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ACTIVE PHARMA INGREDIENTS

35 API Suppliers, 16 USDMF, 9 CEP/COS, 9 JDMF, 2 EU WC, 7 KDMF, 4 NDC API, 14 Listed Suppliers, $ API Reference Price

35 API Suppliers
16 USDMF
9 CEP/COS
9 JDMF
2 EU WC
7 KDMF
4 NDC API
14 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

122 FDF Dossiers, 92 FDA Orange Book, 4 Europe, 16 Canada, 10 Listed Dossiers

122 FDF Dossiers
92 FDA Orange Book
4 Europe
16 Canada
10 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;INTRAVENOUS - EQ 1GM BASE/50ML (EQ 20MG BASE/ML), SOLUTION;INTRAVENOUS - EQ 2GM BASE/100ML (EQ 20MG BASE/ML), SOLUTION;INTRAVENOUS - EQ 3GM BASE/150ML (EQ 20MG BASE/ML), INJECTABLE;INJECTION - EQ 1GM BASE/VIAL, INJECTABLE;INJECTION - EQ 2GM BASE/VIAL

drugProductComposition
SOLUTION;INTRAVENOUS - EQ 1GM BASE/50ML (EQ 20MG BASE/ML)
SOLUTION;INTRAVENOUS - EQ 2GM BASE/100ML (EQ 20MG BASE/ML)
SOLUTION;INTRAVENOUS - EQ 3GM BASE/150ML (EQ 20MG BASE/ML)
INJECTABLE;INJECTION - EQ 1GM BASE/VIAL
INJECTABLE;INJECTION - EQ 2GM BASE/VIAL

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 2 Actylis, 4 Roquette

relatedExcipients
1 SPI Pharma
2 Actylis
4 Roquette

EXCIPIENTS BY APPLICATIONS

4 Parenteral, 2 Fillers, Diluents & Binders, 1 API Stability Enhancers

excipientsByApplications
4 Parenteral
2 Fillers, Diluents & Binders
1 API Stability Enhancers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 7 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
7 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 Finished Drug Prices

globalSalesInformation
2 Finished Drug Prices

MARKET PLACE

15 APIs, 2 FDF Dossiers

marketPlace
15 APIs
2 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM

otherSolutions
2 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 144

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

122

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

7 RELATED EXCIPIENT COMPANIES

7EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Cefazolin sodium salt, 27164-46-1, Cefazoline sodium, Ancef, Cefazil, Totacef

Molecular Formula

C₁₄H₁₃N₈NaO₄S₃

Molecular Weight

476.5 g/mol

InChI Key

FLKYBGKDCCEQQM-WYUVZMMLSA-M

FDA UNII

P380M0454Z

A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.

1 2D Structure

Cefazolin Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.1.2 InChI

InChI=1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1

2.1.3 InChI Key

FLKYBGKDCCEQQM-WYUVZMMLSA-M

2.1.4 Canonical SMILES

CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]

2.1.5 Isomeric SMILES

CC1=NN=C(S1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]

2.2 Other Identifiers

2.2.1 UNII

P380M0454Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ancef

2. Cefamedin

3. Cefamezine

4. Cefazolin

5. Cephamezine

6. Cephazolin

7. Cephazolin Sodium

8. Cephazolin, Sodium

9. Gramaxin

10. Kefzol

11. Sodium Cephazolin

12. Sodium, Cefazolin

13. Sodium, Cephazolin

14. Totacef

2.3.2 Depositor-Supplied Synonyms

1. Cefazolin Sodium Salt

2. 27164-46-1

3. Cefazoline Sodium

4. Ancef

5. Cefazil

6. Totacef

7. Kefzol

8. Sodium Cephazolin

9. Cefamedin

10. Gramaxin

11. Zolicef

12. Sodium Cefazolin

13. Cefacidal

14. Cephazolin Sodium

15. Cefazolin (sodium)

16. Monosodium Cefazolin

17. Sk&f 41558

18. Cefazolin Injection

19. Cefazolin And Dextrose

20. Cefazina

21. Firmacef

22. Liviclina

23. Atirin

24. Acef

25. Chebi:3483

26. Mls000028706

27. Nsc-291561

28. P380m0454z

29. Biazolina

30. Smr000058708

31. Skf 41558

32. Sk&f-41558

33. Sodium Cez

34. Cefazolin Sodium 100 Microg/ml In Acetonitrile/water

35. Ancef In Plastic Container

36. Cefabiozim

37. Cefalomicina

38. Lampocef

39. Neofazol

40. Zolisint

41. Recef

42. Zolin

43. Bor-cefazol

44. Cez Sodium

45. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1h-tetrazol-1-yl)acetyl)amino)-, Monosodium Salt (6r-trans)-

46. Monosodium (6r,7r)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1h-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

47. Lilly 46083

48. Unii-p380m0454z

49. Cefazolin Sodium [usan:usp:jan]

50. Sodium;(6r,7r)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

51. Prestwick_975

52. Einecs 248-278-4

53. Monosodium Cephazolin

54. Mfcd00056883

55. Ancef (tn)

56. Nsc 291561

57. Opera_id_1323

58. Ancef In Dextrose 5% In Plastic Container

59. Schembl40735

60. Spectrum1500164

61. Cefazolin Sodium [jan]

62. Cefazolin Sodium (jp17/usp)

63. Sodium Cez; Skf-41558

64. Cefazolin Sodium [usan]

65. Cefazolin Sodium [vandf]

66. Chembl1200523

67. Hms500a16

68. Ancef In Sodium Chloride 0.9% In Plastic Container

69. Cefazolin Sodium [mart.]

70. Cefazolin Sodium [who-dd]

71. Dtxsid901015786

72. Hms1570c14

73. Hms1920k07

74. Hms2091a10

75. Hms2097c14

76. Hms2230i22

77. Hms3260h10

78. Hms3714c14

79. Cefazolin Sodium Salt [mi]

80. Hy-b1078

81. Tox21_500274

82. Bdbm50247885

83. Ccg-40011

84. S4595

85. Akos015895533

86. Cefazolin Sodium [orange Book]

87. Cefazolin Sodium [ep Monograph]

88. Cs-4634

89. Lp00274

90. Cefazolin Sodium [usp Monograph]

91. Cefazolin Sodium Salt, 89.1-110.1%

92. Ncgc00093731-01

93. Ncgc00260959-01

94. 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-7-(2-(1h-tetrazol-1-yl)acetamido)-3-cephem-4-carboxylate

95. Ac-13166

96. Ac-31729

97. As-12230

98. Sodium (6r,7r)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1h-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

99. Eu-0100274

100. C 5020

101. C-2465

102. C08098

103. D00905

104. Q27106104

105. Cefazolin Sodium Salt, Antibiotic For Culture Media Use Only

106. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1h-tetrazol-1-yl)acetyl)amino)-, (6r-trans)-, Sodium Salt

107. 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1h-tetrazol-1-yl)acetyl]amino]-, Sodium Salt, (6r,7r)- (1:1)

108. 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1h-tetrazol-1-yl)acetyl]amino]-,(6r,7r)-,sodium

109. Sodium (6r,7r)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1h-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

110. Sodium (6r,7r)-7-(2-(1h-tetrazol-1-yl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

111. Sodium (6r,7r)-7-(2-(1h-tetrazol-1-yl)acetamido)-3-((5-methyl-1,3,4-thiadiazol-2-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

112. Sodium (6r-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(1h-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

113. Sodium 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-7beta-[(1h-tetrazol-1-ylacetyl)amino]-3,4-didehydrocepham-4-carboxylate

114. Sodium 7beta-(1h-tetrazol-1-yl)acetamido-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

115. Sodium 7beta-[2-(1h-tetrazol-1-yl)-acetamido]-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

116. Sodium 7beta-[2-(1h-tetrazol-1-yl)acetamido]-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₁₃N₈NaO₄S₃
Molecular Weight	476.5 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	7
Exact Mass	476.01195873 g/mol
Monoisotopic Mass	476.01195873 g/mol
Topological Polar Surface Area	238 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	746
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 8
Drug Name	Ancef in plastic container
Active Ingredient	Cefazolin sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 20mg base/ml; eq 10mg base/ml
Market Status	Prescription
Company	Baxter Hlthcare

2 of 8
Drug Name	Cefazolin and dextrose
Active Ingredient	Cefazolin sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 2gm base/vial; eq 1gm base/vial
Market Status	Prescription
Company	B Braun

3 of 8
Drug Name	Cefazolin sodium
Drug Label	CEFAZOLIN FOR INJECTION is a semi-synthetic cephalosporin for parenteral administration. It is the sodium salt of 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-methyl}-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxy...
Active Ingredient	Cefazolin sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 20gm base/vial; eq 100gm base/vial; eq 500mg base/vial; eq 10gm base/vial; eq 300gm base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Acs Dobfar; Hospira; Steri Pharma; Hikma Farmaceutica; Samson Medcl; Sandoz

4 of 8
Drug Name	Kefzol
Active Ingredient	Cefazolin sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 500mg base/vial; eq 10gm base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Acs Dobfar

5 of 8
Drug Name	Ancef in plastic container
Active Ingredient	Cefazolin sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 20mg base/ml; eq 10mg base/ml
Market Status	Prescription
Company	Baxter Hlthcare

6 of 8
Drug Name	Cefazolin and dextrose
Active Ingredient	Cefazolin sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 2gm base/vial; eq 1gm base/vial
Market Status	Prescription
Company	B Braun

7 of 8
Drug Name	Cefazolin sodium
Drug Label	CEFAZOLIN FOR INJECTION is a semi-synthetic cephalosporin for parenteral administration. It is the sodium salt of 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-methyl}-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxy...
Active Ingredient	Cefazolin sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 20gm base/vial; eq 100gm base/vial; eq 500mg base/vial; eq 10gm base/vial; eq 300gm base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Acs Dobfar; Hospira; Steri Pharma; Hikma Farmaceutica; Samson Medcl; Sandoz

8 of 8
Drug Name	Kefzol
Active Ingredient	Cefazolin sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 500mg base/vial; eq 10gm base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Acs Dobfar

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]

API SUPPLIERS

01

Faran Shimi Pharmaceutical

Iran

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Not Confirmed

Faran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

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HRV Global Life Sciences

India

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HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

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AUDIT

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Israel

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CPhI WW Frankfurt

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TAPI offers customized CDMO Solutions for API development and manufacturing services.

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Israel

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Sandoz B2B

Switzerland

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Not Confirmed

05

Qilu Antibiotics Pharmaceutical Co...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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06

CSPC Pharmaceutical Group

China

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07

Astellas Pharma

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed

08

Astellas Pharma

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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09

Bristol Myers Squibb

U.S.A

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10

Bristol Myers Squibb

U.S.A

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API Reference Price

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KLASSIC","city":"AHMEDABAD\/GUJARAT","supplier":"CSPC PHARMACEUTICAL GROUP","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"INJECT CARE PARENTERALS ","customerCountry":"INDIA","quantity":"150.00","actualQuantity":"150","unit":"KGS","unitRateFc":"120","totalValueFC":"18197.8","currency":"USD","unitRateINR":"10194","date":"18-Oct-2024","totalValueINR":"1529100","totalValueInUsd":"18197.8","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"6193058","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Sterile","supplierPort":"BEIJING","supplierAddress":"D. NO.88 YANGZI ROAD SHIJIAZHUANG H EBEI Hebei, , CHINA SDNF CHINA","customerAddress":"DEV ASHISH, 1ST FLOOR, NR. KLASSIC"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729621800,"product":"CEFAZOLIN SODIUM IP\/BP\/USP","address":"SURVEY NO.144 146, VILLAGE","city":"DIST.VADODARA, GUJARAT","supplier":"HARBIN HEJIA PHARMACEUTICAL CO.,LTD","supplierCountry":"CHINA","foreign_port":"XINGANG","customer":"BHARAT PARENTERALS LIMITED","customerCountry":"INDIA","quantity":"7000.00","actualQuantity":"7000","unit":"KGS","unitRateFc":"94","totalValueFC":"665231.4","currency":"USD","unitRateINR":"7985.3","date":"23-Oct-2024","totalValueINR":"55897100","totalValueInUsd":"665231.4","indian_port":"JNPT","hs_no":"29419090","bill_no":"6277429","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"XINGANG","supplierAddress":".ECONOMIC AND TECHNOLOGICAL DEVELOP MENT ZONESHANGZHI CITY, HEILONGJIAN G, CHINA","customerAddress":"SURVEY NO.144 146, VILLAGE"}]

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 1GM BASE/5...DOSAGE - SOLUTION;INTRAVENOUS - EQ 1GM BASE/50ML (EQ 20MG BASE/ML)

USFDA APPLICATION NUMBER - 207131

DOSAGE - SOLUTION;INTRAVENOUS - EQ 2GM BASE/1...DOSAGE - SOLUTION;INTRAVENOUS - EQ 2GM BASE/100ML (EQ 20MG BASE/ML)

USFDA APPLICATION NUMBER - 207131

DOSAGE - SOLUTION;INTRAVENOUS - EQ 3GM BASE/1...DOSAGE - SOLUTION;INTRAVENOUS - EQ 3GM BASE/150ML (EQ 20MG BASE/ML)

USFDA APPLICATION NUMBER - 207131

DOSAGE - INJECTABLE;INJECTION - EQ 1GM BASE/V...DOSAGE - INJECTABLE;INJECTION - EQ 1GM BASE/VIAL

USFDA APPLICATION NUMBER - 50779

DOSAGE - INJECTABLE;INJECTION - EQ 2GM BASE/V...DOSAGE - INJECTABLE;INJECTION - EQ 2GM BASE/VIAL

USFDA APPLICATION NUMBER - 50779

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SOLUTION;INTRAVENOUS - EQ 1GM BASE/50ML (EQ 20MG BASE/ML)

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SOLUTION;INTRAVENOUS - EQ 3GM BASE/150ML (EQ 20MG BASE/ML)

INJECTABLE;INJECTION - EQ 1GM BASE/VIAL

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