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Carubicin

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

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GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Carubicin, 39472-31-6, Carminomycin i, Karminomycin, 50935-04-1, Carubicin [inn]

Molecular Formula

C₂₆H₂₇NO₁₀

Molecular Weight

513.5 g/mol

InChI Key

XREUEWVEMYWFFA-CSKJXFQVSA-N

FDA UNII

E7437K3983

A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.

1 2D Structure

Carubicin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-4,6,9,11-tetrahydroxy-8,10-dihydro-7H-tetracene-5,12-dione

2.1.2 InChI

InChI=1S/C26H27NO10/c1-9-21(30)13(27)6-16(36-9)37-15-8-26(35,10(2)28)7-12-18(15)25(34)20-19(23(12)32)22(31)11-4-3-5-14(29)17(11)24(20)33/h3-5,9,13,15-16,21,29-30,32,34-35H,6-8,27H2,1-2H3/t9-,13-,15-,16-,21+,26-/m0/s1

2.1.3 InChI Key

XREUEWVEMYWFFA-CSKJXFQVSA-N

2.1.4 Canonical SMILES

CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)O)O)(C(=O)C)O)N)O

2.1.5 Isomeric SMILES

C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)O)O)(C(=O)C)O)N)O

2.2 Other Identifiers

2.2.1 UNII

E7437K3983

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Carminomicin

2. Carminomycin I

3. Carminomycin Ii

4. Carminomycin Iii

5. Carubicin

6. Carubicin Hydrochloride

7. Demethyldaunomycin

8. Demethyldaunorubicin

9. Hydrochloride, Carubicin

10. Karminomicin

11. Karminomycin

12. Nsc 180,024

13. Nsc 180024

14. Nsc-180,024

15. Nsc-180024

16. Nsc180,024

17. Nsc180024

18. Rubeomycin A

19. Rubeomycin A1

2.3.2 Depositor-Supplied Synonyms

1. Carubicin

2. 39472-31-6

3. Carminomycin I

4. Karminomycin

5. 50935-04-1

6. Carubicin [inn]

7. O-demethyldaunomycin

8. Carminomicin I

9. Nsc-180024

10. Ccris 961

11. Chebi:31359

12. Dsstox_cid_2742

13. Dsstox_rid_76711

14. Dsstox_gsid_22742

15. Karminomitsin

16. Ncgc00159344-02

17. 50935-04-1 (free Base)

18. (7s,9s)-9-acetyl-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-4,6,9,11-tetrahydroxy-8,10-dihydro-7h-tetracene-5,12-dione

19. E7437k3983

20. (8s,10s)-8-acetyl-10-(((2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-1,6,8,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione

21. Carubicina

22. Carubicine

23. Carubicinum

24. (1s,3s)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranoside

25. (7s,9s)-9-acetyl-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-4,6,9,11-tetrahydroxy-8,10-dihydro-7h-tetracene-5,12-dione

26. 5,12-naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8s,10s)-

27. Cas-50935-04-1

28. Carubicine [inn-french]

29. Carubicinum [inn-latin]

30. Carubicina [inn-spanish]

31. Ccris 6185

32. Unii-e7437k3983

33. Ncgc00160675-01

34. Carminomycin; Carubicin

35. Carubicin [mi]

36. Schembl9552

37. Chembl474260

38. Dtxsid3022742

39. Ex-a2244

40. Hy-b2171

41. Zinc4654755

42. Tox21_111589

43. Tox21_111978

44. Bdbm50103635

45. (1s,3s)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-tridesoxy-alpha-l-lyxo-hexopyranosid

46. Cs-0021097

47. Carminomycin, O-demethyldaunomycin, Ccris 961

48. 935c041

49. A857268

50. Q5047474

51. (1s,3s)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-.alpha.-l-lyxo-hexopyranoside

52. 5,12-naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-.alpha.-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8s-cis)-

53. 5,12-naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8s-cis)-

54. 5,12-naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8s,10s)-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₂₇NO₁₀
Molecular Weight	513.5 g/mol
XLogP3	1.5
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	3
Exact Mass	513.16349606 g/mol
Monoisotopic Mass	513.16349606 g/mol
Topological Polar Surface Area	197 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	944
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

Antibiotics, Antineoplastic

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

ABOUT THIS PAGE

Carubicin Manufacturers

A Carubicin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Carubicin, including repackagers and relabelers. The FDA regulates Carubicin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Carubicin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Carubicin Suppliers

A Carubicin supplier is an individual or a company that provides Carubicin active pharmaceutical ingredient (API) or Carubicin finished formulations upon request. The Carubicin suppliers may include Carubicin API manufacturers, exporters, distributors and traders.

Carubicin GMP

Carubicin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Carubicin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Carubicin GMP manufacturer or Carubicin GMP API supplier for your needs.

Carubicin CoA

A Carubicin CoA (Certificate of Analysis) is a formal document that attests to Carubicin's compliance with Carubicin specifications and serves as a tool for batch-level quality control.

Carubicin CoA mostly includes findings from lab analyses of a specific batch. For each Carubicin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Carubicin may be tested according to a variety of international standards, such as European Pharmacopoeia (Carubicin EP), Carubicin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Carubicin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.