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Chemistry

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Also known as: 863513-91-1, Grt6005, Grt-6005, Grt 6005, 863513-93-3, 7gdw9s3gn3
Molecular Formula
C24H27FN2O
Molecular Weight
378.5  g/mol
InChI Key
CSMVOZKEWSOFER-UHFFFAOYSA-N
FDA UNII
7GDW9S3GN3

Cebranopadol
Cebranopadol is an orally available benzenoid that acts as an opioid peptide receptor agonist for the nociceptin/orphanin FQ peptide receptor (opioid receptor like -1; OPRL1; ORL-1; NOP; kappa-type 3 opioid receptor) and the classical opioid receptors, mu, delta and kappa, with potential anti-nociceptive activity. Upon oral administration, cebranopadol binds to NOP and the mu, delta and kappa opioid receptors, which enhances NOP- and opioid receptor-mediated signaling, interferes with the sensation of pain and results in an analgesic effect. NOP, a member of the opioid receptor family, and its endogenous ligand nociceptin play key roles in the regulation of various brain activities including pain, and some inflammatory and immune responses.
1 2D Structure

Cebranopadol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-fluoro-N,N-dimethyl-1'-phenylspiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine
2.1.2 InChI
InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3
2.1.3 InChI Key
CSMVOZKEWSOFER-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)C1(CCC2(CC1)C3=C(CCO2)C4=C(N3)C=CC(=C4)F)C5=CC=CC=C5
2.2 Other Identifiers
2.2.1 UNII
7GDW9S3GN3
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6'-fluoro-4',9'-dihydro-n,n-dimethyl-4-phenylspiro(cyclohexane-1,1'(3'h)-pyrano(3,4-b)indol)-4-amine

2.3.2 Depositor-Supplied Synonyms

1. 863513-91-1

2. Grt6005

3. Grt-6005

4. Grt 6005

5. 863513-93-3

6. 7gdw9s3gn3

7. Cebranopadol ((1alpha,4alpha)stereoisomer)

8. 863513-91-1 (free Base)

9. (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine

10. 6-fluoro-n,n-dimethyl-1'-phenylspiro[4,9-dihydro-3h-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine

11. Spiro(cyclohexane-1,1'(3'h)-pyrano(3,4-b)indol)-4-amine, 6'-fluoro-4',9'-dihydro-n,n-dimethyl-4-phenyl-, Trans-

12. Trans-6'-fluoro-n,n-dimethyl-4-phenyl-4',9''-dihydro-3'h-spiro(cyclohexane-1,1'-pyrano(3,4-b)indol)-4-amine

13. 6-fluoro-n,n-dimethyl-1'-phenyl-spiro[4,9-dihydro-3h-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine

14. Cebranopadol [inn]

15. Cebranopadol [usan:inn]

16. Unii-7gdw9s3gn3

17. Cebranopadol (usan/inn)

18. Cebranopadol [usan]

19. Cebranopadol(grt-6005)

20. Schembl154336

21. Schembl566256

22. Gtpl8866

23. Chembl2364605

24. Chembl3545616

25. Chembl3962932

26. Schembl10035739

27. Schembl14183935

28. Schembl19336241

29. Bdbm177926

30. Dtxsid001031965

31. Bcp09612

32. Ex-a1095

33. Zinc3950145

34. Bdbm50101095

35. Bdbm50101112

36. Bdbm50533342

37. Akos025290738

38. Cs-1323

39. Db12830

40. Sb16531

41. Ncgc00378895-01

42. Ncgc00378895-02

43. Ac-36077

44. As-35183

45. Hy-15536

46. Ft-0774945

47. D10436

48. Us9120797, 24

49. Us9120797, 25

50. Q19596315

51. (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine

2.4 Create Date
2006-11-06
3 Chemical and Physical Properties
Molecular Weight 378.5 g/mol
Molecular Formula C24H27FN2O
XLogP34.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass378.21074165 g/mol
Monoisotopic Mass378.21074165 g/mol
Topological Polar Surface Area28.3 Ų
Heavy Atom Count28
Formal Charge0
Complexity553
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of chronic pain


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Looking for 863513-91-1 / Cebranopadol API manufacturers, exporters & distributors?

Cebranopadol manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cebranopadol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cebranopadol manufacturer or Cebranopadol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cebranopadol manufacturer or Cebranopadol supplier.

PharmaCompass also assists you with knowing the Cebranopadol API Price utilized in the formulation of products. Cebranopadol API Price is not always fixed or binding as the Cebranopadol Price is obtained through a variety of data sources. The Cebranopadol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cebranopadol

Synonyms

863513-91-1, Grt6005, Grt-6005, Grt 6005, 863513-93-3, 7gdw9s3gn3

Cas Number

863513-91-1

Unique Ingredient Identifier (UNII)

7GDW9S3GN3

About Cebranopadol

Cebranopadol is an orally available benzenoid that acts as an opioid peptide receptor agonist for the nociceptin/orphanin FQ peptide receptor (opioid receptor like -1; OPRL1; ORL-1; NOP; kappa-type 3 opioid receptor) and the classical opioid receptors, mu, delta and kappa, with potential anti-nociceptive activity. Upon oral administration, cebranopadol binds to NOP and the mu, delta and kappa opioid receptors, which enhances NOP- and opioid receptor-mediated signaling, interferes with the sensation of pain and results in an analgesic effect. NOP, a member of the opioid receptor family, and its endogenous ligand nociceptin play key roles in the regulation of various brain activities including pain, and some inflammatory and immune responses.

Cebranopadol Manufacturers

A Cebranopadol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cebranopadol, including repackagers and relabelers. The FDA regulates Cebranopadol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cebranopadol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cebranopadol Suppliers

A Cebranopadol supplier is an individual or a company that provides Cebranopadol active pharmaceutical ingredient (API) or Cebranopadol finished formulations upon request. The Cebranopadol suppliers may include Cebranopadol API manufacturers, exporters, distributors and traders.

Cebranopadol GMP

Cebranopadol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cebranopadol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cebranopadol GMP manufacturer or Cebranopadol GMP API supplier for your needs.

Cebranopadol CoA

A Cebranopadol CoA (Certificate of Analysis) is a formal document that attests to Cebranopadol's compliance with Cebranopadol specifications and serves as a tool for batch-level quality control.

Cebranopadol CoA mostly includes findings from lab analyses of a specific batch. For each Cebranopadol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cebranopadol may be tested according to a variety of international standards, such as European Pharmacopoeia (Cebranopadol EP), Cebranopadol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cebranopadol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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