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ACTIVE PHARMA INGREDIENTS

66 API Suppliers, 28 USDMF, 19 CEP/COS, 12 JDMF, 7 EU WC, 26 KDMF, 4 NDC API, 26 Listed Suppliers, $ API Reference Price

66 API Suppliers
28 USDMF
19 CEP/COS
12 JDMF
7 EU WC
26 KDMF
4 NDC API
26 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

5 Drugs in Development

5 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

463 FDF Dossiers, 106 FDA Orange Book, 166 Europe, 13 Canada, 5 Australia, 59 South Africa, 114 Listed Dossiers

463 FDF Dossiers
106 FDA Orange Book
166 Europe
13 Canada
5 Australia
59 South Africa
114 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Actylis, 4 Roquette

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1 Actylis
4 Roquette

EXCIPIENTS BY APPLICATIONS

3 Parenteral, 2 Fillers, Diluents & Binders

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3 Parenteral
2 Fillers, Diluents & Binders

DIGITAL CONTENT

4 DATA COMPILATION #PharmaFlow, 29 NEWS #PharmaBuzz

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4 DATA COMPILATION #PharmaFlow
29 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 143 Finished Drug Prices, 9 Annual Reports

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1 US Medicaid Prescriptions
143 Finished Drug Prices
9 Annual Reports

MARKET PLACE

61 APIs, 63 FDF Dossiers

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61 APIs
63 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 8 Others

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2 EDQM
2 USP
8 Others

ANALYTICAL

1 Analytical Methods

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1 Analytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

463

FDF Dossiers

106

FDA Orange Book

166

Europe

Canada

Australia

South Africa

114

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

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DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

832,559

Annual Reports (USD Million)

2,274

Finished Drug Prices

5EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Ceftriaxone sodium, Ceftriaxone, 74578-69-1, 104376-79-6, Ro-139904, Ceftriaxone sodium salt

Molecular Formula

C₁₈H₁₇N₈NaO₇S₃

Molecular Weight

576.6 g/mol

InChI Key

YOBPSXOHCHDCMU-VKZZUTNHSA-M

A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.

1 2D Structure

Ceftriaxone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.1.2 InChI

InChI=1S/C18H18N8O7S3.Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);/q;+1/p-1/b24-8-;/t9-,15-;/m1./s1

2.1.3 InChI Key

YOBPSXOHCHDCMU-VKZZUTNHSA-M

2.1.4 Canonical SMILES

CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+]

2.1.5 Isomeric SMILES

CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Anhydrous Ceftriaxone Sodium

2. Benaxona

3. Cefatriaxone

4. Cefaxona

5. Ceftrex

6. Ceftriaxon

7. Ceftriaxon Curamed

8. Ceftriaxon Hexal

9. Ceftriaxona Andreu

10. Ceftriaxona Ldp Torlan

11. Ceftriaxone

12. Ceftriaxone Irex

13. Ceftriaxone Sodium

14. Ceftriaxone Sodium, Anhydrous

15. Ceftriaxone, Disodium Salt

16. Ceftriaxone, Disodium Salt, Hemiheptahydrate

17. Lendacin

18. Longacef

19. Longaceph

20. Ro 13 9904

21. Ro 13-9904

22. Ro 139904

23. Ro-13-9904

24. Ro13 9904

25. Ro13-9904

26. Ro139904

27. Rocefalin

28. Rocefin

29. Rocephin

30. Rocephine

31. Tacex

32. Terbac

2.2.2 Depositor-Supplied Synonyms

1. Ceftriaxone Sodium

2. Ceftriaxone

3. 74578-69-1

4. 104376-79-6

5. Ro-139904

6. Ceftriaxone Sodium Salt

7. Octx

8. Ceftriaxone Sodium Trihydrate

9. Schembl537013

10. Chembl1200995

11. Mfcd00941454

12. Akos015961150

13. Ac-1851

14. Disodium;(6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

15. Sodium (6r,7r)-7-((e)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

16. Sodium;(6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1h-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.3 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₇N₈NaO₇S₃
Molecular Weight	576.6 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	8
Exact Mass	576.02800271 g/mol
Monoisotopic Mass	576.02800271 g/mol
Topological Polar Surface Area	291 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	1120
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Rocephin
PubMed Health	Ceftriaxone (Injection)
Drug Classes	Antibiotic
Drug Label	Rocephin is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-t...
Active Ingredient	Ceftriaxone sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 500mg base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Hoffmann La Roche

2 of 2
Drug Name	Rocephin
PubMed Health	Ceftriaxone (Injection)
Drug Classes	Antibiotic
Drug Label	Rocephin is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-t...
Active Ingredient	Ceftriaxone sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 500mg base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Hoffmann La Roche

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]

5.3 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DD - Third-generation cephalosporins

J01DD04 - Ceftriaxone

API SUPPLIERS

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USDMF

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CEP/COS

01

ACS DOBFAR S.P.A. Tribiano IT

Italy

ASC 2024

Not Confirmed

02

AUROBINDO PHARMA LIMITED Hyderabad ...

India

ASC 2024

Not Confirmed

03

CJ Corp. Seoul

South Korea

ASC 2024

Not Confirmed

04

F Hoffmann-La Roche Ltd. Basel CH

Switzerland

ASC 2024

Not Confirmed

05

HANMI FINE CHEMICAL CO., LTD. Shihu...

South Korea

ASC 2024

Not Confirmed

06

KOPRAN LIMITED Mumbai IN

India

ASC 2024

Not Confirmed

07

Kukje Pharmaceutical Ind Co Ltd Seo...

South Korea

ASC 2024

Not Confirmed

08

Ribbon S.r.l. Milano IT

Italy

ASC 2024

Not Confirmed

09

SANDOZ GMBH Kundl AT

Switzerland

ASC 2024

Not Confirmed

10

SANDOZ GMBH Kundl AT

Switzerland

ASC 2024

Not Confirmed

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JDMF

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EU WC

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KDMF

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NDC API

01

ACS Dobfar Spa

Italy

Discovery on Target

Not Confirmed

02

ACS Dobfar S.p.A

Italy

Discovery on Target

Not Confirmed

03

Kyongbo Pharmaceutical Co., Ltd

South Korea

Discovery on Target

Not Confirmed

04

Qilu Antibiotics Pharmaceutical Co....

China

Discovery on Target

Not Confirmed

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Listed Suppliers

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API Reference Price

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LTD","customerCountry":"INDIA","quantity":"935.36","actualQuantity":"935.364","unit":"KGS","unitRateFc":"62","totalValueFC":"58664.2","currency":"USD","unitRateINR":"5260.7","date":"24-Aug-2024","totalValueINR":"4920669.55","totalValueInUsd":"58664.2","indian_port":"JNPT","hs_no":"29419090","bill_no":"5230245","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non-sterile","supplierPort":"SHANGHAI","supplierAddress":"NO.6 EAST SHUIJING ROAD, SUQIAO INDUTRIAL PARK, SUQIAO TOWN,YONGFU COUNTRY , CHINA, CHINA CHINA","customerAddress":"1705, 4TH FLOOR, ONKAR BHAWAN"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724437800,"product":"CEFTRIAXONE SODIUM (NON-STERILE)IP","address":"8-3-677\/18, S.K.D.NAGAR","city":"HYDERABAD.AP","supplier":"HENAN KANGDA PHARMACEUTICAL CO.,LTD","supplierCountry":"CHINA","foreign_port":"TIANJIN","customer":"VIRCHOW GROUP","customerCountry":"INDIA","quantity":"2600.00","actualQuantity":"2600","unit":"KGS","unitRateFc":"68","totalValueFC":"178847.6","currency":"USD","unitRateINR":"5769.8","date":"24-Aug-2024","totalValueINR":"15001480","totalValueInUsd":"178847.6","indian_port":"Madras Sea","hs_no":"29419090","bill_no":"5218030","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non-sterile","supplierPort":"TIANJIN","supplierAddress":"NO.66 JINGWU ROAD,XIANGCHENG CITY,HENAM PROVINCE, CHINA","customerAddress":"8-3-677\/18, S.K.D.NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724437800,"product":"CEFTRIAXONE SODIUM NON-STERILE I.P (INV NO:YMQN20240703SR14-3)","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"LIZHU PHARMACEUTICAL TRADING ","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"8682.00","actualQuantity":"8682","unit":"KGS","unitRateFc":"68","totalValueFC":"597213.6","currency":"USD","unitRateINR":"5769.8","date":"24-Aug-2024","totalValueINR":"50093403.6","totalValueInUsd":"597213.6","indian_port":"Madras Sea","hs_no":"29419090","bill_no":"5222823","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non-sterile","supplierPort":"QINGDAO","supplierAddress":"ROOM 513 515-517 FLOOR 5 ADMIN BUILDING LIVZON INDUSTRIAL PARK NO 38CHUANGYE N ORTH RD JINWAN GUANGDONG CHINA","customerAddress":"PLOT NO.2, MAITRIVIHAR,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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All Manufacturers, Suppliers, Distributors and Exporters of Ceftriaxone Sodium with approved in Europe Marketing Authorisations (MA) of Finished Dosage Form listed on PharmaCompass.com

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5EXCIPIENTS BY APPLICATIONS

R1-CEP 2003-169 - Rev 01

Valid

Chemical

2011-02-18

991

01

R1-CEP 2005-189 - Rev 00

Withdrawn by Holder

Chemical

2013-10-09

2014-02-06

991

02

R0-CEP 2001-087 - Rev 01

Expired

Chemical

2004-07-29

2007-04-30

991

03