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Chemistry

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Also known as: 75975-70-1, Cephradine hydrate, Cephradine (monohydrate), Fuc0d71izn, (6r,7r)-7-[[(2r)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate, Cefradine monohydrate
Molecular Formula
C16H21N3O5S
Molecular Weight
367.4  g/mol
InChI Key
VHNPSPMQGXQSET-CYJZLJNKSA-N
FDA UNII
FUC0D71IZN

Cephradine Monohydrate
Cephradine Monohydrate is the monohydrate form of cephradine, a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephradine monohydrate binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
1 2D Structure

Cephradine Monohydrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(6R,7R)-7-[[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate
2.1.2 InChI
InChI=1S/C16H19N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15-;/m1./s1
2.1.3 InChI Key
VHNPSPMQGXQSET-CYJZLJNKSA-N
2.1.4 Canonical SMILES
CC1=C(N2C(C(C2=O)NC(=O)C(C3=CCC=CC3)N)SC1)C(=O)O.O
2.1.5 Isomeric SMILES
CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CCC=CC3)N)SC1)C(=O)O.O
2.2 Other Identifiers
2.2.1 UNII
FUC0D71IZN
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 75975-70-1

2. Cephradine Hydrate

3. Cephradine (monohydrate)

4. Fuc0d71izn

5. (6r,7r)-7-[[(2r)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrate

6. Cefradine Monohydrate

7. 31828-50-9

8. Unii-fuc0d71izn

9. Cephradinemonohydrate

10. Schembl956675

11. Chembl4303427

12. Dtxsid00860560

13. Cephradine Monohydrate [mi]

14. S5296

15. Akos025310716

16. Cefradine Monohydrate [who-dd]

17. Ccg-268254

18. Hy-128449

19. Cs-0099494

20. Q27278208

21. (6r,7r)-7-((r)-2-amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid Monohydrate

2.4 Create Date
2007-12-05
3 Chemical and Physical Properties
Molecular Weight 367.4 g/mol
Molecular Formula C16H21N3O5S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass367.12019195 g/mol
Monoisotopic Mass367.12019195 g/mol
Topological Polar Surface Area139 Ų
Heavy Atom Count25
Formal Charge0
Complexity697
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

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ABOUT THIS PAGE

Cephradine Monohydrate Manufacturers

A Cephradine Monohydrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cephradine Monohydrate, including repackagers and relabelers. The FDA regulates Cephradine Monohydrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cephradine Monohydrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cephradine Monohydrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cephradine Monohydrate Suppliers

A Cephradine Monohydrate supplier is an individual or a company that provides Cephradine Monohydrate active pharmaceutical ingredient (API) or Cephradine Monohydrate finished formulations upon request. The Cephradine Monohydrate suppliers may include Cephradine Monohydrate API manufacturers, exporters, distributors and traders.

click here to find a list of Cephradine Monohydrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cephradine Monohydrate GMP

Cephradine Monohydrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cephradine Monohydrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cephradine Monohydrate GMP manufacturer or Cephradine Monohydrate GMP API supplier for your needs.

Cephradine Monohydrate CoA

A Cephradine Monohydrate CoA (Certificate of Analysis) is a formal document that attests to Cephradine Monohydrate's compliance with Cephradine Monohydrate specifications and serves as a tool for batch-level quality control.

Cephradine Monohydrate CoA mostly includes findings from lab analyses of a specific batch. For each Cephradine Monohydrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cephradine Monohydrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Cephradine Monohydrate EP), Cephradine Monohydrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cephradine Monohydrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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