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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

65 API Suppliers, 28 USDMF, 19 CEP/COS, 12 JDMF, 7 EU WC, 25 KDMF, 4 NDC API, 26 Listed Suppliers, $ API Reference Price

65 API Suppliers
28 USDMF
19 CEP/COS
12 JDMF
7 EU WC
25 KDMF
4 NDC API
26 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

5 Drugs in Development

5 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

464 FDF Dossiers, 106 FDA Orange Book, 166 Europe, 13 Canada, 5 Australia, 59 South Africa, 115 Listed Dossiers

464 FDF Dossiers
106 FDA Orange Book
166 Europe
13 Canada
5 Australia
59 South Africa
115 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Actylis, 4 Roquette

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1 Actylis
4 Roquette

EXCIPIENTS BY APPLICATIONS

3 Parenteral, 2 Fillers, Diluents & Binders

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3 Parenteral
2 Fillers, Diluents & Binders

DIGITAL CONTENT

4 DATA COMPILATION #PharmaFlow, 29 NEWS #PharmaBuzz

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4 DATA COMPILATION #PharmaFlow
29 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 143 Finished Drug Prices, 9 Annual Reports

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1 US Medicaid Prescriptions
143 Finished Drug Prices
9 Annual Reports

MARKET PLACE

61 APIs, 63 FDF Dossiers

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61 APIs
63 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 8 Others

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2 EDQM
2 USP
8 Others

ANALYTICAL

1 Analytical Methods

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1 Analytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

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JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

MARKET PLACE

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464

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106

FDA Orange Book

166

Europe

Canada

Australia

South Africa

115

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REF. STANDARDS OR IMPURITIES

EDQM

USP

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PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

832,559

Annual Reports (USD Million)

2,274

Finished Drug Prices

5EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Ceftriaxone sodium, Ceftriaxone, 74578-69-1, 104376-79-6, Ro-139904, Ceftriaxone sodium salt

Molecular Formula

C₁₈H₁₇N₈NaO₇S₃

Molecular Weight

576.6 g/mol

InChI Key

YOBPSXOHCHDCMU-VKZZUTNHSA-M

A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.

1 2D Structure

Ceftriaxone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.1.2 InChI

InChI=1S/C18H18N8O7S3.Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);/q;+1/p-1/b24-8-;/t9-,15-;/m1./s1

2.1.3 InChI Key

YOBPSXOHCHDCMU-VKZZUTNHSA-M

2.1.4 Canonical SMILES

CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+]

2.1.5 Isomeric SMILES

CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Anhydrous Ceftriaxone Sodium

2. Benaxona

3. Cefatriaxone

4. Cefaxona

5. Ceftrex

6. Ceftriaxon

7. Ceftriaxon Curamed

8. Ceftriaxon Hexal

9. Ceftriaxona Andreu

10. Ceftriaxona Ldp Torlan

11. Ceftriaxone

12. Ceftriaxone Irex

13. Ceftriaxone Sodium

14. Ceftriaxone Sodium, Anhydrous

15. Ceftriaxone, Disodium Salt

16. Ceftriaxone, Disodium Salt, Hemiheptahydrate

17. Lendacin

18. Longacef

19. Longaceph

20. Ro 13 9904

21. Ro 13-9904

22. Ro 139904

23. Ro-13-9904

24. Ro13 9904

25. Ro13-9904

26. Ro139904

27. Rocefalin

28. Rocefin

29. Rocephin

30. Rocephine

31. Tacex

32. Terbac

2.2.2 Depositor-Supplied Synonyms

1. Ceftriaxone Sodium

2. Ceftriaxone

3. 74578-69-1

4. 104376-79-6

5. Ro-139904

6. Ceftriaxone Sodium Salt

7. Octx

8. Ceftriaxone Sodium Trihydrate

9. Schembl537013

10. Chembl1200995

11. Mfcd00941454

12. Akos015961150

13. Ac-1851

14. Disodium;(6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

15. Sodium (6r,7r)-7-((e)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

16. Sodium;(6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1h-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.3 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₇N₈NaO₇S₃
Molecular Weight	576.6 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	8
Exact Mass	576.02800271 g/mol
Monoisotopic Mass	576.02800271 g/mol
Topological Polar Surface Area	291 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	1120
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Rocephin
PubMed Health	Ceftriaxone (Injection)
Drug Classes	Antibiotic
Drug Label	Rocephin is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-t...
Active Ingredient	Ceftriaxone sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 500mg base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Hoffmann La Roche

2 of 2
Drug Name	Rocephin
PubMed Health	Ceftriaxone (Injection)
Drug Classes	Antibiotic
Drug Label	Rocephin is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-t...
Active Ingredient	Ceftriaxone sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 500mg base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Hoffmann La Roche

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]

5.3 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DD - Third-generation cephalosporins

J01DD04 - Ceftriaxone

API SUPPLIERS

01

Faran Shimi Pharmaceutical

Iran

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFlorida Conference

Not Confirmed

Faran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

Contact Supplier

Iran

Virtual Booth

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Corporate PDF

02

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI India 2024

Booth #2.D38

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU, ASMF

AUDIT

03

Sterile India Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFlorida Conference

Not Confirmed

04

ACS DOBFAR SPA

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFlorida Conference

Not Confirmed

05

ACS DOBFAR SPA

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFlorida Conference

Not Confirmed

06

Sinopharm Weiqida Pharmaceutical C...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFlorida Conference

Not Confirmed

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South Korea

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JDMF

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KDMF

VMF Others AUDIT

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Website

Corporate PDF

09

ACS DOBFAR SPA

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFlorida Conference

Not Confirmed

10

Sinopharm Weiqida Pharmaceutical C...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFlorida Conference

Not Confirmed

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USDMF

01

Acs Dobfar Spa

Italy

Fi Europe 2024

Not Confirmed

02

Acs Dobfar Spa

Italy

Fi Europe 2024

Not Confirmed

03

Aurobindo Pharma Ltd

India

India

Fi Europe 2024

Not Confirmed

09

Sandoz Gmbh

Switzerland

Fi Europe 2024

Not Confirmed

10

Sandoz Gmbh

Switzerland

Fi Europe 2024

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CEP/COS

01

ACS DOBFAR S.P.A. Tribiano IT

Italy

Fi Europe 2024

Not Confirmed

02

AUROBINDO PHARMA LIMITED Hyderabad ...

India

South Korea

Fi Europe 2024

Not Confirmed

06

KOPRAN LIMITED Mumbai IN

India

Switzerland

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Listed Suppliers

01

Faran Shimi Pharmaceutical

Iran

American Pharma Summit

Not Confirmed

Faran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

Contact Supplier

Iran

Virtual Booth

Digital Content

Ceftriaxone Sodium

About the Company : Faran Shimi Pharmaceutical Company, established in 2001 and affiliated with Golrang Pharmaceutical Investment Co, manufactures high-quality Active Pharmaceutical Ingredients (APIs)...

Faran Shimi Pharmaceutical Company, established in 2001 and affiliated with Golrang Pharmaceutical Investment Co, manufactures high-quality Active Pharmaceutical Ingredients (APIs) and finished dosage forms. For the past three years, the company focused on extracting alkaloid opiates, controlled substances, and narcotics. The APIs are widely used by major pharmaceutical companies nationwide and exported to the Middle East. All production adheres to local GMP standards in an SOP-driven environment with modern systems and utilities, ensuring the highest quality and safety.

Corporate PDF

02

HRV Global Life Sciences

India

CPhI India 2024

Booth #2.D38

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

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About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

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10

Qilu Pharmaceutical

China

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API Reference Price

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