Find Cerivastatin manufacturers, exporters & distributors on PharmaCompass

Cerivastatin

Cerivastatin

Synopsis, Chemistry

DOSSIERs // Finished Dosage Formulations

6 Dossiers, 6 FDA Orange Book

PATENTS

8 Health Canada Patents

8 Health Canada Patents

DIGITAL CONTENT

1 News

1 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

EU WC

Listed Suppliers

API REF. PRICE (USD / KG)

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Baycol, Rivastatin, 143201-11-0, Lipobay, Bay w 6228, Certa

Molecular Formula

C₂₆H₃₃FNNaO₅

Molecular Weight

481.5 g/mol

InChI Key

GPUADMRJQVPIAS-QCVDVZFFSA-M

FDA UNII

6Q18G1060S

Cerivastatin Sodium is the sodium salt of cerivastatin, a synthetic lipid-lowering agent.

1 2D Structure

Cerivastatin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate

2.1.2 InChI

InChI=1S/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1

2.1.3 InChI Key

GPUADMRJQVPIAS-QCVDVZFFSA-M

2.1.4 Canonical SMILES

CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)C=CC(CC(CC(=O)[O-])O)O.[Na+]

2.1.5 Isomeric SMILES

CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)/C=C/[C@H](C[C@H](CC(=O)[O-])O)O.[Na+]

2.2 Other Identifiers

2.2.1 UNII

6Q18G1060S

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 6-heptenoic Acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, Monosodium Salt, (s-(r*,s*-(e)))-

2. 7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyrid-3-yl)-3,5-dihydroxy-6-heptenoate Sodium Salt

3. Bay W 6228

4. Baycol

5. Cerivastatin

6. Certa

7. Kazak

8. Lipobay

9. Rivastatin

2.3.2 Depositor-Supplied Synonyms

1. Baycol

2. Rivastatin

3. 143201-11-0

4. Lipobay

5. Bay W 6228

6. Certa

7. Cerivastatin Sodium [usan]

8. Cerivastatin, Sodium Salt

9. Bay-w-6228

10. Cerivastatin Na

11. Cerivastatin Sodium Salt

12. Cpd000469148

13. Chebi:3559

14. (+)-sodium (3r,5s,6e)-7-(4-(p-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoate

15. 143201-11-0 (sodium)

16. 6q18g1060s

17. Cerivastatin (sodium)

18. Dsstox_cid_26488

19. Dsstox_rid_81659

20. Dsstox_gsid_46488

21. 6-heptanoic Acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-(s-(r*,s*-(e)))-, Sodium Salt

22. Sodium (3r,5s,e)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoate

23. Cas-143201-11-0

24. Ncgc00164625-02

25. Cerivastatinsodium

26. Unii-6q18g1060s

27. Baycol (tn)

28. 7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyrid-3-yl)-3,5-dihydroxy-6-heptenoate Sodium Salt

29. Bayw6228

30. Schembl41887

31. Schembl41888

32. 6-heptenoic Acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, Monosodium Salt, (s-(r*,s*-(e)))-

33. Mls001424071

34. Chembl1200563

35. Dtxsid0046488

36. Cerivastatin Sodium (jan/usan)

37. Cerivastatin Sodium [jan]

38. Hms2051h13

39. Cerivastatin Sodium [vandf]

40. Cerivastatin Sodium [mart.]

41. Tox21_112244

42. Tox21_303882

43. Cerivastatin Sodium [who-dd]

44. Cerivastatin Sodium Salt [mi]

45. Akos015967306

46. Akos025149364

47. Tox21_112244_1

48. Ccg-100954

49. Nc00204

50. Cerivastatin Sodium [orange Book]

51. Ncgc00164625-04

52. Ncgc00357289-01

53. (3r,5s,6e)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic Acid Sodium Salt

54. 6-heptenoic Acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, Monosodium Salt, (3r,5s,6e)-

55. Smr000469148

56. Hy-109523

57. Cs-0031250

58. D00889

59. A808034

60. J-007766

61. Q27106131

62. Sodium (3r,5s,6e)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate

63. Sodium (e,3r,5s)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoate

64. Sodium (e,3r,5s)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-bis(oxidanyl)hept-6-enoate

65. Sodium;(e,3r,5s)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₃₃FNNaO₅
Molecular Weight	481.5 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Exact Mass	481.22404560 g/mol
Monoisotopic Mass	481.22404560 g/mol
Topological Polar Surface Area	103 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	626
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Compounds that inhibit HYDROXYMETHYLGLUTARYL COA REDUCTASES. They have been shown to directly lower CHOLESTEROL synthesis. (See all compounds classified as Hydroxymethylglutaryl-CoA Reductase Inhibitors.)