASF, 2 Gangwal Chemicals, 1 Ingredion Pharma Solutions, 2 Kerry, 2 Microlex e.U, 1 Pluviaendo, 3 Roquette, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries

relatedExcipients
1 Rochem International Inc
12 SPI Pharma
1 Pfanstiehl
1 BASF
2 Gangwal Chemicals
1 Ingredion Pharma Solutions
2 Kerry
2 Microlex e.U
1 Pluviaendo
3 Roquette
1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders, 10 Chewable & Orodispersible Aids, 9 Taste Masking, 9 Direct Compression, 4 Parenteral, 3 Disintegrants & Superdisintegrants, 3 Co-Processed Excipients, 3 Granulation, 1 API Stability Enhancers, 1 Thickeners and Stabilizers

excipientsByApplications
17 Fillers, Diluents & Binders
10 Chewable & Orodispersible Aids
9 Taste Masking
9 Direct Compression
4 Parenteral
3 Disintegrants & Superdisintegrants
3 Co-Processed Excipients
3 Granulation
1 API Stability Enhancers
1 Thickeners and Stabilizers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 84 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
84 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 74 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
74 Finished Drug Prices

MARKET PLACE

12 APIs, 16 FDF Dossiers

marketPlace
12 APIs
16 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 JP , 1 Others

otherSolutions
1 EDQM
1 USP
1 JP
1 Others

Naprod Carboplatin

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 27,876

MARKET PLACE

API

FDF

6INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

248

FDF Dossiers

114

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

222DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

208,167

Annual Reports (USD Million)

Finished Drug Prices

29 RELATED EXCIPIENT COMPANIES

60EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Paraplatin, Cbdca, Jm-8, Cis-diammine(1,1-cyclobutanedicarboxylato)platinum, Nsc 241240, Nsc-241240

Molecular Formula

C₆H₁₂N₂O₄Pt

Molecular Weight

371.25 g/mol

InChI Key

OLESAACUTLOWQZ-UHFFFAOYSA-L

FDA UNII

BG3F62OND5

An organoplatinum compound that possesses antineoplastic activity.

Carboplatin is a Platinum-based Drug.

1 2D Structure

Carboplatin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

azane;cyclobutane-1,1-dicarboxylate;platinum(2+)

2.1.2 InChI

InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

2.1.3 InChI Key

OLESAACUTLOWQZ-UHFFFAOYSA-L

2.1.4 Canonical SMILES

C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2]

2.2 Other Identifiers

2.2.1 UNII

BG3F62OND5

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Blastocarb

2. Carboplat

3. Carboplatin

4. Carbosin

5. Carbotec

6. Cbdca

7. Cis-diammine(cyclobutanedicarboxylato)platinum Ii

8. Ercar

9. Jm 8

10. Jm-8

11. Jm8

12. Nealorin

13. Neocarbo

14. Nsc 241240

15. Nsc-241240

16. Nsc241240

17. Paraplatin

18. Paraplatine

19. Platinwas

20. Ribocarbo

2.3.2 Depositor-Supplied Synonyms

1. Paraplatin

2. Cbdca

3. Jm-8

4. Cis-diammine(1,1-cyclobutanedicarboxylato)platinum

5. Nsc 241240

6. Nsc-241240

7. Carboplatin [usan]

8. Bg3f62ond5

9. Cis-diammine(1,1-cyclobutanedicarboxylato) Platinum

10. Platinum, Diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0']-,(sp-4-2)

11. Nsc-201345

12. Carboplatin [mi]

13. Carboplatin [inn]

14. Carboplatin [jan]

15. Carboplatin [hsdb]

16. Carboplatin [vandf]

17. Carboplatin [mart.]

18. Carboplatin [usp-rs]

19. Carboplatin [who-dd]

20. Cis-diamine(1,1-cyclobutanedicarboxylato)platinum(ii)

21. Carboplatin [ep Impurity]

22. Carboplatin [orange Book]

23. Carboplatin [ep Monograph]

24. Carboplatin [usp Impurity]

25. Carboplatin [usp Monograph]

26. Amy33401

27. S1215

28. Akos037515487

29. Ccg-268304

30. Ab01568249_01

31. Q415588

32. W-106301

33. Platinum, Diamine(1,1-cyclobutanedicarboxylato (2-)-o,o')-, (sp-4-2)-

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₆H₁₂N₂O₄Pt
Molecular Weight	371.25 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	0
Exact Mass	371.044501 g/mol
Monoisotopic Mass	371.044501 g/mol
Topological Polar Surface Area	82.3 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	153
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Carboplatin
PubMed Health	Carboplatin (Injection)
Drug Classes	Antineoplastic Agent
Drug Label	Carboplatin injection is supplied as a sterile, pyrogen-free, 10 mg/mL aqueous solution of carboplatin. Carboplatin is a platinum coordination compound. The chemical name for carboplatin is platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0...
Active Ingredient	Carboplatin
Dosage Form	Injectable
Route	Iv (infusion)
Strength	450mg/45ml (10mg/ml); 150mg/15ml (10mg/ml); 600mg/60ml (10mg/ml); 1gm/100ml (10mg/ml); 50mg/5ml (10mg/ml)
Market Status	Prescription
Company	Pliva Lachema; Actavis Elizabeth; Fresenius Kabi Usa; Hospira; Mylan Institutional; Fresenius Kabi Oncol; Ebewe Pharma; Pharmachemie Bv; Onco Therapies; Teva Pharms Usa; Eurohlth Intl; Sagent Pharms; Cipla; Sun Pharma Global; Akorn

2 of 2
Drug Name	Carboplatin
PubMed Health	Carboplatin (Injection)
Drug Classes	Antineoplastic Agent
Drug Label	Carboplatin injection is supplied as a sterile, pyrogen-free, 10 mg/mL aqueous solution of carboplatin. Carboplatin is a platinum coordination compound. The chemical name for carboplatin is platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0...
Active Ingredient	Carboplatin
Dosage Form	Injectable
Route	Iv (infusion)
Strength	450mg/45ml (10mg/ml); 150mg/15ml (10mg/ml); 600mg/60ml (10mg/ml); 1gm/100ml (10mg/ml); 50mg/5ml (10mg/ml)
Market Status	Prescription
Company	Pliva Lachema; Actavis Elizabeth; Fresenius Kabi Usa; Hospira; Mylan Institutional; Fresenius Kabi Oncol; Ebewe Pharma; Pharmachemie Bv; Onco Therapies; Teva Pharms Usa; Eurohlth Intl; Sagent Pharms; Cipla; Sun Pharma Global; Akorn

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

Cross-Linking Reagents

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other. (See all compounds classified as Cross-Linking Reagents.)

5.2 FDA Pharmacological Classification

5.2.1 Active Moiety

CARBOPLATIN

5.2.2 FDA UNII

BG3F62OND5

5.2.3 Pharmacological Classes

Platinum-containing Compounds [EXT]

API SUPPLIERS

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NDC API

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API Reference Price

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