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Chemistry

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Also known as: 1083076-69-0, Cariprazine hcl, Vraylar, Rgh188 hydrochloride, Rgh-188 hcl, Cariprazine (hydrochloride)
Molecular Formula
C21H33Cl3N4O
Molecular Weight
463.9  g/mol
InChI Key
GPPJWWMREQHLQT-UHFFFAOYSA-N
FDA UNII
KQD7C255YG

Cariprazine Hydrochloride
1 2D Structure

Cariprazine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea;hydrochloride
2.1.2 InChI
InChI=1S/C21H32Cl2N4O.ClH/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23;/h3-5,16-17H,6-15H2,1-2H3,(H,24,28);1H
2.1.3 InChI Key
GPPJWWMREQHLQT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
KQD7C255YG
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea

2. Cariprazine

3. Cariprazine Hcl

4. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimethylurea Monohydrochloride

5. Rgh-188

6. Trans-4-(2-(4-(2,3-dichlorophenyl)piperazine-1-yl)-ethyl)-n,n-dimethylcarbamoyl-cyclohexyl-amine Hydrochloride

7. Vraylar

2.3.2 Depositor-Supplied Synonyms

1. 1083076-69-0

2. Cariprazine Hcl

3. Vraylar

4. Rgh188 Hydrochloride

5. Rgh-188 Hcl

6. Cariprazine (hydrochloride)

7. Cariprazine Hydrochloride [usan]

8. Kqd7c255yg

9. Mfcd26142670

10. 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea;hydrochloride

11. Unii-kqd7c255yg

12. Cariprazine.hcl

13. Vraylar (tn)

14. Cariprazine Hydrochloride (jan/usan)

15. Cariprazine Monohydrochloride

16. Schembl183803

17. Schembl183804

18. Chembl2024517

19. Chebi:90932

20. Dtxsid101026486

21. Bcp24194

22. Ex-a1644

23. Hy-14763a

24. S5849

25. Cariprazine Hydrochloride [mi]

26. Cariprazine Hydrochloride [jan]

27. Cs-1570

28. Sb16840

29. 3-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-1,1-dimethylurea Hydrochloride

30. Ac-33130

31. Cariprazine Hydrochloride [who-dd]

32. Sy039271

33. Ft-0701196

34. A15036

35. Cariprazine Hydrochloride [orange Book]

36. D09876

37. A857936

38. Q27162922

39. 3-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea Hydrochloride

40. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimethylurea Monohydrochloride

41. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimthylurea Monohydrochloride

42. N'-(trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-n,n-dimethylurea Hydrochloride

43. N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-n,n-dimethylurea Hydrochloride

44. Urea, N'-(trans-4-(2-(4-(2,3-dichlorophenyl)-1-piperazinyl)ethyl)cyclohexyl)-n,n- Dimethyl-, Hydrochloride (1:1)

2.4 Create Date
2008-12-15
3 Chemical and Physical Properties
Molecular Weight 463.9 g/mol
Molecular Formula C21H33Cl3N4O
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass462.171995 g/mol
Monoisotopic Mass462.171995 g/mol
Topological Polar Surface Area38.8 Ų
Heavy Atom Count29
Formal Charge0
Complexity491
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Reagila is indicated for the treatment of schizophrenia in adult patients.


Treatment of schizophrenia


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


5.2 ATC Code

N05AX15


EU WC

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Lee Pharma

India
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Lee Pharma

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Cariprazine Hydrochloride IH

Date of Issue : 2023-03-21

Valid Till : 2025-07-28

Written Confirmation Number : WC-0186

Address of the Firm : Sy. No. 10/G-1, Gaddapotharam Village, Jinnaram Mandal, Sangareddy, Pin-502319, ...

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BePharma
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Cariprazine Hydrochloride IH

Date of Issue : 2020-07-23

Valid Till : 2023-05-11

Written Confirmation Number : WC-0273

Address of the Firm : Plot No. 34A, J.N.Pharma City, Thanam (V), Parawada (M), Vishakhapatnam-District...

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Cariprazine HCl IH

Date of Issue : 2020-03-18

Valid Till : 2020-05-11

Written Confirmation Number : WC-0273A7

Address of the Firm : Plot No. 34A, J.N.Pharma City, Thanam (V), Parawada (M), Vishakhapatnam-District...

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Cariprazine Hydrochloride IH

Date of Issue : 2022-08-08

Valid Till : 2025-07-14

Written Confirmation Number : WC-0168

Address of the Firm : Plot No. 24/2, & 25, Phase -IV, GIDC, Industrial Zone, At & Post - Panoli, Dist....

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NDC API

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CARIPRAZINE HYDROCHLORIDE

NDC Package Code : 59651-400

Start Marketing Date : 2024-01-18

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (25kg/50kg)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

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Maprimed S.A.

Argentina
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Maprimed S.A.

Argentina
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CARIPRAZINE

NDC Package Code : 57741-4100

Start Marketing Date : 2024-09-27

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Maprimed S.A.

Argentina
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Maprimed S.A.

Argentina
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CARIPRAZINE HYDROCHLORIDE

NDC Package Code : 57741-3700

Start Marketing Date : 2015-07-17

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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CARIPRAZINE HYDROCHLORIDE

NDC Package Code : 14501-0035

Start Marketing Date : 2018-12-13

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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CARIPRAZINE HYDROCHLORIDE

NDC Package Code : 76055-0042

Start Marketing Date : 2019-07-25

End Marketing Date : 2026-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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HOSTER LABS PRIVATE LIMITED

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HOSTER LABS PRIVATE LIMITED

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CARIPRAZINE HYDROCHLORIDE

NDC Package Code : 82708-0003

Start Marketing Date : 2015-09-17

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Listed Suppliers

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Virtual BoothDelivering Quality APIs, Drug Intermediates, and Specialty Chemicals to Over 50 Countries Across the Globe.

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Cariprazine Hydrochloride

About the Company : Zeal MediPharma is a globally recognized Star One Export House, serving customers in over 50 countries for more than two decades. We specialize in sourcing and exporting high-quali...

Zeal MediPharma is a globally recognized Star One Export House, serving customers in over 50 countries for more than two decades. We specialize in sourcing and exporting high-quality APIs for human and veterinary use, along with drug intermediates, excipients, and semi-finished formulations such as pellets and DC granules. Our diverse portfolio also includes herbal extracts, phytochemicals, nutraceuticals, food and feed ingredients, agrochemicals, preservatives, surfactants, and specialty chemicals. Committed to excellence, we deliver reliable, high-quality solutions to meet the evolving needs of global healthcare and industry.
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Virtual BoothBiophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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Cariprazine Hydrochloride

About the Company : Biophore, founded in 2007, has established itself as a reliable partner in the development and manufacturing of niche and complex pharmaceutical products. With 4 USFDA and EU-appro...

Biophore, founded in 2007, has established itself as a reliable partner in the development and manufacturing of niche and complex pharmaceutical products. With 4 USFDA and EU-approved API manufacturing facilities, a dedicated intermediate facility, and a R&D laboratory housing 400 scientists, Biophore has positioned itself as a global leader among API companies. It consistently ranks among the top 10 US DMF filers and has obtained over 150 patents worldwide in process and polymorph areas. Biophore's facilities have an impressive track record of successful audits by regulatory bodies such as USFDA, EMEA, ANVISA, COFEPRIS, and WHO GMP.
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Virtual BoothAptra Synthesis produces APIs, Pellets (Semi-finished Formulations), and Intermediates.

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Cariprazine Hydrochloride

About the Company : Aptra Synthesis Private Limited, is a reliable and vertically integrated manufacturer of APIs and intermediates, boasting state-of-the-art manufacturing facilities that adhere to G...

Aptra Synthesis Private Limited, is a reliable and vertically integrated manufacturer of APIs and intermediates, boasting state-of-the-art manufacturing facilities that adhere to GMP standards. We take great pride in producing top-notch intermediates through our fully backward-integrated process. Aptra Synthesis Private Limited (ASPL) stands as one of the rapidly emerging manufacturers of Active Pharmaceutical Ingredients (APIs), Pellets (Semi-finished Formulations), and Intermediates.
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Virtual BoothHRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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Cariprazine Hydrochloride

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
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Virtual BoothPorton Pharma Solutions: Value creation via innovation & discovery through technical platforms.

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Cariprazine Hydrochloride

About the Company : Porton Pharma Solutions Ltd. was founded in 2005, & the company's stock was successfully listed in Shenzhen Stock Exchange in 2014. Our R&D, manufacturing & operation facilities ar...

Porton Pharma Solutions Ltd. was founded in 2005, & the company's stock was successfully listed in Shenzhen Stock Exchange in 2014. Our R&D, manufacturing & operation facilities are located in China, Slovenia, the US, Belgium, Switzerland, Denmark, with more than 6000 employees worldwide. Porton leads the way with its excellent CDMO services, but also supplies APIs & intermediates for the treatment of critical diseases such as HIV/AIDS, diabetes, cancer, & influenza. Our Process Technology Centers & WHO/USFDA/EMA/PDMA/NMPA-inspected Facilities feature state-of-the-art equipment, highly flexible cGMP-compliant production assets.
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Cariprazine Hydrochloride

About the Company : Founded in 1986 by Mr. P.V. Ramaprasad Reddy, Mr. K. Nityananda Reddy and a small group of highly committed professionals, Aurobindo Pharma was born off a vision. The company comme...

Founded in 1986 by Mr. P.V. Ramaprasad Reddy, Mr. K. Nityananda Reddy and a small group of highly committed professionals, Aurobindo Pharma was born off a vision. The company commenced operations in 1988-89 with a single unit manufacturing Semi-Synthetic Penicillin (SSP) at Pondicherry. Aurobindo Pharma became a public company in 1992 and listed its shares in the Indian stock exchanges in 1995. In addition to being the market leader in Semi-Synthetic Penicillins, it has a presence in key therapeutic segments such as neurosciences, cardiovascular, anti-retrovirals, anti-diabetics, gastroenterology and cephalosporins, among others.
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CHEMO

Spain
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CHEMO

Spain
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cariprazine

About the Company : More than 35 years of dedication to quality, service and pursuit of excellence, CHEMO was founded by Hugo Sigman, M.D., and Silvia Gold, Biochemist, in Spain (Barcelona), in 1977, ...

More than 35 years of dedication to quality, service and pursuit of excellence, CHEMO was founded by Hugo Sigman, M.D., and Silvia Gold, Biochemist, in Spain (Barcelona), in 1977, and starts business activities trading with pharmaceutical raw materials. In the 80's, the company expanded its operations into the Industrial Business, developing and manufacturing active pharmaceutical ingredients (APIs) in Italy (Industriale Chimica) and in Spain (Quimica Sintetica). In the 90's, CHEMO starts developing and manufacturing high quality and technology finished dosage forms (FDFs).
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Hetero Drugs

India
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Hetero Drugs

India
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Cariprazine

About the Company : Hetero is a research based global pharmaceutical company focused on development, manufacturing and marketing of Active Pharmaceutical Ingredients (APIs), Intermediate Chemicals & F...

Hetero is a research based global pharmaceutical company focused on development, manufacturing and marketing of Active Pharmaceutical Ingredients (APIs), Intermediate Chemicals & Finished Dosages. Ever since its establishment in 1993, Hetero showed a tradition of excellence and deep sense of commitment in developing cost effective processes to offer wide range of affordable drugs. Hetero is building on the strengths of vertical integration in discovery research, process chemistry, API manufacturing, formulation development and commercialization.
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Cariprazine Hydrochloride

About the Company : Morepen Laboratories Ltd.’ is 31 years old company. Went to public in 1993. Manufacturer and Exporter of complex and high margins molecules (APIs/Intermediates) for regulated mar...

Morepen Laboratories Ltd.’ is 31 years old company. Went to public in 1993. Manufacturer and Exporter of complex and high margins molecules (APIs/Intermediates) for regulated markets of USA, Europe, Russia, Canada and also for non-regulated markets. The first Morepen manufacturing plant was set up on the foothills of the Himalayas in the idyllic surroundings of Parwanoo. The large and spread-out facility is USDFA approved for manufacture of Loratadine, an anti-allergy drug- internationally known as Claritin.
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Cariprazine Hydrochloride

About the Company : Synaptics Labs Private Limited is a young Pharmaceutical Company with a fully integrated and globally specialized in the development, production and marketing of API’s "Active Ph...

Synaptics Labs Private Limited is a young Pharmaceutical Company with a fully integrated and globally specialized in the development, production and marketing of API’s "Active Pharmaceuticals Ingredients" and its advanced Intermediates, thanks to our focus on satisfying our customers' requirements and supporting the consolidation of a robust infrastructure. The Company promoted by a team of technocrats holding a master’s degree in pharmaceuticals and who have been involved in different Pharmaceutical companies since 24years.
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API Reference Price

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09-Dec-2021
18-Dec-2024
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ABOUT THIS PAGE

Looking for 1083076-69-0 / Cariprazine Hydrochloride API manufacturers, exporters & distributors?

Cariprazine Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cariprazine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cariprazine Hydrochloride manufacturer or Cariprazine Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cariprazine Hydrochloride manufacturer or Cariprazine Hydrochloride supplier.

PharmaCompass also assists you with knowing the Cariprazine Hydrochloride API Price utilized in the formulation of products. Cariprazine Hydrochloride API Price is not always fixed or binding as the Cariprazine Hydrochloride Price is obtained through a variety of data sources. The Cariprazine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cariprazine Hydrochloride

Synonyms

1083076-69-0, Cariprazine hcl, Vraylar, Rgh188 hydrochloride, Rgh-188 hcl, Cariprazine (hydrochloride)

Cas Number

1083076-69-0

Unique Ingredient Identifier (UNII)

KQD7C255YG

Cariprazine HCl Manufacturers

A Cariprazine HCl manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cariprazine HCl, including repackagers and relabelers. The FDA regulates Cariprazine HCl manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cariprazine HCl API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cariprazine HCl manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cariprazine HCl Suppliers

A Cariprazine HCl supplier is an individual or a company that provides Cariprazine HCl active pharmaceutical ingredient (API) or Cariprazine HCl finished formulations upon request. The Cariprazine HCl suppliers may include Cariprazine HCl API manufacturers, exporters, distributors and traders.

click here to find a list of Cariprazine HCl suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cariprazine HCl USDMF

A Cariprazine HCl DMF (Drug Master File) is a document detailing the whole manufacturing process of Cariprazine HCl active pharmaceutical ingredient (API) in detail. Different forms of Cariprazine HCl DMFs exist exist since differing nations have different regulations, such as Cariprazine HCl USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Cariprazine HCl DMF submitted to regulatory agencies in the US is known as a USDMF. Cariprazine HCl USDMF includes data on Cariprazine HCl's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cariprazine HCl USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Cariprazine HCl suppliers with USDMF on PharmaCompass.

Cariprazine HCl WC

A Cariprazine HCl written confirmation (Cariprazine HCl WC) is an official document issued by a regulatory agency to a Cariprazine HCl manufacturer, verifying that the manufacturing facility of a Cariprazine HCl active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Cariprazine HCl APIs or Cariprazine HCl finished pharmaceutical products to another nation, regulatory agencies frequently require a Cariprazine HCl WC (written confirmation) as part of the regulatory process.

click here to find a list of Cariprazine HCl suppliers with Written Confirmation (WC) on PharmaCompass.

Cariprazine HCl NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Cariprazine HCl as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Cariprazine HCl API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Cariprazine HCl as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Cariprazine HCl and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Cariprazine HCl NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Cariprazine HCl suppliers with NDC on PharmaCompass.

Cariprazine HCl GMP

Cariprazine HCl Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cariprazine HCl GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cariprazine HCl GMP manufacturer or Cariprazine HCl GMP API supplier for your needs.

Cariprazine HCl CoA

A Cariprazine HCl CoA (Certificate of Analysis) is a formal document that attests to Cariprazine HCl's compliance with Cariprazine HCl specifications and serves as a tool for batch-level quality control.

Cariprazine HCl CoA mostly includes findings from lab analyses of a specific batch. For each Cariprazine HCl CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cariprazine HCl may be tested according to a variety of international standards, such as European Pharmacopoeia (Cariprazine HCl EP), Cariprazine HCl JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cariprazine HCl USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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