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Chemistry

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Also known as: 84957-30-2, Cobactan, Cefquinoma, Hr111v, Z74s078cwp, 1-[[(6r,7r)-7-[[(2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydro-quinolinium inner salt
Molecular Formula
C23H24N6O5S2
Molecular Weight
528.6  g/mol
InChI Key
YWKJNRNSJKEFMK-PQFQYKRASA-N
FDA UNII
Z74S078CWP

Cefquinome
Cefquinome is a semisynthetic, broad-spectrum, fourth-generation aminothiazolyl cephalosporin with antibacterial activity. Cefquinome binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
1 2D Structure

Cefquinome

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C23H24N6O5S2/c1-34-27-16(14-11-36-23(24)25-14)19(30)26-17-20(31)29-18(22(32)33)13(10-35-21(17)29)9-28-8-4-6-12-5-2-3-7-15(12)28/h4,6,8,11,17,21H,2-3,5,7,9-10H2,1H3,(H3-,24,25,26,30,32,33)/b27-16-/t17-,21-/m1/s1
2.1.3 InChI Key
YWKJNRNSJKEFMK-PQFQYKRASA-N
2.1.4 Canonical SMILES
CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC5=C4CCCC5)C(=O)[O-]
2.1.5 Isomeric SMILES
CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=CC5=C4CCCC5)C(=O)[O-]
2.2 Other Identifiers
2.2.1 UNII
Z74S078CWP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hoe 111

2. Hoe-111

3. Hr 111v

4. Hr-111v

2.3.2 Depositor-Supplied Synonyms

1. 84957-30-2

2. Cobactan

3. Cefquinoma

4. Hr111v

5. Z74s078cwp

6. 1-[[(6r,7r)-7-[[(2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydro-quinolinium Inner Salt

7. Cefquinome (inn)

8. (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

9. Cefquinome [inn]

10. Cefquinomum

11. Cefquinome [inn:ban]

12. Cefquinomum [inn-latin]

13. Cefquinoma [inn-spanish]

14. Unii-z74s078cwp

15. Cefquinome [mi]

16. Cobactan [veterinary] (tn)

17. Schembl149896

18. Chembl1631107

19. Dtxsid00894103

20. Akos025402360

21. D07652

22. 1-(((6r,7r)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-5,6,7,8-tetrahydroquinolinium Hydroxide, Inner Salt, 7(sup 2)-(z)-(o-methyloxime)

23. 1-(((6r,7r)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-5,6,7,8-tetrahydroquinolinium Hydroxide, Inner Salt, 72-(z)-(o-methyloxime)

24. Quinolinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-5,6,7,8-tetrahydro-, Hydroxide, Inner Salt, (6r-(6.alpha.,7.beta.(z)))-

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 528.6 g/mol
Molecular Formula C23H24N6O5S2
XLogP31.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass528.12496023 g/mol
Monoisotopic Mass528.12496023 g/mol
Topological Polar Surface Area208 Ų
Heavy Atom Count36
Formal Charge0
Complexity971
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API Reference Price

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29-May-2023
06-Nov-2024
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ABOUT THIS PAGE

Cefquinome Manufacturers

A Cefquinome manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefquinome, including repackagers and relabelers. The FDA regulates Cefquinome manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefquinome API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cefquinome manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cefquinome Suppliers

A Cefquinome supplier is an individual or a company that provides Cefquinome active pharmaceutical ingredient (API) or Cefquinome finished formulations upon request. The Cefquinome suppliers may include Cefquinome API manufacturers, exporters, distributors and traders.

click here to find a list of Cefquinome suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cefquinome GMP

Cefquinome Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cefquinome GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefquinome GMP manufacturer or Cefquinome GMP API supplier for your needs.

Cefquinome CoA

A Cefquinome CoA (Certificate of Analysis) is a formal document that attests to Cefquinome's compliance with Cefquinome specifications and serves as a tool for batch-level quality control.

Cefquinome CoA mostly includes findings from lab analyses of a specific batch. For each Cefquinome CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cefquinome may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefquinome EP), Cefquinome JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefquinome USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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