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Chemistry

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Also known as: 30034-03-8, Cefamandole sodium salt, Sodium cefamandole, Cefamandole (sodium), Cefamandole sodium [jan], Iy6234odvr
Molecular Formula
C18H17N6NaO5S2
Molecular Weight
484.5  g/mol
InChI Key
OJMNTWPPFNMOCJ-CFOLLTDRSA-M
FDA UNII
IY6234ODVR

Cefamandole Sodium Salt
Cefamandole Sodium is the sodium salt form of cefamandole, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
1 2D Structure

Cefamandole Sodium Salt

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C18H18N6O5S2.Na/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9;/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29);/q;+1/p-1/t11-,13-,16-;/m1./s1
2.1.3 InChI Key
OJMNTWPPFNMOCJ-CFOLLTDRSA-M
2.1.4 Canonical SMILES
CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)C(C4=CC=CC=C4)O)SC2)C(=O)[O-].[Na+]
2.1.5 Isomeric SMILES
CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)[C@@H](C4=CC=CC=C4)O)SC2)C(=O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
IY6234ODVR
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 30034-03-8

2. Cefamandole Sodium Salt

3. Sodium Cefamandole

4. Cefamandole (sodium)

5. Cefamandole Sodium [jan]

6. Iy6234odvr

7. Mls000069575

8. Chebi:34614

9. Kefdole

10. Nsc-758169

11. Monosodium (6r,7r)-7-(r)-mandelamido-3-(((1-methyl-1-h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

12. Smr000058843

13. Cefamandole Sodium (jan)

14. Cephamandole Sodium

15. Unii-iy6234odvr

16. Cefamandole Sodium [usp:jan]

17. Prestwick_23

18. Ncgc00017101-01

19. Einecs 250-009-0

20. Kefdole (tn)

21. Cas-30034-03-8

22. Opera_id_59

23. Cephamandole Sodium Salt

24. Sodium;(6r,7r)-7-[[(2r)-2-hydroxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

25. Cefamandolesodiumsalt

26. Dsstox_cid_25579

27. Dsstox_rid_80975

28. Dsstox_gsid_45579

29. Chembl1360024

30. Dtxsid2045579

31. Hy-b1128a

32. Hms1570e16

33. Hms2097e16

34. Hms2235i03

35. Cefamandole Sodium [mart.]

36. Cefamandole Sodium [who-dd]

37. Tox21_110777

38. Akos015967200

39. Akos024288585

40. Cs-5991

41. Nsc 758169

42. Sodium (6r-(6alpha,7beta(r*)))-7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

43. C-2463

44. D02191

45. Q27116182

46. Cefamandole Sodium Salt, Antibiotic For Culture Media Use Only

47. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, (6r-(6a,7b(r*)))-, Monosodium Salt

48. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, (6r-(6alpha,7beta(r*)))-, Monosodium Salt

49. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-mandelamido-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, Monosodium Salt, D-

50. 7beta-(d-mandel-amido)-3-(1-methyl-1h-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic Acid Sodium Salt

51. 7beta-(d-mandelamido)-3-(1-methyl-1h-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic Acid Sodium Salt

52. Sodium (6r,7r)-7-{[(2r)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1h-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

53. Sodium 7beta-[(2r)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1h-tetrazol-5-yl)sulfanyl]methyl}ceph-3-em-4-carboxylate

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 484.5 g/mol
Molecular Formula C18H17N6NaO5S2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass484.05995429 g/mol
Monoisotopic Mass484.05995429 g/mol
Topological Polar Surface Area204 Ų
Heavy Atom Count32
Formal Charge0
Complexity783
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

ABOUT THIS PAGE

Looking for 30034-03-8 / Cefamandole Sodium Salt API manufacturers, exporters & distributors?

Cefamandole Sodium Salt manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cefamandole Sodium Salt API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cefamandole Sodium Salt manufacturer or Cefamandole Sodium Salt supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cefamandole Sodium Salt manufacturer or Cefamandole Sodium Salt supplier.

PharmaCompass also assists you with knowing the Cefamandole Sodium Salt API Price utilized in the formulation of products. Cefamandole Sodium Salt API Price is not always fixed or binding as the Cefamandole Sodium Salt Price is obtained through a variety of data sources. The Cefamandole Sodium Salt Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cefamandole Sodium Salt

Synonyms

30034-03-8, Sodium cefamandole, Cefamandole (sodium), Cefamandole sodium [jan], Iy6234odvr, Mls000069575

Cas Number

30034-03-8

Unique Ingredient Identifier (UNII)

IY6234ODVR

About Cefamandole Sodium Salt

Cefamandole Sodium is the sodium salt form of cefamandole, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Cefamandole Sodium Salt Manufacturers

A Cefamandole Sodium Salt manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefamandole Sodium Salt, including repackagers and relabelers. The FDA regulates Cefamandole Sodium Salt manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefamandole Sodium Salt API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cefamandole Sodium Salt Suppliers

A Cefamandole Sodium Salt supplier is an individual or a company that provides Cefamandole Sodium Salt active pharmaceutical ingredient (API) or Cefamandole Sodium Salt finished formulations upon request. The Cefamandole Sodium Salt suppliers may include Cefamandole Sodium Salt API manufacturers, exporters, distributors and traders.

click here to find a list of Cefamandole Sodium Salt suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cefamandole Sodium Salt USDMF

A Cefamandole Sodium Salt DMF (Drug Master File) is a document detailing the whole manufacturing process of Cefamandole Sodium Salt active pharmaceutical ingredient (API) in detail. Different forms of Cefamandole Sodium Salt DMFs exist exist since differing nations have different regulations, such as Cefamandole Sodium Salt USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Cefamandole Sodium Salt DMF submitted to regulatory agencies in the US is known as a USDMF. Cefamandole Sodium Salt USDMF includes data on Cefamandole Sodium Salt's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cefamandole Sodium Salt USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Cefamandole Sodium Salt suppliers with USDMF on PharmaCompass.

Cefamandole Sodium Salt GMP

Cefamandole Sodium Salt Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cefamandole Sodium Salt GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefamandole Sodium Salt GMP manufacturer or Cefamandole Sodium Salt GMP API supplier for your needs.

Cefamandole Sodium Salt CoA

A Cefamandole Sodium Salt CoA (Certificate of Analysis) is a formal document that attests to Cefamandole Sodium Salt's compliance with Cefamandole Sodium Salt specifications and serves as a tool for batch-level quality control.

Cefamandole Sodium Salt CoA mostly includes findings from lab analyses of a specific batch. For each Cefamandole Sodium Salt CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cefamandole Sodium Salt may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefamandole Sodium Salt EP), Cefamandole Sodium Salt JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefamandole Sodium Salt USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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