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Also known as: 61270-78-8, Monocid, Cefonicid disodium salt, Sk&f d-75073-z2, Cefonicide sodium, Cefonicid (sodium)
Molecular Formula
C18H16N6Na2O8S3
Molecular Weight
586.5  g/mol
InChI Key
NAXFZVGOZUWLEP-RFXDPDBWSA-L
FDA UNII
F74MFL78A1

CEFONICID SODIUM
A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
1 2D Structure

CEFONICID SODIUM

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C18H18N6O8S3.2Na/c25-13(9-4-2-1-3-5-9)14(26)19-11-15(27)24-12(17(28)29)10(6-33-16(11)24)7-34-18-20-21-22-23(18)8-35(30,31)32;;/h1-5,11,13,16,25H,6-8H2,(H,19,26)(H,28,29)(H,30,31,32);;/q;2*+1/p-2/t11-,13-,16-;;/m1../s1
2.1.3 InChI Key
NAXFZVGOZUWLEP-RFXDPDBWSA-L
2.1.4 Canonical SMILES
C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)O)C(=O)[O-])CSC4=NN=NN4CS(=O)(=O)[O-].[Na+].[Na+]
2.1.5 Isomeric SMILES
C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)O)C(=O)[O-])CSC4=NN=NN4CS(=O)(=O)[O-].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
F74MFL78A1
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cefonicid

2. Cefonicid Disodium Salt

3. Cefonicid Monosodium

4. Cefonicid Monosodium Salt

5. Cefonicid, Sodium

6. Monocid

7. Sk And F 75073

8. Sk And F-75073

9. Sk And F75073

10. Skf 75073 2

11. Skf-75073-2

12. Skf750732

13. Sodium Cefonicid

2.3.2 Depositor-Supplied Synonyms

1. 61270-78-8

2. Monocid

3. Cefonicid Disodium Salt

4. Sk&f D-75073-z2

5. Cefonicide Sodium

6. Cefonicid (sodium)

7. Chebi:3492

8. F74mfl78a1

9. Sk&f-d-75073-z2

10. (6r,7r)-7-((r)-mandelamido)-8-oxo-3-(((1-(sulfomethyl)-1-h-tetrazol-5-yl)thio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Disodium Salt

11. Disodium;(6r,7r)-7-[[(2r)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

12. Monocid Sodium

13. Cefonicid Sodium [usan]

14. Cefonicid Disodium

15. Ncgc00167458-01

16. Skf 75073

17. Unii-f74mfl78a1

18. Cefonicid Sodium [usan:usp]

19. Monocid (tn)

20. Cefonicid Sodium (usp)

21. Dsstox_cid_26642

22. Dsstox_rid_81788

23. Dsstox_gsid_46642

24. Schembl41895

25. 190181-58-9

26. Cefonicid Sodium [vandf]

27. Chembl1201005

28. Dtxsid0046642

29. Cefonicid Sodium [mart.]

30. Cefonicid Sodium [usp-rs]

31. Cefonicid Sodium [who-dd]

32. Tox21_112462

33. Cefonicid Disodium Salt [mi]

34. Mfcd00941437

35. Akos015896359

36. Cefonicid Sodium [orange Book]

37. Ccg-270152

38. Cefonicid Sodium [usp Impurity]

39. Sk&f D-75073-z(sub 2)

40. Sk&f-d-75073-z(sub 2)

41. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-((hydroxyphenylacetyl)amino)-8-oxo-3-(((1-(sulfomethyl)-1h-tetrazol-5-yl)thio)methyl)disodium Salt, (6r-(6alpha,7beta(r*)))

42. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-((hydroxyphenylacetyl)amino)-8-oxo-3-(((1-(sulfomethyl)-1h-tetrazol-5-yl)thio)methyl)disodium Salt, (6r-(6alpha,7beta(r*)))-

43. Cas-61270-78-8

44. C08105

45. C75868

46. D00912

47. A833136

48. Q27106106

49. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-((hydroxyphenylacetyl)amino)-8-oxo-3-(((1-(sulfomethyl)-1h-tetrazol-5-yl)thio)methyl)disodium Salt, (6r-(6.alpha.,7.beta.(r*)))-

50. Disodium 7-[(2-hydroxy-2-phenyl-acetyl)amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

51. Sodium (6r,7r)-7-((r)-2-hydroxy-2-phenylacetamido)-8-oxo-3-(((1-(sulfonatomethyl)-1h-tetrazol-5-yl)thio)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

52. Sodium (6r,7r)-7-((r)-2-hydroxy-2-phenylacetamido)-8-oxo-3-((1-(sulfonatomethyl)-1h-tetrazol-5-ylthio)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

53. Sodium(6r,7r)-7-((r)-2-hydroxy-2-phenylacetamido)-8-oxo-3-(((1-(sulfonatomethyl)-1h-tetrazol-5-yl)thio)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 586.5 g/mol
Molecular Formula C18H16N6Na2O8S3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count13
Rotatable Bond Count7
Exact Mass585.99871357 g/mol
Monoisotopic Mass585.99871357 g/mol
Topological Polar Surface Area270 Ų
Heavy Atom Count37
Formal Charge0
Complexity980
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


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