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Chemistry

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Also known as: (+)-norpseudoephedrine, Pseudonorephedrine, Katine, D-cathine, Norpseudoephedrine, Cathinum
Molecular Formula
C9H13NO
Molecular Weight
151.21  g/mol
InChI Key
DLNKOYKMWOXYQA-IONNQARKSA-N
FDA UNII
E1L4ZW2F8O

Cathine
cathine is a natural product found in Catha edulis and Ephedra sinica with data available.
1 2D Structure

Cathine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,2S)-2-amino-1-phenylpropan-1-ol
2.1.2 InChI
InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9+/m0/s1
2.1.3 InChI Key
DLNKOYKMWOXYQA-IONNQARKSA-N
2.1.4 Canonical SMILES
CC(C(C1=CC=CC=C1)O)N
2.1.5 Isomeric SMILES
C[C@@H]([C@H](C1=CC=CC=C1)O)N
2.2 Other Identifiers
2.2.1 UNII
E1L4ZW2F8O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (+)-norpseudoephedrine

2. Benzenemethanol, Alpha-((1r)-1-aminoethyl)-, (alphar)-rel-

3. Cathine Hydrochloride

4. Exponcit

5. Fasupond

6. Fugoa Depot

7. Norpseudoephedrine

8. Norpseudoephedrine Hydrobromide

9. Norpseudoephedrine Hydrochloride

10. Norpseudoephedrine Hydrochloride, (+)-isomer

11. Norpseudoephedrine Hydrochloride, (r*,s*)-(+-)-isomer

12. Norpseudoephedrine Hydrochloride, (r*,s*)-isomer

13. Norpseudoephedrine Hydrochloride, (r-(r*,r*))-isomer

14. Norpseudoephedrine Hydrochloride, (s-(r*,s*))-isomer

15. Norpseudoephedrine Sulfate (2:1), (+)-isomer

16. Norpseudoephedrine Sulfate (2:1), (r-(r*,r*))-isomer

17. Norpseudoephedrine Sulfate, (r-(r*,s*))-isomer

18. Norpseudoephedrine Sulfate, (s-(r*,r*))-isomer

19. Norpseudoephedrine Tartrate, (s-(r*,r*))-(r-(r*,r*))-isomer

20. Norpseudoephedrine, (-)-isomer

21. Norpseudoephedrine, (r*,r*)-(+-)-isomer

22. Norpseudoephedrine, (r*,s*)-isomer

23. Norpseudoephedrine, (r-(r*,s*))-isomer

24. Norpseudoephedrine, (s-(r*,r*))-isomer

25. Norpseudoephedrine, (s-(r*,s*))-isomer

26. Norpseudoephedrine, Conjugate Monoacid, (r-(r*,s*))-isomer

27. Pseudonorephedrine

2.3.2 Depositor-Supplied Synonyms

1. (+)-norpseudoephedrine

2. Pseudonorephedrine

3. Katine

4. D-cathine

5. Norpseudoephedrine

6. Cathinum

7. Exponcit

8. Psi-norephedrine

9. D-norpseudoephedrine

10. D-nor-psi-ephedrine

11. 492-39-7

12. Minusine

13. (1s,2s)-2-amino-1-phenylpropan-1-ol

14. 36393-56-3

15. Cathine [inn]

16. D-(+)-norephedrine

17. Racemic Norpseudoephedrine

18. D-phenylpropanolamine

19. Threo-1-phenyl-1-hydroxy-2-aminopropane

20. Threo-2-amino-1-hydroxy-1-phenylpropane

21. Norpseudoephedrine, D-

22. (+)-norephedrin

23. D-(+)-norpseudoephedrine

24. 27a0hlc3hh

25. E1l4zw2f8o

26. (1s,2s)-pseudonorephedrine

27. Chebi:4109

28. Cathine (inn)

29. L-nor-psi-ephedrine

30. Benzenemethanol, .alpha.-[(1s)-1-aminoethyl]-, (.alpha.s)-

31. (1s,2s)-2-amino-1-phenyl-propan-1-ol

32. L-nor-psi-ephedrin [german]

33. Benzenemethanol, Alpha-((1s)-1-aminoethyl)-, (alphas)-

34. Cathina

35. L-nor-psi-ephedrin

36. (1s,2s)-(+)-norpseudoephedrine

37. Norpseudoephedrine, (+)-

38. Cathinum [inn-latin]

39. Cathina [inn-spanish]

40. Unii-27a0hlc3hh

41. Unii-e1l4zw2f8o

42. Benzenemethanol, .alpha.-(1-aminoethyl)-, [s-(r*,r*)]-

43. Cathin

44. Benzenemethanol, .alpha.-(1-aminoethyl)-, (s-(r*,r*))-

45. Benzenemethanol, .alpha.-((1s)-1-aminoethyl)-, (.alpha.s)-

46. (r*,r*)-alpha-(1-aminoethyl)benzyl Alcohol

47. Nor-psi-ephedrine

48. D-norpseudoephedrin

49. Einecs 207-754-1

50. Einecs 253-014-6

51. Catina

52. Dl-nor-psi-ephedrine

53. Brn 2802895

54. (+)-pseudonorephedrine

55. (1s,2s)-2-amino-1-phenyl-1-propanol

56. Cathine [mart.]

57. Constituent Of Khat Plant

58. Ncgc00016416-01

59. Cathine [who-dd]

60. Cas-154-41-6

61. .omega.-norephedrine

62. Norpseudoephedrine, (+-)-

63. Schembl34132

64. 4-13-00-01874 (beilstein Handbook Reference)

65. Norpseudoephedrine [mi]

66. Zinc1100

67. 492-39-7 (free Base)

68. Dea No. 1230

69. Phenylpropanolamine D-threo-form

70. Benzenemethanol, .alpha.-((1r)-1-aminoethyl)-, (.alpha.r)-rel-

71. Cathine, (+/-)-

72. Chembl1412041

73. Niosh/rc9110000

74. Dtxsid20889399

75. Dtxsid50889347

76. (+/-)-norpseudoephedrine

77. Benzenemethanol, Alpha-((1r)-1-aminoethyl)-, (alphar)-rel-

78. Bdbm50405615

79. Mfcd01711268

80. Pdsp1_001353

81. Pdsp2_001337

82. Akos015891205

83. Db01486

84. As-30504

85. 2-amino-1-phenyl-1-propanol, (+)- #

86. Threo-2-amino-1-phenylpropan-1-ol

87. Phenylpropanolamine D-threo-form [mi]

88. Rc91100000

89. C08300

90. D07627

91. A823766

92. Q423797

93. Benzenemethanol, Alpha-(1-aminoethyl)-, (r*,r*)-

94. J-500428

95. (1s,2s)-(+)-norpseudoephedrine, >=98.0% (nt)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 151.21 g/mol
Molecular Formula C9H13NO
XLogP30.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass151.099714038 g/mol
Monoisotopic Mass151.099714038 g/mol
Topological Polar Surface Area46.2 Ų
Heavy Atom Count11
Formal Charge0
Complexity110
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used to decrease appetite.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Closely related to ephedrine, cathinone and other amphetamines, it may contribute to the stimulant effect of Catha edulis, although another constituent, cathinone appears to show stronger activity.


5.2 MeSH Pharmacological Classification

Appetite Depressants

Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)


5.3 ATC Code

A - Alimentary tract and metabolism

A08 - Antiobesity preparations, excl. diet products

A08A - Antiobesity preparations, excl. diet products

A08AA - Centrally acting antiobesity products

A08AA07 - Cathine


5.4 Absorption, Distribution and Excretion

Absorption

The mucosa of the oral cavity is considered to be the first absorption segment, where the major proportion of the alkaloids is absorbed (mean +/- SD: 84 +/- 6% for cathine). [PMID: 12848785]


5.5 Biological Half-Life

5.2 +/- 3.4 hours


API Reference Price

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02-Aug-2021
28-Aug-2023
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ABOUT THIS PAGE

Cathine Manufacturers

A Cathine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cathine, including repackagers and relabelers. The FDA regulates Cathine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cathine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cathine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cathine Suppliers

A Cathine supplier is an individual or a company that provides Cathine active pharmaceutical ingredient (API) or Cathine finished formulations upon request. The Cathine suppliers may include Cathine API manufacturers, exporters, distributors and traders.

click here to find a list of Cathine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cathine GMP

Cathine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cathine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cathine GMP manufacturer or Cathine GMP API supplier for your needs.

Cathine CoA

A Cathine CoA (Certificate of Analysis) is a formal document that attests to Cathine's compliance with Cathine specifications and serves as a tool for batch-level quality control.

Cathine CoA mostly includes findings from lab analyses of a specific batch. For each Cathine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cathine may be tested according to a variety of international standards, such as European Pharmacopoeia (Cathine EP), Cathine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cathine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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