Find Cefamandole Nafate manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

NDC API

NDC API

0

VMF

NDC API

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

JP

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 42540-40-9, Cephamandole nafate, Cefamandol nafato, Kefadol, Mandokef, O-formylcefamandole sodium
Molecular Formula
C19H17N6NaO6S2
Molecular Weight
512.5  g/mol
InChI Key
ICZOIXFFVKYXOM-YCLOEFEOSA-M
FDA UNII
8HDO7941DO

Cefamandole Nafate
Cefamandole Nafate is the sodium salt form of cefamandole formyl ester. Cefamandole nafate is a pro-drug that is hydrolyzed by plasma esterases to produce cefamandole, a semi-synthetic beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
1 2D Structure

Cefamandole Nafate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;(6R,7R)-7-[[(2R)-2-formyloxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C19H18N6O6S2.Na/c1-24-19(21-22-23-24)33-8-11-7-32-17-12(16(28)25(17)13(11)18(29)30)20-15(27)14(31-9-26)10-5-3-2-4-6-10;/h2-6,9,12,14,17H,7-8H2,1H3,(H,20,27)(H,29,30);/q;+1/p-1/t12-,14-,17-;/m1./s1
2.1.3 InChI Key
ICZOIXFFVKYXOM-YCLOEFEOSA-M
2.1.4 Canonical SMILES
CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)C(C4=CC=CC=C4)OC=O)SC2)C(=O)[O-].[Na+]
2.1.5 Isomeric SMILES
CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)[C@@H](C4=CC=CC=C4)OC=O)SC2)C(=O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
8HDO7941DO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cefamandole Nafate, Monosodium Salt, (6r-(6alpha,7beta(r*)))-isomer

2. Cefamandole Nafate, Monosodium Salt, 14c-labeled, (6r-(6alpha,7beta,(r*)))-isomer

3. Mandol

2.3.2 Depositor-Supplied Synonyms

1. 42540-40-9

2. Cephamandole Nafate

3. Cefamandol Nafato

4. Kefadol

5. Mandokef

6. O-formylcefamandole Sodium

7. Sodium O-formylcefamandole

8. Cemandil Sodium Salt

9. Cefam

10. Cefamandole Nafate Sodium

11. 8hdo7941do

12. Chebi:3481

13. Cefamandole Formate Sodium Salt

14. Cefaseptolo

15. Lampomandol

16. Bergacef

17. Mandolsan

18. Neocefal

19. Pavecef

20. Cedol

21. Cefamandole Nafate [usan]

22. Ncgc00183035-01

23. Lilly 106223

24. Cefamandol Nafato [spanish]

25. Unii-8hdo7941do

26. Kefandol

27. Cemandil Sodium

28. Einecs 255-877-4

29. Mandol (tn)

30. Mfcd00864877

31. Nsc 299588

32. Cefamandole Nafate [usan:usp:inn:ban]

33. Cefamandole Formate Sodium

34. Cefamandole Nafate, 97%

35. Cefamandole Nafate (usp)

36. Dsstox_cid_2751

37. Chembl1618

38. Dsstox_rid_76715

39. Dsstox_gsid_22751

40. Schembl181311

41. Cefamandole Nafate [mi]

42. Dtxsid2022751

43. Cefamandole Nafate [vandf]

44. Cefamandole Nafate [mart.]

45. Cefamandole Nafate [usp-rs]

46. Cefamandole Nafate [who-dd]

47. Hy-b1166

48. Tox21_113487

49. Akos015895550

50. Akos015961133

51. Ac-1642

52. Ccg-269787

53. Cs-4768

54. Gs-3575

55. Cefamandole Nafate [orange Book]

56. Cefamandole Nafate [ep Monograph]

57. Cefamandole Nafate [usp Impurity]

58. As-12360

59. Cas-42540-40-9

60. C-2464

61. C08102

62. D00909

63. Q27106102

64. Cefamandole Nafate, Antibiotic For Culture Media Use Only

65. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((formyloxy)phenylacetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, Monosodium Salt, (6r-(6.alpha.,7.beta.(r*)))

66. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((formyloxy)phenylacetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, Monosodium Salt, (6r-(6alpha,7beta(r*)))-

67. Sodium (6r,7r)-7-((r)-2-(formyloxy)-2-phenylacetamido)-3-((1-methyl-1h-tetrazol-5-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

68. Sodium (6r,7r)-7-[(2r)-2-(formyloxy)-2-phenylacetamido]-3-{[(1-methyl-1h-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

69. Sodium (6r,7r)-7-[[(2r)-2-formyloxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

70. Sodium (6r,7r)-7-{[(2r)-2-(formyloxy)-2-phenylacetyl]amino}-3-{[(1-methyl-1h-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

71. Sodium (6r,7r)-7-{[(2r)-2-(formyloxy)-2-phenylacetyl]amino}-3-{[(1-methyl-1h-tetrazol-5-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

72. Sodium (6r-(6alpha,7beta(r*)))-7-(((formyloxy)phenylacetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

73. Sodium 7beta-[(2r)-2-(formyloxy)-2-phenylacetamido]-3-{[(1-methyl-1h-tetrazol-5-yl)sulfanyl]methyl}ceph-3-em-4-carboxylate

74. Sodium(6r,7r)-7-(r)-mandelamido-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate Formate(ester)

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 512.5 g/mol
Molecular Formula C19H17N6NaO6S2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Exact Mass512.05486891 g/mol
Monoisotopic Mass512.05486891 g/mol
Topological Polar Surface Area210 Ų
Heavy Atom Count34
Formal Charge0
Complexity844
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


USDMF

read-more
read-more

01

Acs Dobfar Spa

Italy

USDMF

arrow
CPHI Middle east
Not Confirmed

02

Eli Lilly And Co

U.S.A

USDMF

arrow
CPHI Middle east
Not Confirmed

03

Eli Lilly And Co

U.S.A

USDMF

arrow
CPHI Middle east
Not Confirmed
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

KDMF

read-more
read-more

01

CPHI Middle east
Not Confirmed
arrow
arrow
CPHI Middle east
Not Confirmed

Sephamandolnaphate

Registrant Name : SPC Co., Ltd.

Registration Date : 2022-03-14

Registration Number : 20220314-210-J-1248

Manufacturer Name : SPC Co., Ltd.

Manufacturer Address : 386 Pyeongtaekhangman-gil, Poseung-eup, Pyeongtaek-si, Gyeonggi-do

blank

02

CPHI Middle east
Not Confirmed
arrow
arrow
CPHI Middle east
Not Confirmed

Sephamandolnaphate

Registrant Name : Insung Trading Co., Ltd.

Registration Date : 2021-07-27

Registration Number : 20210727-210-J-925

Manufacturer Name : Zhejiang Yongning Pharmaceut...

Manufacturer Address : No. 9 Sanjiang Road, Light Industry & Chemical Industry Zone of Huangyan Economic Dev...

blank
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

read-more
read-more

01

CPHI Middle east
Not Confirmed
arrow
arrow
CPHI Middle east
Not Confirmed

Cefamandole Nafate

About the Company : Established on Feb.14th 2003 , China Union is the best and biggest company which is specialized in manufacture and sale of Cephalosporin antibiotics API and upriver intermediates i...

Established on Feb.14th 2003 , China Union is the best and biggest company which is specialized in manufacture and sale of Cephalosporin antibiotics API and upriver intermediates in China. Such as Cefaclor, Cefprozil, Cefalothin Sodium, Cefamandole Nafate, Cefmenoxime Hydrochloride, Cefpirome Sulfate, Cefoxitin Sodium, Ceftriaxone Sodium,etc. As Cefaclor,we made 60% market share in China, got DMF Certificate and we successfully registered in India and South Korea.All products have passed the new National GMP Certificate(2015revised version).
blank

02

CPHI Middle east
Not Confirmed
arrow
arrow
CPHI Middle east
Not Confirmed

Cefamandole Nafate

About the Company : We can help your company solve the payment problems during the trading from chinese factories. We supply you with OEM from china.We are professsionals with the competitive price an...

We can help your company solve the payment problems during the trading from chinese factories. We supply you with OEM from china.We are professsionals with the competitive price and high quality.We help you with professional regulation affair.We help you on documentation and systematizing quality control with factories. We assist you in purchasing and negotiating with various suppliers from China.We are your reliable tool and Platform around chemical ,pharmaceutical and pharm-bottle . We believe in trust and quality-reputation.
blank

03

CPHI Middle east
Not Confirmed
arrow
arrow
CPHI Middle east
Not Confirmed

Cefamandole Nafate

About the Company : Located in Jinan, Qilu Pharmaceutical is one of the leading pharmaceutical companies in China. It focuses on developing, manufacturing and marketing of generic drugs and active pha...

Located in Jinan, Qilu Pharmaceutical is one of the leading pharmaceutical companies in China. It focuses on developing, manufacturing and marketing of generic drugs and active pharmaceutical ingredients in the therapeutic areas of Oncology, Cerebrovascular & Cardiovascular, Infections, Psychological and Neurological System, Respiratory System, Ophthalmological Diseases, etc. Always committing itself to meet the needs of the patients and the society. Qilu pharmaceutical provides high-quality products by adopting advanced technology. Qilu has 8000 employees , 5,000 of them have junior college or above educational backgrounp.
blank
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Market Place

Do you need sourcing support? Ask us

REF. STANDARDS & IMPURITIES

Upload your portfolio for free, ask us

ABOUT THIS PAGE

Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty