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    Chemistry

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    Also known as: 1083076-69-0, Cariprazine hcl, Vraylar, Rgh188 hydrochloride, Rgh-188 hcl, Cariprazine (hydrochloride)
    Molecular Formula
    C21H33Cl3N4O
    Molecular Weight
    463.9  g/mol
    InChI Key
    GPPJWWMREQHLQT-UHFFFAOYSA-N
    FDA UNII
    KQD7C255YG
    Cariprazine Hydrochloride
    1 2D Structure

    Cariprazine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H32Cl2N4O.ClH/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23;/h3-5,16-17H,6-15H2,1-2H3,(H,24,28);1H
    2.1.3 InChI Key
    GPPJWWMREQHLQT-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    KQD7C255YG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea

    2. Cariprazine

    3. Cariprazine Hcl

    4. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimethylurea Monohydrochloride

    5. Rgh-188

    6. Trans-4-(2-(4-(2,3-dichlorophenyl)piperazine-1-yl)-ethyl)-n,n-dimethylcarbamoyl-cyclohexyl-amine Hydrochloride

    7. Vraylar

    2.3.2 Depositor-Supplied Synonyms

    1. 1083076-69-0

    2. Cariprazine Hcl

    3. Vraylar

    4. Rgh188 Hydrochloride

    5. Rgh-188 Hcl

    6. Cariprazine (hydrochloride)

    7. Cariprazine Hydrochloride [usan]

    8. Kqd7c255yg

    9. Mfcd26142670

    10. 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea;hydrochloride

    11. Unii-kqd7c255yg

    12. Cariprazine.hcl

    13. Vraylar (tn)

    14. Cariprazine Hydrochloride (jan/usan)

    15. Cariprazine Monohydrochloride

    16. Schembl183803

    17. Schembl183804

    18. Chembl2024517

    19. Chebi:90932

    20. Dtxsid101026486

    21. Bcp24194

    22. Ex-a1644

    23. Hy-14763a

    24. S5849

    25. Cariprazine Hydrochloride [mi]

    26. Cariprazine Hydrochloride [jan]

    27. Cs-1570

    28. Sb16840

    29. 3-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-1,1-dimethylurea Hydrochloride

    30. Ac-33130

    31. Cariprazine Hydrochloride [who-dd]

    32. Sy039271

    33. Ft-0701196

    34. A15036

    35. Cariprazine Hydrochloride [orange Book]

    36. D09876

    37. A857936

    38. Q27162922

    39. 3-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea Hydrochloride

    40. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimethylurea Monohydrochloride

    41. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimthylurea Monohydrochloride

    42. N'-(trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-n,n-dimethylurea Hydrochloride

    43. N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-n,n-dimethylurea Hydrochloride

    44. Urea, N'-(trans-4-(2-(4-(2,3-dichlorophenyl)-1-piperazinyl)ethyl)cyclohexyl)-n,n- Dimethyl-, Hydrochloride (1:1)

    2.4 Create Date
    2008-12-15
    3 Chemical and Physical Properties
    Molecular Weight 463.9 g/mol
    Molecular Formula C21H33Cl3N4O
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count5
    Exact Mass462.171995 g/mol
    Monoisotopic Mass462.171995 g/mol
    Topological Polar Surface Area38.8 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity491
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Reagila is indicated for the treatment of schizophrenia in adult patients.

    Treatment of schizophrenia

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    5.2 ATC Code

    N05AX15

    API SUPPLIERS

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    Biophore India Pharmaceuticals Pvt...

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VERBEN S.A","supplierCountry":"SWITZERLAND","foreign_port":"BUENOS AIRES, BA","customer":"RUBICON RESEARCH","customerCountry":"INDIA","quantity":"0.15","actualQuantity":"0.15","unit":"KGS","unitRateFc":"35000","totalValueFC":"5285.1","currency":"USD","unitRateINR":"2933000","date":"27-Dec-2023","totalValueINR":"439950","totalValueInUsd":"5285.1","indian_port":"Bombay Air","hs_no":"29222990","bill_no":"9432326","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Micronized","supplierPort":"BUENOS AIRES, BA","supplierAddress":"LIGANO BRANCHVIA F. 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    26-Jun-2021
    11-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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