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Chemistry

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Also known as: Tomiron, 82547-81-7, Cefteram pivaloyloxymethyl ester, T 2588, T-2588, 0od86rt58c
Molecular Formula
C22H27N9O7S2
Molecular Weight
593.6  g/mol
InChI Key
UIYAXIPXULMHAI-JLGRZTKVSA-N
FDA UNII
0OD86RT58C

Cefteram Pivoxil
Cefteram Pivoxil is the pivalate ester prodrug of cefteram, a semi-synthetic, broad-spectrum, third-generation cephalosporin with antibacterial activity. After oral administration of cefteram pivoxil, the ester bond is cleaved, releasing active cefteram.
1 2D Structure

Cefteram Pivoxil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C22H27N9O7S2/c1-10-26-29-30(27-10)6-11-7-39-18-14(25-16(32)13(28-36-5)12-8-40-21(23)24-12)17(33)31(18)15(11)19(34)37-9-38-20(35)22(2,3)4/h8,14,18H,6-7,9H2,1-5H3,(H2,23,24)(H,25,32)/b28-13-/t14-,18-/m1/s1
2.1.3 InChI Key
UIYAXIPXULMHAI-JLGRZTKVSA-N
2.1.4 Canonical SMILES
CC1=NN(N=N1)CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)OCOC(=O)C(C)(C)C
2.1.5 Isomeric SMILES
CC1=NN(N=N1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)OCOC(=O)C(C)(C)C
2.2 Other Identifiers
2.2.1 UNII
0OD86RT58C
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ro 19-5248

2. Ro-19-5248

3. T 2588

4. T-2588

5. Tomiron

2.3.2 Depositor-Supplied Synonyms

1. Tomiron

2. 82547-81-7

3. Cefteram Pivaloyloxymethyl Ester

4. T 2588

5. T-2588

6. 0od86rt58c

7. 2,2-dimethylpropanoyloxymethyl (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

8. Ro-19-5248

9. Antibiotic T 2588

10. Tomiron (tn)

11. Unii-0od86rt58c

12. Brn 4223783

13. Cftm-pi

14. Starbld0016558

15. Cefteram Pivoxil (jp17)

16. Chembl3137676

17. Schembl22718900

18. Chebi:31381

19. Uiyaxipxulmhai-jlgrztkvsa-

20. Cefteram Pivoxil [mart.]

21. Cefteram Pivoxil [who-dd]

22. Dtxsid401316612

23. Act06271

24. Zinc3871962

25. S5354

26. Hy-106571

27. Cefteram Pivaloyloxymethyl Ester [mi]

28. Cs-0026074

29. D01686

30. 547c817

31. (7r)-7beta-[(2-aminothiazol-4-yl)(methoxyimino)acetylamino]-3-(5-methyl-2h-tetrazol-2-yl)methylcepham-3-ene-4-carboxylic Acid Pivaloyloxymethyl Ester

32. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((5-methyl-2h-tetrazol-2-yl)methyl)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r-(6-alpha,7-beta(z)))-

33. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl)amino)-3-((5-methyl-2h-tetrazol-2-yl)methyl)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r,7r)-

34. Pivaloyloxymethyl (z)-7-(2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido)-3-(5-methyl-2h-tetrazol-2-ylmethyl)-3-cephem-4-carboxylate

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 593.6 g/mol
Molecular Formula C22H27N9O7S2
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count15
Rotatable Bond Count12
Exact Mass593.14748658 g/mol
Monoisotopic Mass593.14748658 g/mol
Topological Polar Surface Area260 Ų
Heavy Atom Count40
Formal Charge0
Complexity1100
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


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ABOUT THIS PAGE

Cefteram Pivoxil Manufacturers

A Cefteram Pivoxil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefteram Pivoxil, including repackagers and relabelers. The FDA regulates Cefteram Pivoxil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefteram Pivoxil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cefteram Pivoxil manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cefteram Pivoxil Suppliers

A Cefteram Pivoxil supplier is an individual or a company that provides Cefteram Pivoxil active pharmaceutical ingredient (API) or Cefteram Pivoxil finished formulations upon request. The Cefteram Pivoxil suppliers may include Cefteram Pivoxil API manufacturers, exporters, distributors and traders.

click here to find a list of Cefteram Pivoxil suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cefteram Pivoxil JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Cefteram Pivoxil Drug Master File in Japan (Cefteram Pivoxil JDMF) empowers Cefteram Pivoxil API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Cefteram Pivoxil JDMF during the approval evaluation for pharmaceutical products. At the time of Cefteram Pivoxil JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Cefteram Pivoxil suppliers with JDMF on PharmaCompass.

Cefteram Pivoxil GMP

Cefteram Pivoxil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cefteram Pivoxil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefteram Pivoxil GMP manufacturer or Cefteram Pivoxil GMP API supplier for your needs.

Cefteram Pivoxil CoA

A Cefteram Pivoxil CoA (Certificate of Analysis) is a formal document that attests to Cefteram Pivoxil's compliance with Cefteram Pivoxil specifications and serves as a tool for batch-level quality control.

Cefteram Pivoxil CoA mostly includes findings from lab analyses of a specific batch. For each Cefteram Pivoxil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cefteram Pivoxil may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefteram Pivoxil EP), Cefteram Pivoxil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefteram Pivoxil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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