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    Chemistry

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    Also known as: Cetirizine dihydrochloride, 83881-52-1, Zyrtec, Reactine, Cetirizine dihcl, Cetrine
    Molecular Formula
    C21H27Cl3N2O3
    Molecular Weight
    461.8  g/mol
    InChI Key
    PGLIUCLTXOYQMV-UHFFFAOYSA-N
    FDA UNII
    64O047KTOA
    Cetirizine Dihydrochloride
    A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
    1 2D Structure

    Cetirizine Dihydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride
    2.1.2 InChI
    InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
    2.1.3 InChI Key
    PGLIUCLTXOYQMV-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    64O047KTOA
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic Acid

    2. Alerlisin

    3. Aller-tec

    4. Cetalerg

    5. Ceterifug

    6. Ceti Tad

    7. Ceti-puren

    8. Cetiderm

    9. Cetidura

    10. Cetil Von Ct

    11. Cetilich

    12. Cetirigamma

    13. Cetirizin Al

    14. Cetirizin Azu

    15. Cetirizin Basics

    16. Cetirizine

    17. Cetirizine Dihydrochloride

    18. Cetirlan

    19. Dihydrochloride, Cetirizine

    20. P 071

    21. P-071

    22. P071

    23. Reactine

    24. Virlix

    25. Voltric

    26. Zetir

    27. Zirtek

    28. Zyrtec

    2.3.2 Depositor-Supplied Synonyms

    1. Cetirizine Dihydrochloride

    2. 83881-52-1

    3. Zyrtec

    4. Reactine

    5. Cetirizine Dihcl

    6. Cetrine

    7. 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic Acid Dihydrochloride

    8. Alerlisin

    9. Cetirizine Hcl

    10. Virlix

    11. P 071

    12. Zirtek

    13. P-071

    14. Zerviate

    15. Cetirizine (dihydrochloride)

    16. 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic Acid;dihydrochloride

    17. 83881-52-1 (hcl)

    18. 64o047ktoa

    19. Nsc-759102

    20. Cetirigamma

    21. Alercet

    22. Alergex

    23. Alertisin

    24. Cetalerg

    25. Ceterifug

    26. Cetidura

    27. Cetirlan

    28. Cetriler

    29. Cetzine

    30. Formistin

    31. Ressital

    32. Salvalerg

    33. Setiral

    34. Stopaler

    35. Voltric

    36. Zyrzine

    37. Alerid

    38. Riztec

    39. Virdos

    40. Zirtin

    41. Cezin

    42. Ryzen

    43. Zetir

    44. Cetilich

    45. Triz

    46. Cetirizin Basics

    47. Xero-sed

    48. Ceti-puren

    49. Cetil Von Ct

    50. Cetirizin Azu

    51. Children's Zyrtec

    52. (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic Acid Dihydrochloride

    53. [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride

    54. Dsstox_cid_24268

    55. Dsstox_rid_80138

    56. Dsstox_gsid_44268

    57. Ceti Tad

    58. Alleroff

    59. Allergy Relief

    60. Apo-cetirizine

    61. Zyrtec Allergy

    62. Zyrtec Hives Relief

    63. Cetirizine Hydrochloride [usan]

    64. Ucb-p 071

    65. Topcare All Day Allergy

    66. Sun Mark All Day Allergy

    67. Children's Zyrtec Allergy

    68. Unii-64o047ktoa

    69. Cetirizine Hydrochloride Hives

    70. Cetirizine Di

    71. Children's Zyrtec Hives Relief

    72. Sr-01000688282

    73. Cetirizine Hydrochloride Allergy

    74. Cetirizine 2hcl

    75. Up And Up All Day Allergy Relief

    76. Prestwick_841

    77. Cetirizine Hydrochloride [usan:usp]

    78. Xyzal Dihydrochloride

    79. Zyrtec (tn)

    80. Quzyttir

    81. 774596-22-4

    82. Ox-nla

    83. Children's Cetirizine Hydrochloride Allergy

    84. Ncgc00016949-01

    85. Cetirizine-d8 Hydrochloride

    86. Cas-83881-52-1

    87. Children's Cetirizine Hydrochloride Hives Relief

    88. (+-)-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)acetic Acid, Dihydrochloride

    89. Schembl41107

    90. Spectrum1505371

    91. Chebi:3562

    92. Ucb P071

    93. Cetirizine Hydrochloride (1:2)

    94. Chembl1607273

    95. Dtxsid2044268

    96. Hms1569f07

    97. Hms1922h04

    98. Bcp09018

    99. Tox21_110704

    100. Tox21_302261

    101. Tox21_500362

    102. Hy-17042a

    103. Mfcd00941428

    104. S1291

    105. Cetirizine Hydrochloride (jp17/usp)

    106. Cetirizine Hydrochloride [jan]

    107. Akos000280979

    108. Akos016340521

    109. Tox21_110704_1

    110. Ac-1600

    111. Ccg-213404

    112. Cetirizine Dihydrochloride [mi]

    113. Cs-1798

    114. Ks-1042

    115. Lp00362

    116. Nsc 759102

    117. Cetirizine Hydrochloride [mart.]

    118. Cetirizine Hydrochloride [vandf]

    119. Cetirizine Hydrochloride [usp-rs]

    120. Cetirizine Hydrochloride [who-dd]

    121. Ncgc00095180-01

    122. Ncgc00095180-02

    123. Ncgc00255965-01

    124. Ncgc00261047-01

    125. Ncgc00263567-01

    126. Acetic Acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, Dihydrochloride, (+-)-

    127. Bc164297

    128. Cetirizine Dihydrochloride, >=98% (hplc)

    129. Db-056756

    130. (r)-cetirizine Dihcl (levocetirizine Dihcl)

    131. Ft-0603000

    132. Ft-0631130

    133. Ft-0664487

    134. Sw196972-3

    135. Cetirizin Dihydrochloride, >=98.0% (hplc)

    136. Cetirizine Hydrochloride [orange Book]

    137. Cetirizine Hydrochloride [usp Monograph]

    138. D00664

    139. F20462

    140. Cetirizine Dihydrochloride [ep Monograph]

    141. 881c510

    142. A840675

    143. Zyrtec-d Component Cetirizine Hydrochloride

    144. Sr-01000688282-3

    145. Cetirizine Hydrochloride Component Of Zyrtec-d

    146. Q27263769

    147. Cetirizine Dihydrochloride 1.0 Mg/ml In Water (as Free Base)

    148. Cetirizine Dihydrochloride, European Pharmacopoeia (ep) Reference Standard

    149. Cetirizine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

    150. (rs)-{2-[4-(alpha-phenyl-p-chlorobenzyl)-piperazin-1-yl]ethoxy}-acetic Acid Dihydrochloride

    151. [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]aceticaciddihydrochloride

    152. 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic Acid 2hcl

    153. 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)aceticaciddihydrochloride

    154. Cetirizine Dihydrochloride, United States Pharmacopeia (usp) Reference Standard

    155. Cetirizine For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    156. Cetirizine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    157. (+) {2-[4-(alpha-phenyl-p-chlorobenzyl)-piperazine-1-yl] -ethoxy}-acetic Acid Dihydrochloride

    158. (+/-)-(2-(4-(p-chloro-a-phenylbenzyl)-1-piperazinyl)ethoxy)acetic Acid, Dihydrochloride

    159. (+/-){2-[4-(alpha-phenyl-p-chlorobenzyl)-piperazin-1-yl]-ethoxy}-acetic Acid Dihydrochloride

    160. (rs)-{2-[4-(alpha-phenyl-p-chlorobenzyl)-piperazin-1-yl]ethoxy }-acetic Acid Dihydrochloride

    161. 2-(2-(4-(p-chloro-alpha-phenylbenzyl)1-piperazinyl)ethoxy) Acetic Acid Dihydrochloride

    162. 2-(2-{4-[(4-chlorophenyl)(phenyl)-methyl]piperazino}ethoxy)acetic Acid Dihydrochloride;cetirizine Dihydrochloride

    163. Acetic Acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, Dihydrochloride, (+/-)-

    164. Acetic Acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, Hydrochloride (1:2)

    165. Cetirizine Dihydrochloride Solution, 1.0 Mg/ml In Acetonitrile: Water (9:1) (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.3.3 Other Synonyms

    1. Cetirizin Dihydrochloride

    2. Cetirizine Hcl

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 461.8 g/mol
    Molecular Formula C21H27Cl3N2O3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count8
    Exact Mass460.108726 g/mol
    Monoisotopic Mass460.108726 g/mol
    Topological Polar Surface Area53 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity443
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 20  
    Drug NameCetirizine hydrochloride
    Drug LabelCetirizine hydrochloride is an orally active and selective H1-receptor antagonist. The chemical name is () - [2- [4- [ (4-chlorophenyl) phenylmethyl]- 1 - piperazinyl] ethoxy] acetic acid, dihydrochloride. Cetirizine hydrochloride is a racemic comp...
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength5mg/5ml
    Market StatusPrescription
    CompanyPerrigo R And D; Amneal Pharms; Wockhardt; Silarx; Teva Pharms; Caraco; Breckenridge Pharm; Bio Pharm; Vintage; Taro

    2 of 20  
    Drug NameCetirizine hydrochloride allergy
    Active IngredientCetirizine hydrochloride
    Dosage FormTablet; Capsule; Tablet, chewable
    RouteOral
    Strength5mg; 10mg
    Market StatusOver the Counter
    CompanyPerrigo R And D; Wockhardt; Ranbaxy; Amneal Pharms Ny; Ipca Labs; Unichem; Apotex; Contract Pharmacal; Sun Pharm Inds; Taro; Torrent Pharms; Cadista Pharms; Dr Reddys Labs; Sandoz; Unique Pharm Labs; Banner Pharmacaps; Cipla; Orchid Hlthcare; Mylan

    3 of 20  
    Drug NameCetirizine hydrochloride hives
    Active IngredientCetirizine hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusOver the Counter
    CompanyPerrigo R And D; Ranbaxy; Ipca Labs; Unichem; Sun Pharm Inds; Cadista Pharms; Dr Reddys Labs; Unique Pharm Labs; Orchid Hlthcare; Mylan

    4 of 20  
    Drug NameChildren's cetirizine hydrochloride allergy
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup; Tablet, chewable
    RouteOral
    Strength5mg; 10mg; 5mg/5ml
    Market StatusOver the Counter
    CompanyPerrigo R And D; Amneal Pharms; Silarx; Cypress Pharm; Caraco; Bio Pharm; Aurobindo Pharma; Taro; Sun Pharma Global; Tris Pharma

    5 of 20  
    Drug NameChildren's cetirizine hydrochloride hives relief
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup; Tablet, chewable
    RouteOral
    Strength5mg; 10mg; 5mg/5ml
    Market StatusOver the Counter
    CompanyPerrigo R And D; Amneal Pharms; Silarx; Cypress Pharm; Caraco; Bio Pharm; Aurobindo Pharma; Taro; Sun Pharma Global; Tris Pharma

    6 of 20  
    Drug NameChildren's zyrtec allergy
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength5mg/5ml
    Market StatusOver the Counter
    CompanyMcneil Consumer

    7 of 20  
    Drug NameChildren's zyrtec hives relief
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength5mg/5ml
    Market StatusOver the Counter
    CompanyMcneil Consumer

    8 of 20  
    Drug NameZyrtec
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength5mg/5ml
    Market StatusPrescription
    CompanyMcneil Consumer

    9 of 20  
    Drug NameZyrtec allergy
    Active IngredientCetirizine hydrochloride
    Dosage FormTablet; Tablet, orally disintegrating
    RouteOral
    Strength5mg; 10mg
    Market StatusOver the Counter
    CompanyMcneil Consumer

    10 of 20  
    Drug NameZyrtec hives relief
    Active IngredientCetirizine hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusOver the Counter
    CompanyMcneil Consumer

    11 of 20  
    Drug NameCetirizine hydrochloride
    Drug LabelCetirizine hydrochloride is an orally active and selective H1-receptor antagonist. The chemical name is () - [2- [4- [ (4-chlorophenyl) phenylmethyl]- 1 - piperazinyl] ethoxy] acetic acid, dihydrochloride. Cetirizine hydrochloride is a racemic comp...
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength5mg/5ml
    Market StatusPrescription
    CompanyPerrigo R And D; Amneal Pharms; Wockhardt; Silarx; Teva Pharms; Caraco; Breckenridge Pharm; Bio Pharm; Vintage; Taro

    12 of 20  
    Drug NameCetirizine hydrochloride allergy
    Active IngredientCetirizine hydrochloride
    Dosage FormTablet; Capsule; Tablet, chewable
    RouteOral
    Strength5mg; 10mg
    Market StatusOver the Counter
    CompanyPerrigo R And D; Wockhardt; Ranbaxy; Amneal Pharms Ny; Ipca Labs; Unichem; Apotex; Contract Pharmacal; Sun Pharm Inds; Taro; Torrent Pharms; Cadista Pharms; Dr Reddys Labs; Sandoz; Unique Pharm Labs; Banner Pharmacaps; Cipla; Orchid Hlthcare; Mylan

    13 of 20  
    Drug NameCetirizine hydrochloride hives
    Active IngredientCetirizine hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusOver the Counter
    CompanyPerrigo R And D; Ranbaxy; Ipca Labs; Unichem; Sun Pharm Inds; Cadista Pharms; Dr Reddys Labs; Unique Pharm Labs; Orchid Hlthcare; Mylan

    14 of 20  
    Drug NameChildren's cetirizine hydrochloride allergy
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup; Tablet, chewable
    RouteOral
    Strength5mg; 10mg; 5mg/5ml
    Market StatusOver the Counter
    CompanyPerrigo R And D; Amneal Pharms; Silarx; Cypress Pharm; Caraco; Bio Pharm; Aurobindo Pharma; Taro; Sun Pharma Global; Tris Pharma

    15 of 20  
    Drug NameChildren's cetirizine hydrochloride hives relief
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup; Tablet, chewable
    RouteOral
    Strength5mg; 10mg; 5mg/5ml
    Market StatusOver the Counter
    CompanyPerrigo R And D; Amneal Pharms; Silarx; Cypress Pharm; Caraco; Bio Pharm; Aurobindo Pharma; Taro; Sun Pharma Global; Tris Pharma

    16 of 20  
    Drug NameChildren's zyrtec allergy
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength5mg/5ml
    Market StatusOver the Counter
    CompanyMcneil Consumer

    17 of 20  
    Drug NameChildren's zyrtec hives relief
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength5mg/5ml
    Market StatusOver the Counter
    CompanyMcneil Consumer

    18 of 20  
    Drug NameZyrtec
    Active IngredientCetirizine hydrochloride
    Dosage FormSyrup
    RouteOral
    Strength5mg/5ml
    Market StatusPrescription
    CompanyMcneil Consumer

    19 of 20  
    Drug NameZyrtec allergy
    Active IngredientCetirizine hydrochloride
    Dosage FormTablet; Tablet, orally disintegrating
    RouteOral
    Strength5mg; 10mg
    Market StatusOver the Counter
    CompanyMcneil Consumer

    20 of 20  
    Drug NameZyrtec hives relief
    Active IngredientCetirizine hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusOver the Counter
    CompanyMcneil Consumer

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists, Non-Sedating

    A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. (See all compounds classified as Histamine H1 Antagonists, Non-Sedating.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]

    API Reference Price

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    03-Jan-2021
    31-Aug-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (USD/KGS)    		 Number of Transactions

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    DOSAGE - SOLUTION;ORAL - 5MG/5ML

    USFDA APPLICATION NUMBER - 22155

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    DOSAGE - CAPSULE;ORAL - 5MG

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