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ACTIVE PHARMA INGREDIENTS

3 API Suppliers, 2 USDMF, 1 Listed Suppliers

3 API Suppliers
2 USDMF
1 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

11 FDF Dossiers, 6 Europe, 5 Listed Dossiers

11 FDF Dossiers
6 Europe
5 Listed Dossiers

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3 Finished Drug Prices

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3 APIs

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3 APIs

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 Others

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1 EDQM
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

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API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

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US Patents

US Exclusivities

Health Canada Patents

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Chemistry

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Also known as: Carboxymethylcellulose, Carboxymethyl cellulose, 9000-11-7, Acetic acid;2,3,4,5,6-pentahydroxyhexanal, Cellulose, carboxymethyl ether, Cellulose cm

Molecular Formula

C₈H₁₆O₈

Molecular Weight

240.21 g/mol

InChI Key

VJHCJDRQFCCTHL-UHFFFAOYSA-N

A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.

1 2D Structure

Carboxymethyl Cellulose

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

acetic acid;2,3,4,5,6-pentahydroxyhexanal

2.1.2 InChI

InChI=1S/C6H12O6.C2H4O2/c7-1-3(9)5(11)6(12)4(10)2-8;1-2(3)4/h1,3-6,8-12H,2H2;1H3,(H,3,4)

2.1.3 InChI Key

VJHCJDRQFCCTHL-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(=O)O.C(C(C(C(C(C=O)O)O)O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Aquacel

2. Aquaplast

3. Carboxymethyl Cellulose

4. Carboxymethylcellulose

5. Carboxymethylcellulose Sodium

6. Carboxymethylcellulose, Sodium

7. Carmellose Sodium

8. Cellolax

9. Cellulose, Carboxymethyl

10. Cethylose

11. Croscarmellose Sodium

12. Polycell

13. Ruspol

14. Sodium Carboxymethylcellulose

15. Sodium, Carboxymethylcellulose

16. Sodium, Carmellose

17. Sodium, Croscarmellose

2.2.2 Depositor-Supplied Synonyms

1. Carboxymethylcellulose

2. Carboxymethyl Cellulose

3. 9000-11-7

4. Acetic Acid;2,3,4,5,6-pentahydroxyhexanal

5. Cellulose, Carboxymethyl Ether

6. Cellulose Cm

7. Colloresine

8. Carmellose

9. Almelose

10. Apergel

11. Carbose

12. Duodcel

13. Thylose

14. Apeyel

15. Carboxymethylcellulose Cellulose Carboxymethyl Ether

16. Cm-cellulose

17. Glycocel Ta

18. Kmts

19. 7h (carbohydrate)

20. Cellulose Gum 7h

21. Celluloseglycolic Acid

22. Carboximethylcellulosum

23. Carboxymethylcellulosum

24. Croscarmellosum [latin]

25. Cellulose Carboxymethylate

26. Carmellosum [inn-latin]

27. Carmelosa [inn-spanish]

28. Cmc-4lf

29. Cellulose, (carboxymethyl)

30. Carboxymethyl Cellulose Ether

31. Carmellosum

32. Croscarmellosum

33. Croscarmellosum [inn-latin]

34. Croscarmelosa

35. Croscarmelosa [inn-spanish]

36. Glycolic Acid Cellulose Ether

37. Carmelosa

38. Fema No. 2239

39. Carboxymethylated Cellulose Pulp

40. Carmellose [inn]

41. Cellulose, Ether With Glycolic Acid

42. Intrasite Gel (tn)

43. .carboxymethylcellulose

44. Acetic Acid, Hydroxy-, Cellulose Ether

45. Croscarmellose (inn)

46. Unii-05jzi7b19x

47. 7h

48. Schembl177710

49. Carmellose (jp17/nf/inn)

50. 05jzi7b19x

51. Ft-0623543

52. D07622

53. Q411030

54. 191616-54-3

55. 196886-89-2

2.3 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₈H₁₆O₈
Molecular Weight	240.21 g/mol
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	240.08451746 g/mol
Monoisotopic Mass	240.08451746 g/mol
Topological Polar Surface Area	156 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	169
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Indicated for the symptomatic relief of burning, irritation and discomfort of the eyes due to dryness or exposure to wind or sun.

5 Pharmacology and Biochemistry

5.1 Pharmacology

In a randomized clinical study of patients with mild or moderate forms of eye dryness, ophthalmic treatment with sodium carboxymethylcellulose resulted in a diminished frequency of symptoms compared to the placebo group. Carboxymethylcellulose interacts with human corneal epithelial cells to facilitate corneal epithelial wound healing and attenuate eye irritation in a dose-dependent manner. It exhibits protective actions on the ocular surface in various applications; it mediates cytoprotective effects on the ocular surface when applied prior to contact lenses and reduces the incidence of epithelial defects during LASIK.

5.2 MeSH Pharmacological Classification

Laxatives

Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION. (See all compounds classified as Laxatives.)

5.3 Absorption, Distribution and Excretion

Absorption