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Chemistry

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Also known as: 65243-33-6, Cefetamet pivoxyl, Globocef, Cefyl, Cefetamet pivaloyloxymethyl ester, F6xa85n260
Molecular Formula
C20H25N5O7S2
Molecular Weight
511.6  g/mol
InChI Key
DASYMCLQENWCJG-XUKDPADISA-N
FDA UNII
F6XA85N260

Cefyl
Cefetamet Pivoxil is the pivalate ester prodrug form of cefetamet, a semi-synthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. After oral administration of cefetamet pivoxil, the ester bond is cleaved, releasing active cefetamet.
1 2D Structure

Cefyl

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C20H25N5O7S2/c1-9-6-33-16-12(23-14(26)11(24-30-5)10-7-34-19(21)22-10)15(27)25(16)13(9)17(28)31-8-32-18(29)20(2,3)4/h7,12,16H,6,8H2,1-5H3,(H2,21,22)(H,23,26)/b24-11-/t12-,16-/m1/s1
2.1.3 InChI Key
DASYMCLQENWCJG-XUKDPADISA-N
2.1.4 Canonical SMILES
CC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)OCOC(=O)C(C)(C)C
2.1.5 Isomeric SMILES
CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)OCOC(=O)C(C)(C)C
2.2 Other Identifiers
2.2.1 UNII
F6XA85N260
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 7-(2 (2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-desacetoxyceph-3-em-4-carboxylic Acid Pivaloyloxymethyl Ester

2. Cefetamet Pivaloyloxymethyl Ester

3. Cefetamet Pivoxyl

4. Ro 15-8075

5. Ro-15-8075

2.3.2 Depositor-Supplied Synonyms

1. 65243-33-6

2. Cefetamet Pivoxyl

3. Globocef

4. Cefyl

5. Cefetamet Pivaloyloxymethyl Ester

6. F6xa85n260

7. 2,2-dimethylpropanoyloxymethyl (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

8. 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid,7-[[(2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r,7r)-

9. Unii-f6xa85n260

10. Cefatamet Pivoxil

11. Ncgc00181788-01

12. Schembl74256

13. Cefatamet Pivoxil [mi]

14. Chembl4303443

15. Dasymclqenwcjg-xukdpadisa-

16. Dtxsid40110016

17. Chebi:135812

18. Cefetamet Pivoxil [who-dd]

19. Zinc34027229

20. Cefditoren Impurity 3, Cefetamet Pivoxil

21. Ro-15-8075

22. 7-(2 (2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-desacetoxyceph-3-em-4-carboxylic Acid Pivaloyloxymethyl Ester

23. 243c336

24. (7r)-7beta-[(2-aminothiazol-4-yl)(methoxyimino)acetylamino]-3-methylcepham-3-ene-4-carboxylic Acid Pivaloyloxymethyl Ester

25. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-methyl-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r-(6.alpha.,7.beta.(z)))-

26. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-methyl-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r-(6alpha,7beta(z)))-

27. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-methyl-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r,7r)-

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 511.6 g/mol
Molecular Formula C20H25N5O7S2
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count10
Exact Mass511.11954050 g/mol
Monoisotopic Mass511.11954050 g/mol
Topological Polar Surface Area216 Ų
Heavy Atom Count34
Formal Charge0
Complexity933
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


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ABOUT THIS PAGE

Cefyl Manufacturers

A Cefyl manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefyl, including repackagers and relabelers. The FDA regulates Cefyl manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefyl API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cefyl Suppliers

A Cefyl supplier is an individual or a company that provides Cefyl active pharmaceutical ingredient (API) or Cefyl finished formulations upon request. The Cefyl suppliers may include Cefyl API manufacturers, exporters, distributors and traders.

Cefyl GMP

Cefyl Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cefyl GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefyl GMP manufacturer or Cefyl GMP API supplier for your needs.

Cefyl CoA

A Cefyl CoA (Certificate of Analysis) is a formal document that attests to Cefyl's compliance with Cefyl specifications and serves as a tool for batch-level quality control.

Cefyl CoA mostly includes findings from lab analyses of a specific batch. For each Cefyl CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cefyl may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefyl EP), Cefyl JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefyl USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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