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Chemistry

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Also known as: 26973-24-0, Ceftezol, Ceftezolum, Ceftezole [inn], 2z86syp11w, (6r,7r)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Molecular Formula
C13H12N8O4S3
Molecular Weight
440.5  g/mol
InChI Key
DZMVCVMFETWNIU-LDYMZIIASA-N
FDA UNII
2Z86SYP11W

Ceftezole Sodium
Ceftezole is a semisynthetic first-generation cephalosporin with antibacterial activity. Ceftezole binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
1 2D Structure

Ceftezole Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(6R,7R)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
2.1.2 InChI
InChI=1S/C13H12N8O4S3/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)6(2-26-11(8)21)3-27-13-17-15-5-28-13/h4-5,8,11H,1-3H2,(H,16,22)(H,24,25)/t8-,11-/m1/s1
2.1.3 InChI Key
DZMVCVMFETWNIU-LDYMZIIASA-N
2.1.4 Canonical SMILES
C1C(=C(N2C(S1)C(C2=O)NC(=O)CN3C=NN=N3)C(=O)O)CSC4=NN=CS4
2.1.5 Isomeric SMILES
C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CN3C=NN=N3)C(=O)O)CSC4=NN=CS4
2.2 Other Identifiers
2.2.1 UNII
2Z86SYP11W
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ceftezol

2. Ceftezol, Sodium Salt

3. Ceftezole Sodium

4. Celoslin

5. Demethylcefazolin

6. Falomesin

2.3.2 Depositor-Supplied Synonyms

1. 26973-24-0

2. Ceftezol

3. Ceftezolum

4. Ceftezole [inn]

5. 2z86syp11w

6. (6r,7r)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

7. J01db12

8. Ceftezole (inn)

9. Demethylcefazolin

10. (6r,7r)-8-oxo-7-[(1h-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

11. Demethyl Cefazolin

12. (6r,7r)-8-oxo-7-(2-(1h-tetrazol-1-yl)acetamido)-3-((1,3,4-thiadiazol-2-ylthio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid

13. Cg-b 3 Q

14. Ncgc00182064-02

15. Ceftezol [inn-spanish]

16. Ceftezolum [inn-latin]

17. Unii-2z86syp11w

18. Ceftezole [mi]

19. Ceftezole [who-dd]

20. Mls006010107

21. Schembl147529

22. Chembl1697829

23. Dtxsid0022771

24. Chebi:135716

25. Bcp12070

26. Hy-n7095

27. Zinc3830473

28. Mfcd00274176

29. S5289

30. Akos037643294

31. Ccg-269124

32. Db13821

33. As-13011

34. Smr004701245

35. Cs-0077833

36. D07656

37. 973c240

38. A818761

39. J-016638

40. Q5057295

41. (6r,7r)-3-((1,3,4-thiadiazol-2-ylthio)methyl)-7-(2-(1h-tetrazol-1-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

42. (6r,7r)-8-oxo-7-[[1-oxo-2-(1-tetrazolyl)ethyl]amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

43. (6r,7r)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;ceftezole

44. (6r,7r)-8-oxo-7-[2-(1h-tetrazol-1-yl)acetamido]-3-[(1,3,4-thiadiazol-2-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

45. 7-[2-(1h-tetrazol-1-yl)acetamido]-3-[(1,3,4-thiadiazol-2-ylsulfanyl)methyl]-3,4-didehydrocepham-4-carboxylic Acid

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 440.5 g/mol
Molecular Formula C13H12N8O4S3
XLogP3-0.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count7
Exact Mass440.01436441 g/mol
Monoisotopic Mass440.01436441 g/mol
Topological Polar Surface Area235 Ų
Heavy Atom Count28
Formal Charge0
Complexity709
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


4.2 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DB - First-generation cephalosporins

J01DB12 - Ceftezole


ABOUT THIS PAGE

Ceftezole Sodium Manufacturers

A Ceftezole Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ceftezole Sodium, including repackagers and relabelers. The FDA regulates Ceftezole Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ceftezole Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ceftezole Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ceftezole Sodium Suppliers

A Ceftezole Sodium supplier is an individual or a company that provides Ceftezole Sodium active pharmaceutical ingredient (API) or Ceftezole Sodium finished formulations upon request. The Ceftezole Sodium suppliers may include Ceftezole Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Ceftezole Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ceftezole Sodium KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Ceftezole Sodium Drug Master File in Korea (Ceftezole Sodium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ceftezole Sodium. The MFDS reviews the Ceftezole Sodium KDMF as part of the drug registration process and uses the information provided in the Ceftezole Sodium KDMF to evaluate the safety and efficacy of the drug.

After submitting a Ceftezole Sodium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ceftezole Sodium API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Ceftezole Sodium suppliers with KDMF on PharmaCompass.

Ceftezole Sodium GMP

Ceftezole Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ceftezole Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ceftezole Sodium GMP manufacturer or Ceftezole Sodium GMP API supplier for your needs.

Ceftezole Sodium CoA

A Ceftezole Sodium CoA (Certificate of Analysis) is a formal document that attests to Ceftezole Sodium's compliance with Ceftezole Sodium specifications and serves as a tool for batch-level quality control.

Ceftezole Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Ceftezole Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ceftezole Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Ceftezole Sodium EP), Ceftezole Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ceftezole Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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