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ACTIVE PHARMA INGREDIENTS

16 API Suppliers, 5 USDMF, 3 JDMF, 2 EU WC, 5 KDMF, 10 Listed Suppliers, $ API Reference Price

16 API Suppliers
5 USDMF
3 JDMF
2 EU WC
5 KDMF
10 Listed Suppliers
$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 2 FDA Orange Book, 2 Listed Dossiers

4 FDF Dossiers
2 FDA Orange Book
2 Listed Dossiers

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1 FDF Dossiers

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Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 749

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Chemistry

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Also known as: Spectracef, 117467-28-4, Cefditoren pivaloyloxymethyl ester, Cdtr-pi, Meiact, Cefditoren (pivoxil)

Molecular Formula

C₂₅H₂₈N₆O₇S₃

Molecular Weight

620.7 g/mol

InChI Key

AFZFFLVORLEPPO-UVYJNCLZSA-N

FDA UNII

78THA212DH

Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis. Another consequence of beta-lactam exposure results in the loss of lipoteichoic acids from the cell wall. Lipoteichoic acids inhibit murein hydrolase activity and their absence from the cell wall triggers uncontrolled autolytic activity rendering bacterial cells susceptible to osmotic shock. This results in a reduction of cell wall stability and causes cell lysis.

1 2D Structure

Cefditoren Pivoxil

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.1.2 InChI

InChI=1S/C25H28N6O7S3/c1-12-15(41-10-27-12)7-6-13-8-39-21-17(29-19(32)16(30-36-5)14-9-40-24(26)28-14)20(33)31(21)18(13)22(34)37-11-38-23(35)25(2,3)4/h6-7,9-10,17,21H,8,11H2,1-5H3,(H2,26,28)(H,29,32)/b7-6-,30-16-/t17-,21-/m1/s1

2.1.3 InChI Key

AFZFFLVORLEPPO-UVYJNCLZSA-N

2.1.4 Canonical SMILES

CC1=C(SC=N1)C=CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)OCOC(=O)C(C)(C)C

2.1.5 Isomeric SMILES

CC1=C(SC=N1)/C=C\C2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)OCOC(=O)C(C)(C)C

2.2 Other Identifiers

2.2.1 UNII

78THA212DH

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (-)-(6r,7r)-2,2-dimethylpropionyloxymethyl 7-((z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido)-3-((z)-2-(4-methylthiazol-5-yl)ethenyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

2. 7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(2-(4-methylthiazol-5-yl)ethenyl)cephem-4-carboxylic Acid Pivaloyloxymethyl Ester

3. Cdtr-pi

4. Me 1207

5. Me-1207

6. Spectracef

2.3.2 Depositor-Supplied Synonyms

1. Spectracef

2. 117467-28-4

3. Cefditoren Pivaloyloxymethyl Ester

4. Cdtr-pi

5. Meiact

6. Cefditoren (pivoxil)

7. Cefditoren Pivoxil [jan]

8. Me-1207

9. Cefditorin Pivoxil

10. Me1207

11. Cefditoren Pivoxil Hcl

12. 78tha212dh

13. Cefditorin

14. Chebi:560555

15. Me 1207

16. Nsc-759098

17. 2,2-dimethylpropanoyloxymethyl (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

18. Cefditoren Pi Voxil

19. Cefditoren-pivoxil

20. [(2,2-dimethylpropanoyl)oxy]methyl (6r,7r)-7-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

21. [(2,2-dimethylpropanoyl)oxy]methyl 7beta-(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido-3-[(z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-3,4-didehydrocepham-4-carboxylic Acid

22. 1448435-17-3

23. Pivaloyloxymethyl (+)-(6r,7r)-7-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

24. Ccris 7768

25. Unii-78tha212dh

26. Spectracef (tn)

27. Ncgc00095175-01

28. Meiact (tn)

29. Mfcd00933166

30. Dsstox_cid_28669

31. Dsstox_rid_82939

32. Dsstox_gsid_48743

33. Schembl182876

34. Chembl454446

35. Cefditoren Pivoxil [usan:jan]

36. Dtxsid2048743

37. Cefditoren Pivoxil [usan]

38. Cefditoren Pivoxil (jp17/usan)

39. Cefditoren Pivoxil [vandf]

40. Cefditoren Pivoxil [mart.]

41. Cefditoren Pivoxil [who-dd]

42. Tox21_113197

43. Hy-17452a

44. S1768

45. Akos025311444

46. Ccg-270254

47. Cs-1949

48. Nsc 759098

49. Cefditoren Pivoxil [orange Book]

50. Ncgc00095175-08

51. (pivaloyloxy)methyl (6r,7r)-7-((z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

52. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((1z)-2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo-,2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r,7r)-

53. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r-(3(z),6-alpha,7-beta-(z)))-

54. As-12951

55. B2086

56. Cas-117467-28-4

57. Cefditoren Pivaloyloxymethyl Ester [mi]

58. D01628

59. Ab01274730-01

60. Ab01274730_02

61. 467c284

62. Brd-k72167406-001-03-9

63. (+)-(6r,7r)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-((z)-2-(4-methyl-5-thiazolyl)vinyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate Pivaloyloxy Methyl Ester, 7(sup 2)-(z)-(o-methyloxime)

64. (6r,7r)-(pivaloyloxy)methyl 7-((z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

65. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7(((2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((1z)-2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r,7r)-

2.4 Create Date

2006-04-28

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₂₈N₆O₇S₃
Molecular Weight	620.7 g/mol
XLogP3	4.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	12
Exact Mass	620.11816077 g/mol
Monoisotopic Mass	620.11816077 g/mol
Topological Polar Surface Area	257 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	1160
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Spectracef
PubMed Health	Cefditoren Pivoxil (By mouth)
Drug Classes	Antibiotic
Drug Label	SPECTRACEF tablets contain cefditoren pivoxil, a semi-synthetic cephalosporin antibiotic for oral administration. It is a prodrug which is hydrolyzed by esterases during absorption, and the drug is distributed in the circulating blood as active cef...
Active Ingredient	Cefditoren pivoxil
Dosage Form	Tablet
Route	Oral
Strength	200mg; 400mg
Market Status	Prescription
Company	Vansen Pharma

2 of 2
Drug Name	Spectracef
PubMed Health	Cefditoren Pivoxil (By mouth)
Drug Classes	Antibiotic
Drug Label	SPECTRACEF tablets contain cefditoren pivoxil, a semi-synthetic cephalosporin antibiotic for oral administration. It is a prodrug which is hydrolyzed by esterases during absorption, and the drug is distributed in the circulating blood as active cef...
Active Ingredient	Cefditoren pivoxil
Dosage Form	Tablet
Route	Oral
Strength	200mg; 400mg
Market Status	Prescription
Company	Vansen Pharma

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

API SUPPLIERS

01

ZHEJIANG HUAFANG PHARMACEUTICAL CO...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

SupplySide West 2024

Not Confirmed

02

Orchid Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed

03

Meiji Seika Pharma

Japan

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SupplySide West 2024

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JDMF

01

JEIL PHARMACEUTICAL CO. , LTD.

South Korea

PackExpo

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02

Meiji Seika Pharma Co., Ltd.

Japan

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03

Yungjin Pharm. Co. ,Ltd

South Korea

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EU WC

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Dhanuka Laboratories Ltd

India

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Orchid Pharma

India

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Covalent Laboratories Private Limit...

India

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Jeil Pharmaceutical Co., Ltd

South Korea

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03

Kyongbo Pharmaceutical Co., Ltd

South Korea

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04

Meiji Seika Pharma

Japan

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Youngjin Pharm

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Listed Suppliers

01

Fuan Pharmaceutical

China

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Guangzhou Tosun Pharmaceutical

China

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03

Jeil Pharmaceutical Co., Ltd

South Korea

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04

Lunan Pharmaceutical

China

China

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Suvan Lifesciences

India

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Virchow Group

India

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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INTERMEDIATES SUPPLIERS

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FDF Dossiers

01

Gracure Pharmaceuticals Limited

India

India

SupplySide West 2024

Not Confirmed

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FDA Orange Book

01

VANSEN PHARMA

Canada

SupplySide West 2024

Not Confirmed

02

VANSEN PHARMA

Canada

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Not Confirmed

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Listed Dossiers

01

Gracure Pharmaceuticals Limited

India

SupplySide West 2024

Not Confirmed

02

XL Laboratories Private Limited

India

SupplySide West 2024

Not Confirmed

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Topical

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ABOUT THIS PAGE

Find Cefditoren Pivoxil manufacturers, exporters & distributors on PharmaCompass

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

16 API Suppliers

5 USDMF

3 JDMF

2 EU WC

5 KDMF

10 Listed Suppliers

$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers

2 FDA Orange Book

2 Listed Dossiers

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EXCIPIENTS BY APPLICATIONS

43 Coating Systems & Additives

27 Fillers, Diluents & Binders

21 Controlled & Modified Release

13 Disintegrants & Superdisintegrants

12 Direct Compression

11 Taste Masking

11 Chewable & Orodispersible Aids

10 Topical

9 Film Formers & Plasticizers

8 Granulation

8 Thickeners and Stabilizers

8 Lubricants & Glidants

7 Solubilizers

7 Parenteral

5 Empty Capsules

4 API Stability Enhancers

4 Coloring Agents

4 Co-Processed Excipients

4 Vegetarian Capsules

3 Emulsifying Agents

2 Rheology Modifiers

MARKET PLACE

3 APIs