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    Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

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    Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

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    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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    Also known as: Tak-599, Schembl1464044, Gtpl10899, Q409712, (6r,7r)-7-((z)-2-(ethoxyimino)-2-(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetamido)-3-((4-(1-methylpyridin-1-ium-4-yl)thiazol-2-yl)thio)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    Molecular Formula
    C22H21N8O8PS4
    Molecular Weight
    684.7  g/mol
    InChI Key
    ZCCUWMICIWSJIX-XHNDKCDBSA-N
    Ceftaroline Fosamil
    1 2D Structure

    Ceftaroline Fosamil

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (6R,7R)-7-[[(2E)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    2.1.2 InChI
    InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/b26-13+/t14-,19-/m1/s1
    2.1.3 InChI Key
    ZCCUWMICIWSJIX-XHNDKCDBSA-N
    2.1.4 Canonical SMILES
    CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]
    2.1.5 Isomeric SMILES
    CCO/N=C(\C1=NSC(=N1)NP(=O)(O)O)/C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Ceftaroline Fosamil

    2. Ppi-0903

    3. Ppi0903

    4. Tak-599

    5. Tak599

    6. Teflaro

    2.2.2 Depositor-Supplied Synonyms

    1. Tak-599

    2. Schembl1464044

    3. Gtpl10899

    4. Q409712

    5. (6r,7r)-7-((z)-2-(ethoxyimino)-2-(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetamido)-3-((4-(1-methylpyridin-1-ium-4-yl)thiazol-2-yl)thio)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

    2.3 Create Date
    2014-04-11
    3 Chemical and Physical Properties
    Molecular Weight 684.7 g/mol
    Molecular Formula C22H21N8O8PS4
    XLogP32.3
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count17
    Rotatable Bond Count10
    Exact Mass684.01028135 g/mol
    Monoisotopic Mass684.01028135 g/mol
    Topological Polar Surface Area330 Ų
    Heavy Atom Count43
    Formal Charge0
    Complexity1210
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    4.2 ATC Code

    J01DI02

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

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    Jinan Tantu Chemicals

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    About the Company : Jinan Tantu Chemicals Co., Ltd. operates as a Contract Development and Manufacturing Organization (CDMO) that serves pharmaceutical companies worldwide. Our core services include c...

    Jinan Tantu Chemicals Co., Ltd. operates as a Contract Development and Manufacturing Organization (CDMO) that serves pharmaceutical companies worldwide. Our core services include customized R&D as well as the production of small molecule pharmaceutical intermediates and Active Pharmaceutical Ingredients (APIs) for both international and domestic pharmaceutical firms. Our capabilities span from laboratory-scale kilograms to commercial ton-scale production. Additionally, we are committed to independent research and development, as well as the production and sales of high-end pharmaceutical intermediates and API products.
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    Akums Lifesciences

    India
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    About the Company : Akums Lifescience Ltd. is a research-based, vertically integrated company specializing in the development, manufacturing and sale of APIs and intermediates. Akums has established i...

    Akums Lifescience Ltd. is a research-based, vertically integrated company specializing in the development, manufacturing and sale of APIs and intermediates. Akums has established itself as a leading generic medicine manufacturing company from India, with clients in over 51 countries. It has a facility dedicated to custom research and synthesis. Akums’ manufacturing facilities are spread across three locations in two Indian states. Its stringent policies and procedures ensure that that all regulatory requirements, environmental standards, and technological trends are met. Akums is EU-GMP, KFDA, WHO-GMP and PMDA certified.
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    Gencor

    U.S.A
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    Ceftaroline Fosamil

    About the Company : Our herbal ingredients have been clinically studied and shown effective in both animal and human clinical trials. Many of our clinical trials are peer-reviewed, double-blind contro...

    Our herbal ingredients have been clinically studied and shown effective in both animal and human clinical trials. Many of our clinical trials are peer-reviewed, double-blind controlled trials with impressive results. In addition to formal research tests, our ingredients go through rigorous scientific analysis with our state-of-the-art testing equipment under GLP-certified conditions. Gencor botanicals are grown under the close supervision of our technical team and according to strict quality-assurance processes. For instance, our herbs are always dried in the shade, so they maintain their phytochemical content.
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    Suzhou Ryway Biotech

    China
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    Suzhou Ryway Biotech

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    About the Company : Suzhou Ryway Biotech Co., Ltd. is located in Suzhou of Jiangsu Provice. It is a comprehensive enterprise integrated of product research, manufacturing, marketing and service. There...

    Suzhou Ryway Biotech Co., Ltd. is located in Suzhou of Jiangsu Provice. It is a comprehensive enterprise integrated of product research, manufacturing, marketing and service. There is strong technical strength, advanced testing method, precision manufacturing equipment. Main products are medical intermediate and fine chemicals. The product is popular among domestic users. In addition, they have been exported to Southeast Asia, Europe and America regions. Our operation tenet is “quality first, customer first”. We constantly improve our market competitiveness. We expect to cooperate with wide colleagues and create brilliance together.
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    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1645727400,"product":"CEFTAROLINE FOSAMIL BUFFERED WITH L-ARGI","address":"ORCHID TOWERS, 313, VALLUVAR KOTTAM HIGH ROAD, NUNGAMBAKKAM, Contact No","city":"CHENNAI","supplier":"ORCHID PHARMA LIMITED","supplierCountry":"INDIA","foreign_port":"VIENNA","customer":"FRESENIUS SE & CO. KGAA","customerCountry":"AUSTRIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"2","totalValueFC":"13.3","currency":"EUR","unitRateINR":200,"date":"25-Feb-2022","totalValueINR":"1000","totalValueInUsd":"13.3","indian_port":"BANGALORE AIR","hs_no":"29419090","bill_no":"8505520","productDescription":"API","marketType":"REGULATED MARKET","country":"AUSTRIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"ORCHID TOWERS, 313, VALLUVAR KOTTAM HIGH ROAD, NUNGAMBAKKAM, Contact No, CHENNAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1645727400,"product":"CEFTAROLINE FOSAMIL STERILE BATCH - 1225","address":"ORCHID TOWERS, 313, VALLUVAR KOTTAM HIGH ROAD, NUNGAMBAKKAM, Contact No","city":"CHENNAI","supplier":"ORCHID PHARMA LIMITED","supplierCountry":"INDIA","foreign_port":"LARNACA","customer":"MEDOCHEMIE LTD","customerCountry":"CYPRUS","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"0.2","totalValueFC":"0","currency":"USD","unitRateINR":"","date":"25-Feb-2022","totalValueINR":"0","totalValueInUsd":"0","indian_port":"BANGALORE AIR","hs_no":"29419090","bill_no":"8501354","productDescription":"API","marketType":"REGULATED MARKET","country":"CYPRUS","selfForZScoreResived":"Sterile","supplierPort":"BANGALORE AIR","supplierAddress":"ORCHID TOWERS, 313, VALLUVAR KOTTAM HIGH ROAD, NUNGAMBAKKAM, Contact No, CHENNAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1653676200,"product":"CEFTAROLINE FOSAMIL L ARGININE [STERILE]","address":"ORCHID TOWERS, 313, VALLUVAR KOTTAM HIGH ROAD, NUNGAMBAKKAM, Contact No","city":"CHENNAI","supplier":"ORCHID PHARMA LIMITED","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"M\/S. SOL INTERNATIONAL [PVT] LIMITE","customerCountry":"BANGLADESH","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"2","totalValueFC":"0","currency":"USD","unitRateINR":"","date":"28-May-2022","totalValueINR":"0","totalValueInUsd":"0","indian_port":"BANGALORE AIR","hs_no":"29419090","bill_no":"1718641","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Sterile","supplierPort":"BANGALORE AIR","supplierAddress":"ORCHID TOWERS, 313, VALLUVAR KOTTAM HIGH ROAD, NUNGAMBAKKAM, Contact No, CHENNAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1671042600,"product":"CEFTAROLINE FOSAMIL BUFFERED WITH L -ARG","address":"ORCHID TOWERS, 313, VALLUVAR KOTTAM HIGH ROAD, NUNGAMBAKKAM, CONTACT NO","city":"CHENNAI","supplier":"ORCHID PHARMA LIMITED","supplierCountry":"INDIA","foreign_port":"ATHENS","customer":"DEMO S.A.","customerCountry":"GREECE","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"21000","totalValueFC":"1905.2","currency":"USD","unitRateINR":1570000,"date":"15-Dec-2022","totalValueINR":"157000","totalValueInUsd":"1905.2","indian_port":"BANGALORE AIR","hs_no":"29419090","bill_no":"6174349","productDescription":"API","marketType":"REGULATED MARKET","country":"GREECE","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"ORCHID TOWERS, 313, VALLUVAR KOTTAM HIGH ROAD, NUNGAMBAKKAM, CONTACT NO, CHENNAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706725800,"product":"CEFTAROLINE FOSAMIL WITH L ARGININE STERILE BT NO.CFL0623049,CFL0623050 & CFL0623051 MFG DT:AUG 2023 EXP DT:DEC 2024","address":"SC0-99-100, SECTOR 17-B,","city":"CHANDIGARH.","supplier":"AKUMS LIFESCIENCES","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"BRAC BANK LIMITED.","customerCountry":"BANGLADESH","quantity":"1.50","actualQuantity":"1.5","unit":"KGS","unitRateFc":"17000","totalValueFC":"25216.1","currency":"USD","unitRateINR":1394850.3400000001,"date":"01-Feb-2024","totalValueINR":"2092275.51","totalValueInUsd":"25216.1","indian_port":"Delhi Air","hs_no":"29349990","bill_no":"7191951","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Sterile","supplierPort":"Delhi Air","supplierAddress":"SC0-99-100, SECTOR 17-B,, CHANDIGARH.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723228200,"product":"CEFTAROLINE FOSAMIL STERILE (FOR INJECTION) BATCH NO ,, CFL0524039 MFG: 03.2024 EXP: 02.2025","address":"305, THIRD FLOOR, C-BLOCK,MOHAN PL","city":"DELHI,DELHI","supplier":"PURE AND CURE HEALTHCARE PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"TO PRIME BANK PLC.,TRADE SERVICES","customerCountry":"BANGLADESH","quantity":"0.30","actualQuantity":"300","unit":"GMS","unitRateFc":"13.7","totalValueFC":"3964.2","currency":"USD","unitRateINR":1108.3590000000002,"date":"10-Aug-2024","totalValueINR":"332507.7","totalValueInUsd":"3964.2","indian_port":"Delhi Air","hs_no":"29349990","bill_no":"3108604","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Sterile","supplierPort":"Delhi Air","supplierAddress":"305, THIRD FLOOR, C-BLOCK,MOHAN PL, DELHI,DELHI","customerAddress":""},{"dataSource":"API Import","activeIngredients":"CEFTAROLINE FOSAMIL","year":"2021","qtr":"Q2","strtotime":1621881000,"product":"CEFTAROLINE FOSAMIL (LICENCE VALID UP TO 01.12.2023)","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"BAXTER HEALTHCARE CORPORATION","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"100","unit":"GMS","unitRateFc":"350","totalValueFC":"35406.5","currency":"USD","unitRateINR":"25935","date":"25-May-2021","totalValueINR":"2593500","totalValueInUsd":"35406.5","indian_port":"Biocon-SEZ","hs_no":"29419090","bill_no":"1007218","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"25212 W IL ROUTE 120 ROUND LAKE, IL 60073 UNITED STATES OF AMERICA","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"}]
    25-May-2021
    10-Aug-2024
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    Italy.png
    Ceftaroline Fosamil API needed in Italy [ENA18927]
    A pharmaceutical contract development and manufacturing organization that formulates solids, semi-solids, inhalation, liquid, injectable & ophthalmic medications is looking for suppliers of Ceftaroline Fosamil API for development purposes. The suppliers must support this enquiry with MSDS & CoA.
    19 Jan 2024

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    19 Jan 2024

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    19 Jan 2024

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    Ceftaroline Fosamil (25 g) API needed in India [ENA17865]
    A research-driven company that focuses on custom synthesis of pharmacopeial & non-pharmacopeial reference standards is looking for suppliers of Ceftaroline Fosamil (25 g) API for development purposes. The suppliers must support this enquiry with CoA.
    23 Aug 2023

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    23 Aug 2023

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    23 Aug 2023

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    Ceftaroline Fosamil API needed in Egypt [ENA15036]
    A company that deals in various pharmaceutical products is looking for suppliers of Ceftaroline Fosamil API for commercial purpose. The suppliers must support this enquiry with DMF, GMP & CoA.
    15 Sep 2022

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    15 Sep 2022

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    15 Sep 2022

    Egypt.png
    Ceftaroline Fosamil + L-Arginine API needed Egypt [ENA14782]
    A company operating in the pharmaceutical field for the development, manufacturing, marketing, distribution and export of a comprehensive array of branded and generic drugs is looking for suppliers of Ceftaroline Fosamil + L-Arginine API (blend) for both development & commercial purpose. The suppliers must support this enquiry with GMP & CoA.
    23 Aug 2022

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    23 Aug 2022

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    23 Aug 2022

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    Injectable Grade Ceftaroline Fosamil API needed in Bangladesh [ENA14011]
    An indenting company based in Bangladesh that deals in various pharmaceutical products is looking for suppliers of Injectable Grade Ceftaroline Fosamil API for commercial purpose. The suppliers must support this enquiry with CoA.
    18 Jun 2022

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    18 Jun 2022

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    18 Jun 2022

    Egypt.png
    Various APIs needed in Egypt [ENA12255]
    A company that deals in the distribution of various pharmaceutical products is looking for suppliers of Various APIs for parenteral formulations. The suppliers must support this enquiry with DMF, GMP & CoA. 1. Ceftaroline Fosamil API 2. Ceftazidime + Avibactam API
    29 Dec 2021

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    29 Dec 2021

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    29 Dec 2021

    Egypt.png
    Ceftaroline Fosamil (3 kg) API needed in Egypt [ENA11584]
    A company operating in the pharmaceutical field for development, manufacturing, marketing, distributing and exporting of a comprehensive array of branded and generic drugs is looking for suppliers of Ceftaroline Fosamil (3 kg) API for evaluation purpose. The suppliers must support this enquiry with GMP & CoA.
    07 Oct 2021

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    07 Oct 2021

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    07 Oct 2021

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    Ceftaroline Fosamil API needed in India [ENA09998]
    Well-Being Remedies, a company that deals in medicinal products is looking for suppliers of Ceftaroline Fosamil API. Interested suppliers can contact them via their email: rajeev.tembe@yahoo.in.
    19 Mar 2021

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    19 Mar 2021

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    19 Mar 2021

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    Various APIs needed in India [ENA09702]
    India’s single largest Contract Research and Manufacturing (CRAMS) organization is looking for suppliers of Various APIs for development purposes. The required quantity is MOQ for each. The suppliers must support this enquiry with CoA. 1. USP Grade Tigecycline API 2. Sterile & Lyophilized Micafungin Sodium API 3. Sterile Ceftaroline Fosamil API
    10 Feb 2021

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    10 Feb 2021

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    10 Feb 2021

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    Ceftaroline Fosamil (10 kg/ annum) API needed in India [ENA09403]
    A marketing company that deals in the formulations of various segments such as renal care, gastroenterology, neuropsychiatry, critical care & wound care is looking for suppliers of Ceftaroline Fosamil (10 kg/ annum) API for commercial manufacturing. The suppliers must support this enquiry with GMP.
    04 Jan 2021

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    04 Jan 2021

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