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Chemistry

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Also known as: Sodium cefuroxime, Zinacef, Cefuroxime sodium salt, Biociclin, 56238-63-2, Anaptivan
Molecular Formula
C16H15N4NaO8S
Molecular Weight
446.4  g/mol
InChI Key
URDOHUPGIOGTKV-JTBFTWTJSA-M
FDA UNII
R8A7M9MY61

Cefuroxime Sodium
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
1 2D Structure

Cefuroxime Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;(6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C16H16N4O8S.Na/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20;/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24);/q;+1/p-1/b19-9-;/t10-,14-;/m1./s1
2.1.3 InChI Key
URDOHUPGIOGTKV-JTBFTWTJSA-M
2.1.4 Canonical SMILES
CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)[O-].[Na+]
2.1.5 Isomeric SMILES
CO/N=C(/C1=CC=CO1)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
R8A7M9MY61
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cefuroxime

2. Cephuroxime

3. Ketocef

4. Zinacef

2.3.2 Depositor-Supplied Synonyms

1. Sodium Cefuroxime

2. Zinacef

3. Cefuroxime Sodium Salt

4. Biociclin

5. 56238-63-2

6. Anaptivan

7. Kefurox

8. Cefuroxime (sodium)

9. Cefumax

10. Cefurex

11. Medoxim

12. Kesint

13. Chebi:3517

14. R8a7m9my61

15. Colifossim

16. Sodium (6r,7r)-7-(2-(2-furyl)glyoxylamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate, 7(sup 2)-(z)-(o-methyloxime), Carbamate (ester)

17. Spectrazolr

18. Bioxima

19. Cefofix

20. Curoxim

21. Curoxima

22. Curoxime

23. Furoxil

24. Ketocef

25. Ultroxim

26. Cefuroxim Hexal

27. Cefuroxim Lilly

28. Cefuroxima Fabra

29. Cefuroxim Aj

30. Cefuroxim Mn

31. Cefuroxim Curasan

32. Cefuroxima Richet

33. Cetroxil [inj.]

34. Cefuroxim Fresenius

35. Cefuroxim Genericsn

36. Froxal [inj.]

37. Sharox [inj.]

38. Zinnat [inj.]

39. Cetroxil

40. Froxal

41. Cefuroxim Norcox

42. Cefuroxim Norcox [inj.]

43. Cefuroxime Na

44. Kefurox In Plastic Container

45. Zinacef In Plastic Container

46. Zinacef (tn)

47. Einecs 260-073-1

48. Cefuroxime And Dextrose In Duplex Container

49. Unii-r8a7m9my61

50. Mls000069576

51. Cefuroxime Sodium [usp:ban:jan]

52. Cefuroxime For Injection And Dextrose For Injection In Duplex Container

53. Sodium;(6r,7r)-3-(carbamoyloxymethyl)-7-[[(2z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

54. Ks-1040

55. Smr000058808

56. Mls001332625

57. Mls001332626

58. Sodium (6r-(6alpha,7beta(z)))-3-(((aminocarbonyl)oxy)methyl)-7-(2-furyl(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

59. Cefuroxime Sodium (jan/usp)

60. Schembl719536

61. Cefuroxime Sodium [jan]

62. Chembl2146124

63. Cefuroxime Sodium [vandf]

64. Cefuroxime Sodium [mart.]

65. Dtxsid201015616

66. Hms2097o21

67. Hms3714o21

68. Cefuroxime Sodium [usp-rs]

69. Cefuroxime Sodium [who-dd]

70. Cefuroxime Sodium Salt [mi]

71. Hy-b1256

72. Mfcd09878727

73. S4620

74. Akos015961772

75. Ccg-220720

76. Cefuroxime Sodium [ep Impurity]

77. Cefuroxime Sodium [orange Book]

78. Cs-4733

79. Nsc 758166

80. Cefuroxime Sodium [ep Monograph]

81. Cefuroxime Sodium [usp Impurity]

82. Cefuroxime Sodium [usp Monograph]

83. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)acetyl)amino)-8-oxo-, Monosodium Salt (6r-(6alpha,7beta(z)))-

84. Ac-15028

85. C08108

86. D00915

87. Cefuroxime Sodium 100 Microg/ml In Acetonitrile/water

88. Cefuroxime Sodium 100 Microg/ml In Acetonitrile:water

89. Cefuroxime Sodium, European Pharmacopoeia (ep) Reference Standard

90. Cefuroxime Sodium, United States Pharmacopeia (usp) Reference Standard

91. (6r,7r)-3-(carbamoyloxymethyl)-7-[[(2z)-2-(2-furyl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

92. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)acetyl)amino)-8-oxo-, Monosodium Salt (6r-(6.alpha.,7.beta.(z)))-

93. Sodium (6r,7r)-3-(carbamoyloxymethyl)-7-((e)-2-(furan-2-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 446.4 g/mol
Molecular Formula C16H15N4NaO8S
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass446.05082891 g/mol
Monoisotopic Mass446.05082891 g/mol
Topological Polar Surface Area202 Ų
Heavy Atom Count30
Formal Charge0
Complexity804
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameCefuroxime and dextrose in duplex container
Active IngredientCefuroxime sodium
Dosage FormInjectable
RouteInjection
Strengtheq 750mg base/vial; eq 1.5gm base/vial
Market StatusPrescription
CompanyB Braun

2 of 6  
Drug NameCefuroxime sodium
Active IngredientCefuroxime sodium
Dosage FormInjectable
RouteIntramuscular, intravenous; Im-iv; Injection
Strengtheq 750mg base/vial; eq 7.5gm base/vial; eq 1.5gm base/vial
Market StatusPrescription
CompanyTeva Pharms; Hospira; Steri Pharma; Hikma Farmaceutica

3 of 6  
Drug NameZinacef in plastic container
Drug LabelCefuroxime is a sterile semisynthetic, broad-spectrum, cephalosporin antibiotic for parenteral administration. It is the sodium salt of (6R, 7R)-3-carbamoyloxymethyl-7-[Z-2-methoxyimino-2-(fur-2-yl)acetamido]ceph-3-em-4-carboxylate, and it has the fo...
Active IngredientCefuroxime sodium
Dosage FormInjectable
RouteInjection
Strengtheq 30mg base/ml
Market StatusPrescription
CompanyCovis Injectables

4 of 6  
Drug NameCefuroxime and dextrose in duplex container
Active IngredientCefuroxime sodium
Dosage FormInjectable
RouteInjection
Strengtheq 750mg base/vial; eq 1.5gm base/vial
Market StatusPrescription
CompanyB Braun

5 of 6  
Drug NameCefuroxime sodium
Active IngredientCefuroxime sodium
Dosage FormInjectable
RouteIntramuscular, intravenous; Im-iv; Injection
Strengtheq 750mg base/vial; eq 7.5gm base/vial; eq 1.5gm base/vial
Market StatusPrescription
CompanyTeva Pharms; Hospira; Steri Pharma; Hikma Farmaceutica

6 of 6  
Drug NameZinacef in plastic container
Drug LabelCefuroxime is a sterile semisynthetic, broad-spectrum, cephalosporin antibiotic for parenteral administration. It is the sodium salt of (6R, 7R)-3-carbamoyloxymethyl-7-[Z-2-methoxyimino-2-(fur-2-yl)acetamido]ceph-3-em-4-carboxylate, and it has the fo...
Active IngredientCefuroxime sodium
Dosage FormInjectable
RouteInjection
Strengtheq 30mg base/ml
Market StatusPrescription
CompanyCovis Injectables

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]

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05-Jan-2021
14-Nov-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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USFDA APPLICATION NUMBER - 50558

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USFDA APPLICATION NUMBER - 50558

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DOSAGE - INJECTABLE;INJECTION - EQ 30MG BASE/...DOSAGE - INJECTABLE;INJECTION - EQ 30MG BASE/ML

USFDA APPLICATION NUMBER - 50643

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ABOUT THIS PAGE

Cefuroxime Sodium Manufacturers

A Cefuroxime Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefuroxime Sodium, including repackagers and relabelers. The FDA regulates Cefuroxime Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefuroxime Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cefuroxime Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cefuroxime Sodium Suppliers

A Cefuroxime Sodium supplier is an individual or a company that provides Cefuroxime Sodium active pharmaceutical ingredient (API) or Cefuroxime Sodium finished formulations upon request. The Cefuroxime Sodium suppliers may include Cefuroxime Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Cefuroxime Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cefuroxime Sodium USDMF

A Cefuroxime Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Cefuroxime Sodium active pharmaceutical ingredient (API) in detail. Different forms of Cefuroxime Sodium DMFs exist exist since differing nations have different regulations, such as Cefuroxime Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Cefuroxime Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Cefuroxime Sodium USDMF includes data on Cefuroxime Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cefuroxime Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Cefuroxime Sodium suppliers with USDMF on PharmaCompass.

Cefuroxime Sodium KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Cefuroxime Sodium Drug Master File in Korea (Cefuroxime Sodium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Cefuroxime Sodium. The MFDS reviews the Cefuroxime Sodium KDMF as part of the drug registration process and uses the information provided in the Cefuroxime Sodium KDMF to evaluate the safety and efficacy of the drug.

After submitting a Cefuroxime Sodium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Cefuroxime Sodium API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Cefuroxime Sodium suppliers with KDMF on PharmaCompass.

Cefuroxime Sodium CEP

A Cefuroxime Sodium CEP of the European Pharmacopoeia monograph is often referred to as a Cefuroxime Sodium Certificate of Suitability (COS). The purpose of a Cefuroxime Sodium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Cefuroxime Sodium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Cefuroxime Sodium to their clients by showing that a Cefuroxime Sodium CEP has been issued for it. The manufacturer submits a Cefuroxime Sodium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Cefuroxime Sodium CEP holder for the record. Additionally, the data presented in the Cefuroxime Sodium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Cefuroxime Sodium DMF.

A Cefuroxime Sodium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Cefuroxime Sodium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Cefuroxime Sodium suppliers with CEP (COS) on PharmaCompass.

Cefuroxime Sodium WC

A Cefuroxime Sodium written confirmation (Cefuroxime Sodium WC) is an official document issued by a regulatory agency to a Cefuroxime Sodium manufacturer, verifying that the manufacturing facility of a Cefuroxime Sodium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Cefuroxime Sodium APIs or Cefuroxime Sodium finished pharmaceutical products to another nation, regulatory agencies frequently require a Cefuroxime Sodium WC (written confirmation) as part of the regulatory process.

click here to find a list of Cefuroxime Sodium suppliers with Written Confirmation (WC) on PharmaCompass.

Cefuroxime Sodium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Cefuroxime Sodium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Cefuroxime Sodium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Cefuroxime Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Cefuroxime Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Cefuroxime Sodium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Cefuroxime Sodium suppliers with NDC on PharmaCompass.

Cefuroxime Sodium GMP

Cefuroxime Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cefuroxime Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefuroxime Sodium GMP manufacturer or Cefuroxime Sodium GMP API supplier for your needs.

Cefuroxime Sodium CoA

A Cefuroxime Sodium CoA (Certificate of Analysis) is a formal document that attests to Cefuroxime Sodium's compliance with Cefuroxime Sodium specifications and serves as a tool for batch-level quality control.

Cefuroxime Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Cefuroxime Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cefuroxime Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefuroxime Sodium EP), Cefuroxime Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefuroxime Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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