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Cariprazine

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

23 API Suppliers, 9 USDMF, 4 EU WC, 6 NDC API, 14 Listed Suppliers, $ API Reference Price

23 API Suppliers
9 USDMF
4 EU WC
6 NDC API
14 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

5 Drugs in Development

5 Drugs in Development

INTERMEDIATES

10 Intermediates Suppliers

10 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

24 FDF Dossiers, 12 FDA Orange Book, 8 Europe, 4 Australia

24 FDF Dossiers
12 FDA Orange Book
8 Europe
4 Australia

RELATED EXCIPIENT COMPANIES

3 SPI Pharma, 7 DKSH, 2 Faran Shimi Pharmaceutical, 6 Gangwal Healthcare, 4 ACG Worldwide, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Gangwal Chemicals, 2 Ingredion Pharma Solutions, 1 Kerry, 3 Lonza Capsugel, 5 Microlex e.U, 2 Pluviaendo, 1 Prachin Chemical, 1 Qualicaps, 8 Roquette, 2 Seppic, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Vasa Pharmachem

relatedExcipients
3 SPI Pharma
7 DKSH
2 Faran Shimi Pharmaceutical
6 Gangwal Healthcare
4 ACG Worldwide
2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
1 Gangwal Chemicals
2 Ingredion Pharma Solutions
1 Kerry
3 Lonza Capsugel
5 Microlex e.U
2 Pluviaendo
1 Prachin Chemical
1 Qualicaps
8 Roquette
2 Seppic
2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

24 Fillers, Diluents & Binders, 9 Direct Compression, 8 Empty Capsules, 8 Lubricants & Glidants, 7 Coating Systems & Additives, 7 Thickeners and Stabilizers, 6 Co-Processed Excipients, 4 Taste Masking, 4 Disintegrants & Superdisintegrants, 3 Chewable & Orodispersible Aids, 3 Coloring Agents, 2 Controlled & Modified Release, 2 Film Formers & Plasticizers, 1 Emulsifying Agents, 1 Granulation

excipientsByApplications
24 Fillers, Diluents & Binders
9 Direct Compression
8 Empty Capsules
8 Lubricants & Glidants
7 Coating Systems & Additives
7 Thickeners and Stabilizers
6 Co-Processed Excipients
4 Taste Masking
4 Disintegrants & Superdisintegrants
3 Chewable & Orodispersible Aids
3 Coloring Agents
2 Controlled & Modified Release
2 Film Formers & Plasticizers
1 Emulsifying Agents
1 Granulation

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 1 STOCK RECAP #PipelineProspector, 38 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
1 STOCK RECAP #PipelineProspector
38 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 8 Finished Drug Prices, 8 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
8 Finished Drug Prices
8 Annual Reports

MARKET PLACE

10 APIs

marketPlace
10 APIs

PATENTS & EXCLUSIVITIES

55 US Patents, 4 US Exclusivities

patents
55 US Patents
4 US Exclusivities

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 21,255

MARKET PLACE

API

FDF

10INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

5DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

708,765,555

Annual Reports (USD Million)

9,204

Finished Drug Prices

53 RELATED EXCIPIENT COMPANIES

89EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 1083076-69-0, Cariprazine hcl, Vraylar, Rgh188 hydrochloride, Rgh-188 hcl, Cariprazine (hydrochloride)

Molecular Formula

C₂₁H₃₃Cl₃N₄O

Molecular Weight

463.9 g/mol

InChI Key

GPPJWWMREQHLQT-UHFFFAOYSA-N

FDA UNII

KQD7C255YG

1 2D Structure

Cariprazine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea;hydrochloride

2.1.2 InChI

InChI=1S/C21H32Cl2N4O.ClH/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23;/h3-5,16-17H,6-15H2,1-2H3,(H,24,28);1H

2.1.3 InChI Key

GPPJWWMREQHLQT-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

KQD7C255YG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea

2. Cariprazine

3. Cariprazine Hcl

4. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimethylurea Monohydrochloride

5. Rgh-188

6. Trans-4-(2-(4-(2,3-dichlorophenyl)piperazine-1-yl)-ethyl)-n,n-dimethylcarbamoyl-cyclohexyl-amine Hydrochloride

7. Vraylar

2.3.2 Depositor-Supplied Synonyms

1. 1083076-69-0

2. Cariprazine Hcl

3. Vraylar

4. Rgh188 Hydrochloride

5. Rgh-188 Hcl

6. Cariprazine (hydrochloride)

7. Cariprazine Hydrochloride [usan]

8. Kqd7c255yg

9. Mfcd26142670

10. 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea;hydrochloride

11. Unii-kqd7c255yg

12. Cariprazine.hcl

13. Vraylar (tn)

14. Cariprazine Hydrochloride (jan/usan)

15. Cariprazine Monohydrochloride

16. Schembl183803

17. Schembl183804

18. Chembl2024517

19. Chebi:90932

20. Dtxsid101026486

21. Bcp24194

22. Ex-a1644

23. Hy-14763a

24. S5849

25. Cariprazine Hydrochloride [mi]

26. Cariprazine Hydrochloride [jan]

27. Cs-1570

28. Sb16840

29. 3-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-1,1-dimethylurea Hydrochloride

30. Ac-33130

31. Cariprazine Hydrochloride [who-dd]

32. Sy039271

33. Ft-0701196

34. A15036

35. Cariprazine Hydrochloride [orange Book]

36. D09876

37. A857936

38. Q27162922

39. 3-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea Hydrochloride

40. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimethylurea Monohydrochloride

41. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimthylurea Monohydrochloride

42. N'-(trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-n,n-dimethylurea Hydrochloride

43. N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-n,n-dimethylurea Hydrochloride

44. Urea, N'-(trans-4-(2-(4-(2,3-dichlorophenyl)-1-piperazinyl)ethyl)cyclohexyl)-n,n- Dimethyl-, Hydrochloride (1:1)

2.4 Create Date

2008-12-15

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₃₃Cl₃N₄O
Molecular Weight	463.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	462.171995 g/mol
Monoisotopic Mass	462.171995 g/mol
Topological Polar Surface Area	38.8 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	491
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Reagila is indicated for the treatment of schizophrenia in adult patients.

Treatment of schizophrenia

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

5.2 ATC Code

N05AX15

API SUPPLIERS

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USDMF

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EU WC

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NDC API

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Listed Suppliers

01

Biophore India Pharmaceuticals Pvt ...

India

CPhI China

Booth #E1H39

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

Contact Supplier

India

Virtual Booth

Digital Content

Cariprazine Hydrochloride

About the Company : Biophore, founded in 2007, has established itself as a reliable partner in the development and manufacturing of niche and complex pharmaceutical products. With 4 USFDA and EU-appro...

Biophore, founded in 2007, has established itself as a reliable partner in the development and manufacturing of niche and complex pharmaceutical products. With 4 USFDA and EU-approved API manufacturing facilities, a dedicated intermediate facility, and a R&D laboratory housing 400 scientists, Biophore has positioned itself as a global leader among API companies. It consistently ranks among the top 10 US DMF filers and has obtained over 150 patents worldwide in process and polymorph areas. Biophore's facilities have an impressive track record of successful audits by regulatory bodies such as USFDA, EMEA, ANVISA, COFEPRIS, and WHO GMP.

02

Aptra Synthesis

India

Duphat

Not Confirmed

Aptra Synthesis produces APIs, Pellets (Semi-finished Formulations), and Intermediates.

Contact Supplier

India

Virtual Booth

Digital Content

Cariprazine Hydrochloride

About the Company : Aptra Synthesis Private Limited, is a reliable and vertically integrated manufacturer of APIs and intermediates, boasting state-of-the-art manufacturing facilities that adhere to G...

Aptra Synthesis Private Limited, is a reliable and vertically integrated manufacturer of APIs and intermediates, boasting state-of-the-art manufacturing facilities that adhere to GMP standards. We take great pride in producing top-notch intermediates through our fully backward-integrated process. Aptra Synthesis Private Limited (ASPL) stands as one of the rapidly emerging manufacturers of Active Pharmaceutical Ingredients (APIs), Pellets (Semi-finished Formulations), and Intermediates.

03

Chongqing Sintaho Pharmaceutical

China

Duphat

Not Confirmed

Chongqing Sintaho Pharma: A trusted partner globally for chemosynthetic APIs.

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China

Virtual Booth

Digital Content

Cariprazine Hydrochloride

About the Company : Sintaho Pharmaceutical Co., Ltd., located in Chongqing, China, contributes to being the most dependable partner for global pharmaceutical companies. Sintaho specializes in chemosyn...

Sintaho Pharmaceutical Co., Ltd., located in Chongqing, China, contributes to being the most dependable partner for global pharmaceutical companies. Sintaho specializes in chemosynthetic APIs (application contains oncology, nervous system, and metabolic diseases and etc.,) with a product portfolio ranging from small molecule APIs, ADC compounds (linkers and payloads) to polypeptides, also provides CDMO services of cytotoxic and OEB4/5 grade APIs.

Corporate PDF

04

HRV Global Life Sciences

India

Duphat

Not Confirmed

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

Cariprazine Hydrochloride

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

05

Porton Pharma Solutions

China

Duphat

Not Confirmed

Porton Pharma Solutions: Value creation via innovation & discovery through technical platforms.

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China

Virtual Booth

Digital Content

Cariprazine Hydrochloride

About the Company : Porton Pharma Solutions Ltd. was founded in 2005, & the company's stock was successfully listed in Shenzhen Stock Exchange in 2014. Our R&D, manufacturing & operation facilities ar...

Porton Pharma Solutions Ltd. was founded in 2005, & the company's stock was successfully listed in Shenzhen Stock Exchange in 2014. Our R&D, manufacturing & operation facilities are located in China, Slovenia, the US, Belgium, Switzerland, Denmark, with more than 6000 employees worldwide. Porton leads the way with its excellent CDMO services, but also supplies APIs & intermediates for the treatment of critical diseases such as HIV/AIDS, diabetes, cancer, & influenza. Our Process Technology Centers & WHO/USFDA/EMA/PDMA/NMPA-inspected Facilities feature state-of-the-art equipment, highly flexible cGMP-compliant production assets.

06

Aurobindo Pharma Limited

India

Duphat

Not Confirmed

Not Confirmed

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API Reference Price

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