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Chemistry

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Also known as: 7647-17-8, Caesium chloride, Cesium monochloride, Cscl, Cesium chloride (cscl), Cesiumchloride
Molecular Formula
ClCs
Molecular Weight
168.36  g/mol
InChI Key
AIYUHDOJVYHVIT-UHFFFAOYSA-M
FDA UNII
GNR9HML8BA

Cesium Chloride
1 2D Structure

Cesium Chloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
cesium;chloride
2.1.2 InChI
InChI=1S/ClH.Cs/h1H;/q;+1/p-1
2.1.3 InChI Key
AIYUHDOJVYHVIT-UHFFFAOYSA-M
2.1.4 Canonical SMILES
[Cl-].[Cs+]
2.2 Other Identifiers
2.2.1 UNII
GNR9HML8BA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cesium Chloride, 133cs-labeled

2. Cesium Chloride, 137cs-labeled

3. Cesium Chloride, 35cl-labeled

4. Cscl

2.3.2 Depositor-Supplied Synonyms

1. 7647-17-8

2. Caesium Chloride

3. Cesium Monochloride

4. Cscl

5. Cesium Chloride (cscl)

6. Cesiumchloride

7. Tricesium Trichloride

8. Cesium;chloride

9. Caesium Monochloride

10. Mfcd00010955

11. Gnr9hml8ba

12. Dicesium Dichloride

13. Cesium Monochloride; Nsc 15198

14. Nsc-15198

15. Cesium Chloride, Ultra Dry

16. Hsdb 7149

17. Unii-gnr9hml8ba

18. Einecs 231-600-2

19. Nsc 15198

20. Cesium(i) Chloride

21. Caesium(i) Chloride

22. Cesium Chloride, Ultrapure

23. Wln: Cs G

24. Ec 231-600-2

25. Cesium Chloride [mi]

26. Cesium Chloride, 99.99%

27. Cesium Chloride, >=99.8%

28. Cesium Chloride [hsdb]

29. Cesium Chloride (99.9%-cs)

30. Chembl4460016

31. Dtxsid3040435

32. Chebi:63039

33. Cesium Chloride [who-dd]

34. Cesium Chloride, P.a., 99.8%

35. Nsc15198

36. S3642

37. Cesium Chloride, Grade Ii, >=98%

38. Akos015902586

39. Akos024438091

40. Akos024458317

41. Ccg-266351

42. Cesium Chloride, Grade I, >=99.0%

43. Cesium Chloride, Cabot High-purity Grade

44. Sy009912

45. Cesium Chloride, Reagentplus(r), 99.9%

46. Hy-107754

47. Cesium Chloride, 99.99% Trace Metals Basis

48. Cesium Chloride, Puriss. P.a., >=99.5%

49. Cs-0029480

50. Ft-0623572

51. Cesium Chloride, Bioultra, >=99.0% (at)

52. Cesium Chloride, Trace Metals Grade, 99.9%

53. Cesium Chloride, For Molecular Biology, >=98%

54. F20343

55. Cesium Chloride, >=99.999% Trace Metals Basis

56. Cesium Chloride, Bioxtra, >=99.5% (titration)

57. Cesium Chloride, Ultrapure Grade, 99.99%, P.a.

58. Cesium Chloride, Vetec(tm) Reagent Grade, >=99%

59. Q296694

60. Cesium Chloride, Optical Grade, >=99.5% Trace Metals Basis

61. Cesium Chloride, Bioultra, For Molecular Biology, >=99.5% (at)

62. Cesium Chloride, Anhydrous, Beads, -10 Mesh, 99.999% Trace Metals Basis

63. Cesium Chloride, For Molecular Biology, >=99% (silver Nitrate Titration)

64. Cesium Chloride, Anhydrous, Free-flowing, Redi-dri(tm), Reagentplus(r), 99.9%

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 168.36 g/mol
Molecular Formula ClCs
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass167.8743047 g/mol
Monoisotopic Mass167.8743047 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count2
Formal Charge0
Complexity2
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 Absorption, Distribution and Excretion

Real and simulated particulate fallout solutions of 134CsCl were fed to 102 healthy volunteers. An average of 3% of the radioactivity of week-old fallout was absorbed: the range was 0-9%.

Leroy GV et al; Health Physics 13 (4): 449-473 (1966)


Data were obtained for the distribution-excretion pattern of 137Cs in guinea pigs over a period of 100 days after administration by three different routes. Three groups of twenty guinea pigs were used. Solutions of cesium chloride containing 137Cs as a tracer were administered to the animals by inhalation, by ingestion and by i.p. injection. Urine and feces were collected daily until sacrifice, and the time-tissue distribution patterns were determined after death. All measurements were made by gamma counting with a NaI (Tl) detector. Since cesium chloride is extremely soluble, it was absorbed rapidly from the lungs, the digestive tract and the abdominal cavity. After the first day, the skeletal muscle had the largest concentration of 137Cs. Its retention in muscle may be approximated by a single exponential function with an average biological half-life of 10 days. Concentration in other tissues did not differ significantly from that in the muscle. The 137Cs concentration in total excretion followed an exponential pattern with a rapidly and a slowly decreasing component. The average urine-to-feces ratio was 2.8. More than 95 per cent was excreted within 32 days; at this time, approximately 65 per cent of the remaining radioactivity was located in the skeletal muscle.

PMID:5879911 Stara JF; Health Physics 11(11): 1195-1202 (1965)


Absorption of CsCl, SrCl2, BaCl2 and CeCl3 deposited on nasal membranes directly into the general circulation was studied in Syrian hamsters and compared with gastrointestinal tract absorption. More than 50 % of the cesium, strontium and barium was absorbed directly from the nasal membranes but <4 % of the cerium. For all isotopes, nasal absorption was approximately = or >gastrointestinal absorption during the first 4 hr after administration. This study emphasized the importance of direct nasal absorption of deposited materials in inhalation toxicity evaluations especially with readily soluble aerosols having mass median aerodynamic diameters >5 m when nasopharyngeal deposition predominates.

PMID:4785408 Cuddihy RG, Ozog JA; Health Physics 25 (3): 219-224 (1973)


4.2 Mechanism of Action

... potassium channel blocker ... capable of producing early after-depolarizations (EADs) and polymorphic ventricular tachyarrhythmias resembling torsades de pointes.

PMID:9786077 Satoh T, Zipes DP; J Cardiovasc Electrophysiol 9: 970-5 (1998)


Cesium ions block potassium channels in biological membranes in a voltage dependent manner. For example, external cesium blocks inward current with little or no effect on outward current. Consequently, it produces a characteristic N-shaped current-voltage relationship. /Cesium ions/

PMID:6325824 Clay JR, Shlesinger MF; J Theor Biol 107 (2): 189-201 (1984)


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ABOUT THIS PAGE

Cesium Chloride Manufacturers

A Cesium Chloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cesium Chloride, including repackagers and relabelers. The FDA regulates Cesium Chloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cesium Chloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cesium Chloride Suppliers

A Cesium Chloride supplier is an individual or a company that provides Cesium Chloride active pharmaceutical ingredient (API) or Cesium Chloride finished formulations upon request. The Cesium Chloride suppliers may include Cesium Chloride API manufacturers, exporters, distributors and traders.

Cesium Chloride GMP

Cesium Chloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cesium Chloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cesium Chloride GMP manufacturer or Cesium Chloride GMP API supplier for your needs.

Cesium Chloride CoA

A Cesium Chloride CoA (Certificate of Analysis) is a formal document that attests to Cesium Chloride's compliance with Cesium Chloride specifications and serves as a tool for batch-level quality control.

Cesium Chloride CoA mostly includes findings from lab analyses of a specific batch. For each Cesium Chloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cesium Chloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Cesium Chloride EP), Cesium Chloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cesium Chloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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