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CHEBI:53757

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ACTIVE PHARMA INGREDIENTS

3 API Suppliers, 1 USDMF, 2 CEP/COS, 1 EU WC

3 API Suppliers
1 USDMF
2 CEP/COS
1 EU WC

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

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GLOBAL SALES INFORMATION

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Finished Drug Prices

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0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Ziprasidone mesylate, 199191-69-0, Ziprasidone mesilate, Ziprasidone mesylate trihydrate, Ziprasidone mesylate [usan], Ziprasidone mesilate trihydrate

Molecular Formula

C₂₂H₃₁ClN₄O₇S₂

Molecular Weight

563.1 g/mol

InChI Key

WLQZEFFFIUHSJB-UHFFFAOYSA-N

FDA UNII

3X6SAX83JZ

Ziprasidone Mesylate is the mesylate salt form of ziprasidone, a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone mesylate functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone mesylate also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone mesylate exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors.

1 2D Structure

CHEBI:53757

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one;methanesulfonic acid;trihydrate

2.1.2 InChI

InChI=1S/C21H21ClN4OS.CH4O3S.3H2O/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;1-5(2,3)4;;;/h1-4,11,13H,5-10,12H2,(H,23,27);1H3,(H,2,3,4);3*1H2

2.1.3 InChI Key

WLQZEFFFIUHSJB-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CS(=O)(=O)O.C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54.O.O.O

2.2 Other Identifiers

2.2.1 UNII

3X6SAX83JZ

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 5-(2-(4-(3-benzisothiazolyl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one

2. Cp 88059

3. Cp 88059-01

4. Cp-88,059

5. Cp-88,059-01

6. Cp-88,059-1

7. Ziprasidone

8. Ziprasidone Hydrochloride

9. Ziprasidone Hydrochloride, Monohydrate

10. Ziprazidone

2.3.2 Depositor-Supplied Synonyms

1. Ziprasidone Mesylate

2. 199191-69-0

3. Ziprasidone Mesilate

4. Ziprasidone Mesylate Trihydrate

5. Ziprasidone Mesylate [usan]

6. Ziprasidone Mesilate Trihydrate

7. Ziprasidone Mesylate Hydrate

8. 3x6sax83jz

9. Ziprasidone (mesylate Hydrate)

10. Cp-88, 059-27

11. Nsc-760351

12. Cp-8805927

13. Geodon (tn)

14. Cp-88,059-27

15. Ziprasidone Mesylate (usan)

16. 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one;methanesulfonic Acid;trihydrate

17. Cp-88059-27

18. 2h-indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-, Monomethanesulfonate, Trihydrate

19. 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-2-indolinone Monomethanesulfonate, Trihydrate

20. Unii-3x6sax83jz

21. Chembl3989833

22. Chebi:53757

23. Ziprasidone (mesylate Trihydrate)

24. Bcp12408

25. Ziprasidone Mesylate [vandf]

26. Hy-14542b

27. Ziprasidone Mesilate [mart.]

28. Cp88059

29. Nsc 760351

30. Bz164581

31. Ziprasidone Mesylate [orange Book]

32. D02100

33. 191z690

34. A814073

35. Q27124195

36. Ziprasidone Mesilate Trihydrate [ep Monograph]

37. 2h-indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-, Methanesulfonate, Hydrate (1:1:3)

38. 5-[2-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydroindol-2-one; Methanesulfonic Acid; Trihydrate

39. 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloranyl-1,3-dihydroindol-2-one; Methanesulfonic Acid; Trihydrate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₃₁ClN₄O₇S₂
Molecular Weight	563.1 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	4
Exact Mass	562.1322694 g/mol
Monoisotopic Mass	562.1322694 g/mol
Topological Polar Surface Area	143 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	665
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	5

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

Serotonin Antagonists

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Atypical Antipsychotic [EPC]

API SUPPLIERS

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USDMF

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CEP/COS

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EU WC

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ABOUT THIS PAGE

CHEBI:53757 Manufacturers

A CHEBI:53757 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CHEBI:53757, including repackagers and relabelers. The FDA regulates CHEBI:53757 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CHEBI:53757 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

CHEBI:53757 Suppliers

A CHEBI:53757 supplier is an individual or a company that provides CHEBI:53757 active pharmaceutical ingredient (API) or CHEBI:53757 finished formulations upon request. The CHEBI:53757 suppliers may include CHEBI:53757 API manufacturers, exporters, distributors and traders.

click here to find a list of CHEBI:53757 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

CHEBI:53757 USDMF

A CHEBI:53757 DMF (Drug Master File) is a document detailing the whole manufacturing process of CHEBI:53757 active pharmaceutical ingredient (API) in detail. Different forms of CHEBI:53757 DMFs exist exist since differing nations have different regulations, such as CHEBI:53757 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A CHEBI:53757 DMF submitted to regulatory agencies in the US is known as a USDMF. CHEBI:53757 USDMF includes data on CHEBI:53757's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The CHEBI:53757 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of CHEBI:53757 suppliers with USDMF on PharmaCompass.

CHEBI:53757 CEP

A CHEBI:53757 CEP of the European Pharmacopoeia monograph is often referred to as a CHEBI:53757 Certificate of Suitability (COS). The purpose of a CHEBI:53757 CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of CHEBI:53757 EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of CHEBI:53757 to their clients by showing that a CHEBI:53757 CEP has been issued for it. The manufacturer submits a CHEBI:53757 CEP (COS) as part of the market authorization procedure, and it takes on the role of a CHEBI:53757 CEP holder for the record. Additionally, the data presented in the CHEBI:53757 CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the CHEBI:53757 DMF.

A CHEBI:53757 CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. CHEBI:53757 CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of CHEBI:53757 suppliers with CEP (COS) on PharmaCompass.

CHEBI:53757 WC

A CHEBI:53757 written confirmation (CHEBI:53757 WC) is an official document issued by a regulatory agency to a CHEBI:53757 manufacturer, verifying that the manufacturing facility of a CHEBI:53757 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting CHEBI:53757 APIs or CHEBI:53757 finished pharmaceutical products to another nation, regulatory agencies frequently require a CHEBI:53757 WC (written confirmation) as part of the regulatory process.

click here to find a list of CHEBI:53757 suppliers with Written Confirmation (WC) on PharmaCompass.

CHEBI:53757 GMP

CHEBI:53757 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of CHEBI:53757 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CHEBI:53757 GMP manufacturer or CHEBI:53757 GMP API supplier for your needs.

CHEBI:53757 CoA

A CHEBI:53757 CoA (Certificate of Analysis) is a formal document that attests to CHEBI:53757's compliance with CHEBI:53757 specifications and serves as a tool for batch-level quality control.

CHEBI:53757 CoA mostly includes findings from lab analyses of a specific batch. For each CHEBI:53757 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

CHEBI:53757 may be tested according to a variety of international standards, such as European Pharmacopoeia (CHEBI:53757 EP), CHEBI:53757 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CHEBI:53757 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.