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1. Caerulein
2. Cerulein
3. Ceruletid
4. Fi 6934
5. Fi-6934
6. Fi6934
7. Takus
1. Caerulein
2. 17650-98-5
3. Cerulein
4. Ceruletida
5. Ceruletidum
6. 5-oxo-l-prolyl-l-glutaminyl-l-alpha-aspartyl-o-sulfo-l-tyrosyl-l-threonylglycyl-l-tryptophyl-l-methionyl-l-alpha-aspartyl-l-phenylalaninamide
7. Fi-6934
8. 5-oxo-l-prolyl-l-glutaminyl-l-aspartyl-l-tyrosyl-l-threonylglycyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-l-alaninamide 4-(hydrogen Sulfate) (ester)
9. Chebi:59219
10. 888y08971b
11. Ceruletidum [inn-latin]
12. Ceruletida [inn-spanish]
13. Ceruletide [usan:inn:ban]
14. 5-oxo-l-prolyl-l-glutaminyl-l-a-aspartyl-o-sulfo-l-tyrosyl-l-threonylglycyl-l-tryptophyl-l-methionyl-l-a-aspartyl-l-phenylalaninamide
15. Ccris 3063
16. Ceruletide (usan/inn)
17. Unii-888y08971b
18. Caerulein, Sulfated
19. Fi-6934caerulein
20. Ceruletide [mi]
21. Ceruletide [inn]
22. Ceruletide [usan]
23. Ceruletide [mart.]
24. Ceruletide [who-dd]
25. Schembl29520
26. Gtpl7589
27. Chembl1201355
28. Dtxsid8040434
29. Hy-a0190
30. Pyr-qd-tyr(so3h)-tgwmdf-nh2
31. Mfcd00076478
32. Cs-5876
33. Db00403
34. As-56061
35. C73362
36. D03442
37. Q5065299
38. Pglu-gln-asp-tyr(so3h)-thr-gly-trp-met-asp-phe-nh2
39. (3s)-3-{[(1s)-1-carbamoyl-2-phenylethyl]carbamoyl}-3-[(2s)-2-[(2s)-2-{2-[(2s,3r)-2-[(2s)-2-[(2s)-2-[(2s)-4-carbamoyl-2-{[(2s)-5-oxopyrrolidin-2-yl]formamido}butanamido]-3-carboxypropanamido]-3-[4-(sulfooxy)phenyl]propanamido]-3-hydroxybutanamido]acetamido}-3-(1h-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]propanoic Acid
40. 5-oxo-l-prolyl-l-glutaminyl-l-a-aspartyl-o-sulfo-l-tyrosyl-l-threonylglycyl-l-tryptophyl-l-methionyl-l-.alpha.-aspartyl-l-phenylalaninamide
| Molecular Weight | 1352.4 g/mol |
|---|---|
| Molecular Formula | C58H73N13O21S2 |
| XLogP3 | -3 |
| Hydrogen Bond Donor Count | 17 |
| Hydrogen Bond Acceptor Count | 22 |
| Rotatable Bond Count | 38 |
| Exact Mass | 1351.44853874 g/mol |
| Monoisotopic Mass | 1351.44853874 g/mol |
| Topological Polar Surface Area | 585 Ų |
| Heavy Atom Count | 94 |
| Formal Charge | 0 |
| Complexity | 2840 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 10 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Caerulein is used in the treatment of paralytic ileus and as diagnostic aid in pancreatic malfunction.
Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin that stimulates gastric, biliary, and pancreatic secretion. It also exerts stimulatory actions on certain smooth muscles.
V - Various
V04 - Diagnostic agents
V04C - Other diagnostic agents
V04CC - Tests for bile duct patency
V04CC04 - Ceruletide
Absorption
Absorbed following intravenous administration.
Caerulein acts according to its similarity to the natural gastrointestinal peptide hormone cholecystokinin. Cholecystokinin is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin is secreted by the duodenum, the first segment of the small intestine. There it binds to CCK receptors, activating them and causing downstream effects. Specifically, it results in the release of digestive enzymes and bile from the pancreas and gall bladder, respectively. It also acts as a hunger suppresant. Cholecystokinin is secreted by the duodenum when fat- or protein-rich chyme leaves the stomach and enters the duodenum. The hormone acts on the pancreas to stimulate the secretion of the enzymes lipase, amylase, trypsin, and chymotrypsin. Together these pancreatic enzymes catalyze the digestion of fat and protein. Cholecystokinin also stimulates both the contraction of the gall bladder, and the relaxtion of the Sphincter of Oddi (Glisson's Sphinctor), which delivers, (not secretes) bile into the small intestine. Bile salts serve to emulsify fats, thereby increasing the effectiveness with which enzymes can digest them.
REF. STANDARDS & IMPURITIES
ABOUT THIS PAGE
A Ceruletide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ceruletide, including repackagers and relabelers. The FDA regulates Ceruletide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ceruletide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Ceruletide supplier is an individual or a company that provides Ceruletide active pharmaceutical ingredient (API) or Ceruletide finished formulations upon request. The Ceruletide suppliers may include Ceruletide API manufacturers, exporters, distributors and traders.
click here to find a list of Ceruletide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Ceruletide DMF (Drug Master File) is a document detailing the whole manufacturing process of Ceruletide active pharmaceutical ingredient (API) in detail. Different forms of Ceruletide DMFs exist exist since differing nations have different regulations, such as Ceruletide USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Ceruletide DMF submitted to regulatory agencies in the US is known as a USDMF. Ceruletide USDMF includes data on Ceruletide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ceruletide USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Ceruletide suppliers with USDMF on PharmaCompass.
Ceruletide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Ceruletide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ceruletide GMP manufacturer or Ceruletide GMP API supplier for your needs.
A Ceruletide CoA (Certificate of Analysis) is a formal document that attests to Ceruletide's compliance with Ceruletide specifications and serves as a tool for batch-level quality control.
Ceruletide CoA mostly includes findings from lab analyses of a specific batch. For each Ceruletide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Ceruletide may be tested according to a variety of international standards, such as European Pharmacopoeia (Ceruletide EP), Ceruletide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ceruletide USP).
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