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Chemistry

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Also known as: Casanthranol, Casanthranol [usan:usp], Casakol, 3sj3u7j6v2, Hms3264c12, Pharmakon1600-01506179
Molecular Formula
C21H22O10
Molecular Weight
434.4  g/mol
InChI Key
CPUHNROBVJNNPW-VVBPCJSVSA-N

Cascara
Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
1 2D Structure

Cascara

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(10R)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-10H-anthracen-9-one
2.1.2 InChI
InChI=1S/C21H22O10/c22-6-8-4-10-15(12(25)5-8)17(27)14-9(2-1-3-11(14)24)20(10)31-21-19(29)18(28)16(26)13(7-23)30-21/h1-5,13,16,18-26,28-29H,6-7H2/t13-,16+,18-,19-,20-,21+/m1/s1
2.1.3 InChI Key
CPUHNROBVJNNPW-VVBPCJSVSA-N
2.1.4 Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2OC4C(C(C(C(O4)CO)O)O)O)C=C(C=C3O)CO
2.1.5 Isomeric SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C([C@@H]2O[C@H]4[C@@H]([C@@H]([C@H]([C@H](O4)CO)O)O)O)C=C(C=C3O)CO
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Archin

2. Casanthranol

3. Emodin

4. Emodin, Frangula

5. Emodin, Rheum

6. Frangula Emodin

7. Frangulic Acid

8. Peristim

9. Rheum Emodin

2.2.2 Depositor-Supplied Synonyms

1. Casanthranol

2. Casanthranol [usan:usp]

3. Casakol

4. 3sj3u7j6v2

5. Hms3264c12

6. Pharmakon1600-01506179

7. Nsc760410

8. Zinc66322924

9. Ccg-213629

10. Nsc 760410

11. Nsc-760410

12. Ab01563152_01

2.3 Create Date
2011-05-19
3 Chemical and Physical Properties
Molecular Weight 434.4 g/mol
Molecular Formula C21H22O10
XLogP3-0.4
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass434.12129689 g/mol
Monoisotopic Mass434.12129689 g/mol
Topological Polar Surface Area177 Ų
Heavy Atom Count31
Formal Charge0
Complexity646
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Cathartics

Agents that are used to stimulate evacuation of the bowels. (See all compounds classified as Cathartics.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


ABOUT THIS PAGE

Cascara Manufacturers

A Cascara manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cascara, including repackagers and relabelers. The FDA regulates Cascara manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cascara API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cascara manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cascara Suppliers

A Cascara supplier is an individual or a company that provides Cascara active pharmaceutical ingredient (API) or Cascara finished formulations upon request. The Cascara suppliers may include Cascara API manufacturers, exporters, distributors and traders.

click here to find a list of Cascara suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cascara USDMF

A Cascara DMF (Drug Master File) is a document detailing the whole manufacturing process of Cascara active pharmaceutical ingredient (API) in detail. Different forms of Cascara DMFs exist exist since differing nations have different regulations, such as Cascara USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Cascara DMF submitted to regulatory agencies in the US is known as a USDMF. Cascara USDMF includes data on Cascara's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cascara USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Cascara suppliers with USDMF on PharmaCompass.

Cascara GMP

Cascara Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cascara GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cascara GMP manufacturer or Cascara GMP API supplier for your needs.

Cascara CoA

A Cascara CoA (Certificate of Analysis) is a formal document that attests to Cascara's compliance with Cascara specifications and serves as a tool for batch-level quality control.

Cascara CoA mostly includes findings from lab analyses of a specific batch. For each Cascara CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cascara may be tested according to a variety of international standards, such as European Pharmacopoeia (Cascara EP), Cascara JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cascara USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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