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    Chemistry

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    Also known as: Vantin, Banan, 87239-81-4, Orelox, Doxef, Cs-807
    Molecular Formula
    C21H27N5O9S2
    Molecular Weight
    557.6  g/mol
    InChI Key
    LTINZAODLRIQIX-FBXRGJNPSA-N
    FDA UNII
    2TB00A1Z7N
    Cefpodoxime Proxetil
    Cefpodoxime Proxetil is a third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefpodoxime inhibits bacterial septum and cell wall synthesis formation.
    1 2D Structure

    Cefpodoxime Proxetil

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-propan-2-yloxycarbonyloxyethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    2.1.2 InChI
    InChI=1S/C21H27N5O9S2/c1-9(2)33-21(30)35-10(3)34-19(29)15-11(6-31-4)7-36-18-14(17(28)26(15)18)24-16(27)13(25-32-5)12-8-37-20(22)23-12/h8-10,14,18H,6-7H2,1-5H3,(H2,22,23)(H,24,27)/b25-13-/t10?,14-,18-/m1/s1
    2.1.3 InChI Key
    LTINZAODLRIQIX-FBXRGJNPSA-N
    2.1.4 Canonical SMILES
    CC(C)OC(=O)OC(C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CSC(=N3)N)COC
    2.1.5 Isomeric SMILES
    CC(C)OC(=O)OC(C)OC(=O)C1=C(CS[C@H]2N1C(=O)[C@H]2NC(=O)/C(=N\OC)/C3=CSC(=N3)N)COC
    2.2 Other Identifiers
    2.2.1 UNII
    2TB00A1Z7N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-(isopropoxycarbonyloxy)ethyl-7-(2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido)-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo(4,2,0)-oct-2-ene-2-carboxylate

    2. Cephalosporin 807

    3. Cs 807

    4. Cs-807

    5. Doxef

    6. U 76252

    7. U-76,252

    8. Vantin

    2.3.2 Depositor-Supplied Synonyms

    1. Vantin

    2. Banan

    3. 87239-81-4

    4. Orelox

    5. Doxef

    6. Cs-807

    7. Simplicef

    8. Otreon

    9. U-76252

    10. Podomexef

    11. Chebi:3505

    12. 2tb00a1z7n

    13. Cefodox

    14. Nsc-759161

    15. (rs)-1-((isopropoxycarbonyl)oxy)ethyl (+)-(6r,7r)-7-(2-(2-amino-4-thiazolyl)-2-((z)-methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

    16. Dsstox_cid_2766

    17. Dsstox_rid_76722

    18. Cefpodoxime 1-(isopropyloxycarbonyloxy)ethyl Ester

    19. Dsstox_gsid_22766

    20. Xtum-o

    21. 1-{[(propan-2-yloxy)carbonyl]oxy}ethyl (6r,7r)-7-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

    22. 1-{[(propan-2-yloxy)carbonyl]oxy}ethyl 7beta-[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-3,4-didehydrocepham-4-carboxylate

    23. Cas-87239-81-4

    24. Simplicef [veterinary]

    25. Unii-2tb00a1z7n

    26. Orelox Paed

    27. Ncgc00164598-01

    28. Ncgc00183131-01

    29. Mfcd00865088

    30. Vantin (tn)

    31. Cefpodoxime Proxetil [usan:usp:jan]

    32. Schembl27071

    33. Mls001401428

    34. Chembl1201016

    35. Dtxsid1022766

    36. Cefpodoxime (as Proxetil)

    37. Cefpodoxime Proxetil (jp17/usp)

    38. Cefpodoxime Proxetil [jan]

    39. Hms3715j22

    40. Cefpodoxime Proxetil [usan]

    41. Cefpodoxime Proxetil, Vantin

    42. Hy-n7101

    43. Cefpodoxime Proxetil [vandf]

    44. Tox21_113377

    45. Tox21_113428

    46. Bdbm50248233

    47. Cefpodoxime Proxetil [mart.]

    48. S5350

    49. Cefpodoxime Proxetil [usp-rs]

    50. Cefpodoxime Proxetil [who-dd]

    51. Akos015994692

    52. Ccg-221250

    53. Ks-1149

    54. Nsc 759161

    55. Cefpodoxime Proxetil [green Book]

    56. (+-)-1-hydroxyethyl (+)-(6r,7r)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate, 7(sup 2)-(z)-(o-methyloxime), Isopropyl Carbonate (ester)

    57. Cefpodoxime Proxetil [orange Book]

    58. Ru-51807

    59. Smr000469193

    60. Cefpodoxime Proxetil [ep Monograph]

    61. Cefpodoxime Proxetil [usp Impurity]

    62. Cefpodoxime Proxetil [usp Monograph]

    63. Cefpodoxime Proxetil For Peak Identification

    64. Cs-0027614

    65. C08115

    66. D00920

    67. Ab01209734-01

    68. 239c814

    69. A842048

    70. Cefpodoxime Proxetil For Impurity H Identification

    71. Cefpodoxime 1-(isopropoxycarbonyloxy)ethyl Ester

    72. Cefpodoxime 1-(isopropoxycarbonyloxy)ethyl Ester [mi]

    73. (+/-)-1-hydroxyethyl (+)-(6r,7r)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate, 7 (sup 2)-(z)-(o-methyloxime), Isopropyl Carbonate (ester)

    74. (6r,7r)-1-((isopropoxycarbonyl)oxy)ethyl 7-((z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

    75. (6r,7r)-7-(((2z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid 1-(((1-methylethoxy)carbonyl)oxy)ethyl Ester

    76. 1-({[(1-methylethyl)oxy]carbonyl}oxy)ethyl (6r,7r)-7-({(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-[(methyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

    77. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-, 1-(((1-methylethoxy)carbonyl)oxy)ethyl Ester, (6r-(6.alpha.,7.beta.(z)))-

    78. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-, 1-(((1-methylethoxy)carbonyl)oxy)ethyl Ester, (6r-(6alpha,7beta(z)))-

    79. 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, 7-[[(2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl Ester, (6r,7r)-

    2.4 Create Date
    2006-05-03
    3 Chemical and Physical Properties
    Molecular Weight 557.6 g/mol
    Molecular Formula C21H27N5O9S2
    XLogP30.6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count13
    Exact Mass557.12501980 g/mol
    Monoisotopic Mass557.12501980 g/mol
    Topological Polar Surface Area235 Ų
    Heavy Atom Count37
    Formal Charge0
    Complexity976
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameCefpodoxime proxetil
    PubMed HealthCefpodoxime Proxetil (By mouth)
    Drug ClassesAntibiotic
    Drug LabelCefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class. The chemical name is (RS)-1(isopropoxycarbonyloxy) ethyl (+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-{(Z)methoxyimino}acetamido]-3-m...
    Active IngredientCefpodoxime proxetil
    Dosage FormTablet; For suspension
    RouteOral
    Strengtheq 100mg base; eq 200mg base; eq 100mg base/5ml; eq 50mg base/5ml
    Market StatusPrescription
    CompanyRanbaxy; Aurobindo Pharma; Sandoz; Orchid Hlthcare

    2 of 2  
    Drug NameCefpodoxime proxetil
    PubMed HealthCefpodoxime Proxetil (By mouth)
    Drug ClassesAntibiotic
    Drug LabelCefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class. The chemical name is (RS)-1(isopropoxycarbonyloxy) ethyl (+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-{(Z)methoxyimino}acetamido]-3-m...
    Active IngredientCefpodoxime proxetil
    Dosage FormTablet; For suspension
    RouteOral
    Strengtheq 100mg base; eq 200mg base; eq 100mg base/5ml; eq 50mg base/5ml
    Market StatusPrescription
    CompanyRanbaxy; Aurobindo Pharma; Sandoz; Orchid Hlthcare

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]

    API Reference Price

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    02-Jan-2021
    22-Nov-2024
    KGS
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    ABOUT THIS PAGE

    CAS-87239-81-4 Manufacturers

    A CAS-87239-81-4 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CAS-87239-81-4, including repackagers and relabelers. The FDA regulates CAS-87239-81-4 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CAS-87239-81-4 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of CAS-87239-81-4 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    CAS-87239-81-4 Suppliers

    A CAS-87239-81-4 supplier is an individual or a company that provides CAS-87239-81-4 active pharmaceutical ingredient (API) or CAS-87239-81-4 finished formulations upon request. The CAS-87239-81-4 suppliers may include CAS-87239-81-4 API manufacturers, exporters, distributors and traders.

    click here to find a list of CAS-87239-81-4 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    CAS-87239-81-4 USDMF

    A CAS-87239-81-4 DMF (Drug Master File) is a document detailing the whole manufacturing process of CAS-87239-81-4 active pharmaceutical ingredient (API) in detail. Different forms of CAS-87239-81-4 DMFs exist exist since differing nations have different regulations, such as CAS-87239-81-4 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A CAS-87239-81-4 DMF submitted to regulatory agencies in the US is known as a USDMF. CAS-87239-81-4 USDMF includes data on CAS-87239-81-4's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The CAS-87239-81-4 USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of CAS-87239-81-4 suppliers with USDMF on PharmaCompass.

    CAS-87239-81-4 JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The CAS-87239-81-4 Drug Master File in Japan (CAS-87239-81-4 JDMF) empowers CAS-87239-81-4 API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the CAS-87239-81-4 JDMF during the approval evaluation for pharmaceutical products. At the time of CAS-87239-81-4 JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of CAS-87239-81-4 suppliers with JDMF on PharmaCompass.

    CAS-87239-81-4 KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a CAS-87239-81-4 Drug Master File in Korea (CAS-87239-81-4 KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of CAS-87239-81-4. The MFDS reviews the CAS-87239-81-4 KDMF as part of the drug registration process and uses the information provided in the CAS-87239-81-4 KDMF to evaluate the safety and efficacy of the drug.

    After submitting a CAS-87239-81-4 KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their CAS-87239-81-4 API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of CAS-87239-81-4 suppliers with KDMF on PharmaCompass.

    CAS-87239-81-4 CEP

    A CAS-87239-81-4 CEP of the European Pharmacopoeia monograph is often referred to as a CAS-87239-81-4 Certificate of Suitability (COS). The purpose of a CAS-87239-81-4 CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of CAS-87239-81-4 EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of CAS-87239-81-4 to their clients by showing that a CAS-87239-81-4 CEP has been issued for it. The manufacturer submits a CAS-87239-81-4 CEP (COS) as part of the market authorization procedure, and it takes on the role of a CAS-87239-81-4 CEP holder for the record. Additionally, the data presented in the CAS-87239-81-4 CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the CAS-87239-81-4 DMF.

    A CAS-87239-81-4 CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. CAS-87239-81-4 CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of CAS-87239-81-4 suppliers with CEP (COS) on PharmaCompass.

    CAS-87239-81-4 WC

    A CAS-87239-81-4 written confirmation (CAS-87239-81-4 WC) is an official document issued by a regulatory agency to a CAS-87239-81-4 manufacturer, verifying that the manufacturing facility of a CAS-87239-81-4 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting CAS-87239-81-4 APIs or CAS-87239-81-4 finished pharmaceutical products to another nation, regulatory agencies frequently require a CAS-87239-81-4 WC (written confirmation) as part of the regulatory process.

    click here to find a list of CAS-87239-81-4 suppliers with Written Confirmation (WC) on PharmaCompass.

    CAS-87239-81-4 NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing CAS-87239-81-4 as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for CAS-87239-81-4 API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture CAS-87239-81-4 as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain CAS-87239-81-4 and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a CAS-87239-81-4 NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of CAS-87239-81-4 suppliers with NDC on PharmaCompass.

    CAS-87239-81-4 GMP

    CAS-87239-81-4 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of CAS-87239-81-4 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CAS-87239-81-4 GMP manufacturer or CAS-87239-81-4 GMP API supplier for your needs.

    CAS-87239-81-4 CoA

    A CAS-87239-81-4 CoA (Certificate of Analysis) is a formal document that attests to CAS-87239-81-4's compliance with CAS-87239-81-4 specifications and serves as a tool for batch-level quality control.

    CAS-87239-81-4 CoA mostly includes findings from lab analyses of a specific batch. For each CAS-87239-81-4 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    CAS-87239-81-4 may be tested according to a variety of international standards, such as European Pharmacopoeia (CAS-87239-81-4 EP), CAS-87239-81-4 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CAS-87239-81-4 USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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