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Chemistry

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Also known as: Ceftolozane, Cxa-101 free base, Cxa-101, Chembl2103872
Molecular Formula
C23H30N12O8S2
Molecular Weight
666.7  g/mol
InChI Key
JHFNIHVVXRKLEF-DCZLAGFPSA-N

CHEMBL2103872
Ceftolozane is a semi-synthetic, broad-spectrum, fifth-generation cephalosporin antibiotic with bactericidal activity against certain Gram-negative and Gram-positive bacteria. Upon administration, ceftolozane binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. This interferes with the final transpeptidation step required to form peptidoglycan chain cross-links, which are a key component of and provide strength and rigidity to the bacterial cell wall. This inhibits bacterial cell wall synthesis and reduces cell wall stability, which weakens the bacterial cell wall and causes bacterial cell lysis.
1 2D Structure

CHEMBL2103872

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(Z)-[2-[[(6R,7R)-3-[[3-amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]amino]-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene]amino]oxy-2-methylpropanoate
2.1.2 InChI
InChI=1S/C23H30N12O8S2/c1-23(2,20(40)41)43-31-11(15-30-21(26)45-32-15)16(36)29-12-17(37)35-13(19(38)39)9(8-44-18(12)35)6-34-7-10(14(25)33(34)3)28-22(42)27-5-4-24/h7,12,18,25H,4-6,8,24H2,1-3H3,(H7,26,27,28,29,30,32,36,38,39,40,41,42)/b31-11-/t12-,18-/m1/s1
2.1.3 InChI Key
JHFNIHVVXRKLEF-DCZLAGFPSA-N
2.1.4 Canonical SMILES
CC(C)(C(=O)[O-])ON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC(=C(N4C)N)NC(=O)NCCN)C(=O)O
2.1.5 Isomeric SMILES
CC(C)(C(=O)[O-])O/N=C(/C1=NSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC(=C(N4C)N)NC(=O)NCCN)C(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Ceftolozane

2. Ceftolozane Sulfate

3. Cxa-101

4. Fr 264205

5. Fr-264205

6. Fr26 4205

7. Fr264205

2.2.2 Depositor-Supplied Synonyms

1. Ceftolozane

2. Cxa-101 Free Base

3. Cxa-101

4. Chembl2103872

2.3 Create Date
2013-05-30
3 Chemical and Physical Properties
Molecular Weight 666.7 g/mol
Molecular Formula C23H30N12O8S2
XLogP3-3.2
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count16
Rotatable Bond Count11
Exact Mass666.17509831 g/mol
Monoisotopic Mass666.17509831 g/mol
Topological Polar Surface Area356 Ų
Heavy Atom Count45
Formal Charge0
Complexity1280
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


ABOUT THIS PAGE

Looking for 689293-68-3 / CHEMBL2103872 API manufacturers, exporters & distributors?

CHEMBL2103872 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of CHEMBL2103872 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right CHEMBL2103872 manufacturer or CHEMBL2103872 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred CHEMBL2103872 manufacturer or CHEMBL2103872 supplier.

PharmaCompass also assists you with knowing the CHEMBL2103872 API Price utilized in the formulation of products. CHEMBL2103872 API Price is not always fixed or binding as the CHEMBL2103872 Price is obtained through a variety of data sources. The CHEMBL2103872 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

CHEMBL2103872

Synonyms

Ceftolozane, Cxa-101 free base, Cxa-101

Cas Number

689293-68-3

About CHEMBL2103872

Ceftolozane is a semi-synthetic, broad-spectrum, fifth-generation cephalosporin antibiotic with bactericidal activity against certain Gram-negative and Gram-positive bacteria. Upon administration, ceftolozane binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. This interferes with the final transpeptidation step required to form peptidoglycan chain cross-links, which are a key component of and provide strength and rigidity to the bacterial cell wall. This inhibits bacterial cell wall synthesis and reduces cell wall stability, which weakens the bacterial cell wall and causes bacterial cell lysis.

CHEMBL2103872 Manufacturers

A CHEMBL2103872 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CHEMBL2103872, including repackagers and relabelers. The FDA regulates CHEMBL2103872 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CHEMBL2103872 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

CHEMBL2103872 Suppliers

A CHEMBL2103872 supplier is an individual or a company that provides CHEMBL2103872 active pharmaceutical ingredient (API) or CHEMBL2103872 finished formulations upon request. The CHEMBL2103872 suppliers may include CHEMBL2103872 API manufacturers, exporters, distributors and traders.

CHEMBL2103872 GMP

CHEMBL2103872 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of CHEMBL2103872 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CHEMBL2103872 GMP manufacturer or CHEMBL2103872 GMP API supplier for your needs.

CHEMBL2103872 CoA

A CHEMBL2103872 CoA (Certificate of Analysis) is a formal document that attests to CHEMBL2103872's compliance with CHEMBL2103872 specifications and serves as a tool for batch-level quality control.

CHEMBL2103872 CoA mostly includes findings from lab analyses of a specific batch. For each CHEMBL2103872 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

CHEMBL2103872 may be tested according to a variety of international standards, such as European Pharmacopoeia (CHEMBL2103872 EP), CHEMBL2103872 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CHEMBL2103872 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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