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    Also known as: Hemabate, 58551-69-2, Carboprost trometamol, Prostinfenem, Carboprost trometanol, Carboprost (tromethamine)
    Molecular Formula
    C25H47NO8
    Molecular Weight
    489.6  g/mol
    InChI Key
    UMMADZJLZAPZAW-XOWPVRJPSA-N
    FDA UNII
    U4526F86FJ
    Carboprost Tromethamine
    Carboprost Tromethamine is the tromethamine salt of the (15S)-15 methyl analogue of naturally occurring prostaglandin F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle cells, thereby resulting in smooth muscle contractions. When administered intramuscularly on gravid subjects, this agent induces myometrium contractions, thereby initiating luteolysis and consequently parturition. Furthermore, carboprost's action on vascular smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure and induces vomiting or diarrhea, respectively.
    1 2D Structure

    Carboprost Tromethamine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-amino-2-(hydroxymethyl)propane-1,3-diol;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-3-methyloct-1-enyl]cyclopentyl]hept-5-enoic acid
    2.1.2 InChI
    InChI=1S/C21H36O5.C4H11NO3/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25;5-4(1-6,2-7)3-8/h5,7,12,14,16-19,22-23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25);6-8H,1-3,5H2/b7-5-,14-12+;/t16-,17-,18+,19-,21+;/m1./s1
    2.1.3 InChI Key
    UMMADZJLZAPZAW-XOWPVRJPSA-N
    2.1.4 Canonical SMILES
    CCCCCC(C)(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O.C(C(CO)(CO)N)O
    2.1.5 Isomeric SMILES
    CCCCC[C@@](C)(/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O)O.C(C(CO)(CO)N)O
    2.2 Other Identifiers
    2.2.1 UNII
    U4526F86FJ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 15-methylprostaglandin F2alpha-tromethamine

    2. Carboprost Trometamol

    3. Hemabate

    4. Prostin M-15

    2.3.2 Depositor-Supplied Synonyms

    1. Hemabate

    2. 58551-69-2

    3. Carboprost Trometamol

    4. Prostinfenem

    5. Carboprost Trometanol

    6. Carboprost (tromethamine)

    7. U-32921e

    8. U-32,921e

    9. U4526f86fj

    10. (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((e)-(3s)-3-hydroxy-3-methyl-1-octenyl)cyclopentyl)-5-heptenoic Acid Compound With 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

    11. 2-amino-2-(hydroxymethyl)propane-1,3-diol;(z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(e,3s)-3-hydroxy-3-methyloct-1-enyl]cyclopentyl]hept-5-enoic Acid

    12. 15-methyl Prostaglandin F2alpha

    13. Prostin / 15m

    14. Unii-u4526f86fj

    15. Carboprost Tromethamine [usan]

    16. Hemabate (tn)

    17. Prostin/15

    18. Carboprost Tromethamine [usan:usp]

    19. U 32921e

    20. Carboprost Tromethanimine

    21. 15-methyl Pgf2 Alpha

    22. Prostin/15m

    23. 15(s)15-methyl Pgf2-alpha Tromethamine Salt

    24. Carboprost Tromethamine Salt

    25. Schembl433085

    26. 15(s)15-methyl Prostaglandin F2-alpha Tromethamine

    27. Carboprost Tromethamine (usp)

    28. Chembl1237105

    29. (15s)-15-methylprostaglandin F(sub 2alpha) Tromethamine

    30. Dtxsid601015618

    31. Hy-a0195

    32. Carboprost Trometamol [mart.]

    33. Akos037435222

    34. Carboprost Trometamol [who-dd]

    35. Carboprost Tromethamine [usp-rs]

    36. Carboprost Tromethamine Salt [mi]

    37. Carboprost Trometamol [ep Monograph]

    38. Carboprost Tromethamine [orange Book]

    39. Cs-0017541

    40. Carboprost Tromethamine [usp Monograph]

    41. D00682

    42. E78557

    43. U32921

    44. 551c692

    45. J-507750

    46. Q18578732

    47. (15s)-15-methylprostaglandin F(sub 2.alpha.) Tromethamine

    48. (5z,9?,11?,15e,15s)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-oic Acid Tris(hydroxymethyl)aminomethane Salt

    49. 2-amino-2-(hydroxymethyl)propane-1,3-diol (e)-7-((1s,3s,5r)-3,5-dihydroxy-2-((s,z)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept- 5-enoate

    50. 2-amino-2-(hydroxymethyl)propane-1,3-diol (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((s,e)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoate

    51. Prosta-5,13-dien-1-oic Acid, 9,11,15-trihydroxy-15-methyl-, (5z,9-alpha,11-alpha,13e,15s)-, Compd. With 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

    52. Prosta-5,13-dien-1-oic Acid, 9,11,15-trihydroxy-15-methyl-, (5z,9.alpha.,11.alpha.,13e,15s)-, Compound With 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 489.6 g/mol
    Molecular Formula C25H47NO8
    Hydrogen Bond Donor Count8
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count15
    Exact Mass489.33016746 g/mol
    Monoisotopic Mass489.33016746 g/mol
    Topological Polar Surface Area185 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity527
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count2
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameHemabate
    PubMed HealthCarboprost Tromethamine (Injection)
    Drug ClassesEndocrine-Metabolic Agent
    Drug LabelHEMABATE Sterile Solution, an oxytocic, contains the tromethamine salt of the (15S)-15 methyl analogue of naturally occurring prostaglandin F2 in a solution suitable for intramuscular injection.Carboprost tromethamine is the established name for th...
    Active IngredientCarboprost tromethamine
    Dosage FormInjectable
    RouteInjection
    Strengtheq 0.25mg base/ml
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    2 of 2  
    Drug NameHemabate
    PubMed HealthCarboprost Tromethamine (Injection)
    Drug ClassesEndocrine-Metabolic Agent
    Drug LabelHEMABATE Sterile Solution, an oxytocic, contains the tromethamine salt of the (15S)-15 methyl analogue of naturally occurring prostaglandin F2 in a solution suitable for intramuscular injection.Carboprost tromethamine is the established name for th...
    Active IngredientCarboprost tromethamine
    Dosage FormInjectable
    RouteInjection
    Strengtheq 0.25mg base/ml
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Oxytocics

    Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157) (See all compounds classified as Oxytocics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Prostaglandins [CS]; Prostaglandin Analog [EPC]

    API Reference Price

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ROAD,"},{"dataSource":"API Import","activeIngredients":"TROMETHAMINE","year":"2021","qtr":"Q1","strtotime":1614969000,"product":"CARBOPROST TROMETHAMINE (QTY: 4 X 30 MG, PRICE: USD-760\/EACH)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA ","customerCountry":"INDIA","quantity":"0.12","actualQuantity":"0.00012","unit":"KGS","unitRateFc":"25333333.3","totalValueFC":"3200.6","currency":"USD","unitRateINR":"1941760250","date":"06-Mar-2021","totalValueINR":"233011.23","totalValueInUsd":"3200.6","indian_port":"HYDERABAD AIR","hs_no":"29375000","bill_no":"3037954","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"TROMETHAMINE","year":"2021","qtr":"Q1","strtotime":1614969000,"product":"CARBOPROST TROMETHAMINE (QTY: 5 X 0.05 GMS, PRICE: USD-80.94\/EACH)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA ","customerCountry":"INDIA","quantity":"0.25","actualQuantity":"0.00025","unit":"KGS","unitRateFc":"1618800","totalValueFC":"426.1","currency":"USD","unitRateINR":"124078480","date":"06-Mar-2021","totalValueINR":"31019.62","totalValueInUsd":"426.1","indian_port":"HYDERABAD AIR","hs_no":"29375000","bill_no":"3037954","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"TROMETHAMINE","year":"2021","qtr":"Q1","strtotime":1614969000,"product":"CARBOPROST TROMETHAMINE (QTY: 6 X 0.15 GMS, PRICE: USD-222.59\/EACH)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA ","customerCountry":"INDIA","quantity":"900.00","actualQuantity":"0.9","unit":"KGS","unitRateFc":"1483.9","totalValueFC":"1406.1","currency":"USD","unitRateINR":"113741.2","date":"06-Mar-2021","totalValueINR":"102367.04","totalValueInUsd":"1406.1","indian_port":"HYDERABAD AIR","hs_no":"29375000","bill_no":"3037954","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1626892200,"product":"(FOC) - CARBOPROST TROMETHAMINE - H-005-032","address":"REGD. OFFICE: NO. 16\/2,O.V.H.ROAD, BASAVANGUDI","city":"BANGALORE, KARNATAKA","supplier":"CHIROGATE INTERNATIONAL","supplierCountry":"TAIWAN","foreign_port":"TAIPEI","customer":"WINTAC LIMITED","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"GMS","unitRateFc":"2500","totalValueFC":"7839.6","currency":"USD","unitRateINR":"194754.1","date":"22-Jul-2021","totalValueINR":"584262.28","totalValueInUsd":"7839.6","indian_port":"BANGALORE AIR","hs_no":"29375000","bill_no":"4774784","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"","customerAddress":"REGD. OFFICE: NO. 16\/2,O.V.H.ROAD, BASAVANGUDI"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1640802600,"product":"CARBOPROST TROMETHAMINE(QTY: 1 X 30 MG, PRICE: USD 783)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"USP","supplierCountry":"INDIA","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.03","actualQuantity":"0.00003","unit":"KGS","unitRateFc":"26100000","totalValueFC":"847.8","currency":"USD","unitRateINR":"2131474667","date":"30-Dec-2021","totalValueINR":"63944.24","totalValueInUsd":"847.8","indian_port":"HYDERABAD AIR","hs_no":"29375000","bill_no":"6894792","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1654885800,"product":"CARBOPROST TROMETHAMINE (QTY:1X1 GMS,PRICE: USD 995.45)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"0.001","unit":"KGS","unitRateFc":"995450","totalValueFC":"1036.8","currency":"USD","unitRateINR":"80887610","date":"11-Jun-2022","totalValueINR":"80887.61","totalValueInUsd":"1036.8","indian_port":"HYDERABAD AIR","hs_no":"29375000","bill_no":"9066797","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. 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    01-Mar-2021
    12-Aug-2024
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    ABOUT THIS PAGE

    Carboprost Tromethamine Manufacturers

    A Carboprost Tromethamine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Carboprost Tromethamine, including repackagers and relabelers. The FDA regulates Carboprost Tromethamine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Carboprost Tromethamine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Carboprost Tromethamine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Carboprost Tromethamine Suppliers

    A Carboprost Tromethamine supplier is an individual or a company that provides Carboprost Tromethamine active pharmaceutical ingredient (API) or Carboprost Tromethamine finished formulations upon request. The Carboprost Tromethamine suppliers may include Carboprost Tromethamine API manufacturers, exporters, distributors and traders.

    click here to find a list of Carboprost Tromethamine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Carboprost Tromethamine USDMF

    A Carboprost Tromethamine DMF (Drug Master File) is a document detailing the whole manufacturing process of Carboprost Tromethamine active pharmaceutical ingredient (API) in detail. Different forms of Carboprost Tromethamine DMFs exist exist since differing nations have different regulations, such as Carboprost Tromethamine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Carboprost Tromethamine DMF submitted to regulatory agencies in the US is known as a USDMF. Carboprost Tromethamine USDMF includes data on Carboprost Tromethamine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Carboprost Tromethamine USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Carboprost Tromethamine suppliers with USDMF on PharmaCompass.

    Carboprost Tromethamine CEP

    A Carboprost Tromethamine CEP of the European Pharmacopoeia monograph is often referred to as a Carboprost Tromethamine Certificate of Suitability (COS). The purpose of a Carboprost Tromethamine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Carboprost Tromethamine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Carboprost Tromethamine to their clients by showing that a Carboprost Tromethamine CEP has been issued for it. The manufacturer submits a Carboprost Tromethamine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Carboprost Tromethamine CEP holder for the record. Additionally, the data presented in the Carboprost Tromethamine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Carboprost Tromethamine DMF.

    A Carboprost Tromethamine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Carboprost Tromethamine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Carboprost Tromethamine suppliers with CEP (COS) on PharmaCompass.

    Carboprost Tromethamine WC

    A Carboprost Tromethamine written confirmation (Carboprost Tromethamine WC) is an official document issued by a regulatory agency to a Carboprost Tromethamine manufacturer, verifying that the manufacturing facility of a Carboprost Tromethamine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Carboprost Tromethamine APIs or Carboprost Tromethamine finished pharmaceutical products to another nation, regulatory agencies frequently require a Carboprost Tromethamine WC (written confirmation) as part of the regulatory process.

    click here to find a list of Carboprost Tromethamine suppliers with Written Confirmation (WC) on PharmaCompass.

    Carboprost Tromethamine NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Carboprost Tromethamine as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Carboprost Tromethamine API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Carboprost Tromethamine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Carboprost Tromethamine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Carboprost Tromethamine NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Carboprost Tromethamine suppliers with NDC on PharmaCompass.

    Carboprost Tromethamine GMP

    Carboprost Tromethamine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Carboprost Tromethamine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Carboprost Tromethamine GMP manufacturer or Carboprost Tromethamine GMP API supplier for your needs.

    Carboprost Tromethamine CoA

    A Carboprost Tromethamine CoA (Certificate of Analysis) is a formal document that attests to Carboprost Tromethamine's compliance with Carboprost Tromethamine specifications and serves as a tool for batch-level quality control.

    Carboprost Tromethamine CoA mostly includes findings from lab analyses of a specific batch. For each Carboprost Tromethamine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Carboprost Tromethamine may be tested according to a variety of international standards, such as European Pharmacopoeia (Carboprost Tromethamine EP), Carboprost Tromethamine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Carboprost Tromethamine USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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