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    Also known as: Cefovecin sodium, Uk-287074-02, Cefovecin sodium salt, Chembl2104475, Ex-a3268, A936300
    Molecular Formula
    C17H18N5NaO6S2
    Molecular Weight
    475.5  g/mol
    InChI Key
    QRIBXVGHDLFNNE-BMCBYEKFSA-M
    Cefovecin
    Cefovecin Sodium is the sodium salt form of cefovecin, a semisynthetic, broad-spectrum, third-generation cephalosporin with antibacterial activity. Cefovecin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
    1 2D Structure

    Cefovecin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;(6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    2.1.2 InChI
    InChI=1S/C17H19N5O6S2.Na/c1-27-21-10(8-6-30-17(18)19-8)13(23)20-11-14(24)22-12(16(25)26)7(5-29-15(11)22)9-3-2-4-28-9;/h6,9,11,15H,2-5H2,1H3,(H2,18,19)(H,20,23)(H,25,26);/q;+1/p-1/b21-10+;/t9-,11+,15+;/m0./s1
    2.1.3 InChI Key
    QRIBXVGHDLFNNE-BMCBYEKFSA-M
    2.1.4 Canonical SMILES
    CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C4CCCO4)C(=O)[O-].[Na+]
    2.1.5 Isomeric SMILES
    CO/N=C(\C1=CSC(=N1)N)/C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)[C@@H]4CCCO4)C(=O)[O-].[Na+]
    2.2 Synonyms
    2.2.1 Depositor-Supplied Synonyms

    1. Cefovecin Sodium

    2. Uk-287074-02

    3. Cefovecin Sodium Salt

    4. Chembl2104475

    5. Ex-a3268

    6. A936300

    7. Q27114290

    8. Sodium (6r,7r)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl] Amino]-8-oxo-3-[(2s)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene- 2-carboxylate

    9. Sodium (6r,7r)-7-[2-(2-aminothiazol-4-yl)-2-(z)-methoxyiminoacetamido]-3-[(s) -tetrahydrofuran-2-yl]ceph-3-em-4-carboxylate

    10. Sodium (6r,7r)-7-[2-(2-aminothiazol-4-yl)-2-(z)-methoxyiminoacetamido]-3-[(s)-tetrahydrofuran-2-yl]ceph-3-em-4-carboxylate

    2.3 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 475.5 g/mol
    Molecular Formula C17H18N5NaO6S2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count11
    Rotatable Bond Count6
    Exact Mass475.05961994 g/mol
    Monoisotopic Mass475.05961994 g/mol
    Topological Polar Surface Area213 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity827
    Isotope Atom Count0
    Defined Atom Stereocenter Count3
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2

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    Qilu Animal Health Products

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    Regulatory Info :

    Registration Country : China

    Cefovecin Sodium

    Brand Name :

    Dosage Form : Lyophilized Powder for Injection

    Dosage Strength : 0.8G

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : China

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    ZOETIS MANUFACTURING ITALIA S.R.L. ...

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    Regulatory Info : Prescription

    Registration Country : Canada

    CEFOVECIN (CEFOVECIN SODIUM)

    Brand Name : CONVENIA

    Dosage Form : KIT

    Dosage Strength : 80MG/ML

    Packaging : 1 VIAL OF LYOPHILIZED POWDER, 1 VIAL OF DILUENT (10ML)

    Approval Date :

    Application Number : 2295628

    Regulatory Info : Prescription

    Registration Country : Canada

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    Milbemycin Oxime & Cefovecin APIs needed in India [ENA16017]
    A company that focuses on research, development and manufacturing of OSDs, oral liquids, parenteral & topical solutions for veterinary use is looking for suppliers of Milbemycin Oxime (600 g) & Cefovecin (300 g) APIs for both development and commercial purposes. The suppliers must support this enquiry with CoA.
    07 Jan 2023

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    07 Jan 2023

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    Various APIs needed in India [ENA07421]
    Lord Shiva Pharma, a sourcing & distribution company, specialized in the development, production and marketing of APIs, drug intermediates and many more is looking for suppliers of Various APIs. Interested suppliers can contact them via their email: amar@lorshivapharma.com. 1. Benazepril HCl 5 kg 2. Atipamezole 500 g 3. Cefovecin Sodium 5 kg 4. Medetomidine 100 g 5. Pentosan Polysulfate Sodium 10 kg 6. Xylazine HCl-1 kg 7. Melatonin 1 kg 8. Clomipramine 1 kg 9. Cefpodoxime Proxetil 10 kg
    29 May 2020

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    29 May 2020

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    Cefovecin (1 kg) API needed in India [ENA04990]
    A pharmaceutical company based in India is looking for suppliers of Cefovecin (1 kg) API for the US market. The supplier must support with EUDMF and USDMF.
    27 Aug 2019

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    27 Aug 2019

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    27 Aug 2019

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    Cefovecin and Cefovecin Sodium APIs (MOQ each) needed in India [ENA04506]
    One of the leading custom research and manufacturing organization in India is looking for suppliers of Cefovecin APIs (MOQ) for domestic consumption.
    27 Jun 2019

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    27 Jun 2019

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    Enquiry// Cefovecin API (1kg) needed in Australia [ENA01442]
    A leading high quality Australian manufacturer and distributor of generic veterinary medicines, is looking for the suppliers of Cefovecin API (1kg).
    10 Aug 2018

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    10 Aug 2018

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    Enquiry// Cefovecin Sodium, Maropitant Citrate and Mosapride citrate dihydrate APIs needed in Taiwan [ENA00325]
    A Taiwanese trading company, dealing in import and export business for Pharmaceutical Active Ingredients, Fine Chemicals, Intermediates, etc. is searching for suppliers of Cefovecin Sodium, Maropitant Citrate and Mosapride citrate dihydrate APIs for veterinary R&D use by one of their customers. The requirement is for developmental quantities.
    18 May 2017

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    18 May 2017

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