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1. Cephamandole
2. Compound 83405
1. Cefadole
2. 34444-01-4
3. Cephamandole
4. Cefamandol
5. Cephadole
6. Cefamandolum
7. L-cefamandole
8. Compound 83405
9. Chebi:3480
10. (6r,7r)-7-(r)-mandelamido-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic Acid
11. 5ckp8c2lli
12. (6r,7r)-7-{[(2r)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1h-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
13. Compound-83405
14. (6r,7r)-7-[[(2r)-2-hydroxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
15. J01dc03
16. Kefdole
17. 7-d-mandelamido-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-3-cephem-4-carboxylic Acid
18. Kefamandol
19. Mancef
20. (6r,7r)-7-((r)-2-hydroxy-2-phenylacetamido)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
21. 7-[(2-hydroxy-2-phenylacetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
22. 30034-03-8
23. Unii-5ckp8c2lli
24. Cefamandol [inn-spanish]
25. Cefamandole (usan/inn)
26. Cefamandolum [inn-latin]
27. Free Form
28. Cefamandole [usan:inn:ban]
29. Einecs 252-030-0
30. Brn 0598510
31. Cefamandole [mi]
32. Prestwick0_000747
33. Prestwick1_000747
34. Prestwick2_000747
35. Prestwick3_000747
36. Cefamandole [inn]
37. Cefamandole [usan]
38. Epitope Id:141490
39. Cefamandole [vandf]
40. Cefamandole [mart.]
41. Chembl1146
42. Schembl37287
43. Bspbio_000734
44. Cefamandole [who-dd]
45. Spbio_002673
46. Bpbio1_000808
47. Dtxsid7022750
48. Gtpl12210
49. Hy-b1128
50. Zinc3830394
51. Bdbm50350468
52. Akos025401365
53. Ac-1294
54. Cs-4724
55. Db01326
56. (6r,7r)-7-[[(2r)-2-hydroxy-2-phenyl-acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
57. (6r,7r)-7-{[(2r)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1h-tetrazol-5-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
58. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, (6r-(6alpha,7beta(r*)))-
59. 7beta-[(2r)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1h-tetrazol-5-yl)sulfanyl]methyl}ceph-3-em-4-carboxylic Acid
60. C06879
61. D02344
62. 444c014
63. Cefamandole, Antibiotic For Culture Media Use Only
64. Q2601530
65. W-106736
66. Brd-k27130738-236-03-4
67. (6r,7r)-7-((r)-2-hydroxy-2-phenylacetamido)-3-((1-methyl-1h-tetrazol-5-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
68. (6r,7r)-7-[(2r)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1h-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
69. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, (6r-(6.alpha.,7.beta.(r*)))-
70. 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, 7-[[(2r)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1h-tetrazol-5-yl)thio]methyl]-8-oxo-, (6r,7r)-
71. 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, 7-[[(2r)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1h-tetrazol-5-yl)thio]methyl]-8-oxo-, 6r,7r)-
| Molecular Weight | 462.5 g/mol |
|---|---|
| Molecular Formula | C18H18N6O5S2 |
| XLogP3 | -0.9 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 7 |
| Exact Mass | 462.07801004 g/mol |
| Monoisotopic Mass | 462.07801004 g/mol |
| Topological Polar Surface Area | 201 Ų |
| Heavy Atom Count | 31 |
| Formal Charge | 0 |
| Complexity | 777 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 3 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the treatment of serious infections caused by susceptible strains of microorganisms.
The parenteral prodrug formate ester cefamandole nafate is a broad-spectrum cephalosporin antibiotic. The bactericidal action of cefamandole results from inhibition of cell-wall synthesis. Cephalosporins have in vitro activity against a wide range of gram-positive and gram-negative organisms.
Anti-Bacterial Agents
Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)
J - Antiinfectives for systemic use
J01 - Antibacterials for systemic use
J01D - Other beta-lactam antibacterials
J01DC - Second-generation cephalosporins
J01DC03 - Cefamandole
The half-life after an intravenous dose is 32 minutes; after intramuscular administration, the half-life is 60 minutes.
Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.
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ABOUT THIS PAGE
A Cefamandole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefamandole, including repackagers and relabelers. The FDA regulates Cefamandole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefamandole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Cefamandole supplier is an individual or a company that provides Cefamandole active pharmaceutical ingredient (API) or Cefamandole finished formulations upon request. The Cefamandole suppliers may include Cefamandole API manufacturers, exporters, distributors and traders.
Cefamandole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Cefamandole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefamandole GMP manufacturer or Cefamandole GMP API supplier for your needs.
A Cefamandole CoA (Certificate of Analysis) is a formal document that attests to Cefamandole's compliance with Cefamandole specifications and serves as a tool for batch-level quality control.
Cefamandole CoA mostly includes findings from lab analyses of a specific batch. For each Cefamandole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Cefamandole may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefamandole EP), Cefamandole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefamandole USP).
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