Find Cefotiam Hexetil Hydrochloride manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 95789-30-3, Cefotiam hexetil dihydrochloride, Ctm-he, Cefotiam hexetil hcl, Cefotiam hexetil hydrochloride [jan], 3n1x7e8cle
Molecular Formula
C27H39Cl2N9O7S3
Molecular Weight
768.8  g/mol
InChI Key
FFSANQNELHESQJ-LWBICVDYSA-N
FDA UNII
3N1X7E8CLE

Cefotiam Hexetil Hydrochloride
Cefotiam Hexetil Hydrochloride is the hydrochloride salt of cefotiam hexetil, an ester prodrug of cefotiam for parenteral use. Cefotiam is a semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. After administration of cefotiam hexetil hydrochloride the ester bond is cleaved, releasing active cefotiam.
1 2D Structure

Cefotiam Hexetil Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-cyclohexyloxycarbonyloxyethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;dihydrochloride
2.1.2 InChI
InChI=1S/C27H37N9O7S3.2ClH/c1-15(42-27(40)43-18-7-5-4-6-8-18)41-24(39)21-16(13-46-26-31-32-33-35(26)10-9-34(2)3)12-44-23-20(22(38)36(21)23)30-19(37)11-17-14-45-25(28)29-17;;/h14-15,18,20,23H,4-13H2,1-3H3,(H2,28,29)(H,30,37);2*1H/t15?,20-,23-;;/m1../s1
2.1.3 InChI Key
FFSANQNELHESQJ-LWBICVDYSA-N
2.1.4 Canonical SMILES
CC(OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)CC3=CSC(=N3)N)CSC4=NN=NN4CCN(C)C)OC(=O)OC5CCCCC5.Cl.Cl
2.1.5 Isomeric SMILES
CC(OC(=O)C1=C(CS[C@H]2N1C(=O)[C@H]2NC(=O)CC3=CSC(=N3)N)CSC4=NN=NN4CCN(C)C)OC(=O)OC5CCCCC5.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
3N1X7E8CLE
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cefotiam Hexetil

2. Cefotiam Hexetil, (6r-(3(r*),6alpha,7beta))-isomer

3. Cefotiam Hexetil, (6r-(3(s*),6alpha,7beta))-isomer

4. Cefotiam Hexetil, (6r-(6alpha,7beta))-isomer

2.3.2 Depositor-Supplied Synonyms

1. 95789-30-3

2. Cefotiam Hexetil Dihydrochloride

3. Ctm-he

4. Cefotiam Hexetil Hcl

5. Cefotiam Hexetil Hydrochloride [jan]

6. 3n1x7e8cle

7. Pansporin T

8. Cefotiam 1-(cyclohexyloxycarbonyloxy)ethyl Ester Dihydrochloride

9. 1-cyclohexyloxycarbonyloxyethyl (6r,7r)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;dihydrochloride

10. Cefotiam Hexetil (hydrochloride)

11. Cefotiam Hexetil 2hcl

12. 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl (6r,7r)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Dihydrochloride

13. 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 7beta-(2-amino-1,3-thiazol-4-yl)acetamido-3-[({1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl}sulfanyl)methyl]-3,4-didehydrocepham-4-carboxylate Dihydrochloride

14. Sce 2174

15. Sce-2174

16. Unii-3n1x7e8cle

17. Taketiam

18. Texodil

19. Pansporin-t (tn)

20. Ctm-he Hydrochloride

21. Amy594

22. Cefotiam Cilexetil Hydrochloride

23. Schembl9694268

24. Chebi:31373

25. Hy-a0110a

26. S5637

27. Akos027326844

28. Ccg-270455

29. Cefotiam Hexetil Hydrochloride (jp17)

30. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, 1-(((cyclohexyloxy)carbonyl)oxy)ethyl Ester, Dihydrochloride, (6r-(6-alpha,7-beta))-

31. Cs-0014039

32. Cefotiam Hexetil Hydrochloride [who-dd]

33. D01415

34. 789c303

35. Q27114288

36. Cefotiam Hexetil Hydrochloride (mixture Of Diastereomers)

37. Cefotiam 1-(cyclohexyloxycarbonyloxy)ethyl Ester Dihydrochloride [mi]

38. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-((2-(2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, 1-(((cyclohexyloxy)carbonyl)oxy)ethyl Ester, Hydrochloride (1:2), (6r,7r)-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 768.8 g/mol
Molecular Formula C27H39Cl2N9O7S3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count16
Rotatable Bond Count16
Exact Mass767.1511635 g/mol
Monoisotopic Mass767.1511635 g/mol
Topological Polar Surface Area276 Ų
Heavy Atom Count48
Formal Charge0
Complexity1160
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


ABOUT THIS PAGE

Cefotiam Hexetil Hydrochloride Manufacturers

A Cefotiam Hexetil Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefotiam Hexetil Hydrochloride, including repackagers and relabelers. The FDA regulates Cefotiam Hexetil Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefotiam Hexetil Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cefotiam Hexetil Hydrochloride Suppliers

A Cefotiam Hexetil Hydrochloride supplier is an individual or a company that provides Cefotiam Hexetil Hydrochloride active pharmaceutical ingredient (API) or Cefotiam Hexetil Hydrochloride finished formulations upon request. The Cefotiam Hexetil Hydrochloride suppliers may include Cefotiam Hexetil Hydrochloride API manufacturers, exporters, distributors and traders.

Cefotiam Hexetil Hydrochloride GMP

Cefotiam Hexetil Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cefotiam Hexetil Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefotiam Hexetil Hydrochloride GMP manufacturer or Cefotiam Hexetil Hydrochloride GMP API supplier for your needs.

Cefotiam Hexetil Hydrochloride CoA

A Cefotiam Hexetil Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Cefotiam Hexetil Hydrochloride's compliance with Cefotiam Hexetil Hydrochloride specifications and serves as a tool for batch-level quality control.

Cefotiam Hexetil Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Cefotiam Hexetil Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cefotiam Hexetil Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefotiam Hexetil Hydrochloride EP), Cefotiam Hexetil Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefotiam Hexetil Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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