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CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

37 API Suppliers, 15 USDMF, 21 CEP/COS, 5 JDMF, 10 EU WC, 16 KDMF, 3 NDC API, 16 Listed Suppliers, $ API Reference Price

37 API Suppliers
15 USDMF
21 CEP/COS
5 JDMF
10 EU WC
16 KDMF
3 NDC API
16 Listed Suppliers
$ API Reference Price

INTERMEDIATES

6 Intermediates Suppliers

6 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

213 FDF Dossiers, 21 FDA Orange Book, 39 Europe, 4 Canada, 5 South Africa, 144 Listed Dossiers

213 FDF Dossiers
21 FDA Orange Book
39 Europe
4 Canada
5 South Africa
144 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

FOR SUSPENSION;ORAL - 500MG/5ML, CAPSULE;ORAL - 400MG

drugProductComposition
FOR SUSPENSION;ORAL - 500MG/5ML
CAPSULE;ORAL - 400MG

RELATED EXCIPIENT COMPANIES

4 Rochem International Inc, 16 SPI Pharma, 2 Seqens, 10 DKSH, 2 Pharm-RX Chemical, 6 Faran Shimi Pharmaceutical, 11 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 4 ACG Worldwide, 4 Actylis, 6 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 16 BASF, 1 Bioplus Life Sciences, 10 Corel Pharma Chem, 4 DFE Pharma, 2 Finar, 6 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 31 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 12 Microlex e.U, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 6 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 17 Roquette, 8 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 9 Sigachi Industries, 2 The Dow Chemical Company, 1 Valens Pharmachem, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

74 Fillers, Diluents & Binders, 47 Coating Systems & Additives, 33 Direct Compression, 28 Thickeners and Stabilizers, 25 Controlled & Modified Release, 21 Taste Masking, 18 Granulation, 17 Co-Processed Excipients, 16 Chewable & Orodispersible Aids, 13 Topical, 13 Lubricants & Glidants, 11 Disintegrants & Superdisintegrants, 10 Film Formers & Plasticizers, 9 Empty Capsules, 9 Parenteral, 7 Solubilizers, 6 API Stability Enhancers, 5 Coloring Agents, 5 Emulsifying Agents, 4 Vegetarian Capsules, 4 Rheology Modifiers, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 19 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
19 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 39 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
39 Finished Drug Prices

MARKET PLACE

64 APIs, 14 FDF Dossiers

marketPlace
64 APIs
14 FDF Dossiers

PATENTS & EXCLUSIVITIES

1 US Patents, 3 Health Canada Patents

patents
1 US Patents
3 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 8 Others

otherSolutions
1 EDQM
1 USP
8 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 148

MARKET PLACE

API

FDF

6INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

213

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

144

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,622,984

Annual Reports (USD Million)

Finished Drug Prices

228 RELATED EXCIPIENT COMPANIES

376EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Cefixime, 97164-56-2, 79350-37-1, Cefixime(e)-form, (e)-cefixime, Cefixime anhydrous, (e)-

Molecular Formula

C₁₆H₁₅N₅O₇S₂

Molecular Weight

453.5 g/mol

InChI Key

OKBVVJOGVLARMR-VINNURBNSA-N

FDA UNII

U7RWT9J78O

A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.

1 2D Structure

Cefixime

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

2.1.2 InChI

InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9+/t10-,14-/m1/s1

2.1.3 InChI Key

OKBVVJOGVLARMR-VINNURBNSA-N

2.1.4 Canonical SMILES

C=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCC(=O)O)C3=CSC(=N3)N)SC1)C(=O)O

2.1.5 Isomeric SMILES

C=CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N/OCC(=O)O)/C3=CSC(=N3)N)SC1)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

U7RWT9J78O

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cefixime

2. Cefixime Anhydrous

3. Cefixime Trihydrate

4. Fk 027

5. Fk-027

6. Fk027

7. Fr 17027

8. Fr-17027

9. Fr17027

2.3.2 Depositor-Supplied Synonyms

1. Cefixime

2. 97164-56-2

3. 79350-37-1

4. Cefixime(e)-form

5. (e)-cefixime

6. Cefixime Anhydrous, (e)-

7. U7rwt9j78o

8. Cfix

9. (6r,7r)-7-(((2e)-2-(2-amino-4-thiazolyl)-2-((carboxymethoxy)imino)acetyl)amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid

10. (6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

11. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2e)-2-(2-amino-4-thiazolyl)-2-((carboxymethoxy)imino)acetyl)amino)-3-ethenyl-8-oxo-, (6r,7r)-

12. Cefixime Impurity D

13. Unii-u7rwt9j78o

14. (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

15. Cefiximetrihydrate

16. Prestwick2_000462

17. Epitope Id:116227

18. Schembl24946

19. Schembl49534

20. Chembl427069

21. Bdbm88962

22. Chebi:93248

23. Gtpl10898

24. Cid_56642849

25. Hms1569m06

26. (6r,7r)-7-((z)-2-(2-aminothiazol-4-yl)-2-((carboxymethoxy)imino)acetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

27. Zinc4468778

28. Ncgc00185001-01

29. (e)-cefixime (cefixime Ep Impurity D)

30. Q163901

31. J-005196

32. J-501698

33. Brd-k04993501-001-01-9

34. [6r-[6alpha,7beta(e)]]-7-[[(2-amino-4-thiazolyl)[(car

35. (6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrate

36. (6r,7r)-7-[[(2e)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)-1-oxoethyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrate

37. (6r,7r)-7-[[(2e)-2-(2-aminothiazol-4-yl)-2-(carboxymethyloximino)acetyl]amino]-8-keto-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrate

38. (6r,7r)-7-[[(2e)-2-(2-azanyl-1,3-thiazol-4-yl)-2-(2-hydroxy-2-oxoethyloxyimino)ethanoyl]amino]-3-ethenyl-8-oxidanylidene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrate

39. (6r,7r)-7-[[(2z)-2-(2-amino-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene -2-carboxylic Acid

40. (6r,7r,e)-7-(2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

2.4 Create Date

2005-11-20

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₁₅N₅O₇S₂
Molecular Weight	453.5 g/mol
XLogP3	-0.7
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	8
Exact Mass	453.04129018 g/mol
Monoisotopic Mass	453.04129018 g/mol
Topological Polar Surface Area	238 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	861
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]

4.3 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DD - Third-generation cephalosporins

J01DD08 - Cefixime

API SUPPLIERS

01

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI India 2024

Booth #2.D38

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU, ASMF

AUDIT

02

Akums Lifesciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

03

Qilu Antibiotics Pharmaceutical Co...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

04

Astellas Pharma

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

05

CSPC Pharmaceutical Group

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

06

Kyongbo Pharmaceutical Co., Ltd

South Korea

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

07

ACS DOBFAR SPA

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

08

Qilu Antibiotics Pharmaceutical Co...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

09

Astellas Pharma

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

10

Qilu Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

Only 10 entries up to this point, click to access all

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USDMF

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CEP/COS

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JDMF

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EU WC

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KDMF

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NDC API

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Listed Suppliers

01

HRV Global Life Sciences

India

CPhI India 2024

Booth #2.D38

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

Cefixime

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

02

ACS DOBFAR SPA

Italy

euroPLX 86 Munich

Not Confirmed

03

Akums Lifesciences

India

euroPLX 86 Munich

Not Confirmed

04

Drug Manufacturing Company

Oman

euroPLX 86 Munich

Not Confirmed

05

Freemen Nutra

China

euroPLX 86 Munich

Not Confirmed

06

Nectar Lifesciences

India

euroPLX 86 Munich

Not Confirmed

07

Nishchem International Pvt. Ltd

India

euroPLX 86 Munich

Not Confirmed

08

Orchid Pharma

India

euroPLX 86 Munich

Not Confirmed

09

Otto Brandes

Germany

euroPLX 86 Munich

Not Confirmed

10

Sichuan Renan Pharmaceutical

China

euroPLX 86 Munich

Not Confirmed

Only 10 entries up to this point, click to access all

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API Reference Price

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