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Chemistry

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Also known as: Cefozopran, Cefozopran [inn], 113359-04-9, Czop, Sce 2787, Cefozopranum
Molecular Formula
C19H17N9O5S2
Molecular Weight
515.5  g/mol
InChI Key
QDUIJCOKQCCXQY-WHJQOFBOSA-N
FDA UNII
1LG87K28LW

Cefozopran
Cefozopran is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefozopran binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
1 2D Structure

Cefozopran

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C19H17N9O5S2/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27/h2-6,12,17H,7-8H2,1H3,(H3-,20,22,23,25,29,31,32)/b24-11-/t12-,17-/m1/s1
2.1.3 InChI Key
QDUIJCOKQCCXQY-WHJQOFBOSA-N
2.1.4 Canonical SMILES
CON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=C5C=CC=NN5C=C4)C(=O)[O-]
2.1.5 Isomeric SMILES
CO/N=C(/C1=NSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=C5C=CC=NN5C=C4)C(=O)[O-]
2.2 Other Identifiers
2.2.1 UNII
1LG87K28LW
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cefozopran

2. Czop

3. Sce 2787

4. Sce-2787

2.3.2 Depositor-Supplied Synonyms

1. Cefozopran

2. Cefozopran [inn]

3. 113359-04-9

4. Czop

5. Sce 2787

6. Cefozopranum

7. Cefozopran (inn)

8. 1lg87k28lw

9. Chebi:3502

10. Imidazo[1,2-b]pyridazinium,1-[[(6r,7r)-7-[[(2z)-(5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, Inner Salt

11. Ccris 6737

12. Unii-1lg87k28lw

13. Cefozopran [mi]

14. Cefozopran [who-dd]

15. Schembl49106

16. (-)-1-(((6r,7r)-7-(2-(5-amino-1,2,4-thiadiazol-3-yl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1h-imidazo(1,2-b)pyridazin-4-ium Hydroxide Inner Salt, 7(sup 2)-(z)-(o-methyloxime)

17. Imidazo(1,2-b)pyridazinium, 1-((6r,7r)-7-(((2z)-(5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, Inner Salt

18. Chembl1276663

19. Dtxsid701025943

20. (6r,7r)-7-[[(2z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

21. Hy-b0771

22. Cefozopran Hydrochloride [jan]

23. Akos015896118

24. Db13667

25. Imidazo(1,2-b)pyridazinium, 1-((7-(((5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, Inner Salt, (6r-(6alpha,7beta(z)))-

26. D01052

27. J-504081

28. (-)-1-(((6r,7r)-7-(2-(5-amino-1,2,4-thiadiazol-3-yl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1h-imidazo(1,2-b)pyridazin-4-ium Hydroxide Inner Salt, 7^2-(z)-(o-methyloxime)

29. (6r,7r)-7-{[(2z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino}-3-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

30. 1-[[(6r,7r)-7-[[(2z)-(5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3 -yl]methyl]-imidazo[1,2-b]pyridazinium Hydroxide Inner Salt

31. 7-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-3,4-didehydrocepham-4-carboxylate

2.4 Create Date
2006-10-24
3 Chemical and Physical Properties
Molecular Weight 515.5 g/mol
Molecular Formula C19H17N9O5S2
XLogP30.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count6
Exact Mass515.07940702 g/mol
Monoisotopic Mass515.07940702 g/mol
Topological Polar Surface Area238 Ų
Heavy Atom Count35
Formal Charge0
Complexity960
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DE - Fourth-generation cephalosporins

J01DE03 - Cefozopran


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ABOUT THIS PAGE

Cefozopran Manufacturers

A Cefozopran manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefozopran, including repackagers and relabelers. The FDA regulates Cefozopran manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefozopran API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cefozopran manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cefozopran Suppliers

A Cefozopran supplier is an individual or a company that provides Cefozopran active pharmaceutical ingredient (API) or Cefozopran finished formulations upon request. The Cefozopran suppliers may include Cefozopran API manufacturers, exporters, distributors and traders.

click here to find a list of Cefozopran suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cefozopran GMP

Cefozopran Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cefozopran GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefozopran GMP manufacturer or Cefozopran GMP API supplier for your needs.

Cefozopran CoA

A Cefozopran CoA (Certificate of Analysis) is a formal document that attests to Cefozopran's compliance with Cefozopran specifications and serves as a tool for batch-level quality control.

Cefozopran CoA mostly includes findings from lab analyses of a specific batch. For each Cefozopran CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cefozopran may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefozopran EP), Cefozopran JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefozopran USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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