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1. Abbott 48999
2. Abbott-48999
3. Abbott48999
4. Cefotiam Hydrochloride
5. Ceradolan
6. Cgp 14221 E
7. Cgp-14221-e
8. Cgp14221e
9. Haloapor
10. Halospor
11. Hydrochloride, Cefotiam
12. Sce 963
13. Sce-963
14. Sce963
1. 61622-34-2
2. Cefotiamum
3. Cefotiamum [inn-latin]
4. Ceradon
5. Aspil
6. Ctm
7. Cefotiam (inn)
8. J01dc07
9. Chebi:355510
10. 91w6z2n718
11. Cefotiam [inn]
12. Cefotiam [inn:ban]
13. (6r,7r)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
14. (6r,7r)-7-[2-(2-amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1h-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
15. Cgp 14221e
16. 66309-69-1
17. 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid,7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl]thio]methyl]-8-oxo-, (6r,7r)-
18. Aspil (tn)
19. Sr-01000841230
20. Unii-91w6z2n718
21. Cefotiam,(s)
22. (6r,7r)-7-(2-(2-aminothiazol-4-yl)acetamido)-3-((1-(2-(dimethylamino)ethyl)-1h-tetrazol-5-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
23. Cefotiam [jan]
24. Cefotiam [mi]
25. Prestwick0_000482
26. Prestwick1_000482
27. Prestwick2_000482
28. Prestwick3_000482
29. Cefotiam [who-dd]
30. Chembl1296
31. Bspbio_000343
32. Schembl149538
33. Spbio_002264
34. Bpbio1_000379
35. Dtxsid6022763
36. Schembl11224134
37. Hy-b0734
38. Zinc3830445
39. Bdbm50485561
40. Db00229
41. Ncgc00179594-01
42. (6r,7r)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
43. (6r,7r)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl}thio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
44. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1h-tetrazol-5-yl)thio)methyl)-8-oxo-, (6r-trans)-
45. 7beta-(2-amino-1,3-thiazol-4-yl)acetamido-3-[({1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl}sulfanyl)methyl]-3,4-didehydrocepham-4-carboxylic Acid
46. Ab00514684
47. Cs-0009630
48. C21544
49. D07648
50. 622c342
51. J-700162
52. Q3009984
53. Sr-01000841230-2
54. Brd-k02275692-003-03-4
55. (6r,7r)-7-[2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-[({1-[2-(dimethylamino)ethyl]-1h-1,2,3,4-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
56. 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid,7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl]thio]methyl]-8-oxo-,(6r,7r)-
57. 7beta-(2-imino-4-thiazolin-4-yl)acetamido-3-{1-[2-(n,n-dimethylamino)ethyl]-1h-tetrazol-5-yl}thiomethyl-3-cephem-4-carboxylic Acid
58. 7beta-[ 2-(2-aminothiazol-4-yl) Acetamido]-3-[1-(2-dimethylaminoethyl)-1h-tetrazol-5-yl]thiomethyl-3-cephem-4-carboxylic Acid
Molecular Weight | 525.6 g/mol |
---|---|
Molecular Formula | C18H23N9O4S3 |
XLogP3 | -2.4 |
Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 13 |
Rotatable Bond Count | 10 |
Exact Mass | 525.10351377 g/mol |
Monoisotopic Mass | 525.10351377 g/mol |
Topological Polar Surface Area | 251 Ų |
Heavy Atom Count | 34 |
Formal Charge | 0 |
Complexity | 848 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 2 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
For treatment of severe infections caused by susceptible bacteria.
Cefotiam is a third generation beta-lactam cephalosporin antibiotic that works by inhibiting bacterial cell wall biosynthesis. It is a broad spectrum antibiotic that is effective against Gram positive and Gram negative bacteria.
Anti-Bacterial Agents
Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)
J - Antiinfectives for systemic use
J01 - Antibacterials for systemic use
J01D - Other beta-lactam antibacterials
J01DC - Second-generation cephalosporins
J01DC07 - Cefotiam
Absorption
Rapidly absorbed following intramuscular injection. Bioavailability is 60% following intramuscular injection.
Approximately 1 hour.
The bactericidal activity of cefotiam results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).